Compounds > 3-n-butylphthalide
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3-n-butylphthalide and Cognition Disorders

3-n-butylphthalide has been researched along with Cognition Disorders in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Chi, X; Han, C; Hu, J; Huang, J; Kou, L; Li, Y; Sun, Y; Wan, F; Wang, T; Wu, J; Xia, Y; Yin, S; Zhou, Q; Zou, W1
Dong, Y; Fan, M; Hu, M; Huai, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xu, J1
Chen, S; Chen, X; Chen, Y; Chu, L; Dong, W; Fang, B; Guo, H; Han, X; Huang, L; Jia, J; Jia, Q; Li, D; Liang, J; Lv, P; Niu, X; Peng, D; Peng, M; Song, H; Wang, K; Wei, C; Wu, J; Wu, L; Zhang, J; Zhou, A; Zuo, X1
Chen, G; Feng, Y; Lemere, CA; Liu, B; Peng, Y; Wang, L; Wang, X; Xing, C; Xu, S1
Feng, Y; Hon, S; Lemere, CA; Nylander, AN; Peng, Y; Sun, J; Wang, X; Xia, W1
Feng, N; Hu, Y; Li, J; Li, P; Lu, L; Peng, Y; Wang, L; Wang, X; Xu, S; Yang, H1
Li, N; Wang, Y; Xu, J; Xu, L; Yang, H; Yang, Z1
Chen, G; Feng, Y; Peng, Y; Wang, L; Wang, X; Xu, S1

Reviews

1 review(s) available for 3-n-butylphthalide and Cognition Disorders

ArticleYear
Efficacy and safety of 3-n-butylphthalide for the treatment of cognitive impairment: A systematic review and meta-analysis.
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Benzofurans; Cognition; Cognition Disorders; Cognitive Dysfunction; Humans

2022

Trials

1 trial(s) available for 3-n-butylphthalide and Cognition Disorders

ArticleYear
The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial.
    Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016, Volume: 12, Issue:2

    Topics: Aged; Benzofurans; Cerebral Small Vessel Diseases; China; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests

2016

Other Studies

6 other study(ies) available for 3-n-butylphthalide and Cognition Disorders

ArticleYear
L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury.
    Neurochemical research, 2017, Volume: 42, Issue:10

    Topics: Animals; Apoptosis; Autophagy; Benzofurans; Brain Ischemia; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Male; Memory Disorders; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Reperfusion; TOR Serine-Threonine Kinases

2017
L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats.
    European journal of pharmacology, 2009, Oct-25, Volume: 621, Issue:1-3

    Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzofurans; Cerebral Ventricles; Cognition Disorders; Infusion Pumps; Learning; Male; Memory; Neurons; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; tau Proteins

2009
L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jun-16, Volume: 30, Issue:24

    Topics: ADAM Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cell Line, Tumor; Cell Survival; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indoles; Leukocyte Common Antigens; Male; Maleimides; Malondialdehyde; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neuroglia; Neuroprotective Agents; Oxidative Stress; Presenilin-1; Reaction Time; Spatial Behavior; Statistics, Nonparametric; tau Proteins; Time Factors; Transfection

2010
L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.
    Journal of Alzheimer's disease : JAD, 2012, Volume: 29, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzofurans; Brain; Cell Line, Tumor; Cognition Disorders; Cyclin-Dependent Kinase 5; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Maze Learning; Mice; Mice, Transgenic; Neuroblastoma; Neuroprotective Agents; Phosphorylation; Presenilin-1; Reaction Time; Spatial Behavior; tau Proteins; Time Factors

2012
L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia.
    Neuropharmacology, 2012, Volume: 62, Issue:7

    Topics: Animals; Benzofurans; Brain Ischemia; Chronic Disease; Cognition Disorders; Male; Maze Learning; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar

2012
l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Acetylcholinesterase; Animals; Astrocytes; Benzofurans; Brain Ischemia; Carotid Artery, Common; Catalase; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Corpus Callosum; Glutathione Peroxidase; Hippocampus; Learning Disabilities; Ligation; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Visual Pathways

2007