4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic-acid has been researched along with Edema* in 1 studies
1 other study(ies) available for 4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic-acid and Edema
| Article | Year |
|---|---|
Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects.
Inhibition of the soluble epoxide hydrolase (sEH) is a promising new therapeutic approach in the treatment of inflammation. Driven by the in-house database product lead 1, a hybridization strategy was utilized for the design of a series of novel benzo [d]thiazol derivatives. To our delight, D016, a byproduct of compound 9, was obtained with an extraordinarily low IC Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Carrageenan; Cell Survival; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Epoxide Hydrolases; Hep G2 Cells; Humans; Inflammation; Ligands; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2021 |