3-nitropropionic acid has been researched along with Aging in 15 studies
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE
3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We suggest that compensatory mechanisms exist in the R6/2 mouse brain that protect it against the toxic effect of the transgene and coincidentally protect against exogenous toxins such as 3-NP, QA, and kainic acid." | 1.31 | Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity. ( Hickey, MA; Morton, AJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, CX | 1 |
| Lin, YL | 1 |
| Lu, FF | 1 |
| Yu, LN | 1 |
| Liu, Y | 1 |
| Zhou, JD | 1 |
| Kong, N | 1 |
| Li, D | 1 |
| Yan, GJ | 1 |
| Sun, HX | 1 |
| Cao, GY | 1 |
| Skillings, EA | 1 |
| Morton, AJ | 2 |
| Shinomol, GK | 1 |
| Ranganayaki, S | 1 |
| Joshi, AK | 1 |
| Gayathri, N | 1 |
| Gowda, H | 1 |
| Srinivas Bharath, MM | 1 |
| Rosenstock, TR | 1 |
| Abílio, VC | 1 |
| Frussa-Filho, R | 1 |
| Kiyomoto, BH | 1 |
| Smaili, SS | 1 |
| Hsieh, CC | 3 |
| Papaconstantinou, J | 3 |
| Rosenblatt, JI | 1 |
| Minn, Y | 1 |
| Cho, KJ | 1 |
| Kim, HW | 1 |
| Kim, HJ | 1 |
| Suk, SH | 1 |
| Lee, BI | 1 |
| Kim, GW | 2 |
| Lohmann, P | 1 |
| Riepe, MW | 1 |
| Koutouzis, TK | 1 |
| Borlongan, CV | 1 |
| Scorcia, T | 1 |
| Creese, I | 1 |
| Cahill, DW | 1 |
| Freeman, TB | 1 |
| Sanberg, PR | 1 |
| Brouillet, E | 1 |
| Jenkins, BG | 1 |
| Hyman, BT | 1 |
| Ferrante, RJ | 1 |
| Kowall, NW | 1 |
| Srivastava, R | 1 |
| Roy, DS | 1 |
| Rosen, BR | 1 |
| Beal, MF | 1 |
| Bossi, SR | 1 |
| Simpson, JR | 1 |
| Isacson, O | 1 |
| Alexi, T | 1 |
| Hughes, PE | 1 |
| Knüsel, B | 1 |
| Tobin, AJ | 1 |
| Hickey, MA | 1 |
| Chan, PH | 1 |
15 other studies available for 3-nitropropionic acid and Aging
| Article | Year |
|---|---|
Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.
Topics: Aging; Apoptosis; Feedback, Physiological; Female; Granulosa Cells; Humans; Hydrogen Peroxide; In Vi | 2023 |
Delayed Onset and Reduced Cognitive Deficits through Pre-Conditioning with 3-Nitropropionic Acid is Dependent on Sex and CAG Repeat Length in the R6/2 Mouse Model of Huntington's Disease.
Topics: Aging; Animals; Cognitive Dysfunction; Disease Models, Animal; Female; Humans; Huntington Disease; M | 2016 |
Characterization of age-dependent changes in the striatum: Response to the mitochondrial toxin 3-nitropropionic acid.
Topics: Aging; Animals; Cell Death; Cell Line; Corpus Striatum; Electron Transport Complex II; Gene Expressi | 2017 |
Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid.
Topics: Aging; Animals; Brain; Dyskinesia, Drug-Induced; Immunohistochemistry; Male; Mice; Mice, Inbred CBA; | 2009 |
Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS).
Topics: Acetylcysteine; Activating Transcription Factor 2; Aging; Animals; Antimycin A; Cell Proliferation; | 2009 |
The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid.
Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Liver; Male; MAP Kinase Kinase 3; MAP | 2002 |
Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid.
Topics: Aging; Animals; Convulsants; Liver; Male; MAP Kinase Kinase 7; MAP Kinase Signaling System; Mice; Mi | 2003 |
Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum.
Topics: Aging; Animals; Convulsants; Corpus Striatum; Gene Expression Regulation; In Situ Nick-End Labeling; | 2008 |
Neurotoxic effects of repetitive inhibition of oxidative phosphorylation in young adults surfacing with deficits of spatial learning in old age.
Topics: Aging; Animals; Female; Learning Disabilities; Maze Learning; Mice; Nitro Compounds; Oxidative Phosp | 2007 |
Systemic 3-nitropropionic acid: long-term effects on locomotor behavior.
Topics: Aging; Animals; Benzazepines; Circadian Rhythm; Corpus Striatum; Drug Administration Schedule; Injec | 1994 |
Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.
Topics: Adenosine Triphosphate; Aging; Corpus Striatum; In Vitro Techniques; Lactates; Lactic Acid; Mitochon | 1993 |
Age dependence of striatal neuronal death caused by mitochondrial dysfunction.
Topics: Acetylcholinesterase; Aging; Animals; Cell Death; Corpus Striatum; Histocytochemistry; Male; Mitocho | 1993 |
Metabolic compromise with systemic 3-nitropropionic acid produces striatal apoptosis in Sprague-Dawley rats but not in BALB/c ByJ mice.
Topics: Aging; Animals; Apoptosis; Corpus Striatum; DNA Fragmentation; Mice; Mice, Inbred BALB C; Nerve Dege | 1998 |
Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Corpus Striatum; Crosses, Genetic; Diabetes Mellitus; | 2000 |
Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum.
Topics: Aging; Animals; Apoptosis; Cytochrome c Group; DNA Fragmentation; Electrophoresis, Polyacrylamide Ge | 2001 |