3-nitrocoumarin and Melanoma

3-nitrocoumarin has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for 3-nitrocoumarin and Melanoma

ArticleYear
Phospholipase C inhibitors: a new class of cytotoxic agents.
    Journal of medicinal chemistry, 1994, Jul-08, Volume: 37, Issue:14

    A series of nitrocoumarin and nitrochromene derivatives have been prepared and shown to inhibit the phosphatidylinositol-specific phospholipase C(PLC)(IC50 < 10 micrograms/mL) isolated from human melanoma. The inhibition of PLC by nitrocoumarin 4a was time-dependent and irreversible. The inhibition of PLC was shown to interfere with inositide metabolism in whole cells (IC50 = 4 micrograms/mL) in a manner consistent with their proposed mode of activity. Finally, the compounds were shown to be growth inhibitory to cultured melanoma cells (ID50 = 2 micrograms/mL), suggesting that PLC may be an attractive new target for chemotherapeutic intervention.

    Topics: Animals; Antineoplastic Agents; Chromones; Coumarins; Humans; Melanoma; Mice; Phosphatidylinositols; Structure-Activity Relationship; Tumor Cells, Cultured; Type C Phospholipases

1994