3-n-butylphthalide has been researched along with Disease Models, Animal in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (7.02) | 29.6817 |
| 2010's | 39 (68.42) | 24.3611 |
| 2020's | 14 (24.56) | 2.80 |
| Authors | Studies |
|---|---|
| Abbott, BM; Browne, EC | 1 |
| Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H | 1 |
| Cheng, Y; Guan, Y; Guo, L; Li, P; Liu, Y; Wu, Q | 1 |
| Li, J; Li, Q; Meng, H; Wang, C; Wang, S; Wu, Z; Xu, Y; Zhang, A; Zhang, J | 1 |
| Chang, Z; Huang, Z; Jin, D; Li, H; Que, R; Tan, EK; Wang, HT; Wang, Q; Xie, Z; Xu, J; Yang, W; Zhang, W; Zheng, J | 1 |
| Dong, Y; Gao, L; Guo, X; Hu, M; Liu, S; Lv, P; Qin, X; Sun, Q; Xu, J | 1 |
| Ding, M; Fu, X; Guo, M; Liu, D; Pang, Y; Ren, Y; Wang, Z; Wei, L; Yao, N | 1 |
| Bai, M; Jiang, GX; Pan, CL; Zhang, YM; Zhang, Z | 1 |
| Chen, D; Chen, Z; Liu, L; Teng, C; Wu, F; Wu, Y; Xia, L; Xiao, J; Xu, K; Zhang, H; Zhang, K; Zhang, M | 1 |
| Chen, Q; Tan, L; Tu, E; Wang, Y | 1 |
| Gong, X; Hu, Z; Zeng, Z | 1 |
| Ge, X; Li, Q; Qin, Y; Sun, Y; Wang, C; Wang, G; Wang, X; Zhao, Z | 1 |
| Feng, X; Huang, L; Kang, Y; Lan, J; Peng, Y; Tang, J; Wu, L | 1 |
| Chen, J; E, GJ; Gao, YQ; He, S; Hu, Q; Liu, B; Liu, L; Shi, YK; Sun, BD; Xu, G; Zhang, EL; Zhang, JY | 1 |
| Chen, T; Dong, Y; Fan, Y; Li, X; Lin, W; Liu, F; Wang, N; Wen, J; Yin, J; Zhang, Q | 1 |
| Cui, H; Liang, Z; Liu, Y; Shao, F; Shi, X; Tang, Z; Wu, Y; Yang, S; Yang, Z; Yu, C; Zhao, S | 1 |
| Hu, Z; Liu, J; Pi, Z; Xiao, H | 1 |
| Caslin, A; Chen, D; Gu, X; Lee, JH; Li, J; Wei, L; Yu, SP; Zhao, Y | 1 |
| Cheng, X; Liang, Y; Luo, Y; Mu, X; Qu, H; Sun, Y; Wang, H; Zhao, C | 1 |
| Dong, Y; Fan, M; Hu, M; Huai, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xu, J | 1 |
| Chen, YH; Ge, BB; Jiang, MJ; Li, L; Liu, H; Qu, HD; Qu, XL; Xu, JJ; Xu, L | 1 |
| Huang, Y; Li, Z; Nan, G | 1 |
| Tian, Z; Wang, J; Wang, Y; Zhang, M; Zhou, Y | 1 |
| Fan, CX; Liu, HH; Liu, RZ; Nie, ZX; Pu, XP; Sun, Y; Zhang, ZL; Zhao, X | 1 |
| Dong, Y; Fan, M; Hu, M; Jia, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xiao, Y; Xu, J; Zhang, D | 1 |
| Chen, Y; Ge, B; Jiang, M; Li, L; Wei, D; Xu, W; Ye, M; Yu, M; Zhang, L | 1 |
| Hu, NN; Liu, CF; Xie, CL; Zhu, BL; Zhu, XB | 1 |
| Bai, XM; Ji, SX; Li, J; Yuan, F; Zhang, LH; Zhang, SY | 1 |
| Dong, L; Huang, Q; Liao, Y; Sun, L; Tang, Y; Wu, Y | 1 |
| Chen, R; Gao, X; Li, J; Liu, Y; Xue, J; Zhang, L; Zhang, X | 1 |
| Cheng, W; Dong, LF; Liao, W; Zhong, Y | 1 |
| Gao, P; Hu, J; Li, B; Wen, Q; Wu, Y | 1 |
| Huang, Q; Liu, X; Wei, X; Wu, Y | 1 |
| Lan, Z; Lei, M; Li, J; Liang, Z; Xu, W; Xu, X; Zhang, X; Zhao, C | 1 |
| Cai, J; Cui, DD; Lei, H; Li, J; Liu, DM; Peng, Y; Rong, XF; Wang, L; Wang, XL; Xu, SF; Yang, LC; Zhang, M | 1 |
| Cai, J; Lei, H; Li, L; Li, PP; Peng, Y; Wang, L; Wang, XL; Xu, SF; Zhang, Y; Zhao, CY | 1 |
| Duan, H; Guo, X; Han, F; Jin, C; Li, H; Ma, J; Meng, L; Peng, Y; Sun, Y; Wang, F | 1 |
| Cai, JH; Wang, CY; Wang, T; Wang, X; Wang, ZY; Xie, JW; Xu, Y | 1 |
| Huang, LJ; Peng, Y; Shi, S; Wang, XL; Xu, SF; Zhang, Y | 1 |
| LaManna, JC; Puchowicz, MA; Xu, K; Zhang, L | 1 |
| Ding, H; Ding, K; Li, L; Li, X; Liu, Z; Shi, X; Wang, H; Yang, Y; Zhou, M | 1 |
| Huang, RX; Liao, SJ; Lin, JW; Liu, CL; Pei, Z; Zeng, JS | 1 |
| Chen, K; Hou, DR; Tian, Y; Wan, S; Zhou, J | 1 |
| Chen, K; Hou, D; Tian, Y; Wan, S; Xue, L | 1 |
| Jia, W; Sun, X; Zhang, T | 1 |
| Feng, Y; Hon, S; Lemere, CA; Nylander, AN; Peng, Y; Sun, J; Wang, X; Xia, W | 1 |
| Hou, DR; Sun, JJ; Tang, JC; Xue, L; Zhou, J | 1 |
| Cao, X; Chen, C; Hou, L; Huang, J; Jia, M; Liang, Z; Lin, Z; Sun, S; Wang, T; Xiong, N; Yang, H; Zhang, Y; Zhang, Z; Zhao, Y | 1 |
| Fu, J; Jia, W; Li, Q; Liu, K; Liu, X; Sun, X; Yan, W; Zhang, T | 1 |
| Cui, L; Feng, X; Liu, M; Peng, Y | 1 |
| Chen, L; Ji, H; Wang, X; Zhang, C; Zhang, Y; Zhao, Q | 1 |
| Feng, N; Hu, Y; Li, J; Li, P; Lu, L; Peng, Y; Wang, L; Wang, X; Xu, S; Yang, H | 1 |
| Chan, WM; Dong, J; Huang, Y; Qi, W; Wai, MS; Wang, C; Wang, YX; Yew, DT; Yu, WH; Zhang, L; Zhao, F | 1 |
| Cui, LY; Feng, XH; Liu, MS; Peng, Y; Yuan, W | 1 |
| Feng, N; Li, P; Peng, Y; Wang, L; Wang, W; Wang, X; Yuan, H; Zhang, M | 1 |
| Li, J; Wang, L; Wang, XL; Zhang, Y | 1 |
| Huang, RX; Li, CX; Liao, SJ; Lin, JW; Liu, CL; Shi, XG; Xie, LC; Zeng, JS | 1 |
1 review(s) available for 3-n-butylphthalide and Disease Models, Animal
| Article | Year |
|---|---|
Recent progress towards an effective treatment of amyotrophic lateral sclerosis using the SOD1 mouse model in a preclinical setting.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biological Products; Disease Models, Animal; Drug Discovery; Humans; Mice; Superoxide Dismutase-1 | 2016 |
56 other study(ies) available for 3-n-butylphthalide and Disease Models, Animal
| Article | Year |
|---|---|
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha | 2022 |
Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.
Topics: Animals; Apoptosis Regulatory Proteins; Benzofurans; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Endothelial Cells; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents | 2021 |
Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy.
Topics: Animals; Area Under Curve; Benzofurans; Caco-2 Cells; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Humans; Ischemic Stroke; Liposomes; Male; Neuroprotective Agents; Particle Size; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Cholate; Tissue Distribution | 2021 |
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Topics: alpha-Synuclein; Animals; Apoptosis; Benzofurans; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Humans; Inflammasomes; Mice; Mitochondria; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Protein Aggregation, Pathological | 2021 |
DL-3-n-butylphthalide imparts neuroprotection via Nrf2/SIRT3 pathway in a mouse model of vascular dementia.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; CA1 Region, Hippocampal; Dementia, Vascular; Disease Models, Animal; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Sirtuin 3 | 2022 |
Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF-κB in a murine asthma model.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Benzofurans; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Leukocyte Count; Lung; Mice, Inbred BALB C; Mucin 5AC; Mucus; NF-kappa B; Ovalbumin | 2019 |
Effects of butylphthalide on oxidative stress and inflammatory response in rats with myocardial infarction through Akt/Nrf2 signaling pathway.
Topics: Animals; Benzofurans; Disease Models, Animal; Inflammation; Male; Myocardial Infarction; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Dl-3n-butylphthalide improves traumatic brain injury recovery via inhibiting autophagy-induced blood-brain barrier disruption and cell apoptosis.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; Blood-Brain Barrier; Brain Injuries, Traumatic; Cells, Cultured; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Recovery of Function | 2020 |
Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage.
Topics: Animals; Benzofurans; Brain; Cerebral Hemorrhage; Disease Models, Animal; Male; Nervous System Diseases; Rats, Sprague-Dawley; Stroke; Vascular Endothelial Growth Factor A | 2020 |
L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model.
Topics: Animals; Anti-Inflammatory Agents; Apium; Benzofurans; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Humans; Infusions, Intraventricular; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Permeability; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats.
Topics: Acetylcholinesterase; Animals; Benzofurans; Brain Ischemia; China; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2020 |
L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer's disease mouse model and cultured hippocampal neurons.
Topics: Alzheimer Disease; Animals; Autophagosomes; Autophagy; Axons; Benzofurans; Biomarkers; Cells, Cultured; Cognitive Dysfunction; Dendritic Spines; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Lysosomes; Male; Mice, Transgenic; Morris Water Maze Test; Neurites; Neuronal Plasticity; Synapses | 2021 |
DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia.
Topics: Altitude Sickness; Animals; Benzofurans; Disease Models, Animal; Memory, Short-Term; Rats; Rats, Sprague-Dawley; Survival Analysis | 2021 |
Dl-3-n-butylphthalide pretreatment attenuates renal ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Benzofurans; Caspase 3; Cell Hypoxia; Cell Survival; Creatinine; Disease Models, Animal; Immunohistochemistry; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reperfusion Injury | 2021 |
DL-3-n-butylphthalide-induced neuroprotection in rat models of asphyxia-induced cardiac arrest followed by cardiopulmonary resuscitation.
Topics: Animals; Apoptosis; Asphyxia; Benzofurans; Brain Diseases; Cardiopulmonary Resuscitation; Disease Models, Animal; Heart Arrest; Hippocampus; JNK Mitogen-Activated Protein Kinases; Neurons; Neuroprotection; Neuroprotective Agents; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats, Sprague-Dawley; Return of Spontaneous Circulation; Signal Transduction; tau Proteins; Time Factors | 2021 |
L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage.
Topics: Animals; Benzofurans; Cerebral Hemorrhage; Disease Models, Animal; Hemorrhagic Stroke; Humans; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2021 |
DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice.
Topics: Animals; Behavior, Animal; Benzofurans; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Interleukin-1beta; Male; Mice, Inbred C57BL; Neuroprotection; NF-kappa B; Recovery of Function; Signal Transduction; Up-Regulation | 2017 |
dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats.
Topics: Animals; Benzofurans; Biotin; Brain Infarction; Dextrans; Disease Models, Animal; Disks Large Homolog 4 Protein; Doublecortin Protein; Endothelin-1; Male; Motor Activity; Neuronal Plasticity; Nogo Proteins; Nogo Receptor 1; Platelet Aggregation Inhibitors; Psychomotor Performance; Rats; Rats, Wistar; Recovery of Function; Signal Transduction; Stroke; Vesicular Glutamate Transport Protein 1 | 2017 |
L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; Brain Ischemia; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Male; Memory Disorders; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Reperfusion; TOR Serine-Threonine Kinases | 2017 |
Protective effects of DL‑3‑n‑butylphthalide in the lipopolysaccharide‑induced mouse model of Parkinson's disease.
Topics: Animals; Apoptosis; Benzofurans; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotarod Performance Test; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
Effect of hippocampal L‑NBP on BDNF and TrkB expression and neurological function of vascular dementia rats.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Carotid Artery, Common; Cerebral Cortex; Dementia, Vascular; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Ligation; Male; Maze Learning; Memory, Short-Term; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
Effects of butylphthalide on cognitive decline in diabetic rats.
Topics: Animals; Benzofurans; Blood Glucose; Body Weight; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction; Cytokines; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Gene Expression Regulation; Hippocampus; Inflammation Mediators; Maze Learning; Neuroprotective Agents; Rats | 2017 |
Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Brain Ischemia; Citric Acid; Disease Models, Animal; Glucose; Infarction; Metabolic Networks and Pathways; Neuroprotective Agents; Platelet Aggregation Inhibitors; Rats; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2017 |
DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats.
Topics: Animals; Benzofurans; Brain Ischemia; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
DL‑3‑n‑butylphthalide reduces microglial activation in lipopolysaccharide‑induced Parkinson's disease model mice.
Topics: alpha-Synuclein; Animals; Benzofurans; Disease Models, Animal; Dyskinesias; Gene Expression Regulation; Immunohistochemistry; Lipopolysaccharides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; Neuroprotective Agents; Parkinson Disease, Secondary; Rotarod Performance Test; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2018 |
Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Carrier Proteins; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred ICR; Neuroprotective Agents; Phosphorylation; Reperfusion Injury; Signal Transduction | 2018 |
L-3-n-butylphthalide attenuates cognitive deficits in db/db diabetic mice.
Topics: Animals; Benzofurans; Caspase 3; Cognition; Cognitive Dysfunction; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Hippocampus; Maze Learning; Mice; Neuroprotective Agents; Oxidative Stress | 2019 |
Multiple functional therapeutic effects of DL-3-n-butylphthalide in the cuprizone model of demyelination.
Topics: Animals; Astrocytes; Axons; Benzofurans; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroprotective Agents; NF-kappa B; Oligodendroglia; Signal Transduction | 2019 |
Dl-3-N-Butylphthalide Alleviates the Blood-Brain Barrier Permeability of Focal Cerebral Ischemia Reperfusion in Mice.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillary Permeability; Caveolin 1; Cerebrovascular Circulation; Disease Models, Animal; Male; Mice; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Tight Junctions | 2019 |
3-N-butylphthalide inhibits neuronal apoptosis in rats with cerebral infarction via targeting P38/MAPK.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzofurans; Cerebral Infarction; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation; Injections, Intraperitoneal; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats | 2019 |
The effect of butylphthalide on the brain edema, blood-brain barrier of rats after focal cerebral infarction and the expression of Rho A.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain; Brain Edema; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Immunohistochemistry; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Time Factors; Water | 2014 |
Dl-3-n-butylphthalide is effective for demyelination: a case-combined study.
Topics: Adult; Animals; Benzofurans; Brain; Demyelinating Diseases; Disease Models, Animal; Electroencephalography; Humans; Magnetic Resonance Imaging; Male; Methylprednisolone; Radiography; Rats, Sprague-Dawley; Treatment Outcome | 2015 |
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent.
Topics: Animals; Antioxidants; Antipyrine; Behavior, Animal; Benzofurans; Biological Availability; Brain; Carrageenan; Cell Line; Disease Models, Animal; Edaravone; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Isoindoles; Male; Mice; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Thrombosis; Tissue Distribution | 2015 |
L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats.
Topics: Administration, Oral; Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Survival; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neural Stem Cells; Neurogenesis; Neuronal Plasticity; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Recovery of Function; STAT3 Transcription Factor; Synapses | 2015 |
L-3-n-Butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and upregulating Heme oxygenase-1 in lipopolysaccharide-treated mice.
Topics: Animals; Benzofurans; Brain; Cytokines; Disease Models, Animal; Heme Oxygenase-1; Immunologic Factors; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Microglia; Mitogen-Activated Protein Kinases; Molecular Structure; Neuroprotective Agents; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2016 |
DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model.
Topics: Animals; Benzofurans; Biomarkers; Blood Glucose; Body Weight; Catalase; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Progression; Immunohistochemistry; Lens, Crystalline; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Thioredoxins | 2016 |
Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Brain; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; NF-E2-Related Factor 2; Oxidative Stress; Up-Regulation | 2016 |
L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; beta Catenin; Dendritic Spines; Disease Models, Animal; Disks Large Homolog 4 Protein; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuroprotective Agents; Presenilin-1; Synapses | 2016 |
Protective Effect of Dl-3-n-Butylphthalide on Recovery from Cardiac Arrest and Resuscitation in Rats.
Topics: Animals; Benzofurans; CA1 Region, Hippocampal; Disease Models, Animal; Heart Arrest; Male; Neurons; Neuroprotective Agents; Rats, Wistar; Recovery of Function; Resuscitation; Time Factors | 2016 |
DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling Pathway.
Topics: Animals; Benzofurans; Brain Injuries, Traumatic; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Random Allocation; Signal Transduction | 2017 |
Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP.
Topics: Angiogenesis Inducing Agents; Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Drugs, Chinese Herbal; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neovascularization, Physiologic; Rats; Up-Regulation; Vascular Endothelial Growth Factor A | 2009 |
[Effect of butylphthalide on the expression of S100 and glial fibrillary acidic protein in a rat model of Alzheimer disease].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzofurans; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Male; Nerve Growth Factors; Neuroprotective Agents; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; S100 Proteins | 2009 |
[Effect of butylphthalide on the expression of GFAP and VEGF in the hippocampus of rats with Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Benzofurans; Disease Models, Animal; Drugs, Chinese Herbal; Glial Fibrillary Acidic Protein; Hippocampus; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2010 |
3-n-Butylphthalide (NBP) reduces apoptosis and enhances vascular endothelial growth factor (VEGF) up-regulation in diabetic rats.
Topics: Animals; Apoptosis; Benzofurans; Cerebral Arteries; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Gliosis; Hippocampus; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
Topics: ADAM Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cell Line, Tumor; Cell Survival; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indoles; Leukocyte Common Antigens; Male; Maleimides; Malondialdehyde; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neuroglia; Neuroprotective Agents; Oxidative Stress; Presenilin-1; Reaction Time; Spatial Behavior; Statistics, Nonparametric; tau Proteins; Time Factors; Transfection | 2010 |
[Butylphthalide improves learning and memory abilities of rats with Alzheimer's disease possibly by enhancing protein disulfide isomerase and inhibiting P53 expressions].
Topics: Alzheimer Disease; Animals; Apoptosis; Benzofurans; Brain; Disease Models, Animal; Learning; Male; Memory; Protein Disulfide-Isomerases; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 2010 |
Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease.
Topics: Animals; Antioxidants; Antiparkinson Agents; Benzofurans; Cell Line; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Humans; Neuroprotective Agents; Parkinsonian Disorders; Rats; Rotenone; Treatment Outcome | 2012 |
3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia.
Topics: Amyloid beta-Peptides; Animals; Autophagy; Benzofurans; Brain Ischemia; Dementia; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Random Allocation; Treatment Outcome | 2011 |
DL-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Benzofurans; Disease Models, Animal; Mice; Mice, Transgenic; Motor Neurons; Neuroglia; Neuroprotective Agents; Spinal Cord; Superoxide Dismutase | 2012 |
(S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death.
Topics: Animals; Benzofurans; Cell Death; Cinnamates; Disease Models, Animal; Hypoxia-Ischemia, Brain; Male; Mitochondrial Diseases; Nerve Degeneration; Neuroprotective Agents; Nitrates; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzofurans; Brain; Cell Line, Tumor; Cognition Disorders; Cyclin-Dependent Kinase 5; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Maze Learning; Mice; Mice, Transgenic; Neuroblastoma; Neuroprotective Agents; Phosphorylation; Presenilin-1; Reaction Time; Spatial Behavior; tau Proteins; Time Factors | 2012 |
DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment.
Topics: Analysis of Variance; Animals; Antioxidants; Benzofurans; Brain Infarction; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Nervous System Diseases; Neurologic Examination; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazolium Salts | 2012 |
Therapeutic effects of dl-3-n-butylphthalide in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Benzofurans; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Transgenic | 2012 |
An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy.
Topics: Animals; Benzofurans; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hypertrophy, Left Ventricular; Isoproterenol; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Rats; Rats, Sprague-Dawley | 2013 |
2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia.
Topics: Animals; Benzoates; Benzofurans; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Laser-Doppler Flowmetry; Male; Neuroprotective Agents; Pentanes; Prodrugs; Rats; Rats, Sprague-Dawley | 2006 |
dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP.
Topics: Animals; Aspirin; Benzofurans; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Cold Temperature; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Hypertension, Renal; Male; Microcirculation; Molecular Structure; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Treatment Outcome | 2007 |