Page last updated: 2024-08-24

3-n-butylphthalide and Cerebral Ischemia

3-n-butylphthalide has been researched along with Cerebral Ischemia in 67 studies

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (4.48)18.2507
2000's6 (8.96)29.6817
2010's27 (40.30)24.3611
2020's31 (46.27)2.80

Authors

AuthorsStudies
Ji, H; Lai, Y; Li, T; Ling, J; Liu, J; Peng, S; Tian, J; Wang, X; Wu, J; Zhang, Y1
Chen, N; Chu, S; Li, C; Li, Y; Liu, D; Ma, J; Ren, Q; Song, X; Zang, Y; Zhang, D1
Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H1
Chai, A; Gao, Y; Li, C; Qi, X; Zheng, X1
Cheng, Y; Guan, Y; Guo, L; Li, P; Liu, Y; Wu, Q1
Luo, Y; Zhao, F1
Cao, L; Ding, L; He, X; Huang, W1
Chen, G; Huang, L; Liang, J; Song, K; Xie, X; Zeng, X; Zhu, R1
Chen, Y; Han, B; Han, J; Lin, W; Shi, X; Wang, Y; Xu, J1
Guo, Y; Hu, H; Liu, H; Liu, Y; Xu, G; Yan, J1
Fu, B; Gao, G; Meng, S1
Zhu, C1
Gong, Z; Hu, J; Huang, J; Li, F; Li, L; Liu, S; Luo, W; Song, J; Xie, D; Yang, J; Yang, Q; Yue, C; Zhao, C; Zi, W1
Shen, QQ; Tong, XW; Wang, W; Wu, H1
Gao, F; Gao, L; Guo, X; Huo, K; Liu, J; Liu, Z; Lu, W; Qu, Q; Wang, J1
Che, J; Wang, Z1
Cai, J; Feng, Z; Hu, K; Hu, Y; Li, C; Li, L; Pu, W; Yang, Q; Zhang, J; Zhou, Z1
Chen, Q; Fu, M; Huang, Y; Li, Z; Wang, L; Xiang, R; Xu, J; Yu, C; Yu, H1
Abuduxukuer, R; Chang, J; Fan, L; Guo, ZN; Jin, H; Liu, J; Liu, XL; Lou, Z; Qu, Y; Shen, Z; Shi, B; Sun, X; Yang, Y; Yue, BH; Zhang, KJ; Zhang, P; Zhao, Y; Zhong, J; Zhu, Y1
Luo, Y; Wang, R; Wang, Y; Yang, Z; Zhao, F; Zheng, Y; Zhong, L1
Cai, C; Cui, Y; Deng, L; He, B; Wang, L; Wang, X; Yang, Y; Zhang, H; Zhou, W; Zhu, B1
Cai, Y; Cao, X; Chen, H; Chen, J; Chen, Y; Deng, J; Deng, W; Gao, L; Gui, L; Guo, Z; Han, Y; He, L; Huo, X; Jia, B; Jing, P; Li, C; Li, T; Li, X; Liu, Y; Miao, Z; Peng, Z; Shao, H; Shi, W; Song, C; Sun, H; Sun, Z; Wang, A; Wang, F; Wang, Y; Yang, H; Yang, J; Yang, Y; Yuan, H; Zhang, H; Zhang, P; Zhang, X; Zhao, H; Zhou, Z1
Luan, X; Wang, X; Yang, Z1
Jiang, M; Lu, S; Lyu, Y; Nie, T; Qian, Y; Tang, B1
Liu, JX; Ren, JG; Wang, M; Yao, MJ1
Ge, X; Li, Q; Qin, Y; Sun, Y; Wang, C; Wang, G; Wang, X; Zhao, Z1
Marco-Contelles, J; Zhang, Y1
Liu, L; Qu, M; Sun, J; Wei, L; Zhang, Y; Zhao, J; Zhao, Y1
Huang, Y; Pan, L; Wu, T1
Guo, Y; Li, X; Miao, L; Tian, H; Wang, X; Yuan, R1
Huo, X; Jia, B; Miao, Z; Tian, X; Wang, A; Wang, Y; Zhang, JY; Zhang, X; Zuo, Y1
Han, Y; Liu, Q; Xiang, H; Yang, L; Zhang, L; Zhang, Q; Zhang, Y; Zhang, Z1
Luo, L; Shan Huang, S; Wei Mo, S; Xian Zeng, G; Zhou, B1
Abdoulaye, IA; Guo, Y; Le, K; Liu, F; Tian, X; Wang, J; Yu, D1
Dong, Y; Fan, M; Hu, M; Huai, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xu, J1
Fan, CX; Liu, HH; Liu, RZ; Nie, ZX; Pu, XP; Sun, Y; Zhang, ZL; Zhao, X1
Dong, Y; Fan, M; Hu, M; Jia, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xiao, Y; Xu, J; Zhang, D1
Liu, ZG; Wang, SJ; Xiao, N; Yan, RY; Yao, GT1
Feng, Y; Huang, L; Ma, F; Peng, Y; Wang, S; Wang, X; Xing, C; Zhang, Y1
Hu, NN; Liu, CF; Xie, CL; Zhu, BL; Zhu, XB1
Chen, N; Feng, J; He, D; Li, B; Li, J; Luo, J; Luo, Y; Zhang, J; Zheng, X; Zhou, Z1
Huang, L; Li, W; Liang, J; Song, K; Wei, D; Xie, X1
Liu, M; Lv, PY; Wang, B; Xing, HY; Ye, ZY1
Liu, C; Shao, BZ; Xu, ZQ; Zhang, JJ; Zhou, Y1
Cheng, X; Liu, C; Niu, X; Qi, R; Qu, H; Wang, H; Zhang, X; Zhao, C; Zhao, S; Zhong, S1
Chen, R; Gao, X; Li, J; Liu, Y; Xue, J; Zhang, L; Zhang, X1
Cao, X; Dai, YT; Han, LJ; Han, QY; He, DS; Wang, SW; Xu, Y; Zhang, H; Zhang, X1
Huang, J; Li, Q; Sun, X; Wang, H; Zhang, T1
Cai, J; Cui, DD; Lei, H; Li, J; Liu, DM; Peng, Y; Rong, XF; Wang, L; Wang, XL; Xu, SF; Yang, LC; Zhang, M1
Jiang, Y; Sun, L; Wang, J; Xuan, X1
Cai, X; Hui, G; Li, X; Ni, J; Yun, W; Zhang, Q; Zhao, H; Zhou, X1
Guo, JQ; Huang, XJ; Liu, HZ; Liu, Y; Qi, DS; Song, YJ; Tang, M; Wang, SL; Wang, YL; Wang, YW; Wen, XR; Wu, J; Zhang, F; Zhang, XB1
Guo, ZF; Li, YS; Song, JG; Xu, YM; Zhang, P1
Gui, Y; Niu, X; Wang, J; Yan, H; Yan, Z; Zhang, P1
Huang, RX; Liao, SJ; Lin, JW; Liu, CL; Pei, Z; Zeng, JS1
Li, J; Li, Y; Ogle, M; Song, M; Wei, L; Yu, SP; Zhou, X1
Fu, J; Jia, W; Li, Q; Liu, K; Liu, X; Sun, X; Yan, W; Zhang, T1
Li, N; Wang, Y; Xu, J; Xu, L; Yang, H; Yang, Z1
Chen, F; Huang, Y; Li, J; Li, Y; Wei, W; Zhang, W; Zhu, G1
Chen, G; Feng, Y; Peng, Y; Wang, L; Wang, X; Xu, S1
Huang, RX; Li, CX; Liao, SJ; Lin, JW; Liu, CL; Shi, XG; Xie, LC; Zeng, JS1
Deji, QZ; He, L; Kong, SY; Li, QF; Zhou, D1
Feng, YP; Hu, D; Zhang, LY1
Feng, YP; Hu, D; Huang, XX1
Feng, YP; Hu, D; Huang, XX; Qu, ZW; Zhang, JT1
Feng, YP; Xu, HL1
Dong, GX; Feng, YP1

Reviews

3 review(s) available for 3-n-butylphthalide and Cerebral Ischemia

ArticleYear
[Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2020, Volume: 45, Issue:3

    Topics: Benzofurans; Brain Ischemia; Cerebral Infarction; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Neuroprotective Agents; Panax notoginseng; Pyrazines; Saponins

2020
Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke.
    CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:5

    Topics: Animals; Benzofurans; Brain Ischemia; Humans; Platelet Aggregation Inhibitors; Stroke

2018
A Systematic Review of Neuroprotective Efficacy and Safety of DL-3-N-Butylphthalide in Ischemic Stroke.
    The American journal of Chinese medicine, 2019, Volume: 47, Issue:3

    Topics: Aged; Benzofurans; Brain Ischemia; Databases, Bibliographic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Phytotherapy; Randomized Controlled Trials as Topic; Stroke; Treatment Outcome

2019

Trials

6 trial(s) available for 3-n-butylphthalide and Cerebral Ischemia

ArticleYear
The effect of edaravone combined with DL-3-N-butylphthalide on the levels of tumor necrosis factor-alpha, interleukin-10, neuron-specific enolase and effect in patients with acute cerebral infarction.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2022, Volume: 73, Issue:3

    Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Edaravone; Humans; Interleukin-10; Phosphopyruvate Hydratase; Quality of Life; Stroke; Tumor Necrosis Factor-alpha

2022
Protocol of End-PSCI trial: a multicenter, randomized controlled trial to evaluate the effects of DL-3-n-butylphthalide on delayed-onset post stroke cognitive impairment.
    BMC neurology, 2022, Nov-16, Volume: 22, Issue:1

    Topics: Brain Ischemia; Cognitive Dysfunction; Humans; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Stroke

2022
Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023, Volume: 43, Issue:10

    Topics: Arteries; Atherosclerosis; Brain Ischemia; Homeostasis; Humans; Ischemic Stroke; Stroke; Treatment Outcome

2023
Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.
    JAMA neurology, 2023, 08-01, Volume: 80, Issue:8

    Topics: Aged; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemic Stroke; Male; Stroke; Tissue Plasminogen Activator; Treatment Outcome

2023
Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke.
    Brain and behavior, 2019, Volume: 9, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Brain Ischemia; Drug Therapy, Combination; Edaravone; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Tissue Kallikreins; Treatment Outcome; Young Adult

2019
Efficacy and safety of butylphthalide for patients who had acute ischaemic stroke receiving intravenous thrombolysis or endovascular treatment (BAST trial): study protocol for a randomised placebo-controlled trial.
    BMJ open, 2021, 05-25, Volume: 11, Issue:5

    Topics: Benzofurans; Brain Ischemia; Double-Blind Method; Humans; Ischemic Stroke; Randomized Controlled Trials as Topic; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome

2021

Other Studies

58 other study(ies) available for 3-n-butylphthalide and Cerebral Ischemia

ArticleYear
Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.
    Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16

    Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Fibrinolytic Agents; Free Radical Scavengers; Male; Neuroprotective Agents; PC12 Cells; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stereoisomerism; Stroke; Structure-Activity Relationship; Thiophenes

2012
Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Ischemia; Carbazoles; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Pyrans; Rats; Rats, Sprague-Dawley; Stroke; Structure-Activity Relationship

2018
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
    European journal of medicinal chemistry, 2022, Nov-05, Volume: 241

    Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha

2022
Combination of tetrandrine and 3-n-butylphthalide protects against cerebral ischemia-reperfusion injury via ATF2/TLR4 pathway.
    Immunopharmacology and immunotoxicology, 2021, Volume: 43, Issue:6

    Topics: Activating Transcription Factor 2; Animals; Benzofurans; Benzylisoquinolines; Brain Ischemia; Cells, Cultured; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4

2021
Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.
    Molecular medicine reports, 2021, Volume: 24, Issue:6

    Topics: Animals; Apoptosis Regulatory Proteins; Benzofurans; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Endothelial Cells; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents

2021
Potential Protective Effect of Dl-3-n-butylphthalide on Chronic Cerebral Ischemia Brain Injury.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:9

    Topics: Benzofurans; Brain Injuries; Brain Ischemia; Humans; Neuroprotective Agents

2022
Dl-3-n-butylphthalide induced anaphylactic shock: a case report.
    European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:5

    Topics: Aged; Anaphylaxis; Brain Ischemia; Female; Humans; Ischemic Stroke; Stroke

2023
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
    Stroke and vascular neurology, 2022, Volume: 7, Issue:3

    Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Drainage; Endothelial Cells; Evans Blue; Infarction, Middle Cerebral Artery; Ischemic Stroke; Rats; Rats, Sprague-Dawley; Stroke

2022
DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2022, May-01, Volume: 172

    Topics: Animals; Atherosclerosis; Benzofurans; Brain Ischemia; Endothelial Cells; Mice; Neuroprotective Agents; Oxidative Stress; Rats; Stroke

2022
Cerebral hemodynamic changes assessment by transcranial doppler ultrasound in patients with acute cerebral infarction before and after treatment with butylphthalide.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:2(Special)

    Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Hemodynamics; Humans; Stroke; Ultrasonography, Doppler, Transcranial

2022
A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:3(Special)

    Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Humans; Pyrazines; Retrospective Studies; S100 Calcium Binding Protein beta Subunit; Stroke

2022
Effect and clinical evaluation of butylphthalide combined with ureklin on ischemic low perfusion area in patients with acute cerebral infarction.
    Minerva medica, 2023, Volume: 114, Issue:4

    Topics: Brain Ischemia; Cerebral Infarction; Humans; Perfusion; Stroke

2023
Efficacy and safety of 3-n-butylphthalide combined with endovascular treatment in acute ischemic stroke due to large vessel occlusion.
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:12

    Topics: Brain Ischemia; Endovascular Procedures; Humans; Intracranial Hemorrhages; Ischemic Stroke; Retrospective Studies; Stroke; Thrombectomy; Treatment Outcome

2022
Effectiveness of alteplase intravenous thrombolysis combined with butylphthalide in patients with acute severe cerebral infarction.
    Folia neuropathologica, 2022, Volume: 60, Issue:4

    Topics: Brain Ischemia; Cerebral Infarction; Fibrinolytic Agents; Humans; Quality of Life; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome

2022
Reactive Oxygen Species-Responsive Transformable and Triple-Targeting Butylphthalide Nanotherapy for Precision Treatment of Ischemic Stroke by Normalizing the Pathological Microenvironment.
    ACS nano, 2023, 03-14, Volume: 17, Issue:5

    Topics: Animals; Brain Ischemia; Endothelial Cells; Ischemic Stroke; Mice; Neuroprotective Agents; Reactive Oxygen Species; Stroke

2023
Effect of Butylphthalide Capsules on Smac and XIAP Expression in Rats after Ischemia Reperfusion.
    The Journal of surgical research, 2023, Volume: 283

    Topics: Animals; Apoptosis; Brain Ischemia; Capsules; Carotid Stenosis; Caspases; Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; RNA, Messenger; X-Linked Inhibitor of Apoptosis Protein

2023
Untargeted metabolomics uncovering neuroprotective effect of Dl-3-n-butylphthalide on improving cognitive impairment induced by chronic cerebral hypoperfusion in rats.
    International immunopharmacology, 2023, Volume: 119

    Topics: Animals; Brain Ischemia; Chromatography, Liquid; Cognitive Dysfunction; Metabolomics; Neuroprotective Agents; Rats; Tandem Mass Spectrometry

2023
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats.
    European journal of pharmacology, 2023, Jul-15, Volume: 951

    Topics: Animals; Brain Ischemia; Edaravone; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Rats; Stroke

2023
The effect of butylphthalide on improving the neurological function of patients with acute anterior circulation cerebral infarction after mechanical thrombectomy.
    Medicine, 2023, Aug-25, Volume: 102, Issue:34

    Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Humans; Retrospective Studies; Stroke; Thrombectomy; United States

2023
Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats.
    The Journal of international medical research, 2020, Volume: 48, Issue:7

    Topics: Acetylcholinesterase; Animals; Benzofurans; Brain Ischemia; China; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A

2020
From Seeds of
    Journal of medicinal chemistry, 2020, 11-12, Volume: 63, Issue:21

    Topics: Animals; Apium; Asthma; Benzofurans; Brain Ischemia; Humans; Neuroprotective Agents; Seeds; Stereoisomerism; Stroke

2020
Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice.
    Stroke and vascular neurology, 2021, Volume: 6, Issue:1

    Topics: Animals; Benzofurans; Brain Ischemia; Ischemic Stroke; Mice; Mice, Inbred C57BL; Stroke; Vascular Endothelial Growth Factor A

2021
Improvement of cerebral ischemia-reperfusion injury by L-3-n-butylphthalide through promoting angiogenesis.
    Experimental brain research, 2021, Volume: 239, Issue:1

    Topics: Animals; Benzofurans; Brain Ischemia; Humans; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Rats; Reperfusion Injury

2021
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
    Biochemical and biophysical research communications, 2021, 06-04, Volume: 556

    Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Line; Cell Line, Tumor; Drug Design; Edaravone; Glucose; Humans; Hydrogen Peroxide; Hypoxia; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2021
Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2021, 07-10, Volume: 335

    Topics: Benzofurans; Brain; Brain Ischemia; Humans; Ischemic Stroke; Neuroprotective Agents; Prodrugs; Stroke

2021
Neuroprotective effect and mechanism of butylphthalide after cerebral ischemia-reperfusion injury in rats.
    Folia neuropathologica, 2021, Volume: 59, Issue:2

    Topics: Animals; Benzofurans; Brain Ischemia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2021
N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-α Expressions.
    Annals of clinical and laboratory science, 2021, Volume: 51, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Benzofurans; Biomarkers; Brain Ischemia; Case-Control Studies; Female; Humans; Ischemic Stroke; Kallikreins; Male; Middle Aged; Neuroprotective Agents; Prognosis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Young Adult

2021
L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury.
    Neurochemical research, 2017, Volume: 42, Issue:10

    Topics: Animals; Apoptosis; Autophagy; Benzofurans; Brain Ischemia; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Male; Memory Disorders; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Reperfusion; TOR Serine-Threonine Kinases

2017
Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging.
    International journal of molecular sciences, 2017, Nov-22, Volume: 18, Issue:11

    Topics: Adenosine Triphosphate; Animals; Benzofurans; Brain Ischemia; Citric Acid; Disease Models, Animal; Glucose; Infarction; Metabolic Networks and Pathways; Neuroprotective Agents; Platelet Aggregation Inhibitors; Rats; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2017
DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats.
    Neuroscience letters, 2018, 04-13, Volume: 672

    Topics: Animals; Benzofurans; Brain Ischemia; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction

2018
The protective effect and its mechanism of 3-n-butylphthalide pretreatment on cerebral ischemia reperfusion injury in rats.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:22

    Topics: Animals; Apoptosis; Benzofurans; Blood-Brain Barrier; Body Water; Brain Ischemia; Caspase 3; Hippocampus; Infarction, Middle Cerebral Artery; Malondialdehyde; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase

2017
Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling.
    Behavioural neurology, 2018, Volume: 2018

    Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Carrier Proteins; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred ICR; Neuroprotective Agents; Phosphorylation; Reperfusion Injury; Signal Transduction

2018
3-
    Drug design, development and therapy, 2018, Volume: 12

    Topics: Animals; Antioxidants; Apoptosis; Benzofurans; Brain Ischemia; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Signal Transduction; Stroke

2018
Dl-3-n-Butylphthalide regulates the Ang-1/Ang-2/Tie-2 signaling axis to promote neovascularization in chronic cerebral hypoperfusion.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 113

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Benzofurans; Blotting, Western; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Male; Neovascularization, Physiologic; Protein Array Analysis; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; Signal Transduction

2019
DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins.
    Chinese medical journal, 2019, Jun-05, Volume: 132, Issue:11

    Topics: Animals; Benzofurans; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Cells, Cultured; Claudin-5; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tight Junction Proteins; Zonula Occludens-1 Protein

2019
Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke.
    Brain research, 2019, 08-15, Volume: 1717

    Topics: Animals; Benzofurans; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Differentiation; Male; Myelin Sheath; Nogo Proteins; Oligodendrocyte Precursor Cells; Oligodendroglia; Rats; Rats, Wistar; Recovery of Function; Remyelination; Stroke; White Matter

2019
Dl-3-N-Butylphthalide Alleviates the Blood-Brain Barrier Permeability of Focal Cerebral Ischemia Reperfusion in Mice.
    Neuroscience, 2019, 08-10, Volume: 413

    Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillary Permeability; Caveolin 1; Cerebrovascular Circulation; Disease Models, Animal; Male; Mice; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Tight Junctions

2019
dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion.
    CNS neuroscience & therapeutics, 2019, Volume: 25, Issue:9

    Topics: Animals; Benzofurans; Brain Ischemia; Carotid Stenosis; Cells, Cultured; Cerebrovascular Circulation; Chronic Disease; Cognitive Dysfunction; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; White Matter

2019
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
    Neuroscience, 2014, Mar-28, Volume: 263

    Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; Benzofurans; Brain Ischemia; Cell Survival; Mice; Neuroblastoma; Sirolimus; Stroke; Tumor Cells, Cultured

2014
L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats.
    CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:9

    Topics: Administration, Oral; Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Survival; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neural Stem Cells; Neurogenesis; Neuronal Plasticity; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Recovery of Function; STAT3 Transcription Factor; Synapses

2015
Impacts of N-Butylphthalide on expression of growth factors in rats with focal cerebral ischemia.
    Bosnian journal of basic medical sciences, 2016, Jan-01, Volume: 16, Issue:2

    Topics: Animals; Behavior, Animal; Benzofurans; Brain Ischemia; Cerebral Infarction; Intercellular Signaling Peptides and Proteins; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A

2016
Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:4

    Topics: Aged; Antigens, CD; Benzofurans; Brain Ischemia; Cell Movement; Diffusion Magnetic Resonance Imaging; Endothelial Progenitor Cells; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Statistics as Topic; Stroke; Time Factors; Vascular Endothelial Growth Factor Receptor-2

2016
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats.
    Cellular and molecular neurobiology, 2016, Volume: 36, Issue:7

    Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Caspase 3; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Neurons; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2016
N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 83

    Topics: Animals; Astrocytes; Benzofurans; Brain Ischemia; Cell Survival; Hepatocyte Growth Factor; Humans; Inflammation; Lipopolysaccharides; Male; NF-kappa B; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Up-Regulation

2016
Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study.
    Neurological research, 2017, Volume: 39, Issue:4

    Topics: Benzofurans; Biomarkers; Brain Ischemia; C-Reactive Protein; Cognition; Dementia, Vascular; Female; Homocysteine; Humans; Logistic Models; Male; Mental Status Schedule; Middle Aged; Multivariate Analysis; Neuroprotective Agents; Neuropsychological Tests; Nootropic Agents; Prospective Studies; Risk Factors; Stroke; Treatment Outcome

2017
Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP.
    Brain research, 2009, Sep-15, Volume: 1289

    Topics: Angiogenesis Inducing Agents; Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Drugs, Chinese Herbal; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neovascularization, Physiologic; Rats; Up-Regulation; Vascular Endothelial Growth Factor A

2009
DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway.
    Brain research, 2010, Nov-04, Volume: 1359

    Topics: Animals; Apoptosis; Benzofurans; Blotting, Western; Brain Ischemia; Caspase 3; Caspase 9; Enzyme Activation; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Male; MAP Kinase Kinase 4; Mice; Neurons; Neuroprotective Agents; Signal Transduction

2010
3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia.
    Neurological research, 2011, Volume: 33, Issue:4

    Topics: Amyloid beta-Peptides; Animals; Autophagy; Benzofurans; Brain Ischemia; Dementia; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Random Allocation; Treatment Outcome

2011
L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia.
    Neuropharmacology, 2012, Volume: 62, Issue:7

    Topics: Animals; Benzofurans; Brain Ischemia; Chronic Disease; Cognition Disorders; Male; Maze Learning; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar

2012
The therapeutic effect of (DL)-3-n-butylphthalide in rats with chronic cerebral hypoperfusion through downregulation of amyloid precursor protein and matrix metalloproteinase-2.
    The Journal of international medical research, 2012, Volume: 40, Issue:3

    Topics: Amyloid beta-Protein Precursor; Animals; Benzofurans; Blotting, Western; Brain Ischemia; Chronic Disease; Down-Regulation; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Maze Learning; Rats; Rats, Wistar

2012
l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Acetylcholinesterase; Animals; Astrocytes; Benzofurans; Brain Ischemia; Carotid Artery, Common; Catalase; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Corpus Callosum; Glutathione Peroxidase; Hippocampus; Learning Disabilities; Ligation; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Visual Pathways

2007
dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP.
    Journal of the neurological sciences, 2007, Sep-15, Volume: 260, Issue:1-2

    Topics: Animals; Aspirin; Benzofurans; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Cold Temperature; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Hypertension, Renal; Male; Microcirculation; Molecular Structure; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Treatment Outcome

2007
[Effects of dl-3-n-butylphthalide on expression of VEGF and bFGF in rat brain with permanent focal cerebral ischemia].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2008, Volume: 39, Issue:1

    Topics: Animals; Benzofurans; Brain; Brain Ischemia; Drugs, Chinese Herbal; Fibroblast Growth Factor 2; Infarction, Middle Cerebral Artery; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A

2008
[Effect of DL-butylphthalide (NBP) on mouse brain energy metabolism in complete brain ischemia induced by decapitation].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1995, Volume: 30, Issue:10

    Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Benzofurans; Brain; Brain Ischemia; Decerebrate State; Energy Metabolism; Female; Lactates; Male; Mice; Phosphocreatine

1995
[Effect of dl-3-n-butylphthalide (NBP) on purine metabolites in striatum extracellular fluid in four-vessel occlusion rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1996, Volume: 31, Issue:1

    Topics: Adenosine; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Extracellular Space; Inosine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion; Stereoisomerism; Xanthines

1996
[Effect of dl-3-butylphthalide on the striatum extracellular amino acid and dopamine contents in the rat during cerebral ischemia].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1996, Volume: 31, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Dopamine; Extracellular Space; Glycine; Male; Neuroprotective Agents; Rats; Rats, Wistar

1996
Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:5

    Topics: Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Leukocyte Count; Male; Neuroprotective Agents; Neutrophils; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha

2000
[Effects of 3-N-butylphthalide on cortical calcineurin and calpain activities in focal cerebral ischemia rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2000, Volume: 35, Issue:10

    Topics: Animals; Benzofurans; Brain Ischemia; Calcineurin; Calpain; Cerebral Cortex; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury

2000