3-nitropropionic acid has been researched along with Multiple System Atrophy in 12 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by autonomic failure, parkinsonism, cerebellar ataxia, and oligodendrocytic accumulation of alpha-synuclein (alphasyn)." | 7.75 | Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. ( Adame, A; Inglis, C; Lee, PH; Mante, M; Masliah, E; Rockenstein, E; Stefanova, N; Ubhi, K; Wenning, GK, 2009) |
| "Intrastriatal injection of 3-nitropropionic acid results in secondary excitotoxic local damage and retrograde neuronal cell loss in substantia nigra pars compacta, thus mimicking salient features of striatonigral degeneration, the core pathology underlying Parkinsonism associated with multiple system atrophy." | 7.71 | No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy). ( Jellinger, K; Poewe, W; Puschban, Z; Scherfler, C; Seppi, K; Waldner, R; Wenning, GK, 2001) |
| "Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by autonomic failure, parkinsonism, cerebellar ataxia, and oligodendrocytic accumulation of alpha-synuclein (alphasyn)." | 3.75 | Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. ( Adame, A; Inglis, C; Lee, PH; Mante, M; Masliah, E; Rockenstein, E; Stefanova, N; Ubhi, K; Wenning, GK, 2009) |
| "Intrastriatal injection of 3-nitropropionic acid results in secondary excitotoxic local damage and retrograde neuronal cell loss in substantia nigra pars compacta, thus mimicking salient features of striatonigral degeneration, the core pathology underlying Parkinsonism associated with multiple system atrophy." | 3.71 | No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy). ( Jellinger, K; Poewe, W; Puschban, Z; Scherfler, C; Seppi, K; Waldner, R; Wenning, GK, 2001) |
| "Multiple system atrophy is a rapidly progressive neurodegenerative disorder with a markedly reduced life expectancy." | 1.37 | Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy. ( Köllensperger, M; Krismer, F; Pallua, A; Poewe, W; Stefanova, N; Wenning, GK, 2011) |
| "We developed a primate model of striatonigral degeneration (SND), the neuropathology underlying levodopa-unresponsive parkinsonism associated with multiple systemic atrophy (MSA-P), by sequential systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 3-nitropropionic acid (3NP) in a Macaca fascicularis monkey." | 1.31 | Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration. ( Aubert, I; Bezard, E; Fernagut, PO; Ghorayeb, I; Poewe, W; Tison, F; Wenning, GK, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Glat, MJ | 2 |
| Stefanova, N | 6 |
| Wenning, GK | 8 |
| Offen, D | 2 |
| Kaindlstorfer, C | 1 |
| Sommer, P | 1 |
| Georgievska, B | 1 |
| Mather, RJ | 1 |
| Kugler, AR | 1 |
| Poewe, W | 6 |
| Pukaß, K | 1 |
| Goldbaum, O | 1 |
| Richter-Landsberg, C | 1 |
| Ben-Zur, T | 1 |
| Barhum, Y | 1 |
| Ubhi, K | 2 |
| Lee, PH | 2 |
| Adame, A | 2 |
| Inglis, C | 2 |
| Mante, M | 2 |
| Rockenstein, E | 2 |
| Masliah, E | 2 |
| Patrick, C | 1 |
| Park, HJ | 1 |
| Bang, G | 1 |
| Lee, BR | 1 |
| Kim, HO | 1 |
| Köllensperger, M | 1 |
| Krismer, F | 1 |
| Pallua, A | 1 |
| Reindl, M | 1 |
| Neumann, M | 1 |
| Haass, C | 1 |
| Kahle, PJ | 1 |
| Ghorayeb, I | 1 |
| Fernagut, PO | 1 |
| Aubert, I | 1 |
| Bezard, E | 1 |
| Tison, F | 1 |
| Waldner, R | 1 |
| Puschban, Z | 1 |
| Scherfler, C | 1 |
| Seppi, K | 1 |
| Jellinger, K | 1 |
12 other studies available for 3-nitropropionic acid and Multiple System Atrophy
| Article | Year |
|---|---|
Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy.
Topics: Animals; Behavior, Animal; Convulsants; Corpus Striatum; Disease Models, Animal; Excitatory Amino Ac | 2020 |
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Mice, Tran | 2015 |
Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells.
Topics: alpha-Synuclein; Animals; Autophagy; Cells, Cultured; Cytoplasm; Mitochondria; Multiple System Atrop | 2015 |
Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy.
Topics: Animals; Disease Models, Animal; Male; Mice; Microtubule-Associated Proteins; Multiple System Atroph | 2016 |
Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy.
Topics: alpha-Synuclein; Animals; Brain; Convulsants; Disease Models, Animal; Mice; Mice, Transgenic; Mitoch | 2009 |
Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Mice; Mice, Knockout; Mice, Transgenic; Mul | 2010 |
Neuroprotective effect of human mesenchymal stem cells in an animal model of double toxin-induced multiple system atrophy parkinsonism.
Topics: Animals; bcl-2-Associated X Protein; Corpus Striatum; Cytochromes c; Disease Models, Animal; Humans; | 2011 |
Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy.
Topics: alpha-Synuclein; Animals; Cell Death; Convulsants; Corpus Striatum; Disease Models, Animal; Dopamine | 2011 |
Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.
Topics: alpha-Synuclein; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Disea | 2005 |
Rasagiline is neuroprotective in a transgenic model of multiple system atrophy.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Behavior, Animal; Brain; Disease Models, Animal; Dop | 2008 |
Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Brain Mapping; Corpus S | 2000 |
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy).
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Corpus Striatum; Dextroamphetamine; Disease Mode | 2001 |