3-n-butylphthalide has been researched along with Cerebral Ischemia in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.48) | 18.2507 |
| 2000's | 6 (8.96) | 29.6817 |
| 2010's | 27 (40.30) | 24.3611 |
| 2020's | 31 (46.27) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, H; Lai, Y; Li, T; Ling, J; Liu, J; Peng, S; Tian, J; Wang, X; Wu, J; Zhang, Y | 1 |
| Chen, N; Chu, S; Li, C; Li, Y; Liu, D; Ma, J; Ren, Q; Song, X; Zang, Y; Zhang, D | 1 |
| Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H | 1 |
| Chai, A; Gao, Y; Li, C; Qi, X; Zheng, X | 1 |
| Cheng, Y; Guan, Y; Guo, L; Li, P; Liu, Y; Wu, Q | 1 |
| Luo, Y; Zhao, F | 1 |
| Cao, L; Ding, L; He, X; Huang, W | 1 |
| Chen, G; Huang, L; Liang, J; Song, K; Xie, X; Zeng, X; Zhu, R | 1 |
| Chen, Y; Han, B; Han, J; Lin, W; Shi, X; Wang, Y; Xu, J | 1 |
| Guo, Y; Hu, H; Liu, H; Liu, Y; Xu, G; Yan, J | 1 |
| Fu, B; Gao, G; Meng, S | 1 |
| Zhu, C | 1 |
| Gong, Z; Hu, J; Huang, J; Li, F; Li, L; Liu, S; Luo, W; Song, J; Xie, D; Yang, J; Yang, Q; Yue, C; Zhao, C; Zi, W | 1 |
| Shen, QQ; Tong, XW; Wang, W; Wu, H | 1 |
| Gao, F; Gao, L; Guo, X; Huo, K; Liu, J; Liu, Z; Lu, W; Qu, Q; Wang, J | 1 |
| Che, J; Wang, Z | 1 |
| Cai, J; Feng, Z; Hu, K; Hu, Y; Li, C; Li, L; Pu, W; Yang, Q; Zhang, J; Zhou, Z | 1 |
| Chen, Q; Fu, M; Huang, Y; Li, Z; Wang, L; Xiang, R; Xu, J; Yu, C; Yu, H | 1 |
| Abuduxukuer, R; Chang, J; Fan, L; Guo, ZN; Jin, H; Liu, J; Liu, XL; Lou, Z; Qu, Y; Shen, Z; Shi, B; Sun, X; Yang, Y; Yue, BH; Zhang, KJ; Zhang, P; Zhao, Y; Zhong, J; Zhu, Y | 1 |
| Luo, Y; Wang, R; Wang, Y; Yang, Z; Zhao, F; Zheng, Y; Zhong, L | 1 |
| Cai, C; Cui, Y; Deng, L; He, B; Wang, L; Wang, X; Yang, Y; Zhang, H; Zhou, W; Zhu, B | 1 |
| Cai, Y; Cao, X; Chen, H; Chen, J; Chen, Y; Deng, J; Deng, W; Gao, L; Gui, L; Guo, Z; Han, Y; He, L; Huo, X; Jia, B; Jing, P; Li, C; Li, T; Li, X; Liu, Y; Miao, Z; Peng, Z; Shao, H; Shi, W; Song, C; Sun, H; Sun, Z; Wang, A; Wang, F; Wang, Y; Yang, H; Yang, J; Yang, Y; Yuan, H; Zhang, H; Zhang, P; Zhang, X; Zhao, H; Zhou, Z | 1 |
| Luan, X; Wang, X; Yang, Z | 1 |
| Jiang, M; Lu, S; Lyu, Y; Nie, T; Qian, Y; Tang, B | 1 |
| Liu, JX; Ren, JG; Wang, M; Yao, MJ | 1 |
| Ge, X; Li, Q; Qin, Y; Sun, Y; Wang, C; Wang, G; Wang, X; Zhao, Z | 1 |
| Marco-Contelles, J; Zhang, Y | 1 |
| Liu, L; Qu, M; Sun, J; Wei, L; Zhang, Y; Zhao, J; Zhao, Y | 1 |
| Huang, Y; Pan, L; Wu, T | 1 |
| Guo, Y; Li, X; Miao, L; Tian, H; Wang, X; Yuan, R | 1 |
| Huo, X; Jia, B; Miao, Z; Tian, X; Wang, A; Wang, Y; Zhang, JY; Zhang, X; Zuo, Y | 1 |
| Han, Y; Liu, Q; Xiang, H; Yang, L; Zhang, L; Zhang, Q; Zhang, Y; Zhang, Z | 1 |
| Luo, L; Shan Huang, S; Wei Mo, S; Xian Zeng, G; Zhou, B | 1 |
| Abdoulaye, IA; Guo, Y; Le, K; Liu, F; Tian, X; Wang, J; Yu, D | 1 |
| Dong, Y; Fan, M; Hu, M; Huai, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xu, J | 1 |
| Fan, CX; Liu, HH; Liu, RZ; Nie, ZX; Pu, XP; Sun, Y; Zhang, ZL; Zhao, X | 1 |
| Dong, Y; Fan, M; Hu, M; Jia, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xiao, Y; Xu, J; Zhang, D | 1 |
| Liu, ZG; Wang, SJ; Xiao, N; Yan, RY; Yao, GT | 1 |
| Feng, Y; Huang, L; Ma, F; Peng, Y; Wang, S; Wang, X; Xing, C; Zhang, Y | 1 |
| Hu, NN; Liu, CF; Xie, CL; Zhu, BL; Zhu, XB | 1 |
| Chen, N; Feng, J; He, D; Li, B; Li, J; Luo, J; Luo, Y; Zhang, J; Zheng, X; Zhou, Z | 1 |
| Huang, L; Li, W; Liang, J; Song, K; Wei, D; Xie, X | 1 |
| Liu, M; Lv, PY; Wang, B; Xing, HY; Ye, ZY | 1 |
| Liu, C; Shao, BZ; Xu, ZQ; Zhang, JJ; Zhou, Y | 1 |
| Cheng, X; Liu, C; Niu, X; Qi, R; Qu, H; Wang, H; Zhang, X; Zhao, C; Zhao, S; Zhong, S | 1 |
| Chen, R; Gao, X; Li, J; Liu, Y; Xue, J; Zhang, L; Zhang, X | 1 |
| Cao, X; Dai, YT; Han, LJ; Han, QY; He, DS; Wang, SW; Xu, Y; Zhang, H; Zhang, X | 1 |
| Huang, J; Li, Q; Sun, X; Wang, H; Zhang, T | 1 |
| Cai, J; Cui, DD; Lei, H; Li, J; Liu, DM; Peng, Y; Rong, XF; Wang, L; Wang, XL; Xu, SF; Yang, LC; Zhang, M | 1 |
| Jiang, Y; Sun, L; Wang, J; Xuan, X | 1 |
| Cai, X; Hui, G; Li, X; Ni, J; Yun, W; Zhang, Q; Zhao, H; Zhou, X | 1 |
| Guo, JQ; Huang, XJ; Liu, HZ; Liu, Y; Qi, DS; Song, YJ; Tang, M; Wang, SL; Wang, YL; Wang, YW; Wen, XR; Wu, J; Zhang, F; Zhang, XB | 1 |
| Guo, ZF; Li, YS; Song, JG; Xu, YM; Zhang, P | 1 |
| Gui, Y; Niu, X; Wang, J; Yan, H; Yan, Z; Zhang, P | 1 |
| Huang, RX; Liao, SJ; Lin, JW; Liu, CL; Pei, Z; Zeng, JS | 1 |
| Li, J; Li, Y; Ogle, M; Song, M; Wei, L; Yu, SP; Zhou, X | 1 |
| Fu, J; Jia, W; Li, Q; Liu, K; Liu, X; Sun, X; Yan, W; Zhang, T | 1 |
| Li, N; Wang, Y; Xu, J; Xu, L; Yang, H; Yang, Z | 1 |
| Chen, F; Huang, Y; Li, J; Li, Y; Wei, W; Zhang, W; Zhu, G | 1 |
| Chen, G; Feng, Y; Peng, Y; Wang, L; Wang, X; Xu, S | 1 |
| Huang, RX; Li, CX; Liao, SJ; Lin, JW; Liu, CL; Shi, XG; Xie, LC; Zeng, JS | 1 |
| Deji, QZ; He, L; Kong, SY; Li, QF; Zhou, D | 1 |
| Feng, YP; Hu, D; Zhang, LY | 1 |
| Feng, YP; Hu, D; Huang, XX | 1 |
| Feng, YP; Hu, D; Huang, XX; Qu, ZW; Zhang, JT | 1 |
| Feng, YP; Xu, HL | 1 |
| Dong, GX; Feng, YP | 1 |
3 review(s) available for 3-n-butylphthalide and Cerebral Ischemia
| Article | Year |
|---|---|
[Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia].
Topics: Benzofurans; Brain Ischemia; Cerebral Infarction; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Neuroprotective Agents; Panax notoginseng; Pyrazines; Saponins | 2020 |
Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke.
Topics: Animals; Benzofurans; Brain Ischemia; Humans; Platelet Aggregation Inhibitors; Stroke | 2018 |
A Systematic Review of Neuroprotective Efficacy and Safety of DL-3-N-Butylphthalide in Ischemic Stroke.
Topics: Aged; Benzofurans; Brain Ischemia; Databases, Bibliographic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Phytotherapy; Randomized Controlled Trials as Topic; Stroke; Treatment Outcome | 2019 |
6 trial(s) available for 3-n-butylphthalide and Cerebral Ischemia
| Article | Year |
|---|---|
The effect of edaravone combined with DL-3-N-butylphthalide on the levels of tumor necrosis factor-alpha, interleukin-10, neuron-specific enolase and effect in patients with acute cerebral infarction.
Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Edaravone; Humans; Interleukin-10; Phosphopyruvate Hydratase; Quality of Life; Stroke; Tumor Necrosis Factor-alpha | 2022 |
Protocol of End-PSCI trial: a multicenter, randomized controlled trial to evaluate the effects of DL-3-n-butylphthalide on delayed-onset post stroke cognitive impairment.
Topics: Brain Ischemia; Cognitive Dysfunction; Humans; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Stroke | 2022 |
Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial.
Topics: Arteries; Atherosclerosis; Brain Ischemia; Homeostasis; Humans; Ischemic Stroke; Stroke; Treatment Outcome | 2023 |
Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.
Topics: Aged; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemic Stroke; Male; Stroke; Tissue Plasminogen Activator; Treatment Outcome | 2023 |
Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Brain Ischemia; Drug Therapy, Combination; Edaravone; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Tissue Kallikreins; Treatment Outcome; Young Adult | 2019 |
Efficacy and safety of butylphthalide for patients who had acute ischaemic stroke receiving intravenous thrombolysis or endovascular treatment (BAST trial): study protocol for a randomised placebo-controlled trial.
Topics: Benzofurans; Brain Ischemia; Double-Blind Method; Humans; Ischemic Stroke; Randomized Controlled Trials as Topic; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 2021 |
58 other study(ies) available for 3-n-butylphthalide and Cerebral Ischemia
| Article | Year |
|---|---|
Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.
Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Fibrinolytic Agents; Free Radical Scavengers; Male; Neuroprotective Agents; PC12 Cells; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stereoisomerism; Stroke; Structure-Activity Relationship; Thiophenes | 2012 |
Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Ischemia; Carbazoles; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Pyrans; Rats; Rats, Sprague-Dawley; Stroke; Structure-Activity Relationship | 2018 |
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha | 2022 |
Combination of tetrandrine and 3-n-butylphthalide protects against cerebral ischemia-reperfusion injury via ATF2/TLR4 pathway.
Topics: Activating Transcription Factor 2; Animals; Benzofurans; Benzylisoquinolines; Brain Ischemia; Cells, Cultured; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.
Topics: Animals; Apoptosis Regulatory Proteins; Benzofurans; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Endothelial Cells; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents | 2021 |
Potential Protective Effect of Dl-3-n-butylphthalide on Chronic Cerebral Ischemia Brain Injury.
Topics: Benzofurans; Brain Injuries; Brain Ischemia; Humans; Neuroprotective Agents | 2022 |
Dl-3-n-butylphthalide induced anaphylactic shock: a case report.
Topics: Aged; Anaphylaxis; Brain Ischemia; Female; Humans; Ischemic Stroke; Stroke | 2023 |
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Drainage; Endothelial Cells; Evans Blue; Infarction, Middle Cerebral Artery; Ischemic Stroke; Rats; Rats, Sprague-Dawley; Stroke | 2022 |
DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction.
Topics: Animals; Atherosclerosis; Benzofurans; Brain Ischemia; Endothelial Cells; Mice; Neuroprotective Agents; Oxidative Stress; Rats; Stroke | 2022 |
Cerebral hemodynamic changes assessment by transcranial doppler ultrasound in patients with acute cerebral infarction before and after treatment with butylphthalide.
Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Hemodynamics; Humans; Stroke; Ultrasonography, Doppler, Transcranial | 2022 |
A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study.
Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Humans; Pyrazines; Retrospective Studies; S100 Calcium Binding Protein beta Subunit; Stroke | 2022 |
Effect and clinical evaluation of butylphthalide combined with ureklin on ischemic low perfusion area in patients with acute cerebral infarction.
Topics: Brain Ischemia; Cerebral Infarction; Humans; Perfusion; Stroke | 2023 |
Efficacy and safety of 3-n-butylphthalide combined with endovascular treatment in acute ischemic stroke due to large vessel occlusion.
Topics: Brain Ischemia; Endovascular Procedures; Humans; Intracranial Hemorrhages; Ischemic Stroke; Retrospective Studies; Stroke; Thrombectomy; Treatment Outcome | 2022 |
Effectiveness of alteplase intravenous thrombolysis combined with butylphthalide in patients with acute severe cerebral infarction.
Topics: Brain Ischemia; Cerebral Infarction; Fibrinolytic Agents; Humans; Quality of Life; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 2022 |
Reactive Oxygen Species-Responsive Transformable and Triple-Targeting Butylphthalide Nanotherapy for Precision Treatment of Ischemic Stroke by Normalizing the Pathological Microenvironment.
Topics: Animals; Brain Ischemia; Endothelial Cells; Ischemic Stroke; Mice; Neuroprotective Agents; Reactive Oxygen Species; Stroke | 2023 |
Effect of Butylphthalide Capsules on Smac and XIAP Expression in Rats after Ischemia Reperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; Capsules; Carotid Stenosis; Caspases; Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; RNA, Messenger; X-Linked Inhibitor of Apoptosis Protein | 2023 |
Untargeted metabolomics uncovering neuroprotective effect of Dl-3-n-butylphthalide on improving cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Animals; Brain Ischemia; Chromatography, Liquid; Cognitive Dysfunction; Metabolomics; Neuroprotective Agents; Rats; Tandem Mass Spectrometry | 2023 |
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats.
Topics: Animals; Brain Ischemia; Edaravone; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Rats; Stroke | 2023 |
The effect of butylphthalide on improving the neurological function of patients with acute anterior circulation cerebral infarction after mechanical thrombectomy.
Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Humans; Retrospective Studies; Stroke; Thrombectomy; United States | 2023 |
Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats.
Topics: Acetylcholinesterase; Animals; Benzofurans; Brain Ischemia; China; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2020 |
From Seeds of
Topics: Animals; Apium; Asthma; Benzofurans; Brain Ischemia; Humans; Neuroprotective Agents; Seeds; Stereoisomerism; Stroke | 2020 |
Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice.
Topics: Animals; Benzofurans; Brain Ischemia; Ischemic Stroke; Mice; Mice, Inbred C57BL; Stroke; Vascular Endothelial Growth Factor A | 2021 |
Improvement of cerebral ischemia-reperfusion injury by L-3-n-butylphthalide through promoting angiogenesis.
Topics: Animals; Benzofurans; Brain Ischemia; Humans; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Rats; Reperfusion Injury | 2021 |
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Line; Cell Line, Tumor; Drug Design; Edaravone; Glucose; Humans; Hydrogen Peroxide; Hypoxia; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment.
Topics: Benzofurans; Brain; Brain Ischemia; Humans; Ischemic Stroke; Neuroprotective Agents; Prodrugs; Stroke | 2021 |
Neuroprotective effect and mechanism of butylphthalide after cerebral ischemia-reperfusion injury in rats.
Topics: Animals; Benzofurans; Brain Ischemia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-α Expressions.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Benzofurans; Biomarkers; Brain Ischemia; Case-Control Studies; Female; Humans; Ischemic Stroke; Kallikreins; Male; Middle Aged; Neuroprotective Agents; Prognosis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Young Adult | 2021 |
L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; Brain Ischemia; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Male; Memory Disorders; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Reperfusion; TOR Serine-Threonine Kinases | 2017 |
Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Brain Ischemia; Citric Acid; Disease Models, Animal; Glucose; Infarction; Metabolic Networks and Pathways; Neuroprotective Agents; Platelet Aggregation Inhibitors; Rats; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2017 |
DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats.
Topics: Animals; Benzofurans; Brain Ischemia; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
The protective effect and its mechanism of 3-n-butylphthalide pretreatment on cerebral ischemia reperfusion injury in rats.
Topics: Animals; Apoptosis; Benzofurans; Blood-Brain Barrier; Body Water; Brain Ischemia; Caspase 3; Hippocampus; Infarction, Middle Cerebral Artery; Malondialdehyde; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2017 |
Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Carrier Proteins; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred ICR; Neuroprotective Agents; Phosphorylation; Reperfusion Injury; Signal Transduction | 2018 |
3-
Topics: Animals; Antioxidants; Apoptosis; Benzofurans; Brain Ischemia; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Signal Transduction; Stroke | 2018 |
Dl-3-n-Butylphthalide regulates the Ang-1/Ang-2/Tie-2 signaling axis to promote neovascularization in chronic cerebral hypoperfusion.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Benzofurans; Blotting, Western; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Male; Neovascularization, Physiologic; Protein Array Analysis; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; Signal Transduction | 2019 |
DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Cells, Cultured; Claudin-5; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tight Junction Proteins; Zonula Occludens-1 Protein | 2019 |
Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke.
Topics: Animals; Benzofurans; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Differentiation; Male; Myelin Sheath; Nogo Proteins; Oligodendrocyte Precursor Cells; Oligodendroglia; Rats; Rats, Wistar; Recovery of Function; Remyelination; Stroke; White Matter | 2019 |
Dl-3-N-Butylphthalide Alleviates the Blood-Brain Barrier Permeability of Focal Cerebral Ischemia Reperfusion in Mice.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillary Permeability; Caveolin 1; Cerebrovascular Circulation; Disease Models, Animal; Male; Mice; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Tight Junctions | 2019 |
dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion.
Topics: Animals; Benzofurans; Brain Ischemia; Carotid Stenosis; Cells, Cultured; Cerebrovascular Circulation; Chronic Disease; Cognitive Dysfunction; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; White Matter | 2019 |
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; Benzofurans; Brain Ischemia; Cell Survival; Mice; Neuroblastoma; Sirolimus; Stroke; Tumor Cells, Cultured | 2014 |
L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats.
Topics: Administration, Oral; Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Survival; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neural Stem Cells; Neurogenesis; Neuronal Plasticity; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Recovery of Function; STAT3 Transcription Factor; Synapses | 2015 |
Impacts of N-Butylphthalide on expression of growth factors in rats with focal cerebral ischemia.
Topics: Animals; Behavior, Animal; Benzofurans; Brain Ischemia; Cerebral Infarction; Intercellular Signaling Peptides and Proteins; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2016 |
Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients.
Topics: Aged; Antigens, CD; Benzofurans; Brain Ischemia; Cell Movement; Diffusion Magnetic Resonance Imaging; Endothelial Progenitor Cells; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Statistics as Topic; Stroke; Time Factors; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Caspase 3; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Neurons; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2016 |
N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway.
Topics: Animals; Astrocytes; Benzofurans; Brain Ischemia; Cell Survival; Hepatocyte Growth Factor; Humans; Inflammation; Lipopolysaccharides; Male; NF-kappa B; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Up-Regulation | 2016 |
Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study.
Topics: Benzofurans; Biomarkers; Brain Ischemia; C-Reactive Protein; Cognition; Dementia, Vascular; Female; Homocysteine; Humans; Logistic Models; Male; Mental Status Schedule; Middle Aged; Multivariate Analysis; Neuroprotective Agents; Neuropsychological Tests; Nootropic Agents; Prospective Studies; Risk Factors; Stroke; Treatment Outcome | 2017 |
Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP.
Topics: Angiogenesis Inducing Agents; Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Drugs, Chinese Herbal; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neovascularization, Physiologic; Rats; Up-Regulation; Vascular Endothelial Growth Factor A | 2009 |
DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway.
Topics: Animals; Apoptosis; Benzofurans; Blotting, Western; Brain Ischemia; Caspase 3; Caspase 9; Enzyme Activation; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Male; MAP Kinase Kinase 4; Mice; Neurons; Neuroprotective Agents; Signal Transduction | 2010 |
3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia.
Topics: Amyloid beta-Peptides; Animals; Autophagy; Benzofurans; Brain Ischemia; Dementia; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Random Allocation; Treatment Outcome | 2011 |
L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia.
Topics: Animals; Benzofurans; Brain Ischemia; Chronic Disease; Cognition Disorders; Male; Maze Learning; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar | 2012 |
The therapeutic effect of (DL)-3-n-butylphthalide in rats with chronic cerebral hypoperfusion through downregulation of amyloid precursor protein and matrix metalloproteinase-2.
Topics: Amyloid beta-Protein Precursor; Animals; Benzofurans; Blotting, Western; Brain Ischemia; Chronic Disease; Down-Regulation; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Maze Learning; Rats; Rats, Wistar | 2012 |
l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Acetylcholinesterase; Animals; Astrocytes; Benzofurans; Brain Ischemia; Carotid Artery, Common; Catalase; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Corpus Callosum; Glutathione Peroxidase; Hippocampus; Learning Disabilities; Ligation; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Visual Pathways | 2007 |
dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP.
Topics: Animals; Aspirin; Benzofurans; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Cold Temperature; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Hypertension, Renal; Male; Microcirculation; Molecular Structure; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Treatment Outcome | 2007 |
[Effects of dl-3-n-butylphthalide on expression of VEGF and bFGF in rat brain with permanent focal cerebral ischemia].
Topics: Animals; Benzofurans; Brain; Brain Ischemia; Drugs, Chinese Herbal; Fibroblast Growth Factor 2; Infarction, Middle Cerebral Artery; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2008 |
[Effect of DL-butylphthalide (NBP) on mouse brain energy metabolism in complete brain ischemia induced by decapitation].
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Benzofurans; Brain; Brain Ischemia; Decerebrate State; Energy Metabolism; Female; Lactates; Male; Mice; Phosphocreatine | 1995 |
[Effect of dl-3-n-butylphthalide (NBP) on purine metabolites in striatum extracellular fluid in four-vessel occlusion rats].
Topics: Adenosine; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Extracellular Space; Inosine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion; Stereoisomerism; Xanthines | 1996 |
[Effect of dl-3-butylphthalide on the striatum extracellular amino acid and dopamine contents in the rat during cerebral ischemia].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Dopamine; Extracellular Space; Glycine; Male; Neuroprotective Agents; Rats; Rats, Wistar | 1996 |
Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats.
Topics: Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Leukocyte Count; Male; Neuroprotective Agents; Neutrophils; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
[Effects of 3-N-butylphthalide on cortical calcineurin and calpain activities in focal cerebral ischemia rats].
Topics: Animals; Benzofurans; Brain Ischemia; Calcineurin; Calpain; Cerebral Cortex; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2000 |