3-nitropropionic acid has been researched along with Brain Ischemia in 25 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The serotonin selective reuptake inhibitor fluoxetine (Flx) has tried to treat patients suffered acute ischemic stroke because of its possible neuroprotective actions." | 7.78 | Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke. ( Sun, Y; Sun, ZQ; Yang, G; Zhou, CH; Zhu, BG; Zhu, RS, 2012) |
| "The serotonin selective reuptake inhibitor fluoxetine (Flx) has tried to treat patients suffered acute ischemic stroke because of its possible neuroprotective actions." | 3.78 | Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke. ( Sun, Y; Sun, ZQ; Yang, G; Zhou, CH; Zhu, BG; Zhu, RS, 2012) |
| " We tested the ability of Bcl-xl overexpression to protect primary cultures of embryonic rat septal neurons subjected to one of four different stresses: 6 h of combined oxygen-glucose deprivation, which produces rapid cell death, or a 24 h exposure to hypoglycemia, hyperglycemia, or 1mM 3-nitropropionic acid (an inhibitor of mitochondrial respiration), which results in a more slowly-developing death." | 3.73 | Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress. ( Barrett, JN; Nonner, D; Panickar, KS, 2005) |
| " The injections of MitoTracker Red CM-H(2)XRos revealed generation of mitochondrial free radicals primarily in vulnerable neurons following focal cerebral ischemia as well as administration of Fe(2+) or 3-nitropropionic acid." | 3.71 | Analysis of mitochondrial free radical generation in animal models of neuronal disease. ( Gwag, BJ; Kim, DY; Won, SJ, 2002) |
| "Fifteen minutes global cerebral ischemia was induced by bilateral carotid artery occlusion and hypobaric hypotension." | 1.31 | Early-onset tolerance in rat global cerebral ischemia induced by a mitochondrial inhibitor. ( Heimann, A; Kempski, O; Nakase, H; Riepe, MW; Uranishi, R, 2000) |
| "The authors show that the inhibitor of the succinate dehydrogenase, 3-nitroproprionic acid (3-NPA), which in high doses and with chronic administration is a neurotoxin, can induce profound tolerance to focal cerebral ischemia in the rat when administered in a single dose (20 mg/kg) 3 days before ischemia." | 1.30 | Respiratory chain inhibition induces tolerance to focal cerebral ischemia. ( Busch, C; Castell, S; Diener, HC; Dirnagl, U; Knapp, F; Liao, W; Lindauer, U; Megow, D; Meisel, A; Redetzky, A; Riepe, M; Ruscher, K; Trendelenburg, G; Victorov, I; Wiegand, F, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (28.00) | 18.2507 |
| 2000's | 14 (56.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bracko, O | 1 |
| Di Pietro, V | 1 |
| Lazzarino, G | 1 |
| Amorini, AM | 1 |
| Tavazzi, B | 1 |
| Artmann, J | 1 |
| Wong, EC | 1 |
| Buxton, RB | 1 |
| Weller, M | 1 |
| Luft, AR | 1 |
| Wegener, S | 1 |
| Marini, AM | 1 |
| Popolo, M | 1 |
| Pan, H | 1 |
| Blondeau, N | 1 |
| Lipsky, RH | 1 |
| Cleren, C | 1 |
| Calingasan, NY | 1 |
| Starkov, A | 1 |
| Jacquard, C | 1 |
| Chen, J | 1 |
| Brouillet, E | 1 |
| Beal, MF | 1 |
| Xu, WH | 1 |
| Yao, XY | 1 |
| Yu, HJ | 1 |
| Huang, JW | 1 |
| Cui, LY | 1 |
| Zhu, BG | 1 |
| Sun, Y | 1 |
| Sun, ZQ | 1 |
| Yang, G | 1 |
| Zhou, CH | 1 |
| Zhu, RS | 1 |
| Kim, DY | 1 |
| Won, SJ | 1 |
| Gwag, BJ | 1 |
| Nakagawa, I | 1 |
| Ogawa, Y | 1 |
| Noriyama, Y | 1 |
| Nakase, H | 3 |
| Yamashita, M | 1 |
| Sakaki, T | 1 |
| Frankiewicz, T | 1 |
| Parsons, CG | 1 |
| Brambrink, AM | 1 |
| Noga, H | 1 |
| Astheimer, A | 1 |
| Heimann, A | 2 |
| Kempski, O | 3 |
| Pera, J | 2 |
| Zawadzka, M | 2 |
| Kaminska, B | 2 |
| Szczudlik, A | 2 |
| Hoshi, A | 1 |
| Nakahara, T | 1 |
| Ogata, M | 1 |
| Yamamoto, T | 1 |
| Panickar, KS | 1 |
| Nonner, D | 1 |
| Barrett, JN | 1 |
| Kasischke, K | 2 |
| Ludolph, AC | 4 |
| Riepe, MW | 5 |
| Esclaire, F | 1 |
| Schreiber, S | 1 |
| Dirnagl, U | 3 |
| Hugon, J | 1 |
| Binienda, Z | 1 |
| Sugino, T | 2 |
| Nozaki, K | 2 |
| Takagi, Y | 1 |
| Hashimoto, N | 2 |
| Weih, M | 1 |
| Bergk, A | 1 |
| Isaev, NK | 1 |
| Ruscher, K | 2 |
| Megow, D | 2 |
| Riepe, M | 2 |
| Meisel, A | 2 |
| Victorov, IV | 1 |
| Dirnagi, U | 1 |
| Wiegand, F | 1 |
| Liao, W | 1 |
| Busch, C | 1 |
| Castell, S | 1 |
| Knapp, F | 1 |
| Lindauer, U | 1 |
| Redetzky, A | 1 |
| Trendelenburg, G | 1 |
| Victorov, I | 1 |
| Diener, HC | 1 |
| Uranishi, R | 1 |
| von Arnim, CA | 1 |
| Timmler, M | 1 |
| Demougeot, C | 1 |
| Garnier, P | 1 |
| Mossiat, C | 1 |
| Bertrand, N | 1 |
| Giroud, M | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Massieu, L | 1 |
| Del Río, P | 1 |
| Montiel, T | 1 |
1 review available for 3-nitropropionic acid and Brain Ischemia
| Article | Year |
|---|---|
Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors.
Topics: Adaptation, Physiological; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cortical Spre | 2008 |
24 other studies available for 3-nitropropionic acid and Brain Ischemia
| Article | Year |
|---|---|
3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; | 2014 |
Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Ischemia; Disease Models, Animal; Huntington Disease; | 2010 |
Downregulation of miR-199a may play a role in 3-nitropropionic acid induced ischemic tolerance in rat brain.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Convulsants; Down-Regulation; Gene Expression; Ge | 2012 |
Optimal dosages of fluoxetine in the treatment of hypoxic brain injury induced by 3-nitropropionic acid: implications for the adjunctive treatment of patients after acute ischemic stroke.
Topics: Animals; Brain Ischemia; Fluoxetine; Hypoxia, Brain; Male; Mice; Nitro Compounds; Propionates; Rando | 2012 |
Analysis of mitochondrial free radical generation in animal models of neuronal disease.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Disease Models, Animal; Fluorescent Dyes; Free Radi | 2002 |
Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Calcium; Diazoxide; Excitatory Postsynaptic Potenti | 2003 |
Chronic memantine does not block 3-nitropropionic acid-delayed ischaemic tolerance in rat hippocampal slices ex vivo.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Drug Administration Schedule; Hippocampus; In Vitro Technique | 2004 |
Pharmacological preconditioning in global cerebral ischemia.
Topics: Adaptation, Physiological; Animals; Brain; Brain Ischemia; Cell Survival; Injections, Intraperitonea | 2004 |
Influence of chemical and ischemic preconditioning on cytokine expression after focal brain ischemia.
Topics: Animals; Brain Ischemia; Cytokines; Gene Expression Regulation; Ischemic Preconditioning; Male; Nitr | 2004 |
Neurotrophic factor expression after focal brain ischemia preceded by different preconditioning strategies.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Brain-Derived Neurotrophic Factor; Ciliary Neurotr | 2005 |
The critical threshold of 3-nitropropionic acid-induced ischemic tolerance in the rat.
Topics: Animals; Brain Ischemia; Convulsants; Dose-Response Relationship, Drug; Injections, Intraperitoneal; | 2005 |
Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; bcl-X Protein; Brain Ischemia; Caspase 3; Caspases | 2005 |
NMDA-antagonists reverse increased hypoxic tolerance by preceding chemical hypoxia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antihypertensive Agents; | 1996 |
Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation: "chemical preconditioning".
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cell Hypoxia; Enzyme Inhibitors; Free Radicals; Gly | 1997 |
Chemical preconditioning: a cytoprotective strategy.
Topics: Animals; Brain; Brain Ischemia; Coronary Circulation; Cytoprotection; Electron Transport Complex II; | 1997 |
Compensatory long-term effect of perinatal hypoxia-ischemia. A possible mechanism for neuroprotection?
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Conditioning, Operant; Energy Metabolism; Fetus; H | 1997 |
3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo.
Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Gerbillinae; Hippocampus; Male; Nitro Com | 1999 |
Induction of ischemic tolerance in rat cortical neurons by 3-nitropropionic acid: chemical preconditioning.
Topics: Animals; Biotransformation; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; DNA-Bindin | 1999 |
Respiratory chain inhibition induces tolerance to focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Convulsants; Free Radicals; Ischemic Preconditioning; Male; Nitro Compounds | 1999 |
Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid.
Topics: Animals; Brain Ischemia; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Gerbillinae; Hippocamp | 2000 |
Early-onset tolerance in rat global cerebral ischemia induced by a mitochondrial inhibitor.
Topics: Animals; Brain Ischemia; Convulsants; Male; Mitochondria; Motor Activity; Neurons; Neuroprotective A | 2000 |
Chemical preconditioning in mice is not mediated by upregulation of nitric oxide synthase isoforms.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Central Nervous System; Hippocampus; Ischemic Prec | 2001 |
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Bra | 2001 |
Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acid Transport System X-AG; Animals; Brain Ischemia; Con | 2001 |