3-nitropropionic acid has been researched along with Dyskinesia, Drug-Induced in 11 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Dyskinesia, Drug-Induced: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid (QUIN) was used as a typical excitotoxic/pro-oxidant inducer, 3-nitropropionic acid (3-NP) was employed as a mitochondrial function inhibitor, and their combination (QUIN + 3-NP) was also evaluated in in vitro studies." | 1.36 | Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine. ( Elinos-Calderón, D; Galván-Arzate, S; Maldonado, PD; Pedraza-Chaverrí, J; Pérez-De La Cruz, V; Robledo-Arratia, Y; Santamaría, A, 2010) |
| " In astrocyte cultures, the toxic effects of 3-NPA were associated with corresponding increases in the NO(2)(-) level, and this toxicity was attenuated by hemoglobin (Hb; 20 microM), which quenches NO." | 1.33 | Involvement of nitric oxide in 3-nitropropionic acid-induced striatal toxicity in rats. ( Baba, H; Deshpande, SB; Hida, H; Masuda, T; Nishino, H; Takei-Io, N, 2006) |
| "The effects of a previous long-term administration of the mitochondrial toxin 3-nitropropionic acid were studied on an animal model of tardive dyskinesia, i." | 1.31 | The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats. ( Abilio, VC; Araujo, CC; Bergamo, M; Calvente, PR; D'Almeida, V; Frussa, FR; Ribeiro, Rde A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosenstock, TR | 1 |
| Abílio, VC | 2 |
| Frussa-Filho, R | 1 |
| Kiyomoto, BH | 1 |
| Smaili, SS | 1 |
| Pelegrí, C | 1 |
| Duran-Vilaregut, J | 1 |
| del Valle, J | 1 |
| Crespo-Biel, N | 1 |
| Ferrer, I | 1 |
| Pallàs, M | 1 |
| Camins, A | 1 |
| Vilaplana, J | 1 |
| Elinos-Calderón, D | 1 |
| Robledo-Arratia, Y | 1 |
| Pérez-De La Cruz, V | 1 |
| Maldonado, PD | 1 |
| Galván-Arzate, S | 1 |
| Pedraza-Chaverrí, J | 1 |
| Santamaría, A | 1 |
| Túnez, I | 1 |
| Collado, JA | 1 |
| Medina, FJ | 1 |
| Peña, J | 1 |
| Del C Muñoz, M | 1 |
| Jimena, I | 1 |
| Franco, F | 1 |
| Rueda, I | 1 |
| Feijóo, M | 1 |
| Muntané, J | 1 |
| Montilla, P | 1 |
| Deshpande, SB | 1 |
| Hida, H | 1 |
| Takei-Io, N | 1 |
| Masuda, T | 1 |
| Baba, H | 1 |
| Nishino, H | 1 |
| Andreassen, OA | 2 |
| Jørgensen, HA | 2 |
| Ferrante, RJ | 1 |
| Beal, MF | 1 |
| Dautry, C | 1 |
| Vaufrey, F | 1 |
| Brouillet, E | 2 |
| Bizat, N | 2 |
| Henry, PG | 1 |
| Condé, F | 2 |
| Bloch, G | 1 |
| Hantraye, P | 2 |
| Ouary, S | 1 |
| Altairac, S | 1 |
| Ménétrat, H | 1 |
| Mittoux, V | 1 |
| Calvente, PR | 1 |
| Araujo, CC | 1 |
| Bergamo, M | 1 |
| D'Almeida, V | 1 |
| Ribeiro, Rde A | 1 |
| Frussa, FR | 1 |
| Lastres-Becker, I | 1 |
| Hansen, HH | 1 |
| Berrendero, F | 1 |
| De Miguel, R | 1 |
| Pérez-Rosado, A | 1 |
| Manzanares, J | 1 |
| Ramos, JA | 1 |
| Fernández-Ruiz, J | 1 |
11 other studies available for 3-nitropropionic acid and Dyskinesia, Drug-Induced
| Article | Year |
|---|---|
Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid.
Topics: Aging; Animals; Brain; Dyskinesia, Drug-Induced; Immunohistochemistry; Male; Mice; Mice, Inbred CBA; | 2009 |
Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Convulsants; Corpus Striatum; Cyclin D1; Disease Models, An | 2008 |
Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine.
Topics: Animals; Antioxidants; Brain; Corpus Striatum; Cysteine; Disease Models, Animal; Dyskinesia, Drug-In | 2010 |
17 beta-Estradiol may affect vulnerability of striatum in a 3-nitropropionic acid-induced experimental model of Huntington's disease in ovariectomized rats.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Convulsants; Corpus Striatum; Cytoprotection | 2006 |
Involvement of nitric oxide in 3-nitropropionic acid-induced striatal toxicity in rats.
Topics: Animals; Astrocytes; Cells, Cultured; Convulsants; Corpus Striatum; Disease Models, Animal; Dose-Res | 2006 |
The mitochondrial toxin 3-nitropropionic acid induces vacuous chewing movements in rats. Implications for tardive dyskinesia?
Topics: Animals; Behavior, Animal; Dyskinesia, Drug-Induced; Female; Mastication; Mitochondria; Movement; Ne | 1995 |
Oral Dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid.
Topics: Analysis of Variance; Animals; Anti-Dyskinesia Agents; Antihypertensive Agents; Behavior, Animal; Co | 1998 |
Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid.
Topics: Animals; Aspartic Acid; Biomarkers; Cerebral Cortex; Corpus Striatum; Dyskinesia, Drug-Induced; In S | 2000 |
Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studies.
Topics: Animals; Behavior, Animal; Cell Survival; Convulsants; Disease Models, Animal; Drug Administration R | 2000 |
The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Convulsants; Disease Models, Animal; Drug Synergism; Dyskines | 2002 |
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Convulsants; Disease Mode | 2002 |