4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone has been researched along with Neuroblastoma in 34 studies
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone: Inhibitor of phosphodiesterases.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells." | 7.69 | [3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994) |
| "The elevation of cyclic adenosine 3':5'-monophosphate (cyclic AMP) in response to adenosine in C-1300 murine neuroblastoma (clone N2a) in surface culture is increased in magnitude in cultures pretreated overnight with theophylline or adenosine deaminase." | 7.65 | Control of cyclic adenosine 3':5'-monophosphate-elevating effect of adenosine in C-1300 murine neuroblastoma in tissue culture. ( Green, RD, 1977) |
| "To clarify the functional significance of type IV phosphodiesterase (PDEIV) in neurons and glia cells [3H]rolipram binding and phosphodiesterase (PDE) activity were examined in cytosol and membrane fractions of neuroblastoma N18TG-2 and glioma C6Bu-1 cells." | 3.69 | [3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1. ( Hasegawa, H; Murayama, T; Nogiri, S; Nomura, Y; Tohda, M, 1994) |
| "Following earlier observations that increasing the polyunsaturated fatty-acid (PUFA) content of N1E-115 neuroblastoma cells elevated basal and adenosine (Ado)-stimulated intracellular cyclic AMP (cAMP) formation, we carried out studies to determine the mechanism(s) by which PUFA exerted their modulatory effects." | 3.68 | Further studies of the mechanism(s) of polyunsaturated-fatty-acid-mediated increases in intracellular cAMP formation in N1E-115 neuroblastoma cells. ( Byczko, Z; Murphy, MG, 1992) |
| "Adenosine, 2-chloroadenosine and prostaglandin E1 which are known to increase cyclic AMP in neuroblastoma cells potentiated the acetylcholine-induced muscarinic hyperpolarization of the cells without changing the resting membrane potential." | 3.67 | Cyclic AMP-mediated potentiation of muscarinic hyperpolarization in neuroblastoma cells. ( Narahashi, T; Tsunoo, A, 1984) |
| "The elevation of cyclic adenosine 3':5'-monophosphate (cyclic AMP) in response to adenosine in C-1300 murine neuroblastoma (clone N2a) in surface culture is increased in magnitude in cultures pretreated overnight with theophylline or adenosine deaminase." | 3.65 | Control of cyclic adenosine 3':5'-monophosphate-elevating effect of adenosine in C-1300 murine neuroblastoma in tissue culture. ( Green, RD, 1977) |
| "The inhibitors of cyclic AMP phosphodiesterase (papaverine and 4-(-3-butoxy-4-methoxybenzyl)-2-imidazolidinone), serum-free medium, and x irradiation caused cell death and neurite formation in human neuroblastoma cells in culture (IMR-32), whereas theophylline was ineffective." | 3.65 | Role of cyclic AMP in differentiation of human neuroblastoma cells in culture. ( Kumar, S; Prasad, KN, 1975) |
| "The effect of heat in combination with DL-alpha-tocopheryl (vitamin E) succinate and adenosine 3', 5'-cyclic monophosphate (cAMP) stimulating agents on mouse neuroblastoma cells ( NBP2 ) in culture on the criterion of growth inhibition (due to cell death and inhibition of cell division) was studied." | 1.27 | Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture. ( Prasad, KN; Rama, BN, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (67.65) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, B | 1 |
| Hanson, AJ | 2 |
| Prasad, KN | 17 |
| Nahreini, P | 1 |
| Andreatta, C | 1 |
| Yan, XD | 1 |
| Morrison, MR | 1 |
| Hall, CL | 1 |
| Pardue, S | 1 |
| Brodeur, R | 1 |
| Baskin, F | 1 |
| Rosenberg, RN | 1 |
| Tank, AW | 2 |
| Weiner, N | 2 |
| Williams, LR | 2 |
| Sandquist, D | 2 |
| Black, AC | 1 |
| Williams, TH | 2 |
| Tsunoo, A | 1 |
| Narahashi, T | 1 |
| Rama, BN | 2 |
| Anderson, DW | 1 |
| Crowle, AJ | 1 |
| Sandra, A | 1 |
| Tohda, M | 1 |
| Murayama, T | 1 |
| Hasegawa, H | 1 |
| Nogiri, S | 1 |
| Nomura, Y | 1 |
| Kentroti, S | 2 |
| Edwards-Prasad, J | 2 |
| Vernadakis, A | 3 |
| Imam, M | 1 |
| Carvalho, E | 2 |
| Kumar, S | 2 |
| La Rosa, FG | 3 |
| Prasad, JE | 3 |
| Hovland, AR | 2 |
| Hovland, PG | 1 |
| Cole, WC | 2 |
| Kumar, A | 2 |
| Waymire, JC | 1 |
| Gilmer-Waymire, K | 1 |
| Boehme, RE | 1 |
| Spuhler, K | 2 |
| Arnold, EB | 1 |
| Propst, F | 1 |
| Moroder, L | 1 |
| Wünsch, E | 1 |
| Hamprecht, B | 1 |
| Becker, G | 1 |
| Tripathy, K | 1 |
| Bachrach, U | 1 |
| Fogleman, D | 1 |
| Gaschler, M | 1 |
| Sinha, PK | 2 |
| Brown, JL | 1 |
| Ehrlich, YH | 1 |
| Brunngraber, EG | 1 |
| Green, RD | 2 |
| Noland, TA | 1 |
| Nobles, E | 1 |
| Lichtshtein, D | 1 |
| Boone, G | 1 |
| Blume, A | 1 |
| Prasad, N | 1 |
| Prasad, R | 1 |
| Murphy, MG | 2 |
| Byczko, Z | 2 |
| Cohrs, RJ | 1 |
| Torelli, S | 1 |
| Sharma, OK | 1 |
34 other studies available for 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone and Neuroblastoma
| Article | Year |
|---|---|
Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcysteine; Adenylyl Cyclase Inhibitors; Animals | 2004 |
Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Cell Line, Tumor; Cyclic AMP; Gene Silencing; Genes, | 2005 |
The synthesis and degradation of poly(a)-containing mRNAs in mouse neuroblastoma cells treated with dibutyryl cAMP or with Ro20-1724.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bucladesine; Cell Line; Clone Cells; Imidaz | 1980 |
Effect of carbachol and 56 mm-potassium chloride on the cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Car | 1981 |
Glucocorticoids increase tyrosine hydroxylase activity in cultured murine neuroblastoma.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Androstenedione; Animals; Cells, Cultured; Cortodoxo | 1981 |
Induction of tyrosine hydroxylase by glucocorticoids in mouse neuroblastoma cells. Enhancement of the induction by cyclic AMP.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cells, Cultured; Cyclic AMP; Dactinomycin; | 1982 |
Cyclic AMP-mediated potentiation of muscarinic hyperpolarization in neuroblastoma cells.
Topics: 2-Chloroadenosine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenosine; Alprost | 1984 |
Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Division; Cell Line; Cell Survival; Cy | 1984 |
Regression and differentiation of neuroblastoma tumors in mice treated with differentiating agents--prostaglandin E1 and a phosphodiesterase inhibitor, RO 20-1724.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Animals; Cell Differentiation; Drug The | 1982 |
Acyltransferase activity and cytochemical localization in differentiating neuroblastoma.
Topics: 1-Acylglycerol-3-Phosphate O-Acyltransferase; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acyltr | 1981 |
[3H]Rolipram binding and phosphodiesterase activity in neuroblastoma N18TG-2 and glioma C6Bu-1.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imi | 1994 |
Modification of the expression of adenosine 3',5'-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Animals; beta Carotene; Carotenoids; Ce | 1994 |
Differential regulation of phenotypic expression in a pluripotential neuroblastoma cell line.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Choline O-Acetyltransferase; Humans; Ne | 1994 |
Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Amyloid beta-Peptides; Animals; Buclade | 1998 |
Cyclosporin A regulates the levels of cyclophilin A in neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Animals; Cell Differentiation; Cyclic A | 1999 |
Relative sensitivity of undifferentiated and cyclic adenosine 3',5'-monophosphate-induced differentiated neuroblastoma cells to cyclosporin A: potential role of beta-amyloid and ubiquitin in neurotoxicity.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amyloid beta-Peptides; Amyloid beta-Protein Precurso | 2000 |
Concomitant elevation of tyrosine hydroxylase and dopamine beta-hydroxylase by cyclic AMP in cultured mouse neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bucladesine; Cell Line; Cyclic AMP; Dopamine beta-Hy | 1978 |
Modification of response of mouse neuroblastoma cells in culture by serum type.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Blood; Cell Differentiation; Cell Division; | 1979 |
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP | 1979 |
Differences and similarities between guanosine 3',5'-cyclic monophosphate phosphodiesterase and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in neuroblastoma cells in culture.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Buffer | 1975 |
Cyclic AMP-mediated induction of ornithine decarboxylase of glioma and neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bucladesine; Carboxy-Lyases; Cell Line; Cyclic AMP; | 1975 |
Cyclic nucleotide-dependent protein kinase activity in malignant and cyclic AMP-induced "differentiated" neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Butyrates; Cell Differentiation; Cell Line; | 1976 |
Specific alterations in phosphorylation of cytosol proteins from differentiating neuroblastoma cells grown in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Cell Differentiation; Cells, Cultured; Cyclic AMP; C | 1977 |
Control of cyclic adenosine 3':5'-monophosphate-elevating effect of adenosine in C-1300 murine neuroblastoma in tissue culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Deaminase; Cell Line; Cyclic AM | 1977 |
Activation of cyclic AMP-dependent protein kinase and stimulation of protein phosphorylation in response to adenosine in C-1300 murine neuroblastoma.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Animals; Cell Line; Cyclic AMP; Enzyme Ac | 1979 |
Effect of sodium butyrate in combination with X-irradiation, chemotherapeutic and cyclic AMP stimulating agents on neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antineoplastic Agents; Butyrates; Cell Line | 1979 |
Effects of methylmercuric chloride in the presence of cyclic AMP-stimulating agents on glioma and neuroblastoma cells in culture.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cell Differentiation; Cell Division; Clone | 1979 |
Role of cyclic AMP in differentiation of human neuroblastoma cells in culture.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Bucladesine; Bu | 1975 |
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenylyl Cyclase Inhibitors; Adenylyl | 1979 |
Altered enzyme expression in "differentiated" murine neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alcohol Oxidoreductases; Animals; Brain; Cell Transf | 1976 |
Non-eicosanoid functions of essential fatty acids: regulation of adenosine-related functions in cultured neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Deaminase; Animals; Calcium; Co | 1992 |
Further studies of the mechanism(s) of polyunsaturated-fatty-acid-mediated increases in intracellular cAMP formation in N1E-115 neuroblastoma cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Basal Metabolism; Colfor | 1992 |
Effect of vitamin E succinate and a cAMP-stimulating agent on the expression of c-myc and N-myc and H-ras in murine neuroblastoma cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Blotti | 1991 |
Modification of the hyperthermic response on neuroblastoma cells by cAMP and sodium butyrate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Butyrates; Butyric Acid; Cell Line; Cell Su | 1986 |