Compounds > 4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid
Page last updated: 2024-09-03

4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid and Colorectal Neoplasms

4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid has been researched along with Colorectal Neoplasms in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blakey, DC; Boyle, FT; Burke, PJ; Connors, TA; Davies, DH; Dowell, RI; Hadley, EM; Mauger, AB; Melton, RG; Springer, CJ1
Begent, RH; Martin, J; Napier, M; Poon, GK; Sharma, SK; Springer, CJ; Stribbling, SM1
Begent, RH; Boden, R; Boxer, GM; Davies, L; Pedley, RB; Sharma, SK; Springer, CJ; Stribbling, SM1
Bagshawe, KD; Begent, RH; Cushen, N; Green, AJ; Martin, J; Napier, MP; O'Malley, D; Sharma, SK; Springer, CJ; Stribbling, SM1
Friedlos, F; Marais, R; Martin, J; Spooner, RA; Springer, CJ1

Trials

2 trial(s) available for 4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid and Colorectal Neoplasms

ArticleYear
Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial.
    Cancer chemotherapy and pharmacology, 1997, Volume: 40, Issue:3

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Female; gamma-Glutamyl Hydrolase; Glutamates; Humans; Immunoconjugates; Immunotherapy; Male; Mass Spectrometry; Nitrogen Mustard Compounds; Prodrugs

1997
Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:3

    Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoembryonic Antigen; Colorectal Neoplasms; Female; gamma-Glutamyl Hydrolase; Glutamates; Humans; Male; Middle Aged; Neutropenia; Nitrogen Mustard Compounds; Prodrugs; Survival Analysis; Thrombocytopenia; Treatment Outcome

2000

Other Studies

3 other study(ies) available for 4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid and Colorectal Neoplasms

ArticleYear
New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
    Journal of medicinal chemistry, 1996, Mar-01, Volume: 39, Issue:5

    Topics: Aniline Mustard; Antineoplastic Agents; Cell Death; Cell Division; Colorectal Neoplasms; gamma-Glutamyl Hydrolase; Humans; Immunotoxins; Molecular Structure; Prodrugs; Tumor Cells, Cultured

1996
Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent.
    Cancer research, 1999, Aug-15, Volume: 59, Issue:16

    Topics: Animals; Antineoplastic Agents; Carcinoembryonic Antigen; Colorectal Neoplasms; Female; gamma-Glutamyl Hydrolase; Glutamates; Humans; Immunoconjugates; Immunoglobulin Fab Fragments; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrogen Mustard Compounds; Prodrugs; Transplantation, Heterologous; Xanthenes; Xanthones

1999
In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug.
    Cancer gene therapy, 2000, Volume: 7, Issue:10

    Topics: Animals; Chlorocebus aethiops; Colorectal Neoplasms; COS Cells; DNA Primers; Electrophoresis, Polyacrylamide Gel; Female; gamma-Glutamyl Hydrolase; Genetic Therapy; Genetic Vectors; Glutamates; Humans; Mutation; Nitrogen Mustard Compounds; Ovarian Neoplasms; Polymerase Chain Reaction; Prodrugs; Tumor Cells, Cultured

2000