Compounds > 3-n-butylphthalide
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3-n-butylphthalide and Cognitive Dysfunction

3-n-butylphthalide has been researched along with Cognitive Dysfunction in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (35.29)24.3611
2020's11 (64.71)2.80

Authors

AuthorsStudies
Chi, X; Han, C; Hu, J; Huang, J; Kou, L; Li, Y; Sun, Y; Wan, F; Wang, T; Wu, J; Xia, Y; Yin, S; Zhou, Q; Zou, W1
Shen, J; Wei, W; Yang, L1
Chen, J; Chen, Y; Li, W; Liu, Y; Tan, H; Xiao, L; Yi, F; Zhou, Y1
Gao, F; Gao, L; Guo, X; Huo, K; Liu, J; Liu, Z; Lu, W; Qu, Q; Wang, J1
Cao, H; Gao, J; He, J; Wan, S; Wang, S; Wang, X; Wang, Y; Zhai, L; Zhang, X; Zhao, Y; Zhu, H1
Luo, Y; Wang, R; Wang, Y; Yang, Z; Zhao, F; Zheng, Y; Zhong, L1
Li, H; Li, W; Tian, A; Zai, Q; Zhang, RW1
Ge, X; Li, Q; Qin, Y; Sun, Y; Wang, C; Wang, G; Wang, X; Zhao, Z1
Feng, X; Huang, L; Kang, Y; Lan, J; Peng, Y; Tang, J; Wu, L1
Chen, ZM; Li, PF; Liu, YQ; Mamun, AA; Wang, BN; Wang, J; Wu, CB; Wu, YQ; Xiao, J; Xiong, J; Xu, JY; Ye, LB; Zheng, PP; Zheng, ZL1
Gao, F; Guo, X; Liu, J; Lu, W; Ma, L; Qu, Q; Quan, Q; Su, H; Wang, J; Zhang, H1
Jiang, C; Li, Y; Pang, J; Wang, B; Xiang, W; Xue, H; Zhang, J1
Dong, Y; Fan, M; Hu, M; Huai, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xu, J1
Tian, Z; Wang, J; Wang, Y; Zhang, M; Zhou, Y1
Dong, Y; Fan, M; Hu, M; Jia, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xiao, Y; Xu, J; Zhang, D1
Bai, XM; Ji, SX; Li, J; Yuan, F; Zhang, LH; Zhang, SY1
Cao, X; Dai, YT; Han, LJ; Han, QY; He, DS; Wang, SW; Xu, Y; Zhang, H; Zhang, X1

Reviews

1 review(s) available for 3-n-butylphthalide and Cognitive Dysfunction

ArticleYear
Efficacy and safety of 3-n-butylphthalide for the treatment of cognitive impairment: A systematic review and meta-analysis.
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Benzofurans; Cognition; Cognition Disorders; Cognitive Dysfunction; Humans

2022

Trials

3 trial(s) available for 3-n-butylphthalide and Cognitive Dysfunction

ArticleYear
Dl-3-n-butylphthalide prevents chronic restraint stress-induced depression-like behaviors and cognitive impairment via regulating CaMKII/CREB/BDNF signaling pathway in hippocampus.
    Neuroreport, 2022, 10-05, Volume: 33, Issue:14

    Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Depression; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Signal Transduction; Synaptophysin

2022
Protocol of End-PSCI trial: a multicenter, randomized controlled trial to evaluate the effects of DL-3-n-butylphthalide on delayed-onset post stroke cognitive impairment.
    BMC neurology, 2022, Nov-16, Volume: 22, Issue:1

    Topics: Brain Ischemia; Cognitive Dysfunction; Humans; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Stroke

2022
Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning.
    Medical science monitor : international medical journal of experimental and clinical research, 2017, Mar-29, Volume: 23

    Topics: Acute Disease; Benzofurans; Brain Diseases; Carbon Monoxide Poisoning; Cognitive Dysfunction; Demography; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Neuropsychological Tests; Remission Induction; Treatment Outcome

2017

Other Studies

13 other study(ies) available for 3-n-butylphthalide and Cognitive Dysfunction

ArticleYear
Butylphthalide alleviates sleep deprivation-induced cognitive deficit by regulating Nrf2/HO-1 pathway.
    Sleep medicine, 2022, Volume: 100

    Topics: Animals; Cognition; Cognitive Dysfunction; Heme Oxygenase-1; Hippocampus; Mice; NF-E2-Related Factor 2; Oxidative Stress; Sleep Deprivation

2022
Effects of NBP on postoperative cognitive dysfunction in rats via Nrf 2/ARE pathway.
    Aging, 2023, 01-09, Volume: 15, Issue:1

    Topics: Aging; Animals; Cognition; Cognitive Dysfunction; Hippocampus; Neuroprotective Agents; Postoperative Cognitive Complications; Quality of Life; Rats; Signal Transduction

2023
Untargeted metabolomics uncovering neuroprotective effect of Dl-3-n-butylphthalide on improving cognitive impairment induced by chronic cerebral hypoperfusion in rats.
    International immunopharmacology, 2023, Volume: 119

    Topics: Animals; Brain Ischemia; Chromatography, Liquid; Cognitive Dysfunction; Metabolomics; Neuroprotective Agents; Rats; Tandem Mass Spectrometry

2023
3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway.
    Molecular medicine reports, 2020, Volume: 22, Issue:1

    Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Dementia, Vascular; Male; Maze Learning; Memory; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1

2020
Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats.
    The Journal of international medical research, 2020, Volume: 48, Issue:7

    Topics: Acetylcholinesterase; Animals; Benzofurans; Brain Ischemia; China; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A

2020
L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer's disease mouse model and cultured hippocampal neurons.
    Molecular neurobiology, 2021, Volume: 58, Issue:3

    Topics: Alzheimer Disease; Animals; Autophagosomes; Autophagy; Axons; Benzofurans; Biomarkers; Cells, Cultured; Cognitive Dysfunction; Dendritic Spines; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Lysosomes; Male; Mice, Transgenic; Morris Water Maze Test; Neurites; Neuronal Plasticity; Synapses

2021
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:3

    Topics: Animals; Apoptosis; Benzofurans; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Dendrites; Diabetes Mellitus, Type 2; Hippocampus; Male; Mice, Inbred C57BL; Morris Water Maze Test; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Synapses

2021
Donepezil Combined with DL-3-n-Butylphthalide Delays Cognitive Decline in Patients with Mild to Moderate Alzheimer's Disease: A Multicenter, Prospective Cohort Study.
    Journal of Alzheimer's disease : JAD, 2021, Volume: 80, Issue:2

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Benzofurans; Cognitive Dysfunction; Cohort Studies; Donepezil; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Prospective Studies; Treatment Outcome

2021
L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury.
    Neurochemical research, 2017, Volume: 42, Issue:10

    Topics: Animals; Apoptosis; Autophagy; Benzofurans; Brain Ischemia; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Male; Memory Disorders; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Reperfusion; TOR Serine-Threonine Kinases

2017
Effects of butylphthalide on cognitive decline in diabetic rats.
    Molecular medicine reports, 2017, Volume: 16, Issue:6

    Topics: Animals; Benzofurans; Blood Glucose; Body Weight; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction; Cytokines; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Gene Expression Regulation; Hippocampus; Inflammation Mediators; Maze Learning; Neuroprotective Agents; Rats

2017
DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats.
    Neuroscience letters, 2018, 04-13, Volume: 672

    Topics: Animals; Benzofurans; Brain Ischemia; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction

2018
L-3-n-butylphthalide attenuates cognitive deficits in db/db diabetic mice.
    Metabolic brain disease, 2019, Volume: 34, Issue:1

    Topics: Animals; Benzofurans; Caspase 3; Cognition; Cognitive Dysfunction; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Hippocampus; Maze Learning; Mice; Neuroprotective Agents; Oxidative Stress

2019
dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion.
    CNS neuroscience & therapeutics, 2019, Volume: 25, Issue:9

    Topics: Animals; Benzofurans; Brain Ischemia; Carotid Stenosis; Cells, Cultured; Cerebrovascular Circulation; Chronic Disease; Cognitive Dysfunction; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; White Matter

2019