3-nitropropionic acid has been researched along with Neurodegenerative Diseases in 48 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Resveratrol is a naturally occurring stilbene which has shown promising results as treatment for several neurodegenerative diseases." | 7.88 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. ( Adán, N; Belmonte-Reche, E; Caro, M; Delgado, M; González-Rey, E; Mateos-Martín, ML; Morales, JC; Peñalver, P, 2018) |
| "Resveratrol is a naturally occurring stilbene which has shown promising results as treatment for several neurodegenerative diseases." | 3.88 | Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases. ( Adán, N; Belmonte-Reche, E; Caro, M; Delgado, M; González-Rey, E; Mateos-Martín, ML; Morales, JC; Peñalver, P, 2018) |
| " The injections of MitoTracker Red CM-H(2)XRos revealed generation of mitochondrial free radicals primarily in vulnerable neurons following focal cerebral ischemia as well as administration of Fe(2+) or 3-nitropropionic acid." | 3.71 | Analysis of mitochondrial free radical generation in animal models of neuronal disease. ( Gwag, BJ; Kim, DY; Won, SJ, 2002) |
| "The 3-nitropropionic acid animal model is a model where excitotoxicity, mitochondrial dysfunction and oxidative stress, mechanisms common to various neurodegenerative diseases, are involved." | 3.71 | Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation. ( Angevaren, M; Appels, M; de Bruijn, C; de Vente, J; Prickaerts, J; Steinbusch, HW; Teunissen, CE, 2001) |
| "Creatine, however, was still neuroprotective in mice, which were deficient in mitochondrial creatine kinase." | 2.47 | Neuroprotective effects of creatine. ( Beal, MF, 2011) |
| "Fluconazole was able to prevent neurite retraction and cell death in in vitro and in vivo models of toxicity." | 1.72 | Fluconazole Is Neuroprotective via Interactions with the IGF-1 Receptor. ( Bachani, M; Johnson, TP; Lee, MH; Malik, N; Nath, A; Ruffin, A; Steiner, JP; Toodle, V; Vivekanandhan, S; Wang, T, 2022) |
| "Treatment with naringin ameliorated the reduced glutathione/oxidized glutathione ratio with concomitant decrease in the levels of hydroxyl radical, hydroperoxide and nitrite in 3-NP-induced rats." | 1.38 | Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. ( Gopinath, K; Sudhandiran, G, 2012) |
| "Quinolinic acid (QUIN) was used as a typical excitotoxic/pro-oxidant inducer, 3-nitropropionic acid (3-NP) was employed as a mitochondrial function inhibitor, and their combination (QUIN + 3-NP) was also evaluated in in vitro studies." | 1.36 | Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine. ( Elinos-Calderón, D; Galván-Arzate, S; Maldonado, PD; Pedraza-Chaverrí, J; Pérez-De La Cruz, V; Robledo-Arratia, Y; Santamaría, A, 2010) |
| "Several human neurodegenerative disorders are characterized by the accumulation of 8-oxo-7,8-dihydroguanine (8-oxodG) in the DNA of affected neurons." | 1.35 | A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration. ( Bignami, M; Crescenzi, M; De Luca, G; Degan, P; Mattei, E; Meccia, E; Nakabeppu, Y; Pepponi, R; Pèzzola, A; Popoli, P; Russo, MT; Tiveron, C; Ventura, I; Zijno, A, 2008) |
| "5 h after each dose were exposed to microwave radiation at a whole body averaged specific absorption rate (SAR) of 0 (sham exposure), 0." | 1.33 | Acute effects of pulsed microwaves and 3-nitropropionic acid on neuronal ultrastructure in the rat caudate-putamen. ( Phelix, CF; Seaman, RL, 2005) |
| " These results indicate that antagonists of NMDA-type glutamate receptors are protective during the toxic outcome associated with mitochondrial dysfunction." | 1.33 | 3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism. ( Bahr, BA; Baude, AS; Brown, QB; Karanian, DA; Parsons, CG, 2006) |
| "Striatal gliosis induced by 3-NP treatment was prevented by (+/-)-huprine Y pretreatment, as demonstrated by the attenuation of both the increase in [(3)H]PK 11195 specific binding indicative of microgliosis and the expression of hsp27 kDa, a chaperone expressed mainly in astrocytes." | 1.32 | Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage. ( Camins, A; Camps, P; Canudas, AM; Jiménez, A; Muñoz-Torrero, D; Pallàs, M; Pubill, D; Sureda, FX; Verdaguer, E, 2003) |
| "The precise cause of neuronal death in Huntington's disease (HD) is unknown." | 1.32 | Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. ( Beesen, A; Ferrante, RJ; Hersch, SM; Kowall, NW; Kubilus, JK; Lee, J; Luthi-Carter, R; Ratan, RR; Ryu, H; Smith, K; Zucker, B, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.17) | 18.2507 |
| 2000's | 27 (56.25) | 29.6817 |
| 2010's | 15 (31.25) | 24.3611 |
| 2020's | 4 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| El-Shamarka, ME | 1 |
| El-Sahar, AE | 1 |
| Saad, MA | 1 |
| Assaf, N | 1 |
| Sayed, RH | 1 |
| Toodle, V | 1 |
| Lee, MH | 1 |
| Bachani, M | 1 |
| Ruffin, A | 1 |
| Vivekanandhan, S | 1 |
| Malik, N | 1 |
| Wang, T | 1 |
| Johnson, TP | 1 |
| Nath, A | 1 |
| Steiner, JP | 1 |
| Okada, N | 1 |
| Nakamura, S | 1 |
| Shimazawa, M | 1 |
| Ranganayaki, S | 1 |
| Jamshidi, N | 1 |
| Aiyaz, M | 1 |
| Rashmi, SK | 1 |
| Gayathri, N | 1 |
| Harsha, PK | 1 |
| Padmanabhan, B | 1 |
| Srinivas Bharath, MM | 1 |
| Peñalver, P | 1 |
| Belmonte-Reche, E | 1 |
| Adán, N | 1 |
| Caro, M | 1 |
| Mateos-Martín, ML | 1 |
| Delgado, M | 1 |
| González-Rey, E | 1 |
| Morales, JC | 1 |
| Cho, KJ | 2 |
| Kim, HW | 1 |
| Cheon, SY | 2 |
| Lee, JE | 1 |
| Kim, GW | 3 |
| Brouillet, E | 3 |
| Ayyappan, P | 1 |
| Palayyan, SR | 1 |
| Kozhiparambil Gopalan, R | 1 |
| Qi, L | 1 |
| Sun, X | 1 |
| Li, FE | 1 |
| Zhu, BS | 1 |
| Braun, FK | 1 |
| Liu, ZQ | 1 |
| Tang, JL | 1 |
| Wu, C | 1 |
| Xu, F | 1 |
| Wang, HH | 1 |
| Velasquez, LA | 1 |
| Zhao, K | 1 |
| Lei, FR | 1 |
| Zhang, JG | 1 |
| Shen, YT | 1 |
| Zou, JX | 1 |
| Meng, HM | 1 |
| An, GL | 1 |
| Yang, L | 2 |
| Zhang, XD | 1 |
| Calderón Guzmán, D | 1 |
| Brizuela, NO | 1 |
| Ortíz Herrera, M | 1 |
| Hernández García, E | 1 |
| Barragán Mejía, G | 1 |
| Juárez Olguín, H | 1 |
| Valenzuela Peraza, A | 1 |
| Attilus, J | 1 |
| Labra Ruíz, N | 1 |
| Mu, S | 1 |
| Li, Y | 1 |
| Liu, B | 1 |
| Wang, W | 1 |
| Chen, S | 1 |
| Wu, J | 1 |
| OuYang, L | 1 |
| Zhu, Y | 1 |
| Li, K | 1 |
| Zhan, M | 1 |
| Liu, Z | 1 |
| Jia, Y | 1 |
| Ma, Y | 1 |
| Lei, W | 1 |
| Chen, SD | 1 |
| Wu, CL | 1 |
| Hwang, WC | 1 |
| Yang, DI | 1 |
| De Luca, G | 1 |
| Russo, MT | 1 |
| Degan, P | 1 |
| Tiveron, C | 1 |
| Zijno, A | 1 |
| Meccia, E | 1 |
| Ventura, I | 1 |
| Mattei, E | 1 |
| Nakabeppu, Y | 2 |
| Crescenzi, M | 1 |
| Pepponi, R | 1 |
| Pèzzola, A | 1 |
| Popoli, P | 1 |
| Bignami, M | 1 |
| Crespo-Biel, N | 1 |
| Camins, A | 3 |
| Gutiérrez-Cuesta, J | 1 |
| Melchiorri, D | 1 |
| Nicoletti, F | 1 |
| Pallàs, M | 3 |
| Canudas, AM | 2 |
| Kumar, P | 1 |
| Kumar, A | 1 |
| Elinos-Calderón, D | 1 |
| Robledo-Arratia, Y | 1 |
| Pérez-De La Cruz, V | 2 |
| Maldonado, PD | 1 |
| Galván-Arzate, S | 1 |
| Pedraza-Chaverrí, J | 1 |
| Santamaría, A | 2 |
| Beal, MF | 5 |
| Duran-Vilaregut, J | 1 |
| Manich, G | 1 |
| Del Valle, J | 1 |
| Vilaplana, J | 1 |
| Pelegrí, C | 1 |
| Gopinath, K | 1 |
| Sudhandiran, G | 1 |
| Sheng, Z | 1 |
| Oka, S | 1 |
| Tsuchimoto, D | 1 |
| Abolhassani, N | 1 |
| Nomaru, H | 1 |
| Sakumi, K | 1 |
| Yamada, H | 1 |
| Kim, DY | 1 |
| Won, SJ | 1 |
| Gwag, BJ | 1 |
| Ryu, JK | 1 |
| Nagai, A | 1 |
| Kim, J | 1 |
| Lee, MC | 1 |
| McLarnon, JG | 1 |
| Kim, SU | 1 |
| Pubill, D | 1 |
| Sureda, FX | 1 |
| Verdaguer, E | 1 |
| Camps, P | 1 |
| Muñoz-Torrero, D | 1 |
| Jiménez, A | 1 |
| Bizat, N | 2 |
| Hermel, JM | 1 |
| Humbert, S | 1 |
| Jacquard, C | 1 |
| Créminon, C | 1 |
| Escartin, C | 1 |
| Saudou, F | 1 |
| Krajewski, S | 1 |
| Hantraye, P | 2 |
| Gasche, Y | 1 |
| Grzeschik, S | 1 |
| Copin, JC | 1 |
| Maier, CM | 1 |
| Chan, PH | 1 |
| Hellweg, R | 1 |
| von Arnim, CA | 1 |
| Büchner, M | 1 |
| Huber, R | 1 |
| Riepe, MW | 1 |
| Ferrante, RJ | 3 |
| Kubilus, JK | 1 |
| Lee, J | 2 |
| Ryu, H | 2 |
| Beesen, A | 1 |
| Zucker, B | 1 |
| Smith, K | 1 |
| Kowall, NW | 1 |
| Ratan, RR | 3 |
| Luthi-Carter, R | 1 |
| Hersch, SM | 1 |
| Klivenyi, P | 2 |
| Starkov, AA | 1 |
| Calingasan, NY | 1 |
| Gardian, G | 1 |
| Browne, SE | 1 |
| Bubber, P | 1 |
| Gibson, GE | 1 |
| Patel, MS | 1 |
| Rosenstock, TR | 1 |
| Carvalho, AC | 1 |
| Jurkiewicz, A | 1 |
| Frussa-Filho, R | 1 |
| Smaili, SS | 1 |
| Chin, PC | 1 |
| Liu, L | 1 |
| Morrison, BE | 1 |
| Siddiq, A | 1 |
| Bottiglieri, T | 1 |
| D'Mello, SR | 1 |
| Seaman, RL | 1 |
| Phelix, CF | 1 |
| Lian, XY | 1 |
| Zhang, Z | 1 |
| Stringer, JL | 1 |
| Canonaco, M | 1 |
| Madeo, M | 1 |
| Alò, R | 1 |
| Giusi, G | 1 |
| Granata, T | 1 |
| Carelli, A | 1 |
| Canonaco, A | 1 |
| Facciolo, RM | 1 |
| Ueberham, U | 1 |
| Ueberham, E | 1 |
| Brückner, MK | 1 |
| Seeger, G | 1 |
| Gärtner, U | 1 |
| Gruschka, H | 1 |
| Gebhardt, R | 1 |
| Arendt, T | 1 |
| Kim, CH | 1 |
| Simon, DK | 1 |
| Aminova, LR | 1 |
| Andreyev, AY | 1 |
| Kushnareva, YE | 1 |
| Murphy, AN | 1 |
| Lonze, BE | 1 |
| Kim, KS | 1 |
| Ginty, DD | 1 |
| Karanian, DA | 1 |
| Baude, AS | 1 |
| Brown, QB | 1 |
| Parsons, CG | 1 |
| Bahr, BA | 1 |
| Bjugstad, KB | 1 |
| Crnic, LS | 1 |
| Goodman, SI | 1 |
| Freed, CR | 1 |
| Ayala, A | 1 |
| Venero, JL | 1 |
| Cano, J | 1 |
| Machado, A | 1 |
| Lee, ST | 1 |
| Park, JE | 1 |
| Kim, DH | 1 |
| Kim, S | 1 |
| Im, WS | 1 |
| Kang, L | 1 |
| Jung, SH | 1 |
| Kim, MW | 1 |
| Chu, K | 1 |
| Kim, M | 1 |
| Silva-Adaya, D | 1 |
| Herrera-Mundo, MN | 1 |
| Mendoza-Macedo, K | 1 |
| Villeda-Hernández, J | 1 |
| Binienda, Z | 1 |
| Ali, SF | 1 |
| Schulz, JB | 1 |
| Matthews, RT | 1 |
| Klockgether, T | 1 |
| Dichgans, J | 1 |
| Nishino, H | 1 |
| Nakajima, K | 1 |
| Kumazaki, M | 1 |
| Fukuda, A | 1 |
| Muramatsu, K | 1 |
| Deshpande, SB | 1 |
| Inubushi, T | 1 |
| Morikawa, S | 1 |
| Borlongan, CV | 1 |
| Sanberg, PR | 1 |
| Seidel, B | 1 |
| Jiang1, L | 1 |
| Wolf, G | 1 |
| Dautry, C | 1 |
| Vaufrey, F | 1 |
| Henry, PG | 1 |
| Condé, F | 1 |
| Bloch, G | 1 |
| Andreassen, OA | 1 |
| Dedeoglu, A | 1 |
| Albers, DW | 1 |
| Carlson, EJ | 1 |
| Epstein, CJ | 1 |
| Teunissen, CE | 1 |
| Steinbusch, HW | 1 |
| Angevaren, M | 1 |
| Appels, M | 1 |
| de Bruijn, C | 1 |
| Prickaerts, J | 1 |
| de Vente, J | 1 |
4 reviews available for 3-nitropropionic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy.
Topics: Animals; Apoptosis; Autophagy; Brain-Derived Neurotrophic Factor; Cells, Cultured; Disease Models, A | 2017 |
Neuroprotective effects of creatine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Creatine; Humans; Neurodegenerative Diseases; | 2011 |
Mitochondrial toxins and neurodegenerative diseases.
Topics: Animals; Disease Models, Animal; Humans; Huntington Disease; Mitochondria; MPTP Poisoning; Neurodege | 2007 |
The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine Agents; Hydr | 1997 |
44 other studies available for 3-nitropropionic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Complement Factor B; Cyclic AMP Response Element-Binding | 2022 |
Fluconazole Is Neuroprotective via Interactions with the IGF-1 Receptor.
Topics: Animals; Antifungal Agents; D-Aspartic Acid; Fluconazole; Insulins; Neurodegenerative Diseases; Neur | 2022 |
3-Nitropropionic Acid Enhances Ferroptotic Cell Death via NOX2-Mediated ROS Generation in STHdhQ111 Striatal Cells Carrying Mutant Huntingtin.
Topics: Animals; Caspases; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurodegenerat | 2023 |
Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Autophagy; Cell Death; Cell Line; Cell Survival; Cells, Cultur | 2021 |
Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases.
Topics: Alkylation; Animals; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Humans; Inflammatio | 2018 |
Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice.
Topics: Animals; Apoptosis; Corpus Striatum; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Mic | 2013 |
The 3-NP Model of Striatal Neurodegeneration.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Male; Neurodegenerative Diseas | 2014 |
Attenuation of Oxidative Damage by Boerhaavia diffusa L. Against Different Neurotoxic Agents in Rat Brain Homogenate.
Topics: Animals; Antioxidants; Brain; DNA Damage; Edetic Acid; Ferrous Compounds; Free Radicals; Lipid Perox | 2016 |
HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation.
Topics: Animals; Apoptosis; Autophagy; Caspase 3; Cell Proliferation; Cells, Cultured; Corpus Striatum; Dise | 2015 |
Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q.
Topics: Animals; Astrocytes; Cell Death; Complement C1q; Corpus Striatum; Dendrites; Disease Models, Animal; | 2016 |
Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid.
Topics: Amino Acids; Animals; Antioxidants; Calcium; Cerebellar Cortex; Cerebellum; Cerebrum; Convulsants; D | 2016 |
Dihydromyricetin Ameliorates 3NP-induced Behavioral Deficits and Striatal Injury in Rats.
Topics: Animals; Apoptosis; Corpus Striatum; Flavonols; Locomotion; Male; Malondialdehyde; Maze Learning; Ne | 2016 |
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Corpus Striatum; Deoxyguanosine; DNA Damage; DNA Repair Enzyme | 2008 |
Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model.
Topics: Amino Acid Chloromethyl Ketones; Aminophenols; Animals; Calpain; Caspases; Cell Survival; Cells, Cul | 2010 |
Protective effects of epigallocatechin gallate following 3-nitropropionic acid-induced brain damage: possible nitric oxide mechanisms.
Topics: Animals; Antioxidants; Behavior, Animal; Catechin; Disease Models, Animal; Dose-Response Relationshi | 2009 |
Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine.
Topics: Animals; Antioxidants; Brain; Corpus Striatum; Cysteine; Disease Models, Animal; Dyskinesia, Drug-In | 2010 |
Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3β in the striatum of rats treated with 3-nitropropionic acid.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Convulsants; Corpus Striatum; | 2012 |
Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway.
Topics: Administration, Oral; Analysis of Variance; Animals; Convulsants; Corpus Striatum; Cyclooxygenase 2; | 2012 |
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.
Topics: Animals; Apoptosis Inducing Factor; Benzamides; Calpain; Cell Nucleus; Corpus Striatum; Dipeptides; | 2012 |
Analysis of mitochondrial free radical generation in animal models of neuronal disease.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Disease Models, Animal; Fluorescent Dyes; Free Radi | 2002 |
Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Apoptosis; Avian Proteins; Basigin; Bl | 2003 |
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Co | 2003 |
In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Brain; Calpain; Caspase 3; Caspase 9; Caspases; Cel | 2003 |
Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Corpus Striatum; Guanosine; Immunohisto | 2003 |
Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation.
Topics: Action Potentials; Amyloid beta-Protein Precursor; Animals; Cell Survival; Drug Administration Sched | 2003 |
Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice.
Topics: Acetylation; Animals; Body Weight; Brain; Butyrates; Disease Models, Animal; Dose-Response Relations | 2003 |
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Caudate Nucleus; Cell Count; Cerebral Cortex; | 2004 |
Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid.
Topics: Animals; Antioxidants; Apoptosis; Astrocytes; Behavior, Animal; Calcium; Cell Survival; Cells, Cultu | 2004 |
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Farnesol; Huntingto | 2004 |
Acute effects of pulsed microwaves and 3-nitropropionic acid on neuronal ultrastructure in the rat caudate-putamen.
Topics: Acute Disease; Animals; Corpus Striatum; Dose-Response Relationship, Radiation; Male; Microwaves; Ne | 2005 |
Protective effects of ginseng components in a rodent model of neurodegeneration.
Topics: Animals; Behavior, Animal; Body Weight; Energy Metabolism; Enzyme Inhibitors; Ginsenosides; Heat-Sho | 2005 |
The histaminergic signaling system exerts a neuroprotective role against neurodegenerative-induced processes in the hamster.
Topics: Animals; Cricetinae; Mesocricetus; Neurodegenerative Diseases; Nitro Compounds; Propionates; Rats; R | 2005 |
Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects.
Topics: Animals; Anti-Bacterial Agents; Apolipoproteins E; Benzothiazoles; Brain; Doxycycline; Gene Expressi | 2005 |
Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.
Topics: Animals; Base Sequence; Brain; Cell Survival; Cerebral Cortex; Cyclic AMP; Cyclic AMP Response Eleme | 2005 |
3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism.
Topics: Animals; Animals, Newborn; Cytoskeleton; Dose-Response Relationship, Drug; Excitatory Amino Acid Ant | 2006 |
Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity.
Topics: Animals; Animals, Newborn; Brain; Brain Diseases, Metabolic, Inborn; Disease Models, Animal; Dose-Re | 2006 |
Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Drug Interactions; Fluoresceins; Gene Expression R | 2008 |
Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.
Topics: Animals; Antioxidants; Brain; Carnitine; Convulsants; Disease Models, Animal; Dose-Response Relation | 2008 |
Estrogen protects against while testosterone exacerbates vulnerability of the lateral striatal artery to chemical hypoxia by 3-nitropropionic acid.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Antineoplastic Agents, Hormonal; Astrocytes; Blo | 1998 |
Differentially displayed genes in neuroblastoma cells treated with a mitochondrial toxin: evidence for possible involvement of ICAM-1 in 3-nitropropionic acid-mediated neurodegeneration.
Topics: Animals; Blotting, Northern; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Gene Expressi | 2000 |
Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid.
Topics: Animals; Aspartic Acid; Biomarkers; Cerebral Cortex; Corpus Striatum; Dyskinesia, Drug-Induced; In S | 2000 |
Limited-time exposure to mitochondrial toxins may lead to chronic progressive neurodegenerative diseases.
Topics: Animals; Cebus; Chronic Disease; Humans; Mitochondria; Neurodegenerative Diseases; Neurotoxins; Nitr | 2000 |
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Carrier Prote | 2001 |
Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation.
Topics: Animals; Behavior, Animal; Discrimination Learning; Disease Models, Animal; Gait Disorders, Neurolog | 2001 |