Compounds > 3-n-methylspiperone
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3-n-methylspiperone and Schizophrenia

3-n-methylspiperone has been researched along with Schizophrenia in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19905 (23.81)18.7374
1990's15 (71.43)18.2507
2000's1 (4.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gjedde, A; Reith, J; Wong, D1
Eriksson, L; Farde, L; Halldin, C; Nordström, AL1
Farde, L; Halldin, C; Karlsson, P; Nordström, AL; Nyberg, S; Sedvall, G1
Brodie, JD; Fowler, JS; Schlyer, DJ; Smith, MR; Volkow, ND; Wang, GJ; Warner, D; Wolf, AP; Yousef, KA1
Farde, L; Halldin, C; Nordström, AL1
Dannals, RF; Pearlson, G; Ravert, HT; Sapp, J; Shaya, EK; Strauss, M; Tune, LE; Wilson, AA; Wong, DF; Young, T1
Berridge, MS; Compton-Toth, BA; Goyer, PF; Meltzer, HY; Miraldi, F; Morris, ED; Schulz, SC; Semple, WE; Wong, DF1
Gjedde, A; Meltzer, CC; Wilson, PD; Wong, DF; Young, D1
Dannals, RF; Gjedde, A; Kuhar, MJ; Meltzer, CC; Pearlson, GD; Ravert, HT; Reith, J; Tune, LE; Wong, DF; Young, LT1
Bergström, M; Gefvert, O; Hagberg, G; Långström, B; Lindström, L; Wiesel, FA; Wieselgren, IM1
Eriksson, B; Farde, L; Halldin, C; Nyberg, S; Oxenstierna, G1
Inoue, O; Iyo, M; Kobayashi, K; Matsushima, E; Okubo, Y; Sassa, T; Someya, Y; Sudo, Y; Suhara, T; Suzuki, K; Tateno, Y; Terasaki, O; Toru, M1
Wong, DF1
Bendriem, B; Dewey, SL; Fowler, JS; Hitzemann, R; Logan, J; Raulli, R; Schlyer, DJ; Shiue, CY; Volkow, ND; Wolf, AP1
Coppens, HJ; Korf, J; Paans, AM; Slooff, CJ; Vaalburg, W; Wiegman, T1
Coenen, HH; Hamacher, K; Heiss, WD; Herholz, K; Huber, M; Karbe, H; Lövenich, A; Stöcklin, G; Wienhard, K1
Barouche, F; Brodie, JD; Cooper, TB; Fowler, JS; Rotrosen, J; Shiue, CY; Wolf, AP; Wolkin, A1
Broussolle, EP; Dannals, RF; Gjedde, A; Kuhar, MJ; Links, JM; Malat, J; O'Tuama, LA; Pearlson, GD; Ravert, HT; Snyder, SH; Tamminga, CA; Toung, JK; Tune, LE; Wagner, HN; Williams, JA; Wilson, AA; Wong, DF1
Arnett, CD; Barouche, F; Brodie, JD; Fowler, JS; MacGregor, RR; Russell, JA; Shiue, CY; Smith, M; Wolf, AP; Wolkin, A1
Andreasen, NC; Carson, R; Diksic, M; Evans, A; Farde, L; Gjedde, A; Hakim, A; Lal, S; Nair, N; Sedvall, G1
Bjorvvinssen, E; Dannals, RF; Kuhar, MJ; Links, JM; Pearlson, G; Ravert, HT; Suneja, S; Wagner, HN; Wilson, AA; Wong, DF1

Reviews

1 review(s) available for 3-n-methylspiperone and Schizophrenia

ArticleYear
Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
    Schizophrenia bulletin, 1988, Volume: 14, Issue:3

    Topics: Adult; Corpus Striatum; Haloperidol; Humans; National Institute of Mental Health (U.S.); Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; United States

1988

Trials

3 trial(s) available for 3-n-methylspiperone and Schizophrenia

ArticleYear
High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET.
    Psychopharmacology, 1993, Volume: 110, Issue:3

    Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agonists; Female; Humans; Male; Middle Aged; Prefrontal Cortex; Psychotic Disorders; Raclopride; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed

1993
N-[11C]methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic.
    Psychiatry research, 1998, Jun-30, Volume: 82, Issue:3

    Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Cerebellum; Dibenzothiazepines; Dopamine; Dose-Response Relationship, Drug; Humans; Male; Putamen; Quetiapine Fumarate; Raclopride; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed

1998
Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients.
    The American journal of psychiatry, 1999, Volume: 156, Issue:6

    Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorine Radioisotopes; Humans; Male; Psychiatric Status Rating Scales; Raclopride; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; Treatment Outcome

1999

Other Studies

17 other study(ies) available for 3-n-methylspiperone and Schizophrenia

ArticleYear
Dopamine receptors in schizophrenia.
    Lancet (London, England), 1995, Nov-11, Volume: 346, Issue:8985

    Topics: Antipsychotic Agents; Corpus Striatum; Dopamine Antagonists; Female; Humans; Male; Putamen; Receptors, Dopamine; Schizophrenia; Spiperone

1995
No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone.
    Psychiatry research, 1995, Aug-08, Volume: 61, Issue:2

    Topics: Adult; Carbon Radioisotopes; Cerebellum; Dopamine Agonists; Female; Frontal Lobe; Haloperidol; Humans; Male; Putamen; Radioligand Assay; Receptors, Dopamine D2; Reproducibility of Results; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed

1995
D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients.
    The American journal of psychiatry, 1995, Volume: 152, Issue:10

    Topics: Adult; Benzazepines; Brain; Clozapine; Female; Humans; Male; Middle Aged; Raclopride; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed; Treatment Outcome

1995
Haloperidol blocks the uptake of [18F]N-methylspiroperidol by extrastriatal dopamine receptors in schizophrenic patients.
    Synapse (New York, N.Y.), 1995, Volume: 19, Issue:1

    Topics: Adult; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed

1995
Dopamine D2 receptor density estimates in schizophrenia: a positron emission tomography study with 11C-N-methylspiperone.
    Psychiatry research, 1993, Volume: 49, Issue:3

    Topics: Adult; Carbon Radioisotopes; Chronic Disease; Cohort Studies; Corpus Striatum; Dopamine Agents; Female; Humans; Male; Psychiatric Status Rating Scales; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed

1993
PET measurement of neuroreceptor occupancy by typical and atypical neuroleptics.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1996, Volume: 37, Issue:7

    Topics: Adult; Antipsychotic Agents; Basal Ganglia; Bipolar Disorder; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Clozapine; Dopamine Agonists; Female; Humans; Male; Receptors, Dopamine D2; Receptors, Serotonin; Schizophrenia; Spiperone; Tomography, Emission-Computed

1996
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine Agonists; Guinea Pigs; Haloperidol; Humans; Image Processing, Computer-Assisted; Kinetics; Male; Models, Neurological; Nerve Tissue Proteins; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1997
Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Adult; Aged; Aging; Basal Ganglia; Bipolar Disorder; Brain Chemistry; Caudate Nucleus; Chromatography, High Pressure Liquid; Dopamine Agonists; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1997
Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography.
    Life sciences, 2000, Volume: 66, Issue:25

    Topics: Adult; Carbon Isotopes; Cerebral Cortex; Humans; Receptors, Serotonin; Schizophrenia; Spiperone; Tomography, Emission-Computed

2000
PET studies of neuroreceptors in schizophrenia. Commentary on "The current status of PET scanning with respect to schizophrenia".
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 7, Issue:1

    Topics: Brain; Carbon Radioisotopes; Dopamine Antagonists; Humans; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tritium

1992
Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:1

    Topics: Adult; Animals; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Male; Mice; Schizophrenia; Spiperone; Tomography, Emission-Computed

1992
High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients.
    Biological psychiatry, 1991, Apr-01, Volume: 29, Issue:7

    Topics: Adult; Antipsychotic Agents; Brain; Dyskinesia, Drug-Induced; Female; Humans; Male; Psychiatric Status Rating Scales; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed

1991
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol.
    Journal of neural transmission. General section, 1991, Volume: 86, Issue:3

    Topics: Adult; Aged; Brain Chemistry; Clozapine; Female; Fluorine Radioisotopes; Glucose; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tomography, X-Ray Computed

1991
Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia.
    The American journal of psychiatry, 1989, Volume: 146, Issue:7

    Topics: Adolescent; Adult; Cerebellum; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Fluorine Radioisotopes; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed

1989
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
    Science (New York, N.Y.), 1986, Dec-19, Volume: 234, Issue:4783

    Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Haloperidol; Humans; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1986
Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients.
    Biological psychiatry, 1988, Apr-01, Volume: 23, Issue:7

    Topics: Adult; Binding, Competitive; Chlorpromazine; Corpus Striatum; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1988
Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.
    Psychopharmacology bulletin, 1985, Volume: 21, Issue:3

    Topics: Adult; Bipolar Disorder; Butyrophenones; Caudate Nucleus; Humans; Receptors, Dopamine; Schizophrenia; Spiperone

1985