Page last updated: 2024-08-24

3-n-butylphthalide and Acute Ischemic Stroke

3-n-butylphthalide has been researched along with Acute Ischemic Stroke in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's26 (100.00)2.80

Authors

AuthorsStudies
Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H1
Cheng, Y; Guan, Y; Guo, L; Li, P; Liu, Y; Wu, Q1
Li, J; Li, Q; Meng, H; Wang, C; Wang, S; Wu, Z; Xu, Y; Zhang, A; Zhang, J1
Chen, Y; Du, J; Li, H; Wu, Y; Yang, L; Zhang, H1
Cao, L; Ding, L; He, X; Huang, W1
Chen, G; Huang, L; Liang, J; Song, K; Xie, X; Zeng, X; Zhu, R1
Li, K; Lu, X; Yao, S; Zhang, Q1
Li, G; Liu, W; Meng, H; Ruan, L; Wang, J; Yu, J; Zhang, L; Zhong, X; Zhu, M1
Huang, Z; Ji, D; Jia, J; Jiao, W; Wang, X; Wu, J; Zhang, Y1
Lv, J; Xie, Z; Zhao, D; Zhao, G1
Gong, Z; Hu, J; Huang, J; Li, F; Li, L; Liu, S; Luo, W; Song, J; Xie, D; Yang, J; Yang, Q; Yue, C; Zhao, C; Zi, W1
Fan, L; Guo, B; Li, Y; Luo, B; Luo, Z; Tang, L; Yu, Q; Zhang, Y; Zhong, X; Zhu, G1
Cai, J; Feng, Z; Hu, K; Hu, Y; Li, C; Li, L; Pu, W; Yang, Q; Zhang, J; Zhou, Z1
Abuduxukuer, R; Guo, ZN; He, Q; Huang, S; Qu, Y; Ren, J; Sun, X; Yang, Y; Zhang, K1
Abuduxukuer, R; Chang, J; Fan, L; Guo, ZN; Jin, H; Liu, J; Liu, XL; Lou, Z; Qu, Y; Shen, Z; Shi, B; Sun, X; Yang, Y; Yue, BH; Zhang, KJ; Zhang, P; Zhao, Y; Zhong, J; Zhu, Y1
Hong, Z; Li, S; Li, Y; Liu, Y; Wang, J; Xie, S1
Cai, C; Cui, Y; Deng, L; He, B; Wang, L; Wang, X; Yang, Y; Zhang, H; Zhou, W; Zhu, B1
Cai, Y; Cao, X; Chen, H; Chen, J; Chen, Y; Deng, J; Deng, W; Gao, L; Gui, L; Guo, Z; Han, Y; He, L; Huo, X; Jia, B; Jing, P; Li, C; Li, T; Li, X; Liu, Y; Miao, Z; Peng, Z; Shao, H; Shi, W; Song, C; Sun, H; Sun, Z; Wang, A; Wang, F; Wang, Y; Yang, H; Yang, J; Yang, Y; Yuan, H; Zhang, H; Zhang, P; Zhang, X; Zhao, H; Zhou, Z1
Li, MR; Li, NS; Lu, LQ; Luo, XJ; Peng, J; Peng, JY; Tang, LJ1
Cui, W; Dai, MJ; Dou, H; Gui, XX; Jia, SM; Lv, ST1
Jia, Y; Liu, Y; Shang, H; Sun, G; Tian, Y; Wang, J; Wang, X; Xiao, H; Xie, H1
Liu, L; Qu, M; Sun, J; Wei, L; Zhang, Y; Zhao, J; Zhao, Y1
Fu, D; Liu, R; Liu, X; Pu, X; Sun, Y; Wang, M; Wu, H; Zhao, X1
Huo, X; Jia, B; Miao, Z; Tian, X; Wang, A; Wang, Y; Zhang, JY; Zhang, X; Zuo, Y1
Han, Y; Liu, Q; Xiang, H; Yang, L; Zhang, L; Zhang, Q; Zhang, Y; Zhang, Z1
Abdoulaye, IA; Guo, Y; Le, K; Liu, F; Tian, X; Wang, J; Yu, D1

Trials

5 trial(s) available for 3-n-butylphthalide and Acute Ischemic Stroke

ArticleYear
Efficacy of sequential N-butylphthalide therapy on psychiatric and behavioral functions in acute ischemic stroke.
    Medicine, 2021, Nov-19, Volume: 100, Issue:46

    Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Behavioral Symptoms; Benzofurans; Double-Blind Method; Female; Humans; Ischemic Stroke; Male; Mental Disorders; Middle Aged; Treatment Outcome

2021
Efficacy and safety of butylphthalide in secondary prevention of stroke: study protocol for a multicenter, real world trial based on Internet.
    BMC neurology, 2022, Aug-19, Volume: 22, Issue:1

    Topics: Aspirin; Benzofurans; Clopidogrel; Double-Blind Method; Humans; Internet; Ischemic Stroke; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome

2022
Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023, Volume: 43, Issue:10

    Topics: Arteries; Atherosclerosis; Brain Ischemia; Homeostasis; Humans; Ischemic Stroke; Stroke; Treatment Outcome

2023
Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.
    JAMA neurology, 2023, 08-01, Volume: 80, Issue:8

    Topics: Aged; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemic Stroke; Male; Stroke; Tissue Plasminogen Activator; Treatment Outcome

2023
Efficacy and safety of butylphthalide for patients who had acute ischaemic stroke receiving intravenous thrombolysis or endovascular treatment (BAST trial): study protocol for a randomised placebo-controlled trial.
    BMJ open, 2021, 05-25, Volume: 11, Issue:5

    Topics: Benzofurans; Brain Ischemia; Double-Blind Method; Humans; Ischemic Stroke; Randomized Controlled Trials as Topic; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome

2021

Other Studies

21 other study(ies) available for 3-n-butylphthalide and Acute Ischemic Stroke

ArticleYear
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
    European journal of medicinal chemistry, 2022, Nov-05, Volume: 241

    Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha

2022
Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.
    Molecular medicine reports, 2021, Volume: 24, Issue:6

    Topics: Animals; Apoptosis Regulatory Proteins; Benzofurans; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Endothelial Cells; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents

2021
Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy.
    Drug delivery, 2021, Volume: 28, Issue:1

    Topics: Animals; Area Under Curve; Benzofurans; Caco-2 Cells; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Humans; Ischemic Stroke; Liposomes; Male; Neuroprotective Agents; Particle Size; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Cholate; Tissue Distribution

2021
Dl-3-n-butylphthalide induced anaphylactic shock: a case report.
    European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:5

    Topics: Aged; Anaphylaxis; Brain Ischemia; Female; Humans; Ischemic Stroke; Stroke

2023
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
    Stroke and vascular neurology, 2022, Volume: 7, Issue:3

    Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Drainage; Endothelial Cells; Evans Blue; Infarction, Middle Cerebral Artery; Ischemic Stroke; Rats; Rats, Sprague-Dawley; Stroke

2022
Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke.
    Journal of healthcare engineering, 2022, Volume: 2022

    Topics: Benzofurans; Edaravone; Humans; Interleukin-6; Ischemic Stroke; Quality of Life; Sodium Chloride; Stroke; Treatment Outcome; Tumor Necrosis Factor-alpha

2022
    Neurochemical research, 2022, Volume: 47, Issue:10

    Topics: Animals; Benzofurans; Chemical and Drug Induced Liver Injury; Ischemia; Ischemic Stroke; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Rats; Stroke

2022
Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents.
    Bioorganic & medicinal chemistry, 2022, 09-01, Volume: 69

    Topics: Animals; Benzofurans; Edaravone; Ischemic Stroke; Neuroprotective Agents; Rats; Stroke

2022
Efficacy and safety of 3-n-butylphthalide combined with endovascular treatment in acute ischemic stroke due to large vessel occlusion.
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:12

    Topics: Brain Ischemia; Endovascular Procedures; Humans; Intracranial Hemorrhages; Ischemic Stroke; Retrospective Studies; Stroke; Thrombectomy; Treatment Outcome

2022
Synthesis of Novel 3-Butylphthalide Derivatives Containing Isopentenylphenol Moiety as Potential Antiplatelet Agents for the Treatment of Ischemic Stroke.
    Chemistry & biodiversity, 2023, Volume: 20, Issue:1

    Topics: Animals; Ischemic Stroke; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thrombosis

2023
Reactive Oxygen Species-Responsive Transformable and Triple-Targeting Butylphthalide Nanotherapy for Precision Treatment of Ischemic Stroke by Normalizing the Pathological Microenvironment.
    ACS nano, 2023, 03-14, Volume: 17, Issue:5

    Topics: Animals; Brain Ischemia; Endothelial Cells; Ischemic Stroke; Mice; Neuroprotective Agents; Reactive Oxygen Species; Stroke

2023
DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis.
    Current neurovascular research, 2023, Volume: 20, Issue:1

    Topics: Animals; Apoptosis; Cerebral Infarction; High-Temperature Requirement A Serine Peptidase 2; Ischemic Stroke; Male; Mitochondria; Mitochondrial Proteins; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2023
Efficacy of Butylphthalide in Combination with Edaravone in the Treatment of Acute Ischemic Stroke and the Effect on Serum Inflammatory Factors.
    Disease markers, 2023, Volume: 2023

    Topics: Benzofurans; Edaravone; Humans; Inflammation; Interleukin-6; Ischemic Stroke; Stroke

2023
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats.
    European journal of pharmacology, 2023, Jul-15, Volume: 951

    Topics: Animals; Brain Ischemia; Edaravone; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Rats; Stroke

2023
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE
    European journal of pharmacology, 2023, Oct-05, Volume: 956

    Topics: Animals; Apolipoproteins E; Apoptosis; Atherosclerosis; Atorvastatin; Cytokines; Diet, High-Fat; Endothelium; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Ischemic Stroke; Male; Mice; Mice, Knockout; Necroptosis; Vasodilation

2023
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:12

    Topics: Animals; Hedgehog Proteins; Human Umbilical Vein Endothelial Cells; Humans; Ischemic Stroke; Mice; Stroke

2023
Design, synthesis, and evaluation of n-butylphthalide and ligustrazine hybrids as potent neuroprotective agents for the treatment of ischemic stroke in vitro and in vivo.
    Bioorganic chemistry, 2024, Volume: 142

    Topics: Animals; Apoptosis; Glucose; Humans; Ischemic Stroke; Neuroblastoma; Neuroprotective Agents; Oxygen; Rats

2024
Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice.
    Stroke and vascular neurology, 2021, Volume: 6, Issue:1

    Topics: Animals; Benzofurans; Brain Ischemia; Ischemic Stroke; Mice; Mice, Inbred C57BL; Stroke; Vascular Endothelial Growth Factor A

2021
Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model.
    Aging, 2021, 01-10, Volume: 13, Issue:3

    Topics: Animals; Benzofurans; Brain; Caspase 1; Cyclic AMP Response Element-Binding Protein; Forkhead Transcription Factors; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Ki-67 Antigen; Molecular Docking Simulation; Neovascularization, Physiologic; Nerve Regeneration; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Phospholipids; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2021
Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2021, 07-10, Volume: 335

    Topics: Benzofurans; Brain; Brain Ischemia; Humans; Ischemic Stroke; Neuroprotective Agents; Prodrugs; Stroke

2021
N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-α Expressions.
    Annals of clinical and laboratory science, 2021, Volume: 51, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Benzofurans; Biomarkers; Brain Ischemia; Case-Control Studies; Female; Humans; Ischemic Stroke; Kallikreins; Male; Middle Aged; Neuroprotective Agents; Prognosis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Young Adult

2021