3-nitrocoumarin has been researched along with Melanoma* in 1 studies
1 other study(ies) available for 3-nitrocoumarin and Melanoma
Article | Year |
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Phospholipase C inhibitors: a new class of cytotoxic agents.
A series of nitrocoumarin and nitrochromene derivatives have been prepared and shown to inhibit the phosphatidylinositol-specific phospholipase C(PLC)(IC50 < 10 micrograms/mL) isolated from human melanoma. The inhibition of PLC by nitrocoumarin 4a was time-dependent and irreversible. The inhibition of PLC was shown to interfere with inositide metabolism in whole cells (IC50 = 4 micrograms/mL) in a manner consistent with their proposed mode of activity. Finally, the compounds were shown to be growth inhibitory to cultured melanoma cells (ID50 = 2 micrograms/mL), suggesting that PLC may be an attractive new target for chemotherapeutic intervention. Topics: Animals; Antineoplastic Agents; Chromones; Coumarins; Humans; Melanoma; Mice; Phosphatidylinositols; Structure-Activity Relationship; Tumor Cells, Cultured; Type C Phospholipases | 1994 |