3-nitropropionic acid has been researched along with Neuroblastoma in 9 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since carvedilol and melatonin act as free-radical scavengers, this study examined the effect of carvedilol (10(-5) M) and melatonin (10(-5) M) on oxidative and cell damage induced by 3NP in N1E-115 neuroblastoma cells." | 7.75 | Neuroprotective effect of carvedilol and melatonin on 3-nitropropionic acid-induced neurotoxicity in neuroblastoma. ( Collado, JA; Espínola, C; Feijóo, M; Gómez, MM; Medina, FJ; Montilla, P; Moreno, E; Muñoz, C; Muntané, J; Ruiz, C; Tasset, I; Túnez, I, 2009) |
| " Since carvedilol and melatonin act as free-radical scavengers, this study examined the effect of carvedilol (10(-5) M) and melatonin (10(-5) M) on oxidative and cell damage induced by 3NP in N1E-115 neuroblastoma cells." | 3.75 | Neuroprotective effect of carvedilol and melatonin on 3-nitropropionic acid-induced neurotoxicity in neuroblastoma. ( Collado, JA; Espínola, C; Feijóo, M; Gómez, MM; Medina, FJ; Montilla, P; Moreno, E; Muñoz, C; Muntané, J; Ruiz, C; Tasset, I; Túnez, I, 2009) |
| " Neuroblastoma SH-SY5Y cells stably overexpressing human tTG or mutated inactive tTG were treated with 3-nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase." | 3.70 | Impaired mitochondrial function results in increased tissue transglutaminase activity in situ. ( Johnson, GV; Lesort, M; Tucholski, J; Zhang, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Kaur, P | 1 |
| Attri, S | 1 |
| Singh, D | 1 |
| Rashid, F | 1 |
| Singh, S | 1 |
| Kumar, A | 1 |
| Kaur, H | 1 |
| Bedi, N | 1 |
| Arora, S | 1 |
| Park, SJ | 1 |
| Jo, DS | 1 |
| Shin, JH | 1 |
| Kim, ES | 1 |
| Jo, YK | 1 |
| Choi, ES | 1 |
| Seo, HM | 1 |
| Kim, SH | 1 |
| Hwang, JJ | 1 |
| Jo, DG | 1 |
| Koh, JY | 1 |
| Cho, DH | 1 |
| Tasset, I | 1 |
| Espínola, C | 1 |
| Medina, FJ | 1 |
| Feijóo, M | 1 |
| Ruiz, C | 1 |
| Moreno, E | 1 |
| Gómez, MM | 1 |
| Collado, JA | 1 |
| Muñoz, C | 1 |
| Muntané, J | 1 |
| Montilla, P | 1 |
| Túnez, I | 1 |
| Jaworska-Feil, L | 1 |
| Jantas, D | 1 |
| Leskiewicz, M | 1 |
| Budziszewska, B | 1 |
| Kubera, M | 1 |
| Basta-Kaim, A | 1 |
| Lipkowski, AW | 1 |
| Lason, W | 1 |
| Raut, A | 1 |
| Iglewski, M | 1 |
| Ratka, A | 1 |
| Seidel, B | 1 |
| Jiang1, L | 1 |
| Wolf, G | 1 |
| Lesort, M | 1 |
| Tucholski, J | 1 |
| Zhang, J | 1 |
| Johnson, GV | 1 |
| Wang, J | 1 |
| Green, PS | 1 |
| Simpkins, JW | 1 |
| Reynolds, LM | 1 |
| Dalton, CF | 1 |
| Reynolds, GP | 1 |
9 other studies available for 3-nitropropionic acid and Neuroblastoma
| Article | Year |
|---|---|
Neuromodulatory effect of 4-(methylthio)butyl isothiocyanate against 3-nitropropionic acid induced oxidative impairments in human dopaminergic SH-SY5Y cells via BDNF/CREB/TrkB pathway.
Topics: Apoptosis; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Survival; Cyclic AMP Response E | 2023 |
Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Chaperonin 10; Down-Regulation; Dynamins; GTP Phosphohydrolases; Humans | 2014 |
Neuroprotective effect of carvedilol and melatonin on 3-nitropropionic acid-induced neurotoxicity in neuroblastoma.
Topics: Animals; Carbazoles; Carvedilol; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Lipi | 2009 |
Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Amyloid beta-Peptides; Animals; Antineoplastic Agents; Apoptosis; Caspa | 2010 |
Differential effects of impaired mitochondrial energy production on the function of mu and delta opioid receptors in neuronal SK-N-SH cells.
Topics: Cell Line, Tumor; Energy Metabolism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamin | 2006 |
Differentially displayed genes in neuroblastoma cells treated with a mitochondrial toxin: evidence for possible involvement of ICAM-1 in 3-nitropropionic acid-mediated neurodegeneration.
Topics: Animals; Blotting, Northern; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Gene Expressi | 2000 |
Impaired mitochondrial function results in increased tissue transglutaminase activity in situ.
Topics: Adenosine Triphosphate; Antioxidants; Calcium; Dose-Response Relationship, Drug; GTP-Binding Protein | 2000 |
Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells.
Topics: Adenosine Triphosphate; Apoptosis; Enzyme Inhibitors; Estradiol; Humans; Membrane Potentials; Mitoch | 2001 |
Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells.
Topics: Animals; Arachidonic Acid; Cell Death; Convulsants; Docosahexaenoic Acids; Dose-Response Relationshi | 2001 |