3-nitropropionic acid has been researched along with Body Weight in 34 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Remarkably, in a rat model of Huntington's disease generated by subcutaneous infusion of the mitochondrial inhibitor 3-nitropropionic acid (3NP), we have observed that an acute treatment with ADAC (100 microg x kg(-1) x d(-1)) not only strongly reduces the size of the striatal lesion (-40%) and the remaining ongoing striatal degeneration (-30%), but also prevents the development of severe dystonia of hindlimbs." | 3.71 | The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity. ( Bantubungi, K; Blum, D; d'Alcantara, P; Galas, MC; Gall, D; Schiffmann, SN, 2002) |
| "Pretreatment with spermidine significantly attenuated 3-NP-induced alterations in motor coordination, oxidative stress, and the levels of neuroinflammatory markers and striatal neurotransmitters." | 1.43 | Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters. ( Jamwal, S; Kumar, P, 2016) |
| "Trandolapril is a centrally active ACE inhibitor." | 1.40 | Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: mitochondrial dysfunction and neurodegeneration. ( Hariharan, A; Jagtap, AG; Shetty, S; Shirole, T, 2014) |
| " Chronic administration of 3-NP produced significant decrease in body weight, showed marked abnormalities in cognitive and motor functions." | 1.39 | Neuroprotective role of PDE4 and PDE5 inhibitors in 3-nitropropionic acid induced behavioral and biochemical toxicities in rats. ( Deshmukh, R; Kumar, K; Sharma, PL; Sharma, S; Thakur, T, 2013) |
| "Fenofibrate treatment significantly attenuated oxidative damage, cytokines and improved mitochondrial complexes enzyme activity in brain." | 1.38 | Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms. ( Bhateja, DK; Dhull, DK; Gill, A; Padi, SS; Reddy, BV; Sharma, S; Sidhu, A, 2012) |
| "Huntington's disease is a progressive neurodegenerative disorder that gradually reduces memory, cognitive skills and normal movements of affected individuals." | 1.38 | Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity. ( Kalonia, H; Kumar, A; Kumar, P, 2012) |
| "Treatment with sertraline (5 and 10 mg/kg) significantly reversed behavioral, biochemical and mitochondrial enzyme dysfunctions in 3-nitropropionic acid treated group." | 1.35 | Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain. ( Kumar, A; Kumar, P, 2009) |
| " To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic administration of 3-NP using an osmotic mini pump, were examined in the Lewis rats." | 1.33 | Behavioral alterations in Lewis rats following two-day continuous 3-nitropropionic acid administration. ( Brown, WD; Garbuzova-Davis, S; Newcomb, JD; Rodriguez, AI; Sanberg, PR; Saporta, S; Willing, AE, 2005) |
| "The precise cause of neuronal death in Huntington's disease (HD) is unknown." | 1.32 | Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. ( Beesen, A; Ferrante, RJ; Hersch, SM; Kowall, NW; Kubilus, JK; Lee, J; Luthi-Carter, R; Ratan, RR; Ryu, H; Smith, K; Zucker, B, 2003) |
| " We suggest that compensatory mechanisms exist in the R6/2 mouse brain that protect it against the toxic effect of the transgene and coincidentally protect against exogenous toxins such as 3-NP, QA, and kainic acid." | 1.31 | Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity. ( Hickey, MA; Morton, AJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (35.29) | 29.6817 |
| 2010's | 19 (55.88) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Gendy, AM | 1 |
| El-Sadek, HM | 1 |
| Amin, MM | 1 |
| Ahmed, KA | 1 |
| El-Sayed, MK | 1 |
| El-Haddad, AE | 1 |
| Soubh, A | 1 |
| Mahdi, WA | 1 |
| AlGhamdi, SA | 1 |
| Alghamdi, AM | 1 |
| Imam, SS | 1 |
| Alshehri, S | 1 |
| Almaniea, MA | 1 |
| Hajjar, BM | 1 |
| Al-Abbasi, FA | 1 |
| Sayyed, N | 1 |
| Kazmi, I | 1 |
| Fotoohi, A | 1 |
| Moloudi, MR | 1 |
| Hosseini, S | 1 |
| Hassanzadeh, K | 1 |
| Feligioni, M | 1 |
| Izadpanah, E | 1 |
| Shivasharan, BD | 1 |
| Nagakannan, P | 2 |
| Thippeswamy, BS | 2 |
| Veerapur, VP | 2 |
| Bansal, P | 1 |
| Unnikrishnan, MK | 1 |
| Thakur, T | 1 |
| Sharma, S | 2 |
| Kumar, K | 1 |
| Deshmukh, R | 1 |
| Sharma, PL | 1 |
| Thangarajan, S | 1 |
| Deivasigamani, A | 1 |
| Natarajan, SS | 1 |
| Krishnan, P | 1 |
| Mohanan, SK | 1 |
| Mahdy, HM | 1 |
| Mohamed, MR | 1 |
| Emam, MA | 1 |
| Karim, AM | 1 |
| Abdel-Naim, AB | 1 |
| Khalifa, AE | 2 |
| Hariharan, A | 1 |
| Shetty, S | 1 |
| Shirole, T | 1 |
| Jagtap, AG | 1 |
| Khan, A | 1 |
| Jamwal, S | 2 |
| Bijjem, KR | 1 |
| Prakash, A | 2 |
| Kumar, P | 8 |
| Hanna, DM | 1 |
| Tadros, MG | 1 |
| Kaur, M | 1 |
| Kalia, AN | 1 |
| Ahmed, LA | 1 |
| Darwish, HA | 1 |
| Abdelsalam, RM | 1 |
| Amin, HA | 1 |
| Dhadde, SB | 1 |
| Roopesh, M | 1 |
| Anand Kumar, SR | 1 |
| Badami, S | 1 |
| Milutinović, A | 1 |
| Suganya, SN | 1 |
| Sumathi, T | 1 |
| Maya-López, M | 1 |
| Ruiz-Contreras, HA | 1 |
| de Jesús Negrete-Ruíz, M | 1 |
| Martínez-Sánchez, JE | 1 |
| Benítez-Valenzuela, J | 1 |
| Colín-González, AL | 1 |
| Villeda-Hernández, J | 1 |
| Sánchez-Chapul, L | 1 |
| Parra-Cid, C | 1 |
| Rangel-López, E | 1 |
| Santamaría, A | 1 |
| Kumar, A | 6 |
| Kalonia, H | 4 |
| Bhateja, DK | 1 |
| Dhull, DK | 1 |
| Gill, A | 1 |
| Sidhu, A | 1 |
| Reddy, BV | 1 |
| Padi, SS | 1 |
| Blum, D | 2 |
| Gall, D | 2 |
| Galas, MC | 2 |
| d'Alcantara, P | 1 |
| Bantubungi, K | 2 |
| Schiffmann, SN | 2 |
| Pintor, A | 1 |
| Brouillet, E | 1 |
| Ledent, C | 1 |
| Muller, CE | 1 |
| Galluzzo, M | 1 |
| Cuvelier, L | 1 |
| Rolland, AS | 1 |
| Popoli, P | 1 |
| Ferrante, RJ | 1 |
| Kubilus, JK | 1 |
| Lee, J | 1 |
| Ryu, H | 1 |
| Beesen, A | 1 |
| Zucker, B | 1 |
| Smith, K | 1 |
| Kowall, NW | 1 |
| Ratan, RR | 1 |
| Luthi-Carter, R | 1 |
| Hersch, SM | 1 |
| Brownell, AL | 1 |
| Chen, YI | 1 |
| Yu, M | 1 |
| Wang, X | 1 |
| Dedeoglu, A | 1 |
| Cicchetti, F | 1 |
| Jenkins, BG | 1 |
| Beal, MF | 1 |
| Lian, XY | 1 |
| Zhang, Z | 1 |
| Stringer, JL | 1 |
| Newcomb, JD | 1 |
| Brown, WD | 1 |
| Rodriguez, AI | 1 |
| Garbuzova-Davis, S | 1 |
| Saporta, S | 1 |
| Sanberg, PR | 1 |
| Willing, AE | 1 |
| Pandey, M | 1 |
| Varghese, M | 1 |
| Sindhu, KM | 1 |
| Sreetama, S | 1 |
| Navneet, AK | 1 |
| Mohanakumar, KP | 1 |
| Usha, R | 1 |
| Ahuja, M | 1 |
| Bishnoi, M | 1 |
| Chopra, K | 1 |
| Hickey, MA | 1 |
| Morton, AJ | 1 |
| Pubill, D | 1 |
| Verdaguer, E | 1 |
| Canudas, AM | 1 |
| Sureda, FX | 1 |
| Escubedo, E | 1 |
| Camarasa, J | 1 |
| Pallàs, M | 1 |
| Camins, A | 1 |
34 other studies available for 3-nitropropionic acid and Body Weight
| Article | Year |
|---|---|
Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats.
Topics: Animals; Apoptosis; Body Weight; Glycyrrhizic Acid; HMGB1 Protein; Huntington Disease; Inflammation; | 2023 |
Neuroprotectant Effects of Hibiscetin in 3-Nitropropionic Acid-Induced Huntington's Disease via Subsiding Oxidative Stress and Modulating Monoamine Neurotransmitters in Rats Brain.
Topics: Animals; Body Weight; Brain; Huntington Disease; Neuroprotective Agents; Neurotransmitter Agents; Ni | 2023 |
A Novel Pharmacological Protective Role for Safranal in an Animal Model of Huntington's Disease.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Catalase; Cerebral Cortex; Cyclohexenes; Gluta | 2021 |
Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats.
Topics: Analysis of Variance; Animals; Body Weight; Calendula; Chromatography, High Pressure Liquid; Disease | 2013 |
Neuroprotective role of PDE4 and PDE5 inhibitors in 3-nitropropionic acid induced behavioral and biochemical toxicities in rats.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Behavior, Animal; Body Weight; Brain; Gluta | 2013 |
Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum.
Topics: Animals; Body Weight; Brain; Catalase; Convulsants; Corpus Striatum; Exploratory Behavior; Glutamate | 2014 |
Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms.
Topics: Animals; Antioxidants; Behavior, Animal; Biomarkers; Body Temperature; Body Weight; Brain; Isoflavon | 2014 |
Potential of protease inhibitor in 3-nitropropionic acid induced Huntington's disease like symptoms: mitochondrial dysfunction and neurodegeneration.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Female; Huntington Disease; Indoles; | 2014 |
Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid-induced neurotoxicity in rats.
Topics: Animals; Body Weight; Corpus Striatum; Encephalitis; Glycogen Synthase Kinase 3; Glycogen Synthase K | 2015 |
ADIOL protects against 3-NP-induced neurotoxicity in rats: Possible impact of its anti-oxidant, anti-inflammatory and anti-apoptotic actions.
Topics: Analysis of Variance; Androstenedione; Animals; Antioxidants; Apoptosis; Body Weight; Caspase 3; Cat | 2015 |
Neuroprotective potential of antioxidant potent fractions from Convolvulus pluricaulis Chois. in 3-nitropropionic acid challenged rats.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Convolvulus; Corpus Striatum; Glutathione; Hun | 2016 |
Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; bcl-2-Associated X Protein; Behavior, Animal | 2016 |
Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters.
Topics: Animals; Body Weight; Corpus Striatum; Male; Motor Activity; Neuroprotective Agents; Nitro Compounds | 2016 |
Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats.
Topics: Animals; Behavior, Animal; Benzoquinones; Body Weight; Brain; Catalase; Disease Models, Animal; Dose | 2016 |
Lithium chloride could aggravate brain injury caused by 3-nitropropionic acid.
Topics: Animals; Body Weight; Brain Chemistry; Brain Diseases; Electron Transport Complex IV; Female; Hippoc | 2016 |
Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington's disease model in rats.
Topics: Acetylcholinesterase; Animals; Antioxidants; Body Weight; Corpus Striatum; Glial Fibrillary Acidic P | 2017 |
URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.
Topics: Amidohydrolases; Animals; Apomorphine; Behavior, Animal; Benzamides; Body Weight; Carbamates; Inject | 2017 |
Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain.
Topics: Animals; Antioxidants; Body Weight; Brain; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Mito | 2009 |
Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide.
Topics: Analysis of Variance; Animals; Antioxidants; Body Weight; Catalase; Corpus Striatum; Disease Models, | 2010 |
Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carotenoids; Catalase; Coloring Agents; Electron Tran | 2009 |
Possible nitric oxide modulation in protective effect of FK-506 against 3-nitropropionic acid-induced behavioral, oxidative, neurochemical, and mitochondrial alterations in rat brain.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Disease Models, Animal; Huntington D | 2010 |
Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone.
Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Body Weight; Caspase 3; Corpus Striatum; Dinopro | 2011 |
Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Catalase; Cytokines; Extremities; Fenofibrate; Glutat | 2012 |
Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity.
Topics: Amines; Animals; Body Weight; Brain; Catalase; Cyclohexanecarboxylic Acids; GABAergic Neurons; Gabap | 2012 |
The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.
Topics: Adenosine; Animals; Behavior, Animal; Binding, Competitive; Body Weight; Cerebral Cortex; Corpus Str | 2002 |
A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.
Topics: Adenosine; Animals; Body Weight; Cell Death; Corpus Striatum; Disease Models, Animal; Drug Administr | 2003 |
Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice.
Topics: Acetylation; Animals; Body Weight; Brain; Butyrates; Disease Models, Animal; Dose-Response Relations | 2003 |
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.
Topics: Acute Disease; Animals; Behavior, Animal; Body Weight; Brain; Choline; Chronic Disease; Disease Mode | 2004 |
Protective effects of ginseng components in a rodent model of neurodegeneration.
Topics: Animals; Behavior, Animal; Body Weight; Energy Metabolism; Enzyme Inhibitors; Ginsenosides; Heat-Sho | 2005 |
Behavioral alterations in Lewis rats following two-day continuous 3-nitropropionic acid administration.
Topics: Animals; Behavior, Animal; Body Weight; Convulsants; Corpus Striatum; Dopamine and cAMP-Regulated Ph | 2005 |
Mitochondrial NAD+-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Cerebral Cortex; Citrate (si)-Synthase | 2008 |
Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Body Weight; Brain Chemistry; Enzyme Inhibitors; E | 2008 |
Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Corpus Striatum; Crosses, Genetic; Diabetes Mellitus; | 2000 |
Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Body Weight; Cell Survival; Cerebellum; Corpus | 2001 |