4-(3--4--dimethoxyphenyl)but-3-en-1-ol and Edema

An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded thermal-accelerated decomposition of compound D in the gel (p < 0.05) but did not change the activation energy of compound D. Niosomes enhanced in vitro permeation rate of compound D from the gel. Topical applications of ZC noisome gel gave a faster change in tail flick latency than piroxicam gel and hydrocortisone cream (p < 0.05) while there were insignificant differences in anti-inflammatory activity up to 6 h using croton oil-induced ear edema model in mice (p > 0.05). Thus, encapsulation of ZC extract in niosomes enhanced chemical stability and skin permeation with comparable topical anti-inflammatory effects to steroid and NSAID.

Topics: Administration, Topical; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Butanols; Drug Stability; Edema; Gels; Liposomes; Male; Mice; Mice, Inbred ICR; Organ Culture Techniques; Pain Measurement; Plant Extracts; Random Allocation; Skin Absorption; Swine; Zingiber officinale