3-nitropropionic acid has been researched along with Cerebral Ischemia in 25 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The serotonin selective reuptake inhibitor fluoxetine (Flx) has tried to treat patients suffered acute ischemic stroke because of its possible neuroprotective actions." | 7.78 | Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke. ( Sun, Y; Sun, ZQ; Yang, G; Zhou, CH; Zhu, BG; Zhu, RS, 2012) |
| "The serotonin selective reuptake inhibitor fluoxetine (Flx) has tried to treat patients suffered acute ischemic stroke because of its possible neuroprotective actions." | 3.78 | Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke. ( Sun, Y; Sun, ZQ; Yang, G; Zhou, CH; Zhu, BG; Zhu, RS, 2012) |
| " We tested the ability of Bcl-xl overexpression to protect primary cultures of embryonic rat septal neurons subjected to one of four different stresses: 6 h of combined oxygen-glucose deprivation, which produces rapid cell death, or a 24 h exposure to hypoglycemia, hyperglycemia, or 1mM 3-nitropropionic acid (an inhibitor of mitochondrial respiration), which results in a more slowly-developing death." | 3.73 | Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress. ( Barrett, JN; Nonner, D; Panickar, KS, 2005) |
| " The injections of MitoTracker Red CM-H(2)XRos revealed generation of mitochondrial free radicals primarily in vulnerable neurons following focal cerebral ischemia as well as administration of Fe(2+) or 3-nitropropionic acid." | 3.71 | Analysis of mitochondrial free radical generation in animal models of neuronal disease. ( Gwag, BJ; Kim, DY; Won, SJ, 2002) |
| "Fifteen minutes global cerebral ischemia was induced by bilateral carotid artery occlusion and hypobaric hypotension." | 1.31 | Early-onset tolerance in rat global cerebral ischemia induced by a mitochondrial inhibitor. ( Heimann, A; Kempski, O; Nakase, H; Riepe, MW; Uranishi, R, 2000) |
| "The authors show that the inhibitor of the succinate dehydrogenase, 3-nitroproprionic acid (3-NPA), which in high doses and with chronic administration is a neurotoxin, can induce profound tolerance to focal cerebral ischemia in the rat when administered in a single dose (20 mg/kg) 3 days before ischemia." | 1.30 | Respiratory chain inhibition induces tolerance to focal cerebral ischemia. ( Busch, C; Castell, S; Diener, HC; Dirnagl, U; Knapp, F; Liao, W; Lindauer, U; Megow, D; Meisel, A; Redetzky, A; Riepe, M; Ruscher, K; Trendelenburg, G; Victorov, I; Wiegand, F, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (28.00) | 18.2507 |
| 2000's | 14 (56.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bracko, O | 1 |
| Di Pietro, V | 1 |
| Lazzarino, G | 1 |
| Amorini, AM | 1 |
| Tavazzi, B | 1 |
| Artmann, J | 1 |
| Wong, EC | 1 |
| Buxton, RB | 1 |
| Weller, M | 1 |
| Luft, AR | 1 |
| Wegener, S | 1 |
| Marini, AM | 1 |
| Popolo, M | 1 |
| Pan, H | 1 |
| Blondeau, N | 1 |
| Lipsky, RH | 1 |
| Cleren, C | 1 |
| Calingasan, NY | 1 |
| Starkov, A | 1 |
| Jacquard, C | 1 |
| Chen, J | 1 |
| Brouillet, E | 1 |
| Beal, MF | 1 |
| Xu, WH | 1 |
| Yao, XY | 1 |
| Yu, HJ | 1 |
| Huang, JW | 1 |
| Cui, LY | 1 |
| Zhu, BG | 1 |
| Sun, Y | 1 |
| Sun, ZQ | 1 |
| Yang, G | 1 |
| Zhou, CH | 1 |
| Zhu, RS | 1 |
| Kim, DY | 1 |
| Won, SJ | 1 |
| Gwag, BJ | 1 |
| Nakagawa, I | 1 |
| Ogawa, Y | 1 |
| Noriyama, Y | 1 |
| Nakase, H | 3 |
| Yamashita, M | 1 |
| Sakaki, T | 1 |
| Frankiewicz, T | 1 |
| Parsons, CG | 1 |
| Brambrink, AM | 1 |
| Noga, H | 1 |
| Astheimer, A | 1 |
| Heimann, A | 2 |
| Kempski, O | 3 |
| Pera, J | 2 |
| Zawadzka, M | 2 |
| Kaminska, B | 2 |
| Szczudlik, A | 2 |
| Hoshi, A | 1 |
| Nakahara, T | 1 |
| Ogata, M | 1 |
| Yamamoto, T | 1 |
| Panickar, KS | 1 |
| Nonner, D | 1 |
| Barrett, JN | 1 |
| Kasischke, K | 2 |
| Ludolph, AC | 4 |
| Riepe, MW | 5 |
| Esclaire, F | 1 |
| Schreiber, S | 1 |
| Dirnagl, U | 3 |
| Hugon, J | 1 |
| Binienda, Z | 1 |
| Sugino, T | 2 |
| Nozaki, K | 2 |
| Takagi, Y | 1 |
| Hashimoto, N | 2 |
| Weih, M | 1 |
| Bergk, A | 1 |
| Isaev, NK | 1 |
| Ruscher, K | 2 |
| Megow, D | 2 |
| Riepe, M | 2 |
| Meisel, A | 2 |
| Victorov, IV | 1 |
| Dirnagi, U | 1 |
| Wiegand, F | 1 |
| Liao, W | 1 |
| Busch, C | 1 |
| Castell, S | 1 |
| Knapp, F | 1 |
| Lindauer, U | 1 |
| Redetzky, A | 1 |
| Trendelenburg, G | 1 |
| Victorov, I | 1 |
| Diener, HC | 1 |
| Uranishi, R | 1 |
| von Arnim, CA | 1 |
| Timmler, M | 1 |
| Demougeot, C | 1 |
| Garnier, P | 1 |
| Mossiat, C | 1 |
| Bertrand, N | 1 |
| Giroud, M | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Massieu, L | 1 |
| Del Río, P | 1 |
| Montiel, T | 1 |
1 review available for 3-nitropropionic acid and Cerebral Ischemia
| Article | Year |
|---|---|
Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors.
Topics: Adaptation, Physiological; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cortical Spre | 2008 |
24 other studies available for 3-nitropropionic acid and Cerebral Ischemia
| Article | Year |
|---|---|
3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; | 2014 |
Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Disease Models, Animal; Huntington Disease; | 2010 |
Downregulation of miR-199a may play a role in 3-nitropropionic acid induced ischemic tolerance in rat brain.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Convulsants; Down-Regulation; Gene Expression; Ge | 2012 |
Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke.
Topics: Animals; Brain Ischemia; Fluoxetine; Hypoxia, Brain; Male; Mice; Nitro Compounds; Propionates; Rando | 2012 |
Analysis of mitochondrial free radical generation in animal models of neuronal disease.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Disease Models, Animal; Fluorescent Dyes; Free Radi | 2002 |
Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Calcium; Diazoxide; Excitatory Postsynaptic Potenti | 2003 |
Chronic memantine does not block 3-nitropropionic acid-delayed ischaemic tolerance in rat hippocampal slices ex vivo.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Drug Administration Schedule; Hippocampus; In Vitro Technique | 2004 |
Pharmacological preconditioning in global cerebral ischemia.
Topics: Adaptation, Physiological; Animals; Brain; Brain Ischemia; Cell Survival; Injections, Intraperitonea | 2004 |
Influence of chemical and ischemic preconditioning on cytokine expression after focal brain ischemia.
Topics: Animals; Brain Ischemia; Cytokines; Gene Expression Regulation; Ischemic Preconditioning; Male; Nitr | 2004 |
Neurotrophic factor expression after focal brain ischemia preceded by different preconditioning strategies.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Brain-Derived Neurotrophic Factor; Ciliary Neurotr | 2005 |
The critical threshold of 3-nitropropionic acid-induced ischemic tolerance in the rat.
Topics: Animals; Brain Ischemia; Convulsants; Dose-Response Relationship, Drug; Injections, Intraperitoneal; | 2005 |
Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; bcl-X Protein; Brain Ischemia; Caspase 3; Caspases | 2005 |
NMDA-antagonists reverse increased hypoxic tolerance by preceding chemical hypoxia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antihypertensive Agents; | 1996 |
Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation: "chemical preconditioning".
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Hypoxia; Enzyme Inhibitors; Free Radicals; Gly | 1997 |
Chemical preconditioning: a cytoprotective strategy.
Topics: Animals; Brain; Brain Ischemia; Coronary Circulation; Cytoprotection; Electron Transport Complex II; | 1997 |
Compensatory long-term effect of perinatal hypoxia-ischemia. A possible mechanism for neuroprotection?
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Conditioning, Operant; Energy Metabolism; Fetus; H | 1997 |
3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Gerbillinae; Hippocampus; Male; Nitro Com | 1999 |
Induction of ischemic tolerance in rat cortical neurons by 3-nitropropionic acid: chemical preconditioning.
Topics: Animals; Biotransformation; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; DNA-Bindin | 1999 |
Respiratory chain inhibition induces tolerance to focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Convulsants; Free Radicals; Ischemic Preconditioning; Male; Nitro Compounds | 1999 |
Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid.
Topics: Animals; Brain Ischemia; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Gerbillinae; Hippocamp | 2000 |
Early-onset tolerance in rat global cerebral ischemia induced by a mitochondrial inhibitor.
Topics: Animals; Brain Ischemia; Convulsants; Male; Mitochondria; Motor Activity; Neurons; Neuroprotective A | 2000 |
Chemical preconditioning in mice is not mediated by upregulation of nitric oxide synthase isoforms.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Central Nervous System; Hippocampus; Ischemic Prec | 2001 |
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Bra | 2001 |
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con | 2001 |