3-n-butylphthalide has been researched along with Alzheimer Disease in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 8 (38.10) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z | 1 |
| Cao, Z; Cong, S; Deng, Y; Liu, Z; Song, Q; Tan, Z; Yu, G | 1 |
| Cong, S; Deng, Y; Li, J; Liu, Z; Shi, Y; Yu, G; Zhang, X | 1 |
| Jia, JP; Li, BQ; Li, FY; Li, Y; Quan, MN; Xu, LZ; Zhang, H; Zhao, Y | 1 |
| Buzoianu, AD; Chen, L; Feng, L; Huang, H; Lafuente, JV; Manzhulo, I; Muresanu, DF; Nozari, A; Sharma, A; Sharma, HS; Tian, ZR; Wang, ZG; Wiklund, L | 1 |
| Feng, X; Huang, L; Kang, Y; Lan, J; Peng, Y; Tang, J; Wu, L | 1 |
| Gao, Q; Li, W; Liu, H; Tan, S; Xiang, H; Xie, L; Zhang, B; Zhuo, Y | 1 |
| Gao, F; Guo, X; Liu, J; Lu, W; Ma, L; Qu, Q; Quan, Q; Su, H; Wang, J; Zhang, H | 1 |
| Guo, C; Wang, CY; Wang, T; Wang, X; Wang, ZY; Xu, Y | 1 |
| Huang, L; Lei, H; Li, J; Peng, Y; Wang, L; Wang, X; Xing, C; Xu, S; Yang, L; Zhang, Y | 1 |
| Huang, JK; Sun, XJ; Wang, HM; Zhang, T | 1 |
| Lei, H; Li, L; Liu, DM; Peng, Y; Wang, XL; Zhang, Y; Zhao, CY | 1 |
| Cai, JH; Wang, CY; Wang, T; Wang, X; Wang, ZY; Xie, JW; Xu, Y | 1 |
| Huang, LJ; Peng, Y; Shi, S; Wang, XL; Xu, SF; Zhang, Y | 1 |
| Chen, K; Hou, DR; Tian, Y; Wan, S; Zhou, J | 2 |
| Chen, K; Hou, D; Tian, Y; Wan, S; Xue, L | 1 |
| Feng, Y; Hon, S; Lemere, CA; Nylander, AN; Peng, Y; Sun, J; Wang, X; Xia, W | 1 |
| Hou, DR; Sun, JJ; Tang, JC; Xue, L; Zhou, J | 1 |
| Feng, N; Hu, Y; Li, J; Li, P; Lu, L; Peng, Y; Wang, L; Wang, X; Xu, S; Yang, H | 1 |
21 other study(ies) available for 3-n-butylphthalide and Alzheimer Disease
| Article | Year |
|---|---|
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Female; Male; Membranes, Artificial; Mice; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Permeability; Protein Aggregation, Pathological; Random Allocation; Rats | 2020 |
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Benzylidene Compounds; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Copper; Dose-Response Relationship, Drug; Electrophorus; Female; Humans; Male; Mannich Bases; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2021 |
Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Electrophorus; Humans; Mannich Bases; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Structure-Activity Relationship | 2022 |
CaMKIIα Signaling Is Required for the Neuroprotective Effects of Dl-3-n-Butylphthalide in Alzheimer's Disease.
Topics: Alzheimer Disease; Benzofurans; Humans; Neurodegenerative Diseases; Neuroprotective Agents | 2022 |
Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain Concussion; Humans; Neprilysin; Neuroprotection; Neuroprotective Agents; Parkinson Disease | 2023 |
L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer's disease mouse model and cultured hippocampal neurons.
Topics: Alzheimer Disease; Animals; Autophagosomes; Autophagy; Axons; Benzofurans; Biomarkers; Cells, Cultured; Cognitive Dysfunction; Dendritic Spines; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Lysosomes; Male; Mice, Transgenic; Morris Water Maze Test; Neurites; Neuronal Plasticity; Synapses | 2021 |
L-3-n-Butylphthalide Effectively Improves the Glymphatic Clearance and Reduce Amyloid-β Deposition in Alzheimer's Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzofurans; Brain; Glymphatic System; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neuroprotective Agents | 2021 |
Donepezil Combined with DL-3-n-Butylphthalide Delays Cognitive Decline in Patients with Mild to Moderate Alzheimer's Disease: A Multicenter, Prospective Cohort Study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Benzofurans; Cognitive Dysfunction; Cohort Studies; Donepezil; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Prospective Studies; Treatment Outcome | 2021 |
Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Apoptosis; Benzofurans; Carrier Proteins; Cell Line, Tumor; HEK293 Cells; Humans; Inflammasomes; Interleukin-1beta; Male; Mice; Mice, Transgenic; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Binding; Thioredoxins | 2019 |
L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cell Differentiation; Cell Movement; Cell Proliferation; Embryo, Mammalian; Humans; Intercellular Signaling Peptides and Proteins; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; Presenilin-1 | 2018 |
3-N-butylphthalide (NBP) attenuates the amyloid-β-induced inflammatory responses in cultured astrocytes via the nuclear factor-κB signaling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzofurans; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; I-kappa B Proteins; Interleukin-6; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neuroprotective Agents; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
l-3-n-Butylphthalide attenuates β-amyloid-induced toxicity in neuroblastoma SH-SY5Y cells through regulating mitochondrion-mediated apoptosis and MAPK signaling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Benzofurans; Caspase 3; Caspase 9; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Neuroblastoma; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Reactive Oxygen Species; Signal Transduction | 2014 |
Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Brain; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; NF-E2-Related Factor 2; Oxidative Stress; Up-Regulation | 2016 |
L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; beta Catenin; Dendritic Spines; Disease Models, Animal; Disks Large Homolog 4 Protein; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuroprotective Agents; Presenilin-1; Synapses | 2016 |
[Butylphthalide improves learning and memory abilities of rats with Alzheimer's disease possibly by inhibiting P38 mitogen-activated protein kinase and enhancing extra-cellular signal regulated kinase expressions].
Topics: Alzheimer Disease; Animals; Benzofurans; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Hippocampus; Male; Memory; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley | 2009 |
[Effect of butylphthalide on the expression of S100 and glial fibrillary acidic protein in a rat model of Alzheimer disease].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzofurans; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Male; Nerve Growth Factors; Neuroprotective Agents; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; S100 Proteins | 2009 |
[Effect of butylphthalide on the expression of GFAP and VEGF in the hippocampus of rats with Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Benzofurans; Disease Models, Animal; Drugs, Chinese Herbal; Glial Fibrillary Acidic Protein; Hippocampus; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2010 |
L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
Topics: ADAM Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cell Line, Tumor; Cell Survival; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indoles; Leukocyte Common Antigens; Male; Maleimides; Malondialdehyde; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neuroglia; Neuroprotective Agents; Oxidative Stress; Presenilin-1; Reaction Time; Spatial Behavior; Statistics, Nonparametric; tau Proteins; Time Factors; Transfection | 2010 |
[Butylphthalide improves learning and memory abilities of rats with Alzheimer's disease possibly by enhancing protein disulfide isomerase and inhibiting P53 expressions].
Topics: Alzheimer Disease; Animals; Apoptosis; Benzofurans; Brain; Disease Models, Animal; Learning; Male; Memory; Protein Disulfide-Isomerases; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 2010 |
L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzofurans; Brain; Cell Line, Tumor; Cognition Disorders; Cyclin-Dependent Kinase 5; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Maze Learning; Mice; Mice, Transgenic; Neuroblastoma; Neuroprotective Agents; Phosphorylation; Presenilin-1; Reaction Time; Spatial Behavior; tau Proteins; Time Factors | 2012 |