Page last updated: 2024-08-24

3-n-butylphthalide and Reperfusion Injury

3-n-butylphthalide has been researched along with Reperfusion Injury in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (7.41)	18.2507
2000's	3 (11.11)	29.6817
2010's	13 (48.15)	24.3611
2020's	9 (33.33)	2.80

Authors

Authors	Studies
Ji, H; Lai, Y; Li, T; Ling, J; Liu, J; Peng, S; Tian, J; Wang, X; Wu, J; Zhang, Y	1
Chai, A; Gao, Y; Li, C; Qi, X; Zheng, X	1
Abuduxukuer, R; Guo, ZN; He, Q; Huang, S; Qu, Y; Ren, J; Sun, X; Yang, Y; Zhang, K	1
Chen, Q; Fu, M; Huang, Y; Li, Z; Wang, L; Xiang, R; Xu, J; Yu, C; Yu, H	1
Lu, JD; Sun, ML; Wang, XP	1
Chen, Q; Gu, Q; Liu, T; Min, J; Pan, M; Sun, R; Zhang, D	1
Huang, Y; Pan, L; Wu, T	1
Guo, Y; Li, X; Miao, L; Tian, H; Wang, X; Yuan, R	1
Chen, T; Dong, Y; Fan, Y; Li, X; Lin, W; Liu, F; Wang, N; Wen, J; Yin, J; Zhang, Q	1
Luo, L; Shan Huang, S; Wei Mo, S; Xian Zeng, G; Zhou, B	1
Liu, ZG; Wang, SJ; Xiao, N; Yan, RY; Yao, GT	1
Li, W; Mamtilahun, M; Qin, C; Wang, L; Wang, Y; Yang, GY; Zhang, Z; Zhou, P	1
Hu, NN; Liu, CF; Xie, CL; Zhu, BL; Zhu, XB	1
Chen, DP; Chen, MS; Chen, YG; Hou, SH; Hu, ZZ; Zhang, ZJ	1
Chen, R; Gao, X; Li, J; Liu, Y; Xue, J; Zhang, L; Zhang, X	1
Lan, Z; Lei, M; Li, J; Liang, Z; Xu, W; Xu, X; Zhang, X; Zhao, C	1
Guo, L; Niu, LJ; Qi, FM; Zhou, Y	1
Jiang, Y; Sun, L; Wang, J; Xuan, X	1
Guo, JQ; Huang, XJ; Liu, HZ; Liu, Y; Qi, DS; Song, YJ; Tang, M; Wang, SL; Wang, YL; Wang, YW; Wen, XR; Wu, J; Zhang, F; Zhang, XB	1
Ji, H; Ling, JJ; Ping, FF; Qian, J; Song, HZ; Wang, L; Wang, XL; Zhang, YH; Zhou, J	1
Guo, ZF; Li, YS; Song, JG; Xu, YM; Zhang, P	1
Chen, L; Ji, H; Wang, X; Zhang, C; Zhang, Y; Zhao, Q	1
Dong, GX; Feng, YP	2
Chong, ZZ; Feng, YP	2
Feng, YP; Xu, HL	1

Other Studies

27 other study(ies) available for 3-n-butylphthalide and Reperfusion Injury

Article	Year
Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one. Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16 Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Fibrinolytic Agents; Free Radical Scavengers; Male; Neuroprotective Agents; PC12 Cells; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stereoisomerism; Stroke; Structure-Activity Relationship; Thiophenes	2012
Combination of tetrandrine and 3-n-butylphthalide protects against cerebral ischemia-reperfusion injury via ATF2/TLR4 pathway. Immunopharmacology and immunotoxicology, 2021, Volume: 43, Issue:6 Topics: Activating Transcription Factor 2; Animals; Benzofurans; Benzylisoquinolines; Brain Ischemia; Cells, Cultured; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4	2021
DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis. Current neurovascular research, 2023, Volume: 20, Issue:1 Topics: Animals; Apoptosis; Cerebral Infarction; High-Temperature Requirement A Serine Peptidase 2; Ischemic Stroke; Male; Mitochondria; Mitochondrial Proteins; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2023
Effect of Butylphthalide Capsules on Smac and XIAP Expression in Rats after Ischemia Reperfusion. The Journal of surgical research, 2023, Volume: 283 Topics: Animals; Apoptosis; Brain Ischemia; Capsules; Carotid Stenosis; Caspases; Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; RNA, Messenger; X-Linked Inhibitor of Apoptosis Protein	2023
Butylphthalide protects against ischemia-reperfusion injury in rats via reducing neuron ferroptosis and oxidative stress. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2023, Volume: 71, Issue:6 Topics: Animals; Ferroptosis; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2023
Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2/HO-1 and NOD2/MAPK/NF-κB pathways. Renal failure, 2023, Volume: 45, Issue:2 Topics: Animals; Brain; Brain Injuries; Endothelial Cells; Heme Oxygenase-1; NF-E2-Related Factor 2; NF-kappa B; Nod2 Signaling Adaptor Protein; Rats; Reperfusion Injury	2023
Improvement of cerebral ischemia-reperfusion injury by L-3-n-butylphthalide through promoting angiogenesis. Experimental brain research, 2021, Volume: 239, Issue:1 Topics: Animals; Benzofurans; Brain Ischemia; Humans; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Rats; Reperfusion Injury	2021
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives. Biochemical and biophysical research communications, 2021, 06-04, Volume: 556 Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Line; Cell Line, Tumor; Drug Design; Edaravone; Glucose; Humans; Hydrogen Peroxide; Hypoxia; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2021
Dl-3-n-butylphthalide pretreatment attenuates renal ischemia/reperfusion injury. Biochemical and biophysical research communications, 2021, 06-11, Volume: 557 Topics: Animals; Apoptosis; Benzofurans; Caspase 3; Cell Hypoxia; Cell Survival; Creatinine; Disease Models, Animal; Immunohistochemistry; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reperfusion Injury	2021
Neuroprotective effect and mechanism of butylphthalide after cerebral ischemia-reperfusion injury in rats. Folia neuropathologica, 2021, Volume: 59, Issue:2 Topics: Animals; Benzofurans; Brain Ischemia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2021
The protective effect and its mechanism of 3-n-butylphthalide pretreatment on cerebral ischemia reperfusion injury in rats. European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:22 Topics: Animals; Apoptosis; Benzofurans; Blood-Brain Barrier; Body Water; Brain Ischemia; Caspase 3; Hippocampus; Infarction, Middle Cerebral Artery; Malondialdehyde; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase	2017
Dl-3-N-butylphthalide attenuates ischemic reperfusion injury by improving the function of cerebral artery and circulation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:10 Topics: Animals; Benzofurans; Cerebral Arteries; Cerebrovascular Circulation; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Reperfusion Injury; Vasodilator Agents	2019
Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling. Behavioural neurology, 2018, Volume: 2018 Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Carrier Proteins; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred ICR; Neuroprotective Agents; Phosphorylation; Reperfusion Injury; Signal Transduction	2018
L-butyl phthalein improves neural function of vascular dementia mice by regulating the PI3K/AKT signaling pathway. European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:16 Topics: Animals; Apoptosis; Benzofurans; Dementia, Vascular; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction	2018
Dl-3-N-Butylphthalide Alleviates the Blood-Brain Barrier Permeability of Focal Cerebral Ischemia Reperfusion in Mice. Neuroscience, 2019, 08-10, Volume: 413 Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillary Permeability; Caveolin 1; Cerebrovascular Circulation; Disease Models, Animal; Male; Mice; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Tight Junctions	2019
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. Drug design, development and therapy, 2015, Volume: 9 Topics: Animals; Antioxidants; Antipyrine; Behavior, Animal; Benzofurans; Biological Availability; Brain; Carrageenan; Cell Line; Disease Models, Animal; Edaravone; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Isoindoles; Male; Mice; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Thrombosis; Tissue Distribution	2015
[Effect of 3-n-butylphthalide pretreatment on expression of the HSP70 after brain ischemia/reperfusion]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2015, Volume: 31, Issue:2 Topics: Animals; Benzofurans; CA1 Region, Hippocampal; Cell Death; Cerebral Infarction; HSP70 Heat-Shock Proteins; Ischemic Preconditioning; Neurons; Rats; Rats, Wistar; Reperfusion Injury	2015
Impacts of N-Butylphthalide on expression of growth factors in rats with focal cerebral ischemia. Bosnian journal of basic medical sciences, 2016, Jan-01, Volume: 16, Issue:2 Topics: Animals; Behavior, Animal; Benzofurans; Brain Ischemia; Cerebral Infarction; Intercellular Signaling Peptides and Proteins; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A	2016
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats. Cellular and molecular neurobiology, 2016, Volume: 36, Issue:7 Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Caspase 3; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Neurons; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction	2016
5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury. Oncotarget, 2016, Jun-28, Volume: 7, Issue:26 Topics: Animals; Benzofurans; Brain; Casein Kinase II; Cell Membrane; Cell Survival; Cytosol; Gene Expression Regulation, Enzymologic; Infarction, Middle Cerebral Artery; Male; NADPH Oxidases; Neurons; Neuroprotective Agents; Oxidative Stress; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; RNA Interference	2016
N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 83 Topics: Animals; Astrocytes; Benzofurans; Brain Ischemia; Cell Survival; Hepatocyte Growth Factor; Humans; Inflammation; Lipopolysaccharides; Male; NF-kappa B; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Up-Regulation	2016
(S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death. Neurochemistry international, 2012, Volume: 60, Issue:2 Topics: Animals; Benzofurans; Cell Death; Cinnamates; Disease Models, Animal; Hypoxia-Ischemia, Brain; Male; Mitochondrial Diseases; Nerve Degeneration; Neuroprotective Agents; Nitrates; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2012
[Effects of NBP on ATPase and anti-oxidant enzymes activities and lipid peroxidation in transient focal cerebral ischemic rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2002, Volume: 24, Issue:1 Topics: Adenosine Triphosphatases; Animals; Benzofurans; Cerebral Cortex; Drugs, Chinese Herbal; Glutathione Peroxidase; Ischemic Attack, Transient; Lipid Peroxidation; Male; Mitochondria; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase	2002
Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Benzofurans; Brain; Ischemic Attack, Transient; Neuroprotective Agents; Rats; Reperfusion Injury; Thromboxane B2	1997
dl-3-n-butylphthalide attenuates reperfusion-induced blood-brain barrier damage after focal cerebral ischemia in rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:8 Topics: Animals; Benzofurans; Blood-Brain Barrier; Capillaries; Capillary Permeability; Cerebral Cortex; Immunoglobulin G; Ischemic Attack, Transient; Male; Microscopy, Electron; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury	1999
Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats. Acta pharmacologica Sinica, 2000, Volume: 21, Issue:5 Topics: Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Leukocyte Count; Male; Neuroprotective Agents; Neutrophils; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha	2000
[Effects of 3-N-butylphthalide on cortical calcineurin and calpain activities in focal cerebral ischemia rats]. Yao xue xue bao = Acta pharmaceutica Sinica, 2000, Volume: 35, Issue:10 Topics: Animals; Benzofurans; Brain Ischemia; Calcineurin; Calpain; Cerebral Cortex; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury	2000