3-nitropropionic acid has been researched along with Dystonia in 7 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The toxin 3-Nitropropionic acid (3-NP) can induce neuropathologies in the mice striatum and nigra substance, including excitotoxicity, neuroinflammation, and extensive neuronal atrophy, characterized by progressive motor dysfunction, dystonia, and memory loss, mimicking those observed in humans." | 8.02 | Combined treatment with C16 peptide and angiopoietin-1 confers neuroprotection and reduces inflammation in 3-nitropropionic acid-induced dystonia mice. ( Cai, HY; Fu, XX; Han, S; Jiang, H, 2021) |
| "A levodopa-responsive parkinsonism emerged in all MPTP-treated monkeys." | 5.31 | Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys. ( Bioulac, B; Fernagut, PO; Ghorayeb, I; Stefanova, N; Tison, F; Wenning, GK, 2002) |
| "The dystonia was manifested as choreoathetosis, torsion spasms, or painful paroxysmal spasms of the extremities and was neither progressive nor reversible." | 5.29 | Delayed dystonia with striatal CT lucencies induced by a mycotoxin (3-nitropropionic acid). ( He, F; Qian, F; Zhang, C; Zhang, S, 1995) |
| " The toxin 3-Nitropropionic acid (3-NP) can induce neuropathologies in the mice striatum and nigra substance, including excitotoxicity, neuroinflammation, and extensive neuronal atrophy, characterized by progressive motor dysfunction, dystonia, and memory loss, mimicking those observed in humans." | 4.02 | Combined treatment with C16 peptide and angiopoietin-1 confers neuroprotection and reduces inflammation in 3-nitropropionic acid-induced dystonia mice. ( Cai, HY; Fu, XX; Han, S; Jiang, H, 2021) |
| " Remarkably, in a rat model of Huntington's disease generated by subcutaneous infusion of the mitochondrial inhibitor 3-nitropropionic acid (3NP), we have observed that an acute treatment with ADAC (100 microg x kg(-1) x d(-1)) not only strongly reduces the size of the striatal lesion (-40%) and the remaining ongoing striatal degeneration (-30%), but also prevents the development of severe dystonia of hindlimbs." | 3.71 | The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity. ( Bantubungi, K; Blum, D; d'Alcantara, P; Galas, MC; Gall, D; Schiffmann, SN, 2002) |
| "A levodopa-responsive parkinsonism emerged in all MPTP-treated monkeys." | 1.31 | Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys. ( Bioulac, B; Fernagut, PO; Ghorayeb, I; Stefanova, N; Tison, F; Wenning, GK, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, XX | 1 |
| Cai, HY | 1 |
| Jiang, H | 1 |
| Han, S | 1 |
| Fernagut, PO | 2 |
| Diguet, E | 1 |
| Stefanova, N | 2 |
| Biran, M | 1 |
| Wenning, GK | 2 |
| Canioni, P | 1 |
| Bioulac, B | 2 |
| Tison, F | 2 |
| Blum, D | 1 |
| Gall, D | 1 |
| Galas, MC | 1 |
| d'Alcantara, P | 1 |
| Bantubungi, K | 1 |
| Schiffmann, SN | 1 |
| Ghorayeb, I | 1 |
| He, F | 1 |
| Zhang, S | 1 |
| Qian, F | 1 |
| Zhang, C | 1 |
| Palfi, S | 1 |
| Leventhal, L | 1 |
| Goetz, CG | 1 |
| Hantraye, T | 1 |
| Roitberg, BZ | 1 |
| Sramek, J | 1 |
| Emborg, M | 1 |
| Kordower, JH | 1 |
| Liu, X | 1 |
| Luo, X | 1 |
| Hu, W | 1 |
7 other studies available for 3-nitropropionic acid and Dystonia
| Article | Year |
|---|---|
Combined treatment with C16 peptide and angiopoietin-1 confers neuroprotection and reduces inflammation in 3-nitropropionic acid-induced dystonia mice.
Topics: Angiopoietin-1; Animals; Anti-Inflammatory Agents; Brain; Capillary Permeability; Central Nervous Sy | 2021 |
Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation.
Topics: Age Factors; Animals; Basal Ganglia Diseases; Convulsants; Corpus Striatum; Disease Models, Animal; | 2002 |
The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.
Topics: Adenosine; Animals; Behavior, Animal; Binding, Competitive; Body Weight; Cerebral Cortex; Corpus Str | 2002 |
Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Corpus Striatum; Diseas | 2002 |
Delayed dystonia with striatal CT lucencies induced by a mycotoxin (3-nitropropionic acid).
Topics: Carbohydrates; Child; Child, Preschool; Corpus Striatum; Dystonia; Female; Food Contamination; Human | 1995 |
Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys.
Topics: Animals; Basal Ganglia; Brain Mapping; Cebus; Chorea; Dystonia; Mitochondria; Neurotoxins; Nitro Com | 2000 |
Studies on the epidemiology and etiology of moldy sugarcane poisoning in China.
Topics: Adolescent; Adult; Animals; Child; Child, Preschool; China; Disease Models, Animal; Dystonia; Food M | 1992 |