3-n-butylphthalide has been researched along with Dementia, Vascular in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 8 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, Y; Gao, L; Guo, X; Hu, M; Liu, S; Lv, P; Qin, X; Sun, Q; Xu, J | 1 |
| Che, P; Lin, A; Tang, P; Wang, Y; Xu, J; Yu, M; Zhang, J; Zhang, N | 1 |
| Dong, Y; Fang, T; Li, Q; Liang, P; Shen, L; Song, Y; Wang, L | 1 |
| Gao, TC; Hu, Y; Kang, LJ; Li, P; Qi, FX; Zhang, X | 1 |
| Li, H; Li, W; Tian, A; Zai, Q; Zhang, RW | 1 |
| Ge, X; Li, Q; Qin, Y; Sun, Y; Wang, C; Wang, G; Wang, X; Zhao, Z | 1 |
| Ma, Y; Sun, W | 1 |
| Wu, F; Yang, R; Zhou, L | 1 |
| Huang, Y; Li, Z; Nan, G | 1 |
| Chen, DP; Chen, MS; Chen, YG; Hou, SH; Hu, ZZ; Zhang, ZJ | 1 |
| Gui, Y; Niu, X; Wang, J; Yan, H; Yan, Z; Zhang, P | 1 |
| Chan, WM; Huang, Y; Lü, L; Wai, MS; Yew, DT; Zhang, L | 1 |
1 trial(s) available for 3-n-butylphthalide and Dementia, Vascular
| Article | Year |
|---|---|
Effects of Butyphthalide Combined with Idebenone on Inflammatory Cytokines and Vascular Endothelial Functions of Patients with Vascular Dementia.
Topics: Activities of Daily Living; Aged; Antioxidants; Benzofurans; C-Reactive Protein; Cytokines; Dementia, Vascular; Drug Therapy, Combination; Endothelin-1; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Ubiquinone; Vascular Endothelial Growth Factor A | 2020 |
11 other study(ies) available for 3-n-butylphthalide and Dementia, Vascular
| Article | Year |
|---|---|
DL-3-n-butylphthalide imparts neuroprotection via Nrf2/SIRT3 pathway in a mouse model of vascular dementia.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; CA1 Region, Hippocampal; Dementia, Vascular; Disease Models, Animal; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Sirtuin 3 | 2022 |
Dl-3-n-butylphthalide promotes synaptic plasticity by activating the Akt/ERK signaling pathway and reduces the blood-brain barrier leakage by inhibiting the HIF-1α/MMP signaling pathway in vascular dementia model mice.
Topics: Animals; Blood-Brain Barrier; Dementia, Vascular; Mice; Neuronal Plasticity; Proto-Oncogene Proteins c-akt; Signal Transduction | 2023 |
Dl-3-n-Butylphthalide Protects against Memory Deficits in Vascular Dementia Rats by Attenuating Pyroptosis via TLR-4/NF-κB Signaling Pathway.
Topics: Animals; Dementia, Vascular; Maze Learning; Memory Disorders; Neuroprotective Agents; NF-kappa B; Pyroptosis; Rats; Signal Transduction; Toll-Like Receptor 4 | 2023 |
3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Dementia, Vascular; Male; Maze Learning; Memory; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1 | 2020 |
Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats.
Topics: Acetylcholinesterase; Animals; Benzofurans; Brain Ischemia; China; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2020 |
Effects of Dengzhan Shengmai Capsule combined with butylphthalide soft capsule on oxidative stress indexes and serum Hcy and CRP levels in patients with vascular dementia.
Topics: Aged; Benzofurans; C-Reactive Protein; Dementia, Vascular; Drugs, Chinese Herbal; Female; Homocysteine; Humans; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase | 2020 |
Efficacy and safety of butylphthalide as adjunctive therapy for vascular dementia: A protocol for systematic review and meta-analysis.
Topics: Benzofurans; Clinical Protocols; Dementia, Vascular; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Systematic Reviews as Topic; Treatment Outcome | 2020 |
Effect of hippocampal L‑NBP on BDNF and TrkB expression and neurological function of vascular dementia rats.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Carotid Artery, Common; Cerebral Cortex; Dementia, Vascular; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Ligation; Male; Maze Learning; Memory, Short-Term; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
L-butyl phthalein improves neural function of vascular dementia mice by regulating the PI3K/AKT signaling pathway.
Topics: Animals; Apoptosis; Benzofurans; Dementia, Vascular; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction | 2018 |
Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study.
Topics: Benzofurans; Biomarkers; Brain Ischemia; C-Reactive Protein; Cognition; Dementia, Vascular; Female; Homocysteine; Humans; Logistic Models; Male; Mental Status Schedule; Middle Aged; Multivariate Analysis; Neuroprotective Agents; Neuropsychological Tests; Nootropic Agents; Prospective Studies; Risk Factors; Stroke; Treatment Outcome | 2017 |
Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis.
Topics: Animals; Benzofurans; Cell Line, Tumor; Chick Embryo; Dementia, Vascular; Drugs, Chinese Herbal; Humans; Immunohistochemistry; Male; Maze Learning; Neovascularization, Physiologic; Neuroprotective Agents; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2012 |