Page last updated: 2024-08-24

3-n-butylphthalide and Apoplexy

3-n-butylphthalide has been researched along with Apoplexy in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (3.64)	29.6817
2010's	20 (36.36)	24.3611
2020's	33 (60.00)	2.80

Authors

Authors	Studies
Ji, H; Lai, Y; Li, T; Ling, J; Liu, J; Peng, S; Tian, J; Wang, X; Wu, J; Zhang, Y	1
Hua, K; Huang, Z; Ji, H; Sheng, X; Wang, X; Xu, J; Yang, C; Zhang, Y	1
Fang, J; Huang, Z; Ji, H; Ji, J; Lan, L; Peng, S; Wang, X; Xu, J; Yin, W; Zhang, Y	1
Chen, N; Chu, S; Li, C; Li, Y; Liu, D; Ma, J; Ren, Q; Song, X; Zang, Y; Zhang, D	1
Guo, Z; Huang, Z; Li, J; Wang, G; Zhang, Q; Zhang, Y; Zhang, Z	1
Chu, Z; He, G; Hu, M; Huang, Y; Li, J; Ma, X; Xu, Q; Zhang, Y; Zhu, P; Zhu, Q	1
Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H	1
Cao, L; Ding, L; He, X; Huang, W	1
Chen, G; Huang, L; Liang, J; Song, K; Xie, X; Zeng, X; Zhu, R	1
Chen, Y; Han, B; Han, J; Lin, W; Shi, X; Wang, Y; Xu, J	1
Li, K; Lu, X; Yao, S; Zhang, Q	1
Guo, Y; Hu, H; Liu, H; Liu, Y; Xu, G; Yan, J	1
Li, G; Liu, W; Meng, H; Ruan, L; Wang, J; Yu, J; Zhang, L; Zhong, X; Zhu, M	1
Huang, Z; Ji, D; Jia, J; Jiao, W; Wang, X; Wu, J; Zhang, Y	1
Fu, B; Gao, G; Meng, S	1
Zhu, C	1
Gong, Z; Hu, J; Huang, J; Li, F; Li, L; Liu, S; Luo, W; Song, J; Xie, D; Yang, J; Yang, Q; Yue, C; Zhao, C; Zi, W	1
Shen, QQ; Tong, XW; Wang, W; Wu, H	1
Gao, F; Gao, L; Guo, X; Huo, K; Liu, J; Liu, Z; Lu, W; Qu, Q; Wang, J	1
Che, J; Wang, Z	1
Cai, J; Feng, Z; Hu, K; Hu, Y; Li, C; Li, L; Pu, W; Yang, Q; Zhang, J; Zhou, Z	1
Liu, X; Ma, Y; Wang, Y; Zhang, Q	1
Abuduxukuer, R; Chang, J; Fan, L; Guo, ZN; Jin, H; Liu, J; Liu, XL; Lou, Z; Qu, Y; Shen, Z; Shi, B; Sun, X; Yang, Y; Yue, BH; Zhang, KJ; Zhang, P; Zhao, Y; Zhong, J; Zhu, Y	1
Hong, Z; Li, S; Li, Y; Liu, Y; Wang, J; Xie, S	1
Cai, C; Cui, Y; Deng, L; He, B; Wang, L; Wang, X; Yang, Y; Zhang, H; Zhou, W; Zhu, B	1
Cai, Y; Cao, X; Chen, H; Chen, J; Chen, Y; Deng, J; Deng, W; Gao, L; Gui, L; Guo, Z; Han, Y; He, L; Huo, X; Jia, B; Jing, P; Li, C; Li, T; Li, X; Liu, Y; Miao, Z; Peng, Z; Shao, H; Shi, W; Song, C; Sun, H; Sun, Z; Wang, A; Wang, F; Wang, Y; Yang, H; Yang, J; Yang, Y; Yuan, H; Zhang, H; Zhang, P; Zhang, X; Zhao, H; Zhou, Z	1
Wang, X; Yang, D; Zhang, J; Zhang, M	1
Cui, W; Dai, MJ; Dou, H; Gui, XX; Jia, SM; Lv, ST	1
Luan, X; Wang, X; Yang, Z	1
Fang, M; Feng, B; Hou, H; Liu, Z; Zhang, T; Zhu, X	1
Jiang, M; Lu, S; Lyu, Y; Nie, T; Qian, Y; Tang, B	1
Jia, LN; Ma, R; Song, Y; Zhang, YJ	1
Chen, Q; Tan, L; Tu, E; Wang, Y	1
Marco-Contelles, J; Zhang, Y	1
Ding, Y; Gu, Z; Liu, Y; Niu, J; Wang, W; Wei, C; Zhai, T; Zhang, Y	1
Liu, L; Qu, M; Sun, J; Wei, L; Zhang, Y; Zhao, J; Zhao, Y	1
Huo, X; Jia, B; Miao, Z; Tian, X; Wang, A; Wang, Y; Zhang, JY; Zhang, X; Zuo, Y	1
Han, Y; Liu, Q; Xiang, H; Yang, L; Zhang, L; Zhang, Q; Zhang, Y; Zhang, Z	1
Cheng, X; Liang, Y; Luo, Y; Mu, X; Qu, H; Sun, Y; Wang, H; Zhao, C	1
Fan, XH; Li, K; Luo, CJ; Ning, LP; Tang, SC; Xue, P; Zhang, KH	1
Lin, Z; Rao, X; Xuan, J; Zhang, Z	1
Feng, Y; Huang, L; Ma, F; Peng, Y; Wang, S; Wang, X; Xing, C; Zhang, Y	2
Chen, N; Feng, J; He, D; Li, B; Li, J; Luo, J; Luo, Y; Zhang, J; Zheng, X; Zhou, Z	1
Liu, C; Shao, BZ; Xu, ZQ; Zhang, JJ; Zhou, Y	1
Cheng, X; Liu, C; Niu, X; Qi, R; Qu, H; Wang, H; Zhang, X; Zhao, C; Zhao, S; Zhong, S	1
Huang, Z; Ji, H; Lai, Y; Li, T; Tian, J; Wan, X; Wang, L; Wang, X; Xu, J; Zhang, Y	1
Cui, LY; Peng, B	1
Cui, LY; Gao, S; He, J; Ma, XQ; Ni, J; Peng, B; Wang, JM; Zhou, LX; Zhu, YC	1
Huang, J; Li, Q; Sun, X; Wang, H; Zhang, T	1
Cai, X; Hui, G; Li, X; Ni, J; Yun, W; Zhang, Q; Zhao, H; Zhou, X	1
Gui, Y; Niu, X; Wang, J; Yan, H; Yan, Z; Zhang, P	1
Jia, W; Sun, X; Zhang, T	1
Huang, RX; Li, CX; Liao, SJ; Lin, JW; Liu, CL; Shi, XG; Xie, LC; Zeng, JS	1
He, L; Kong, SY; Li, QF; Yang, J	1

Reviews

5 review(s) available for 3-n-butylphthalide and Apoplexy

Article	Year
Effects of NBP injection on the inflammatory response, oxidative stress response and vascular endothelial function in patients with ACI: A systematic review and meta-analysis. Medicine, 2023, Mar-10, Volume: 102, Issue:10 Topics: Cerebral Infarction; Drugs, Chinese Herbal; Humans; Retrospective Studies; Stroke; Vascular Endothelial Growth Factor A	2023
Clinical Efficacy and Short-Term Prognosis of Butylphthalide and Sodium Chloride Injection Compared to Edaravone in the Treatment of Patients with Acute Stroke. Alternative therapies in health and medicine, 2023, Volume: 29, Issue:7 Topics: Antipyrine; Edaravone; Humans; Sodium Chloride; Stroke; Treatment Outcome	2023
Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke. CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:5 Topics: Animals; Benzofurans; Brain Ischemia; Humans; Platelet Aggregation Inhibitors; Stroke	2018
From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacological research, 2018, Volume: 135 Topics: Animals; Benzofurans; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Stroke	2018
A Systematic Review of Neuroprotective Efficacy and Safety of DL-3-N-Butylphthalide in Ischemic Stroke. The American journal of Chinese medicine, 2019, Volume: 47, Issue:3 Topics: Aged; Benzofurans; Brain Ischemia; Databases, Bibliographic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Phytotherapy; Randomized Controlled Trials as Topic; Stroke; Treatment Outcome	2019

Trials

9 trial(s) available for 3-n-butylphthalide and Apoplexy

Article	Year
The effect of edaravone combined with DL-3-N-butylphthalide on the levels of tumor necrosis factor-alpha, interleukin-10, neuron-specific enolase and effect in patients with acute cerebral infarction. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2022, Volume: 73, Issue:3 Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Edaravone; Humans; Interleukin-10; Phosphopyruvate Hydratase; Quality of Life; Stroke; Tumor Necrosis Factor-alpha	2022
Protocol of End-PSCI trial: a multicenter, randomized controlled trial to evaluate the effects of DL-3-n-butylphthalide on delayed-onset post stroke cognitive impairment. BMC neurology, 2022, Nov-16, Volume: 22, Issue:1 Topics: Brain Ischemia; Cognitive Dysfunction; Humans; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Stroke	2022
Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023, Volume: 43, Issue:10 Topics: Arteries; Atherosclerosis; Brain Ischemia; Homeostasis; Humans; Ischemic Stroke; Stroke; Treatment Outcome	2023
Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial. JAMA neurology, 2023, 08-01, Volume: 80, Issue:8 Topics: Aged; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemic Stroke; Male; Stroke; Tissue Plasminogen Activator; Treatment Outcome	2023
Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke. Brain and behavior, 2019, Volume: 9, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Brain Ischemia; Drug Therapy, Combination; Edaravone; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Tissue Kallikreins; Treatment Outcome; Young Adult	2019
Efficacy and safety of butylphthalide for patients who had acute ischaemic stroke receiving intravenous thrombolysis or endovascular treatment (BAST trial): study protocol for a randomised placebo-controlled trial. BMJ open, 2021, 05-25, Volume: 11, Issue:5 Topics: Benzofurans; Brain Ischemia; Double-Blind Method; Humans; Ischemic Stroke; Randomized Controlled Trials as Topic; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome	2021
Effects of dl-3-n-butylphthalide on serum VEGF and bFGF levels in acute cerebral infarction. European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:19 Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Benzofurans; Cerebral Infarction; Female; Fibroblast Growth Factor 2; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Vascular Endothelial Growth Factor A; Young Adult	2017
Economic evaluation of human urinary kallindinogenase for patients with acute ischemic stroke in China. Journal of medical economics, 2018, Volume: 21, Issue:8 Topics: Benzofurans; Cerebrovascular Circulation; China; Cost-Benefit Analysis; Female; Health Services; Humans; Male; Models, Econometric; Prospective Studies; Quality-Adjusted Life Years; Stroke	2018
Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chinese medical journal, 2013, Volume: 126, Issue:18 Topics: Adult; Aged; Benzofurans; Double-Blind Method; Female; Humans; Male; Middle Aged; Stroke; Treatment Outcome	2013

Other Studies

41 other study(ies) available for 3-n-butylphthalide and Apoplexy

Article	Year
Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one. Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16 Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Fibrinolytic Agents; Free Radical Scavengers; Male; Neuroprotective Agents; PC12 Cells; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stereoisomerism; Stroke; Structure-Activity Relationship; Thiophenes	2012
Novel hybrids of 3-n-butylphthalide and edaravone: Design, synthesis and evaluations as potential anti-ischemic stroke agents. Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17 Topics: Animals; Antipyrine; Benzofurans; Cell Line; Drug Design; Edaravone; Free Radical Scavengers; Humans; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Stroke	2015
Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agent. European journal of medicinal chemistry, 2016, Jun-10, Volume: 115 Topics: Animals; Antioxidants; Benzofurans; Drug Discovery; Male; Rats; Stroke	2016
Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo. European journal of medicinal chemistry, 2018, Jan-01, Volume: 143 Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Ischemia; Carbazoles; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Pyrans; Rats; Rats, Sprague-Dawley; Stroke; Structure-Activity Relationship	2018
Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction. European journal of medicinal chemistry, 2021, Jun-05, Volume: 218 Topics: Animals; Brain Infarction; Dose-Response Relationship, Drug; Drug Design; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Mice; Mice, Inbred C57BL; Molecular Structure; Neuroprotective Agents; Stroke; Structure-Activity Relationship	2021
Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents. European journal of medicinal chemistry, 2022, Jan-05, Volume: 227 Topics: Benzofurans; Brain; Dose-Response Relationship, Drug; Drug Discovery; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Stroke; Structure-Activity Relationship	2022
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment. European journal of medicinal chemistry, 2022, Nov-05, Volume: 241 Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha	2022
Dl-3-n-butylphthalide induced anaphylactic shock: a case report. European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:5 Topics: Aged; Anaphylaxis; Brain Ischemia; Female; Humans; Ischemic Stroke; Stroke	2023
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance. Stroke and vascular neurology, 2022, Volume: 7, Issue:3 Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Drainage; Endothelial Cells; Evans Blue; Infarction, Middle Cerebral Artery; Ischemic Stroke; Rats; Rats, Sprague-Dawley; Stroke	2022
DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2022, May-01, Volume: 172 Topics: Animals; Atherosclerosis; Benzofurans; Brain Ischemia; Endothelial Cells; Mice; Neuroprotective Agents; Oxidative Stress; Rats; Stroke	2022
Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke. Journal of healthcare engineering, 2022, Volume: 2022 Topics: Benzofurans; Edaravone; Humans; Interleukin-6; Ischemic Stroke; Quality of Life; Sodium Chloride; Stroke; Treatment Outcome; Tumor Necrosis Factor-alpha	2022
Cerebral hemodynamic changes assessment by transcranial doppler ultrasound in patients with acute cerebral infarction before and after treatment with butylphthalide. Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:2(Special) Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Hemodynamics; Humans; Stroke; Ultrasonography, Doppler, Transcranial	2022
Neurochemical research, 2022, Volume: 47, Issue:10 Topics: Animals; Benzofurans; Chemical and Drug Induced Liver Injury; Ischemia; Ischemic Stroke; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Rats; Stroke	2022
Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents. Bioorganic & medicinal chemistry, 2022, 09-01, Volume: 69 Topics: Animals; Benzofurans; Edaravone; Ischemic Stroke; Neuroprotective Agents; Rats; Stroke	2022
A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study. Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:3(Special) Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Humans; Pyrazines; Retrospective Studies; S100 Calcium Binding Protein beta Subunit; Stroke	2022
Effect and clinical evaluation of butylphthalide combined with ureklin on ischemic low perfusion area in patients with acute cerebral infarction. Minerva medica, 2023, Volume: 114, Issue:4 Topics: Brain Ischemia; Cerebral Infarction; Humans; Perfusion; Stroke	2023
Efficacy and safety of 3-n-butylphthalide combined with endovascular treatment in acute ischemic stroke due to large vessel occlusion. CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:12 Topics: Brain Ischemia; Endovascular Procedures; Humans; Intracranial Hemorrhages; Ischemic Stroke; Retrospective Studies; Stroke; Thrombectomy; Treatment Outcome	2022
Effectiveness of alteplase intravenous thrombolysis combined with butylphthalide in patients with acute severe cerebral infarction. Folia neuropathologica, 2022, Volume: 60, Issue:4 Topics: Brain Ischemia; Cerebral Infarction; Fibrinolytic Agents; Humans; Quality of Life; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome	2022
Reactive Oxygen Species-Responsive Transformable and Triple-Targeting Butylphthalide Nanotherapy for Precision Treatment of Ischemic Stroke by Normalizing the Pathological Microenvironment. ACS nano, 2023, 03-14, Volume: 17, Issue:5 Topics: Animals; Brain Ischemia; Endothelial Cells; Ischemic Stroke; Mice; Neuroprotective Agents; Reactive Oxygen Species; Stroke	2023
Efficacy of Butylphthalide in Combination with Edaravone in the Treatment of Acute Ischemic Stroke and the Effect on Serum Inflammatory Factors. Disease markers, 2023, Volume: 2023 Topics: Benzofurans; Edaravone; Humans; Inflammation; Interleukin-6; Ischemic Stroke; Stroke	2023
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats. European journal of pharmacology, 2023, Jul-15, Volume: 951 Topics: Animals; Brain Ischemia; Edaravone; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Rats; Stroke	2023
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog. Acta pharmacologica Sinica, 2023, Volume: 44, Issue:12 Topics: Animals; Hedgehog Proteins; Human Umbilical Vein Endothelial Cells; Humans; Ischemic Stroke; Mice; Stroke	2023
The effect of butylphthalide on improving the neurological function of patients with acute anterior circulation cerebral infarction after mechanical thrombectomy. Medicine, 2023, Aug-25, Volume: 102, Issue:34 Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Humans; Retrospective Studies; Stroke; Thrombectomy; United States	2023
The neuroprotective effect of dl-3-n-butylphthalide on the brain with experimental intracerebral hemorrhage. European journal of pharmacology, 2023, Nov-15, Volume: 959 Topics: Animals; Brain; Cerebral Hemorrhage; Neuroprotective Agents; Rats; Stroke	2023
Does butylphthalide affect on hemodynamics in patients with watershed stroke?: A protocol of systematic review and meta-analysis. Medicine, 2020, Volume: 99, Issue:20 Topics: Benzofurans; China; Hemodynamics; Humans; Meta-Analysis as Topic; Neuroprotective Agents; Quality of Life; Randomized Controlled Trials as Topic; Stroke; Systematic Review as Topic; Treatment Outcome	2020
Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage. BMC neuroscience, 2020, 05-29, Volume: 21, Issue:1 Topics: Animals; Benzofurans; Brain; Cerebral Hemorrhage; Disease Models, Animal; Male; Nervous System Diseases; Rats, Sprague-Dawley; Stroke; Vascular Endothelial Growth Factor A	2020
From Seeds of Journal of medicinal chemistry, 2020, 11-12, Volume: 63, Issue:21 Topics: Animals; Apium; Asthma; Benzofurans; Brain Ischemia; Humans; Neuroprotective Agents; Seeds; Stereoisomerism; Stroke	2020
Effect of butylphthalide on new cerebral microbleeds in patients with acute ischemic stroke. Medicine, 2020, Aug-07, Volume: 99, Issue:32 Topics: Benzofurans; Cerebral Hemorrhage; Clinical Protocols; Humans; Ischemia; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Prospective Studies; Stroke	2020
Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice. Stroke and vascular neurology, 2021, Volume: 6, Issue:1 Topics: Animals; Benzofurans; Brain Ischemia; Ischemic Stroke; Mice; Mice, Inbred C57BL; Stroke; Vascular Endothelial Growth Factor A	2021
Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment. Journal of controlled release : official journal of the Controlled Release Society, 2021, 07-10, Volume: 335 Topics: Benzofurans; Brain; Brain Ischemia; Humans; Ischemic Stroke; Neuroprotective Agents; Prodrugs; Stroke	2021
dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats. Behavioural brain research, 2017, 06-30, Volume: 329 Topics: Animals; Benzofurans; Biotin; Brain Infarction; Dextrans; Disease Models, Animal; Disks Large Homolog 4 Protein; Doublecortin Protein; Endothelin-1; Male; Motor Activity; Neuronal Plasticity; Nogo Proteins; Nogo Receptor 1; Platelet Aggregation Inhibitors; Psychomotor Performance; Rats; Rats, Wistar; Recovery of Function; Signal Transduction; Stroke; Vesicular Glutamate Transport Protein 1	2017
3- Drug design, development and therapy, 2018, Volume: 12 Topics: Animals; Antioxidants; Apoptosis; Benzofurans; Brain Ischemia; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Signal Transduction; Stroke	2018
Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke. Brain research, 2019, 08-15, Volume: 1717 Topics: Animals; Benzofurans; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Differentiation; Male; Myelin Sheath; Nogo Proteins; Oligodendrocyte Precursor Cells; Oligodendroglia; Rats; Rats, Wistar; Recovery of Function; Remyelination; Stroke; White Matter	2019
Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents. Journal of medicinal chemistry, 2013, Apr-11, Volume: 56, Issue:7 Topics: Animals; Benzofurans; Blood-Brain Barrier; Isosorbide; Platelet Aggregation Inhibitors; Rats; Stereoisomerism; Stroke	2013
Treatment for acute ischemic stroke: new evidence from China. Chinese medical journal, 2013, Volume: 126, Issue:18 Topics: Benzofurans; China; Fibrinolytic Agents; Humans; Stroke	2013
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model. Neuroscience, 2014, Mar-28, Volume: 263 Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; Benzofurans; Brain Ischemia; Cell Survival; Mice; Neuroblastoma; Sirolimus; Stroke; Tumor Cells, Cultured	2014
Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:4 Topics: Aged; Antigens, CD; Benzofurans; Brain Ischemia; Cell Movement; Diffusion Magnetic Resonance Imaging; Endothelial Progenitor Cells; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Statistics as Topic; Stroke; Time Factors; Vascular Endothelial Growth Factor Receptor-2	2016
Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study. Neurological research, 2017, Volume: 39, Issue:4 Topics: Benzofurans; Biomarkers; Brain Ischemia; C-Reactive Protein; Cognition; Dementia, Vascular; Female; Homocysteine; Humans; Logistic Models; Male; Mental Status Schedule; Middle Aged; Multivariate Analysis; Neuroprotective Agents; Neuropsychological Tests; Nootropic Agents; Prospective Studies; Risk Factors; Stroke; Treatment Outcome	2017
3-n-Butylphthalide (NBP) reduces apoptosis and enhances vascular endothelial growth factor (VEGF) up-regulation in diabetic rats. Neurological research, 2010, Volume: 32, Issue:4 Topics: Animals; Apoptosis; Benzofurans; Cerebral Arteries; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Gliosis; Hippocampus; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Up-Regulation; Vascular Endothelial Growth Factor A	2010
dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP. Journal of the neurological sciences, 2007, Sep-15, Volume: 260, Issue:1-2 Topics: Animals; Aspirin; Benzofurans; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Cold Temperature; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Hypertension, Renal; Male; Microcirculation; Molecular Structure; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Treatment Outcome	2007
[The effect of butylphthalide on expression of NGF and BDNF in ischemia stroke tissue of rat cerebrum]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2007, Volume: 38, Issue:3 Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Cerebrum; Gene Expression Regulation; Ischemia; Male; Nerve Growth Factor; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stroke	2007