3-n-butylphthalide has been researched along with Acute Ischemic Stroke in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 26 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H | 1 |
| Cheng, Y; Guan, Y; Guo, L; Li, P; Liu, Y; Wu, Q | 1 |
| Li, J; Li, Q; Meng, H; Wang, C; Wang, S; Wu, Z; Xu, Y; Zhang, A; Zhang, J | 1 |
| Chen, Y; Du, J; Li, H; Wu, Y; Yang, L; Zhang, H | 1 |
| Cao, L; Ding, L; He, X; Huang, W | 1 |
| Chen, G; Huang, L; Liang, J; Song, K; Xie, X; Zeng, X; Zhu, R | 1 |
| Li, K; Lu, X; Yao, S; Zhang, Q | 1 |
| Li, G; Liu, W; Meng, H; Ruan, L; Wang, J; Yu, J; Zhang, L; Zhong, X; Zhu, M | 1 |
| Huang, Z; Ji, D; Jia, J; Jiao, W; Wang, X; Wu, J; Zhang, Y | 1 |
| Lv, J; Xie, Z; Zhao, D; Zhao, G | 1 |
| Gong, Z; Hu, J; Huang, J; Li, F; Li, L; Liu, S; Luo, W; Song, J; Xie, D; Yang, J; Yang, Q; Yue, C; Zhao, C; Zi, W | 1 |
| Fan, L; Guo, B; Li, Y; Luo, B; Luo, Z; Tang, L; Yu, Q; Zhang, Y; Zhong, X; Zhu, G | 1 |
| Cai, J; Feng, Z; Hu, K; Hu, Y; Li, C; Li, L; Pu, W; Yang, Q; Zhang, J; Zhou, Z | 1 |
| Abuduxukuer, R; Guo, ZN; He, Q; Huang, S; Qu, Y; Ren, J; Sun, X; Yang, Y; Zhang, K | 1 |
| Abuduxukuer, R; Chang, J; Fan, L; Guo, ZN; Jin, H; Liu, J; Liu, XL; Lou, Z; Qu, Y; Shen, Z; Shi, B; Sun, X; Yang, Y; Yue, BH; Zhang, KJ; Zhang, P; Zhao, Y; Zhong, J; Zhu, Y | 1 |
| Hong, Z; Li, S; Li, Y; Liu, Y; Wang, J; Xie, S | 1 |
| Cai, C; Cui, Y; Deng, L; He, B; Wang, L; Wang, X; Yang, Y; Zhang, H; Zhou, W; Zhu, B | 1 |
| Cai, Y; Cao, X; Chen, H; Chen, J; Chen, Y; Deng, J; Deng, W; Gao, L; Gui, L; Guo, Z; Han, Y; He, L; Huo, X; Jia, B; Jing, P; Li, C; Li, T; Li, X; Liu, Y; Miao, Z; Peng, Z; Shao, H; Shi, W; Song, C; Sun, H; Sun, Z; Wang, A; Wang, F; Wang, Y; Yang, H; Yang, J; Yang, Y; Yuan, H; Zhang, H; Zhang, P; Zhang, X; Zhao, H; Zhou, Z | 1 |
| Li, MR; Li, NS; Lu, LQ; Luo, XJ; Peng, J; Peng, JY; Tang, LJ | 1 |
| Cui, W; Dai, MJ; Dou, H; Gui, XX; Jia, SM; Lv, ST | 1 |
| Jia, Y; Liu, Y; Shang, H; Sun, G; Tian, Y; Wang, J; Wang, X; Xiao, H; Xie, H | 1 |
| Liu, L; Qu, M; Sun, J; Wei, L; Zhang, Y; Zhao, J; Zhao, Y | 1 |
| Fu, D; Liu, R; Liu, X; Pu, X; Sun, Y; Wang, M; Wu, H; Zhao, X | 1 |
| Huo, X; Jia, B; Miao, Z; Tian, X; Wang, A; Wang, Y; Zhang, JY; Zhang, X; Zuo, Y | 1 |
| Han, Y; Liu, Q; Xiang, H; Yang, L; Zhang, L; Zhang, Q; Zhang, Y; Zhang, Z | 1 |
| Abdoulaye, IA; Guo, Y; Le, K; Liu, F; Tian, X; Wang, J; Yu, D | 1 |
5 trial(s) available for 3-n-butylphthalide and Acute Ischemic Stroke
| Article | Year |
|---|---|
Efficacy of sequential N-butylphthalide therapy on psychiatric and behavioral functions in acute ischemic stroke.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Behavioral Symptoms; Benzofurans; Double-Blind Method; Female; Humans; Ischemic Stroke; Male; Mental Disorders; Middle Aged; Treatment Outcome | 2021 |
Efficacy and safety of butylphthalide in secondary prevention of stroke: study protocol for a multicenter, real world trial based on Internet.
Topics: Aspirin; Benzofurans; Clopidogrel; Double-Blind Method; Humans; Internet; Ischemic Stroke; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome | 2022 |
Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial.
Topics: Arteries; Atherosclerosis; Brain Ischemia; Homeostasis; Humans; Ischemic Stroke; Stroke; Treatment Outcome | 2023 |
Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.
Topics: Aged; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemic Stroke; Male; Stroke; Tissue Plasminogen Activator; Treatment Outcome | 2023 |
Efficacy and safety of butylphthalide for patients who had acute ischaemic stroke receiving intravenous thrombolysis or endovascular treatment (BAST trial): study protocol for a randomised placebo-controlled trial.
Topics: Benzofurans; Brain Ischemia; Double-Blind Method; Humans; Ischemic Stroke; Randomized Controlled Trials as Topic; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 2021 |
21 other study(ies) available for 3-n-butylphthalide and Acute Ischemic Stroke
| Article | Year |
|---|---|
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha | 2022 |
Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.
Topics: Animals; Apoptosis Regulatory Proteins; Benzofurans; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Endothelial Cells; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents | 2021 |
Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy.
Topics: Animals; Area Under Curve; Benzofurans; Caco-2 Cells; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Humans; Ischemic Stroke; Liposomes; Male; Neuroprotective Agents; Particle Size; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Cholate; Tissue Distribution | 2021 |
Dl-3-n-butylphthalide induced anaphylactic shock: a case report.
Topics: Aged; Anaphylaxis; Brain Ischemia; Female; Humans; Ischemic Stroke; Stroke | 2023 |
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Drainage; Endothelial Cells; Evans Blue; Infarction, Middle Cerebral Artery; Ischemic Stroke; Rats; Rats, Sprague-Dawley; Stroke | 2022 |
Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke.
Topics: Benzofurans; Edaravone; Humans; Interleukin-6; Ischemic Stroke; Quality of Life; Sodium Chloride; Stroke; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Topics: Animals; Benzofurans; Chemical and Drug Induced Liver Injury; Ischemia; Ischemic Stroke; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Rats; Stroke | 2022 |
Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents.
Topics: Animals; Benzofurans; Edaravone; Ischemic Stroke; Neuroprotective Agents; Rats; Stroke | 2022 |
Efficacy and safety of 3-n-butylphthalide combined with endovascular treatment in acute ischemic stroke due to large vessel occlusion.
Topics: Brain Ischemia; Endovascular Procedures; Humans; Intracranial Hemorrhages; Ischemic Stroke; Retrospective Studies; Stroke; Thrombectomy; Treatment Outcome | 2022 |
Synthesis of Novel 3-Butylphthalide Derivatives Containing Isopentenylphenol Moiety as Potential Antiplatelet Agents for the Treatment of Ischemic Stroke.
Topics: Animals; Ischemic Stroke; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thrombosis | 2023 |
Reactive Oxygen Species-Responsive Transformable and Triple-Targeting Butylphthalide Nanotherapy for Precision Treatment of Ischemic Stroke by Normalizing the Pathological Microenvironment.
Topics: Animals; Brain Ischemia; Endothelial Cells; Ischemic Stroke; Mice; Neuroprotective Agents; Reactive Oxygen Species; Stroke | 2023 |
DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis.
Topics: Animals; Apoptosis; Cerebral Infarction; High-Temperature Requirement A Serine Peptidase 2; Ischemic Stroke; Male; Mitochondria; Mitochondrial Proteins; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2023 |
Efficacy of Butylphthalide in Combination with Edaravone in the Treatment of Acute Ischemic Stroke and the Effect on Serum Inflammatory Factors.
Topics: Benzofurans; Edaravone; Humans; Inflammation; Interleukin-6; Ischemic Stroke; Stroke | 2023 |
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats.
Topics: Animals; Brain Ischemia; Edaravone; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Rats; Stroke | 2023 |
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE
Topics: Animals; Apolipoproteins E; Apoptosis; Atherosclerosis; Atorvastatin; Cytokines; Diet, High-Fat; Endothelium; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Ischemic Stroke; Male; Mice; Mice, Knockout; Necroptosis; Vasodilation | 2023 |
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog.
Topics: Animals; Hedgehog Proteins; Human Umbilical Vein Endothelial Cells; Humans; Ischemic Stroke; Mice; Stroke | 2023 |
Design, synthesis, and evaluation of n-butylphthalide and ligustrazine hybrids as potent neuroprotective agents for the treatment of ischemic stroke in vitro and in vivo.
Topics: Animals; Apoptosis; Glucose; Humans; Ischemic Stroke; Neuroblastoma; Neuroprotective Agents; Oxygen; Rats | 2024 |
Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice.
Topics: Animals; Benzofurans; Brain Ischemia; Ischemic Stroke; Mice; Mice, Inbred C57BL; Stroke; Vascular Endothelial Growth Factor A | 2021 |
Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model.
Topics: Animals; Benzofurans; Brain; Caspase 1; Cyclic AMP Response Element-Binding Protein; Forkhead Transcription Factors; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Ki-67 Antigen; Molecular Docking Simulation; Neovascularization, Physiologic; Nerve Regeneration; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Phospholipids; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2021 |
Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment.
Topics: Benzofurans; Brain; Brain Ischemia; Humans; Ischemic Stroke; Neuroprotective Agents; Prodrugs; Stroke | 2021 |
N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-α Expressions.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Benzofurans; Biomarkers; Brain Ischemia; Case-Control Studies; Female; Humans; Ischemic Stroke; Kallikreins; Male; Middle Aged; Neuroprotective Agents; Prognosis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Young Adult | 2021 |