3-methylcholanthrene has been researched along with Pregnancy in 174 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Time-mated Swiss-Webster mice were pretreated in separate experiments with phenobarbital (60 mg/kg X d sc on d 7-10 of pregnancy), SKF-525A (40 mg/kg ip on d 12 of pregnancy) or 3-methylcholanthrene (20 mg/kg X d on d 10-12 of pregnancy)." | 3.67 | Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence. ( Khera, KS, 1984) |
| "To test the hypothesis that mice exposed prenatally to diethylstilbestrol (DES) develop adenocarcinomas due to sensitivity of vaginal and cervical adenosis to carcinogens, sponges impregnated with methylcholanthrene (MCA) were lodged against the cervix and vaginal fornices of 6-month-old strain CD-1 mice exposed prenatally to DES." | 3.67 | Vaginal tumors in mice from methylcholanthrene and prenatal exposure to diethylstilbestrol. ( Walker, BE, 1988) |
| "The ability of alpha-fetoprotein (AFP), derived from mouse amniotic fluid, to alter qualitative and quantitative characteristics of pristane-induced plasmacytomas and the carcinogenic action of 3-methylcholanthrene (MCA) and 7,12-dimethylbenz]a[-anthracene (DMBA) was studied and compared to analogous treatment with murine albumin and transferrin in BALB/c mice." | 3.66 | Accelerated plasmacytoma formation in mice treated with alpha-fetoprotein. ( Castles, JJ; Gershwin, ME; Makishima, R, 1980) |
| "Pretreatment with phenobarbital resulted in the precocious onset of PB-B in fetal and neonatal rat liver accompanied by an increase in classically associated monooxygenase activities." | 1.27 | Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene. ( Beaune, P; Celier, C; Cresteil, T; Guengerich, FP; Leroux, JP, 1986) |
| " The difference held for offspring of both (C57BL/6 X DBA)F1 and DBA mothers and it was of statistical significance for one or both sexes at most dosage levels." | 1.27 | Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene: positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism. ( Anderson, LM; Jones, AB; Ohshima, M; Riggs, CW, 1985) |
| " MMI and ETU were dosed simultaneously, one hour after dosing with SKF." | 1.26 | Effects of pretreatment with SKF-525A, N-Methyl-2-thioimidazole, sodium phenobarbital, or methyl cholanthrene on ethylenethiourea-induced teratogenicity in rats. ( Iverson, F; Khera, KS, 1981) |
| " The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo(alpha)pyrene and 3-methylcholanthrene." | 1.25 | Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity. ( Dipaolo, JA; Donovan, PJ; Nelson, RL, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 148 (85.06) | 18.7374 |
| 1990's | 16 (9.20) | 18.2507 |
| 2000's | 8 (4.60) | 29.6817 |
| 2010's | 1 (0.57) | 24.3611 |
| 2020's | 1 (0.57) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, Q | 1 |
| Hu, L | 1 |
| Miao, W | 1 |
| Fu, Z | 1 |
| Jin, Y | 1 |
| Stejskalova, L | 1 |
| Rulcova, A | 1 |
| Vrzal, R | 1 |
| Dvorak, Z | 1 |
| Pavek, P | 1 |
| Naruse, M | 1 |
| Ishihara, Y | 1 |
| Miyagawa-Tomita, S | 1 |
| Koyama, A | 1 |
| Hagiwara, H | 1 |
| Moriguchi, T | 1 |
| Motohashi, H | 1 |
| Hosoya, T | 1 |
| Nakajima, O | 1 |
| Takahashi, S | 1 |
| Ohsako, S | 1 |
| Aoki, Y | 1 |
| Nishimura, N | 1 |
| Tohyama, C | 1 |
| Fujii-Kuriyama, Y | 1 |
| Yamamoto, M | 1 |
| MARCHANT, J | 5 |
| JACKSON, D | 1 |
| ROBSON, JM | 1 |
| DAO, TL | 3 |
| BOCK, FG | 1 |
| GREINER, MJ | 1 |
| SUNDERLAND, H | 1 |
| TOMATIS, L | 3 |
| SAVKUR, LD | 1 |
| BATRA, BK | 1 |
| SRIDHARAN, BN | 1 |
| SANGHVI, LD | 1 |
| Xu, M | 3 |
| Miller, MS | 13 |
| Nelson, GB | 2 |
| Moore, JE | 2 |
| McCoy, TP | 2 |
| Dai, J | 1 |
| Manderville, RA | 1 |
| Ross, JA | 2 |
| Leone-Kabler, S | 6 |
| Swank, A | 1 |
| Townsend, AJ | 2 |
| Kapoor, N | 1 |
| Pant, AB | 1 |
| Dhawan, A | 2 |
| Dwievedi, UN | 1 |
| Seth, PK | 1 |
| Parmar, D | 2 |
| Johri, A | 1 |
| Yadav, S | 1 |
| Nagata, I | 1 |
| Sutou, K | 1 |
| Misonou, Y | 1 |
| Miura, Y | 1 |
| McCormick, GM | 1 |
| Moon, RC | 2 |
| Gershwin, ME | 1 |
| Castles, JJ | 1 |
| Makishima, R | 1 |
| Arnerić, SP | 1 |
| McCormack, KM | 1 |
| Braselton, WE | 1 |
| Hook, JB | 1 |
| Chao, ST | 1 |
| Omiecinski, CJ | 1 |
| Namkung, MJ | 4 |
| Nelson, SD | 2 |
| Dvorchik, BH | 1 |
| Juchau, MR | 10 |
| Ritter, CL | 3 |
| Malejka-Giganti, D | 3 |
| Soyka, LF | 1 |
| Mizokami, K | 3 |
| Sunouchi, M | 3 |
| Inoue, K | 3 |
| Fujimori, K | 3 |
| Takanaka, A | 3 |
| Omori, Y | 3 |
| Yubisui, T | 1 |
| Faustman-Watts, E | 1 |
| Decker, RW | 2 |
| Kasuya, Y | 1 |
| Wrba, H | 1 |
| Murota, T | 1 |
| Shibuya, T | 1 |
| Shiverick, KT | 2 |
| Ortiz, E | 1 |
| Fuhrman-Lane, C | 1 |
| Crowley, P | 1 |
| Khera, KS | 2 |
| Manchester, DK | 2 |
| Parker, NB | 1 |
| Bowman, CM | 1 |
| York, RG | 2 |
| Manson, JM | 3 |
| Stemmer, K | 1 |
| Robbins, MS | 1 |
| Mannering, GJ | 3 |
| Rády, P | 1 |
| Arany, I | 1 |
| Uzvölgyi, E | 1 |
| Boján, F | 1 |
| Kertai, P | 1 |
| Mukhtar, H | 2 |
| Bickers, DR | 2 |
| Greenaway, JC | 3 |
| Fantel, AG | 2 |
| Shepard, TH | 2 |
| Boeryd, B | 1 |
| Hallgren, B | 1 |
| Chandradasa, KD | 2 |
| Gelboin, HV | 4 |
| West, D | 1 |
| Gozukara, E | 1 |
| Natori, S | 1 |
| Nagao, M | 1 |
| Sugimura, T | 1 |
| Anderson, LM | 10 |
| Priest, LJ | 1 |
| Saito, H | 1 |
| Naminohira, S | 1 |
| Sakai, T | 1 |
| Ueno, K | 1 |
| Kitagawa, H | 1 |
| Iverson, F | 1 |
| Laine, BM | 1 |
| Hitchins, VM | 1 |
| Hutton, JJ | 1 |
| Coceani, F | 1 |
| Kelsey, L | 1 |
| Ackerley, C | 1 |
| Rabinovitch, M | 1 |
| Gelboin, H | 1 |
| Wessner, LL | 2 |
| Fan, M | 1 |
| Schaeffer, DO | 1 |
| McEntee, MF | 2 |
| Ruskie, S | 1 |
| Carter, J | 1 |
| Pittinger, S | 1 |
| Kovatch, RM | 2 |
| Riggs, CW | 4 |
| D'Agostino, RB | 1 |
| Rollins, LA | 2 |
| O'Sullivan, MG | 3 |
| Patel, HR | 1 |
| Hewer, A | 1 |
| Hayes, JD | 1 |
| Phillips, DH | 1 |
| Campbell, FC | 1 |
| Gressani, KM | 3 |
| Cline, JM | 1 |
| Case, LD | 1 |
| Malkinson, AM | 2 |
| Khlood, EB | 1 |
| Miyoshi, H | 1 |
| Iwata, H | 1 |
| Kazusaka, A | 1 |
| Kon, Y | 1 |
| Hadid, AH | 1 |
| Moustafe, EK | 1 |
| Ghonim, MH | 1 |
| Fujita, S | 1 |
| Michalopoulos, G | 1 |
| Sattler, G | 1 |
| Sattler, C | 1 |
| Pitot, HC | 1 |
| Dannan, GA | 1 |
| Moore, RW | 1 |
| Aust, SD | 1 |
| Robinson, JR | 1 |
| Felton, JS | 2 |
| Levitt, RC | 1 |
| Thorgeirsson, SS | 4 |
| Nebert, DW | 13 |
| Atlas, SA | 3 |
| Vesell, ES | 2 |
| Wishart, GJ | 1 |
| Campbell, MT | 1 |
| Shum, S | 1 |
| Boobis, AR | 2 |
| Cresteil, T | 3 |
| Flinois, JP | 1 |
| Pfister, A | 1 |
| Leroux, JP | 2 |
| Stutman, O | 1 |
| Barnes, RM | 1 |
| Guenthner, TM | 2 |
| Medina, D | 1 |
| O'Bryan, SB | 1 |
| Warner, MR | 1 |
| Sinha, YN | 1 |
| VanderLaan, WP | 1 |
| McCormack, S | 1 |
| Hahn, P | 1 |
| Alvares, AP | 3 |
| Kappas, A | 2 |
| Lambert, GH | 3 |
| Kinoshita, K | 1 |
| Takahashi, G | 4 |
| Yasuhira, K | 3 |
| Embleton, MJ | 1 |
| Heidelberger, C | 2 |
| Parke, DV | 1 |
| Grilli, S | 1 |
| Rocchi, P | 1 |
| Prodi, G | 1 |
| McLaughlin, AP | 1 |
| Effron, MK | 1 |
| West, CE | 1 |
| Horton, BJ | 1 |
| Schmid, R | 1 |
| McDonagh, AF | 1 |
| Oesch, F | 2 |
| Hellström, I | 2 |
| Hellström, KE | 2 |
| Stahn, R | 1 |
| Rose, S | 1 |
| Sanborn, S | 1 |
| West, G | 1 |
| Herschman, H | 1 |
| Bürki, K | 3 |
| Liebelt, AG | 2 |
| Bresnick, E | 4 |
| Mukherjee, P | 1 |
| Das, SK | 1 |
| Jones, AB | 7 |
| Chauhan, DP | 3 |
| Park, SS | 4 |
| Guyda, HJ | 1 |
| Lu, LJ | 1 |
| Harvey, RG | 1 |
| Lee, H | 1 |
| Baxter, JR | 1 |
| Dey, A | 1 |
| Westphal, H | 1 |
| Vähäkangas, K | 1 |
| Raunio, H | 1 |
| Pasanen, M | 1 |
| Sivonen, P | 1 |
| Pelkonen, O | 1 |
| Elangbam, CS | 1 |
| Qualls, CW | 1 |
| Bauduy, M | 1 |
| Yang, HY | 1 |
| Prough, RA | 1 |
| Sherratt, AJ | 1 |
| Banet, DE | 1 |
| Linder, MW | 1 |
| Mathis, JM | 1 |
| Simpson, ER | 1 |
| Marie, S | 1 |
| Anderson, A | 1 |
| Squartini, F | 1 |
| Bistocchi, M | 1 |
| Sarnelli, R | 1 |
| Basolo, F | 1 |
| Gordon, SK | 1 |
| Golas, CL | 1 |
| Roberts, EA | 1 |
| Okey, AB | 1 |
| Khan, WA | 1 |
| Das, M | 1 |
| Stick, S | 1 |
| Javed, S | 1 |
| Walker, BE | 1 |
| Conney, AH | 3 |
| Kimura, S | 1 |
| Donovan, JC | 1 |
| Faustman-Watts, EM | 2 |
| Giachelli, CM | 2 |
| Swanson, C | 1 |
| Salhab, AS | 1 |
| James, MO | 1 |
| George, JD | 1 |
| Beaune, P | 1 |
| Celier, C | 1 |
| Guengerich, FP | 1 |
| Polovina, MR | 1 |
| Porubek, DJ | 1 |
| Lum, PY | 1 |
| Walker, S | 1 |
| Ioannides, C | 1 |
| Ohshima, M | 1 |
| Tuteja, N | 1 |
| Gonzalez, FJ | 1 |
| Bark, DH | 1 |
| Shewey, LM | 1 |
| Gielen, JE | 2 |
| Goujon, FM | 2 |
| Huberman, E | 1 |
| Kuroki, T | 1 |
| Marquardt, H | 1 |
| Selkirk, JK | 1 |
| Grover, PL | 1 |
| Sims, P | 1 |
| Page, JG | 1 |
| Stárka, L | 1 |
| Holmes, EC | 1 |
| Morton, DL | 1 |
| Rózewicki, S | 1 |
| Pohnke, B | 1 |
| Feuer, G | 2 |
| Liscio, A | 2 |
| Anisimov, VN | 1 |
| Young, S | 1 |
| Handa, H | 1 |
| Handa, J | 1 |
| Koyama, M | 1 |
| Baldwin, RW | 2 |
| Glaves, D | 2 |
| Pimm, MV | 1 |
| Vose, BM | 2 |
| Bogdan, D | 1 |
| Jacobson, M | 1 |
| Levin, W | 1 |
| Poppers, PJ | 1 |
| Wood, AW | 1 |
| Shendrikova, IA | 1 |
| Aleksandrov, VA | 1 |
| Parmiani, G | 1 |
| Della Porta, G | 1 |
| Shats, VI | 1 |
| Southam, CM | 1 |
| Welch, RM | 2 |
| Cavallito, J | 1 |
| Loh, A | 1 |
| Nomura, T | 1 |
| Okamoto, E | 1 |
| Sato, T | 1 |
| Moroi, K | 1 |
| Malaveille, C | 2 |
| Duperray, B | 2 |
| Pacheco, H | 2 |
| Inch, WR | 1 |
| McCredie, JA | 1 |
| Knispel, RR | 1 |
| Thompson, RT | 1 |
| Pintar, MM | 1 |
| Smith, MS | 1 |
| Hartman, S | 1 |
| Michelson, AM | 1 |
| Buckingham, ME | 1 |
| Buttle, GA | 1 |
| Frayn, A | 1 |
| Gommi, B | 1 |
| Younger, LR | 1 |
| Salomon, R | 1 |
| Wilson, RW | 1 |
| Peacock, AC | 1 |
| Andrianova, MM | 2 |
| Seibert, RA | 1 |
| Turusov, V | 1 |
| Guibbert, D | 1 |
| Dipaolo, JA | 1 |
| Donovan, PJ | 1 |
| Nelson, RL | 1 |
| Mano, S | 1 |
| Brawn, RJ | 1 |
| Klinger, W | 1 |
| Elger, J | 1 |
| Franke, H | 1 |
| Reinicke, C | 1 |
| Traeger, A | 1 |
| Volkmann, H | 1 |
| Wahrenberg, I | 1 |
| Ankermann, H | 1 |
| Bausserman, LL | 1 |
| Bates, RR | 1 |
| Stevenson, JG | 1 |
| Taki, I | 1 |
| Griciute, L | 1 |
| Rudali, G | 1 |
| Rigdon, RH | 1 |
| Rennels, EG | 1 |
| Haran-Ghera, N | 1 |
| Rees, ED | 1 |
| Shuck, AE | 1 |
| Ackermann, H | 1 |
10 reviews available for 3-methylcholanthrene and Pregnancy
| Article | Year |
|---|---|
Differential sensitivity to lung tumorigenesis following transplacental exposure of mice to polycyclic hydrocarbons, heterocyclic amines, and lung tumor promoters.
Topics: Adenocarcinoma; Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Butylated Hydroxytoluene; Carcinoge | 2000 |
Interaction of chemical carcinogens and drug-metabolizing enzymes in primary cultures of hepatic cells from the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cells, Cultured; Collagen; Cytochrome P-450 Enz | 1976 |
Induction of the drug-metabolizing enzymes.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Barbiturates; Benzopyrene Hydroxylase; Benzopyrene | 1975 |
The enzymatic formation of bilirubin.
Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Human | 1975 |
Early pathologic changes in experimental and human breast cancer: facts and comments.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast; Breast Neoplasms; Cell Transformation, Neoplastic | 1986 |
Induction of microsomal cytochrome P-450 enzymes: the first Bernard B. Brodie lecture at Pennsylvania State University.
Topics: Amino Acid Sequence; Amino Acids; Animals; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzym | 1986 |
[Antiandrogens].
Topics: Acetates; Adrenal Cortex Hormones; Androgen Antagonists; Animals; Antimetabolites; Castration; Chick | 1970 |
[Brain tumors].
Topics: Animals; Astrocytoma; Benz(a)Anthracenes; Brain Neoplasms; Diethylstilbestrol; Ependymoma; Female; G | 1972 |
[Effect of antilymphocyte serum on tumor growth (literature survey)].
Topics: Animals; Antilymphocyte Serum; Benz(a)Anthracenes; Carcinoma; Carcinoma 256, Walker; Carcinoma, Ehrl | 1972 |
Areas of relationship between immunology and clinical oncology.
Topics: Adenocarcinoma; Allergy and Immunology; Animals; Antigens, Neoplasm; Antineoplastic Agents; Carcinoe | 1974 |
164 other studies available for 3-methylcholanthrene and Pregnancy
| Article | Year |
|---|---|
Parental exposure to 3-methylcholanthrene before gestation adversely affected the endocrine system and spermatogenesis in male F1 offspring.
Topics: Adult; Animals; Endocrine System; Female; Humans; Male; Methylcholanthrene; Mice; Pregnancy; Prenata | 2022 |
Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Dexametha | 2013 |
3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Bone and Bones; Calcification, Physiologic; | 2002 |
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.
Topics: Animals; Base Sequence; Dioxins; DNA Primers; Female; Humans; Kidney; Methylcholanthrene; Mice; Mice | 2003 |
Influence of pregnancy and lactation on the incidence of mammary carcinoma induced with methylcholanthrene in female mice of the "IF" strain.
Topics: Animals; Breast Feeding; Breast Neoplasms; Female; Humans; Incidence; Lactation; Methylcholanthrene; | 1955 |
The effect of methyl cholanthrene on growth and pregnancy.
Topics: Benz(a)Anthracenes; Biological Phenomena; Female; Humans; Kidney; Methylcholanthrene; Physiological | 1958 |
Mammary carcinogenesis by 3-methylcholanthrene. II. Inhibitory effect of pregnancy and lactation on tumor induction.
Topics: Animals; Breast Feeding; Breast Neoplasms; Carcinogenesis; Female; Humans; Lactation; Mammary Neopla | 1960 |
Mammary carcinogenesis by 3-methylcholanthrene. I. Hormonal aspects in tumor induction and growth.
Topics: Carcinoma; Cell Transformation, Neoplastic; Female; Gonadal Steroid Hormones; Humans; Methylcholanth | 1959 |
THE INFLUENCE OF PSEUDOPREGNANCY, PREGNANCY AND LACTATION ON THE INDUCTION OF BREAST TUMOURS IN AGENT-FREE MICE BY METHYLCHOLANTHRENE (MC).
Topics: Animals; Breast Feeding; Breast Neoplasms; Female; Genetics; Humans; Lactation; Mammary Neoplasms, A | 1964 |
INCREASED INCIDENCE OF TUMORS IN F1 AND F2 GENERATIONS FROM PREGNANT MICE INJECTED WITH A POLYCYCLIC HYDROCARBON.
Topics: Animals; Carcinoma; Cystadenoma; Female; Granulosa Cell Tumor; Humans; Incidence; Mammary Neoplasms, | 1965 |
Chemical induction of breast tumours in mice of the C57B1 strain. The influence of pseudopregnancy, pregnancy and lactation on induction by methylcholanthrene.
Topics: Animals; Breast Feeding; Breast Neoplasms; Female; Humans; Lactation; Mammary Neoplasms, Experimenta | 1961 |
Effect of 20-methylcholanthrene on mouse embryos. III. Strain C3H(Jax)--by caesarean section.
Topics: Animals; Cesarean Section; Embryo, Mammalian; Embryo, Nonmammalian; Female; Methylcholanthrene; Mice | 1962 |
Determination of murine fetal Cyp1a1 and 1b1 expression by real-time fluorescence reverse transcription-polymerase chain reaction.
Topics: Algorithms; Animals; Aryl Hydrocarbon Hydroxylases; Computer Systems; Cytochrome P-450 CYP1A1; Cytoc | 2004 |
Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA Adduct | 2005 |
Expression of glutathione S-transferases in fetal lung and liver tissue from parental strains and F1 crosses between C57BL/6 and BALB/c F1 mice following in utero exposure to 3-methylcholanthrene.
Topics: Animals; Carcinogens; Crosses, Genetic; Female; Glutathione Transferase; Isoenzymes; Liver; Lung; Ma | 2006 |
Cytochrome P450 1A isoenzymes in brain cells: Expression and inducibility in cultured rat brain neuronal and glial cells.
Topics: Animals; Brain; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Enzyme Induction; | 2006 |
Responsiveness of cerebral and hepatic cytochrome P450s in rat offspring prenatally exposed to lindane.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction | 2008 |
Effect of estrogen on the uterine cancer induced by 20-methylcholanthrene (from the autoradiographic observation).
Topics: Animals; Autoradiography; Carcinoma; Castration; Cell Division; Estradiol; Estrus; Female; In Vitro | 1966 |
Hormones influencing postpartum growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Brenner Tumor; Cattle; Drug Synergism; Female; Mammary | 1967 |
The effects of different social conditions on breast cancer induction in three genetic types of mice by dibenz[a,h]anthracene and a comparison with breast carcinogenesis by 3-methylcholanthrene.
Topics: Animals; Behavior, Animal; Benz(a)Anthracenes; Estrogens; Female; Genetics; Lactation; Liver Neoplas | 1967 |
Accelerated plasmacytoma formation in mice treated with alpha-fetoprotein.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Albumins; alpha-Fetoproteins; Animals; Female; Immunoglobulins; Ma | 1980 |
Altered metabolism of progesterone by hepatic microsomes from rats following dietary exposure to polybrominated biphenyls.
Topics: Animals; Biphenyl Compounds; Endocrine Glands; Female; Hydroxyprogesterones; In Vitro Techniques; Ma | 1980 |
Catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits.
Topics: Animals; Aroclors; Benzopyrenes; Catechols; Estrogens; Estrogens, Catechol; Female; Fetus; Hemin; Hu | 1981 |
Mixed function oxidase in the mammary gland and liver microsomes of lactating rats. Effects of 3-methylcholanthrene and beta-naphthoflavone.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Fe | 1982 |
Hepatic drug metabolizing enzyme activity and tumorigenesis in mice following perinatal exposure to benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Female; Gestational Age; Leukemia L1210; Liver; | 1980 |
The heterogeneity of arylhydrocarbon hydroxylase in fetal liver microsomes of rats.
Topics: 4-Chloromercuribenzenesulfonate; Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome b G | 1983 |
Hematin-mediated increases of benzo(a)pyrene mono-oxygenation in maternal, fetal and placental tissues of inducible and non-inducible mouse strains.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Carci | 1983 |
Modifications of carcinogen metabolism in hepatic microsomes of suckling young by 3-methylcholanthrene or beta-naphthoflavone administered to lactating rats.
Topics: 2-Acetylaminofluorene; Animal Population Groups; Animals; Animals, Suckling; Benzo(a)pyrene; Benzofl | 1983 |
Comparison of hepatic drug-metabolizing enzymes induced by 3-methylcholanthrene and phenobarbital between pre- and postnatal rats.
Topics: Aminopyrine; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System | 1984 |
Experimental cancer prophylaxis.
Topics: Adenoma; Animals; Diterpenes; Ethylnitrosourea; Female; Fetus; Leukemia, Experimental; Lung Neoplasm | 1983 |
Modifying effects of the enzyme inducers, phenobarbital and 3-methylcholanthrene, on dominant lethal events induced by 7, 12-dimethylbenz[a]anthracene in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Genes, Dominant; Genes, Letha | 1983 |
Effects of beta-naphthoflavone and 3-methylcholanthrene administered to pregnant rats on steroid metabolism in the isolated basal zone of the placenta.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Chromatography, T | 1984 |
Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Foot | 1984 |
Maternal smoking increases xenobiotic metabolism in placenta but not umbilical vein endothelium.
Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Dose-Response Re | 1984 |
Neonatal toxicity in mice associated with the Ahb allele following transplacental exposure to 3-methylcholanthrene.
Topics: Administration, Oral; Alleles; Animals; Aryl Hydrocarbon Hydroxylases; Body Weight; Female; Fetus; M | 1984 |
Lung tumorigenesis and hyperplasia in offspring associated with the Ahd allele following in utero exposure to 3-methylcholanthrene.
Topics: Alleles; Animals; Female; Fetus; Genotype; Hyperplasia; Lung; Lung Neoplasms; Male; Maternal-Fetal E | 1984 |
Effects of the interferon inducing agents tilorone and polyriboinosinic acid . polyribocytidylic acid (poly IC) on the hepatic monooxygenase systems of pregnant and fetal rats.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Dose-Re | 1984 |
3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Female; Fetus; Hemepr | 1982 |
Transplacental effects of carcinogens and non-carcinogens on activities of pyruvate kinase and lactate dehydrogenase as well as isozymic pattern of LDH in mouse lung.
Topics: Animals; Carbamates; Carcinogens; Dimethylnitrosamine; Female; Isoenzymes; L-Lactate Dehydrogenase; | 1982 |
Evidence that coal tar is a mixed inducer of microsomal drug-metabolizing enzymes.
Topics: Animals; Animals, Newborn; Aroclors; Chlorodiphenyl (54% Chlorine); Coal Tar; Cytochrome P-450 Enzym | 1982 |
The in vitro teratogenicity of cyclophosphamide in rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aroclors; Brain; Chlorodiphenyl (54% Chlorine); Culture Techni | 1982 |
The influence of the lipid composition of the feed given to mice on the immunocompetence and tumour resistance of the progeny.
Topics: Animals; Dietary Fats; Female; Glycerol; Immunocompetence; Lactation; Male; Methylcholanthrene; Mice | 1980 |
Resistance to growth of 3-methylcholanthrene(3-MC)-induced primary tumours in BALB/c mice following pregnancy or immunization against foetal tissues.
Topics: Animals; Antigens; Embryo, Mammalian; Female; Immunization; Methylcholanthrene; Mice; Mice, Inbred B | 1980 |
(-)Maackiain acetate specifically inhibits different forms of aryl hydrocarbon hydroxylase in rat and man.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrans; Female; Humans; Kidney; Kinetics; Lung; Male; M | 1981 |
Reduction in the transplacental carcinogenic effect of methylcholanthrene in mice by prior treatment with beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens; Female; Fetus; Flavonoids; Liver; Lung Neo | 1980 |
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; M | 1981 |
Effects of pretreatment with SKF-525A, N-Methyl-2-thioimidazole, sodium phenobarbital, or methyl cholanthrene on ethylenethiourea-induced teratogenicity in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethylenethiourea; Female; Imid | 1981 |
Genetic regulation of aryl hydrocarbon hydroxylase activity in cultures of mouse fetal liver cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; DNA; Enzyme Induction; Female; Liver; Methy | 1981 |
Cytochrome P450 during ontogenic development: occurrence in the ductus arteriosus and other tissues.
Topics: Aging; Animals; Animals, Newborn; Aorta; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethas | 1994 |
Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene.
Topics: Animals; Base Sequence; Body Weight; Carcinogens; Crosses, Genetic; Cytochrome P-450 CYP1A1; Cytochr | 1996 |
Fetal mouse susceptibility to transplacental carcinogenesis: differential influence of Ah receptor phenotype on effects of 3-methylcholanthrene, 12-dimethylbenz[a]anthracene, and benzo[a]pyrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Crosses, Genetic; Female; Li | 1995 |
Ki-ras mutations are an early event and correlate with tumor stage in transplacentally-induced murine lung tumors.
Topics: Animals; Blotting, Northern; Carcinogens; Cytochrome P-450 CYP1A1; Female; Genes, ras; Lung Neoplasm | 1997 |
Role of tumor suppressor genes in transplacental lung carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p16; Exons; Female; Genes, p | 1998 |
Age-dependent change of metabolic capacity and genotoxic injury in rat intestine.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; DNA Adducts; Enzyme Induction; Female; Glucuronosylt | 1998 |
Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene.
Topics: Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p16; DNA Primers; Female; Genes, ras; Liver | 1998 |
Strain-dependent lung tumor formation in mice transplacentally exposed to 3-methylcholanthrene and post-natally exposed to butylated hydroxytoluene.
Topics: Animals; Base Sequence; Butylated Hydroxytoluene; DNA Primers; Female; Genes, Tumor Suppressor; Lung | 1999 |
Effects of concurrent exposure to 3-methylcholanthrene and vitamin A on fetal development in rats.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Femal | 1999 |
Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs).
Topics: Animals; Biotransformation; Biphenyl Compounds; DNA; Female; Lactation; Male; Methylcholanthrene; Mi | 1978 |
Relationship between "aromatic hydrocarbon responsiveness" and the survival times in mice treated with various drugs and environmental compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Benz | 1975 |
Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes.
Topics: Adolescent; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Culture Media; Dicuma | 1976 |
Demonstration of two functionally heterogenous groups within the activities of UDP-glucuronosyltransferase towards a series of 4-alkyl-substituted phenols.
Topics: Animals; Chemical Phenomena; Chemistry; Colorimetry; Dexamethasone; Female; Glucuronosyltransferase; | 1979 |
Developmental pharmacology and the Ah locus: regulatory and temporal genes affecting teratogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Alleles; Animals; Animals, Newborn; A | 1979 |
Effect of microsomal preparations and induction on cytochrome P-450-dependent monooxygenases in fetal and neonatal rat liver.
Topics: Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fetus; Glucose- | 1979 |
Chemical carcinogenesis in nude mice: comparison between nude mice from homozygous matings and heterozygous matings and effect of age and carcinogen dose.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Female; Heterozygote; Homozygote; Immunosupp | 1979 |
Immunological resistance to growth of tumours in syngeneic multiparous mice.
Topics: Animals; Female; Graft Rejection; Immunization, Passive; Male; Methylcholanthrene; Mice; Mice, Inbre | 1979 |
Induction of hepatic mono-oxygenase systems in fetal and neonatal rats with phenobarbital, polycylic hydrocarbons and other xenobiotics.
Topics: Aminopyrine N-Demethylase; Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hyd | 1977 |
Induction of hepatic mono-oxygenase systems of pregnant rats with phenobarbital and 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Binding Sites; C | 1977 |
Mammary tumorigenesis in chemical carcinogen-treated mice. VII. Prolactin and progesterone levels in BALB/c mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Glands; Adrenalectomy; Age Factors; Animals; Castration; C | 1977 |
The inducing properties of polychlorinated biphenyls on hepatic monooxygenases.
Topics: Animals; Aroclors; Cytochromes; Dactinomycin; Enzyme Induction; Female; In Vitro Techniques; Liver; | 1977 |
Genetically mediated induction of drug-metabolizing enzymes associated with congenital defects in the mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Ary | 1977 |
Lung tumors in mice suckled by 3-methylcholanthrene-treated mothers.
Topics: Adenocarcinoma; Adenoma; Animals; Animals, Suckling; Female; Lung Neoplasms; Male; Methylcholanthren | 1979 |
Induction of aryl hydrocarbon hydroxylase by polychlorinated biphenyls in the foeto-placental unit and neonatal livers during lactation.
Topics: Animals; Animals, Newborn; Benzopyrenes; Enzyme Induction; Female; Lactation; Methylcholanthrene; Mi | 1975 |
Neoantigens on chemically transformed cloned C3H mouse embryo cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Neoplasm; Cell Transformation, Neoplastic; Cell | 1975 |
Non-enzymatic and microsome-dependent binding of poly-cyclic hydrocarbons to DNA and polynucleotides.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrenes; Binding Sites; DNA; Fem | 1975 |
Genetic aspects of toxicity during development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Acetaminophen; Alleles; Animals; Aryl | 1976 |
The effect of pregnancy on the growth of primary methylcholanthrene sarcoma isografts.
Topics: Animals; Female; Graft Rejection; Immunization; Liver; Methylcholanthrene; Mice; Mice, Inbred C3H; M | 1977 |
Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.
Topics: Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Electropho | 1977 |
Glutathione in the developing mouse liver--I. Developmental curve and depletion after acetaminophen treatment.
Topics: Acetaminophen; Aging; Animals; Female; Fetus; Glutathione; Liver; Methylcholanthrene; Mice; Mice, In | 1976 |
Transfer of polycyclic hydrocarbons from diet to milk in rats, rabbits and sheep.
Topics: Animals; Benzopyrenes; Feces; Female; Lactation; Methylcholanthrene; Milk; Pregnancy; Rabbits; Rats; | 1976 |
Chromatographic analyses of 3-methylcholanthrene metabolism in adult and fetal mice and the occurrence of conjugating enzymes in the fetus.
Topics: Animals; Bile; Brain; Chromatography, Gel; Female; Fetus; Gestational Age; Glucuronidase; Hydrolysis | 1975 |
Transplacental control of epoxide hydratase and its relationship to the control of microsomal monooxygenase.
Topics: Animals; Benzopyrenes; Epoxide Hydrolases; Female; Hydro-Lyases; Liver; Maternal-Fetal Exchange; Met | 1975 |
Cytotoxic effect of lymphocytes from pregnant mice on cultivated tumor cells. I. Specificity, nature of effector cells and blocking by serum.
Topics: Animals; Antilymphocyte Serum; Cell Fractionation; Cell Line; Cell Transformation, Neoplastic; Clone | 1975 |
Cytotoxic effect of lymphocytes from pregnant mice on cultivated tumor cells. II. Blocking and unblocking of cytotoxicity.
Topics: Animals; Antigens, Neoplasm; Antilymphocyte Serum; Cell Line; Cell Transformation, Neoplastic; Cytot | 1975 |
Effects of nerve growth factor administration of N-ethyl-N-nitrosourea carcinogenesis.
Topics: Animals; Brain Neoplasms; Cells, Cultured; Drug Interactions; Ethylnitrosourea; Female; Male; Methyl | 1975 |
Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Crosses, Genetic; Enzyme Induction; Female; Fetus; Gene Freq | 1975 |
Differential control of rat microsomal "aryl hydrocarbon" monooxygenase and epoxide hydratase.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Epoxide Hydrolases; Female; Fetus; Hydro-Lyases; Live | 1976 |
Partial characterization, progressive development and correlations of some neoplastic characters in 20-methylcholanthrene-induced transformed murine embryonal fibroblasts.
Topics: Animals; Blood Physiological Phenomena; Cell Count; Cell Division; Cell Transformation, Neoplastic; | 1992 |
Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Crosses, Genetic; Cytochrome P-450 Enzyme System; Disease Su | 1990 |
Induction of cytochrome P-450IA1 in fetal rat liver by a single dose of 3-methylcholanthrene.
Topics: Animals; Blotting, Western; Cloning, Molecular; Cytochrome P-450 Enzyme System; Enzyme Induction; Fe | 1991 |
Long-term (imprinting) effects of transplacental treatment of mice with 3-methylcholanthrene or beta-naphthoflavone on hepatic metabolism of 3-methylcholanthrene.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Female; Gene Expression | 1991 |
Metabolic effects of growth factors and polycyclic aromatic hydrocarbons on cultured human placental cells of early and late gestation.
Topics: Aminoisobutyric Acids; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; ErbB Receptors; Female; | 1991 |
The formation of 3-methylcholanthrene-initiated lung tumors correlates with induction of cytochrome P450IA1 by the carcinogen in fetal but not adult mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenicity Tests; Cytochrome P-450 Enzyme System; Enzym | 1990 |
Age-, tissue-, and Ah genotype-dependent differences in the binding of 3-methylcholanthrene and its metabolite(s) to mouse DNA.
Topics: Animals; Autoradiography; Biotransformation; DNA; Female; Fetus; Genotype; Methylcholanthrene; Mice; | 1990 |
Differential induction of fetal mouse liver and lung cytochromes P-450 by beta-naphthoflavone and 3-methylcholanthrene.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme | 1989 |
Cell-specific induction of mouse Cyp1a1 mRNA during development.
Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Decidua; Embryonic and Fetal Developmen | 1989 |
Comparison of the formation of benzo[a]pyrene diolepoxide-DNA adducts in vitro by rat and human microsomes: evidence for the involvement of P-450IA1 and P-450IA2.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antibodies, Monoclonal; Aryl Hydrocarbo | 1989 |
Modification of transplacental tumorigenesis by 3-methylcholanthrene in mice by genotype at the Ah locus and pretreatment with beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Female; Fetal Diseases; Fetus; Flavonoids; Genotype; Li | 1989 |
Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Arvicolinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Methylcholant | 1989 |
Immunodetection, immunoinhibition, immunoquantitation and biochemical analyses of cytochrome P-450IA1 in tissues of the ratoffceptus during the progression of organogenesis.
Topics: 2-Acetylaminofluorene; Amnion; Animals; Benzo(a)pyrene; Benzoflavones; Chorion; Cytochrome P-450 Enz | 1989 |
Modulation of the polycyclic aromatic hydrocarbon-dependent induction of cytochrome P450IA1 by glucocorticoids.
Topics: Adrenalectomy; Animals; Blotting, Western; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme I | 1989 |
Transplacental induction of cytochromes P-450IA1 and P-450IA2 by polycyclic aromatic carcinogens: TCDD-binding protein level as the rate-limiting step.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Induction; Female; Gene Expression Regulati | 1988 |
Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.
Topics: Benzo(a)pyrene; Centrifugation, Density Gradient; Charcoal; Cytosol; Dioxins; Female; Humans; In Vit | 1987 |
Induction of epidermal NAD(P)H:quinone reductase by chemical carcinogens: a possible mechanism for the detoxification.
Topics: Animals; Animals, Newborn; Aroclors; Carcinogens; Chlorodiphenyl (54% Chlorine); Coal Tar; Cytosol; | 1987 |
Vaginal tumors in mice from methylcholanthrene and prenatal exposure to diethylstilbestrol.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Diethylstilbestrol; Female; Fetus; Methylcholanth | 1988 |
Expression of the mouse P(1)450 gene during differentiation without foreign chemical stimulation.
Topics: Animals; Cell Differentiation; Cell Line; Cytochrome P-450 Enzyme System; Embryo, Mammalian; Embryon | 1987 |
Carbon monoxide inhibits monooxygenation by the conceptus and embryotoxic effects of proteratogens in vitro.
Topics: 2-Acetylaminofluorene; Animals; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P- | 1986 |
Differential induction of ethoxyresorufin-O-deethylase in tissues of the rat placenta.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Ear, Inner; Enzyme Induction; | 1986 |
Strain-dependent differences in the metabolism of 3-methylcholanthrene by maternal, placental, and fetal tissues of C57BL/6J and DBA/2J mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Enzyme Induction; Female | 1986 |
Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enz | 1986 |
Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P | 1985 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-4 | 1985 |
Foetal and neonatal development of cytochrome P-450 and cytochrome P-448 catalysed mixed function oxidases in the rat: induction by 3-methylcholanthrene.
Topics: Age Factors; Animals; Animals, Newborn; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome | 1985 |
Effects of 3-methylcholanthrene and phenobarbital on the capacity of embryos to bioactivate teratogens during organogenesis.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Biotransformation; Cyclophosphamide; Em | 1985 |
Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene: positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism.
Topics: Animals; Biotransformation; Female; Fetus; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mate | 1985 |
Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromosome Mapping; Cytochrome P-450 CYP1A1; Cytochrome P-45 | 1985 |
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Ch | 1985 |
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Crosses, Genetic; Cytochromes; Enzyme Induction; Fema | 1972 |
Transformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons.
Topics: Animals; Benz(a)Anthracenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clone Ce | 1972 |
Genetic control of dicumarol levels in man.
Topics: Adult; Antipyrine; Caffeine; Centrifugation; Coffee; Dicumarol; Female; Genetics, Medical; Humans; M | 1968 |
Detection of antibodies against the mammary tumor virus with the antiglobulin consumption test.
Topics: Absorption; Adenocarcinoma; Animals; Antibodies; Coombs Test; Erythrocytes; Ethiodized Oil; Female; | 1969 |
Methylcholanthrene-induced hormonally active ovarian tumors in rabbits after two years of experimenting.
Topics: Animals; Estrus; Female; Fertility; Methylcholanthrene; Ovarian Neoplasms; Pregnancy; Rabbits; Theco | 1969 |
Effect of drugs on hepatic drug metabolism in the fetus and newborn.
Topics: Animals; Animals, Newborn; Coumarins; Female; Fetus; Glucose-6-Phosphatase; Liver; Maternal-Fetal Ex | 1970 |
[Blastomogenesis in rats with persistent estrus].
Topics: Adenocarcinoma; Adenofibroma; Adenoma; Adrenal Gland Neoplasms; Animals; Carcinoma, Squamous Cell; E | 1971 |
Progestin secretion in 3-methylcholanthrene-treated rats.
Topics: Adrenal Glands; Adrenalectomy; Animals; Castration; Cattle; Estrus; Female; Hydatidiform Mole, Invas | 1972 |
Tumour specific and embryonic antigen expression of chemically induced rat tumours.
Topics: Animals; Antigens; Antigens, Neoplasm; Carcinoma, Hepatocellular; Cell Membrane; Cytotoxicity Tests, | 1972 |
Embryonic antigen expression in chemically induced rat hepatomas and sarcomas.
Topics: Animals; Antigen-Antibody Reactions; Antigens, Neoplasm; Carcinoembryonic Antigen; Carcinoma, Hepato | 1972 |
Charateristics of induced benzpyrene hydrylase activity in the rat foeto-placental unit.
Topics: Animals; Benzopyrenes; Enzyme Induction; Female; Liver; Maternal-Fetal Exchange; Methylcholanthrene; | 1970 |
Human placental hydroxylation of 3,4-benzpyrene during early gestation and at term.
Topics: 17-Ketosteroids; Androstanes; Animals; Benzopyrenes; Cholesterol; Dehydroepiandrosterone; Depression | 1971 |
Comparison of the O-dealkylation of 7-ethoxycoumarin and the hydroxylation of benzo(a)pyrene in human placenta. Effect of cigarette smoking.
Topics: Animals; Benzopyrenes; Coumarins; Dealkylation; Enzyme Induction; Ethyl Ethers; Female; Humans; Hydr | 1974 |
Comparative penetration of polycyclic hydrocarbons through the rat placenta into the fetus.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Female; Fetus; Liver; Maternal-Fetal Exchange; Methylchol | 1974 |
Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse.
Topics: Animals; Animals, Newborn; Crosses, Genetic; Enzyme Induction; Female; Fetus; Genes, Dominant; Genet | 1972 |
Effects of antitumour immunity on pregnancy in the mouse.
Topics: Animals; Antigens; Antigens, Neoplasm; Embryo, Mammalian; Female; Fetal Death; Fetal Diseases; Histo | 1973 |
Effect of exposure to cigarette smoke on the metabolism of benzo(a)pyrene and acetophenetidin by lung and intestine of rats.
Topics: Animals; Benzopyrenes; Carbon Isotopes; Dactinomycin; Enzyme Induction; Female; Hydrocarbons; Intest | 1972 |
Induction of tumors by direct injection of carcinogen into mouse fetus.
Topics: Animals; Carcinogens; Female; Fetus; Injections; Lung Neoplasms; Methylcholanthrene; Mice; Neoplasms | 1972 |
Macroautoradiographic and radiometric studies on the distribution of 3-methylcholanthrene in mice and their fetuses.
Topics: Animals; Animals, Newborn; Autoradiography; Bile; Carbon Isotopes; Female; Fetus; Injections, Intrap | 1973 |
Species differences in induction and inhibition of liver isocarboxazid hydrolase.
Topics: Aging; Animals; Animals, Newborn; Enzyme Induction; Female; Guinea Pigs; Hydrolases; In Vitro Techni | 1973 |
[Distribution of (14C)MCA and its derivatives in mouse tissues (author's transl)].
Topics: Animals; Animals, Newborn; Carbon Radioisotopes; Cell Nucleus; Chromatography, DEAE-Cellulose; Color | 1973 |
Expression of aryl hydrocarbon hydroxylase induction in mouse tissues in vivo and in organ culture.
Topics: Animals; Enzyme Induction; Female; Fetus; Flavonoids; Gestational Age; Kinetics; Liver; Lung; Male; | 1973 |
[Metabolsim of 3-methylcholanthrene and carcinogenesis].
Topics: Animals; Autoradiography; Female; Kidney; Liver; Lung; Maternal-Fetal Exchange; Methylcholanthrene; | 1973 |
Water content and proton spin relaxation time for neoplastic and non-neoplastic tissues from mice and humans.
Topics: Adenocarcinoma; Animals; Body Water; Female; Fibrosarcoma; Hepatectomy; Humans; Kidney; Liver; Liver | 1974 |
Proceedings: Sarcoma cells as a blastocyst analogue in the mouse uterus.
Topics: Animals; Blastocyst; Decidua; Embryo Implantation; Female; Methylcholanthrene; Mice; Neoplasm Transp | 1974 |
Effects of superoxide radicals on myoblast growth and differentiation.
Topics: Animals; Anthracenes; Benzopyrenes; Cattle; Cell Differentiation; Cell Division; Cell Fusion; Cells, | 1974 |
Effect of previous injection of homologous embryonic tissue on the growth of certain transplantable mouse tumours.
Topics: Animals; Female; Fetus; Inbreeding; Iron-Dextran Complex; Liver; Liver Transplantation; Methylcholan | 1967 |
The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.
Topics: Adrenalectomy; Age Factors; Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Line; Cell Membrane; Chi | 1969 |
Effect of enzyme induction on the metabolism of benzo(a)pyrene and 3'-methyl-4-monomethylaminoazobenzene in the pregnant and fetal rat.
Topics: Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Carcinogens; Cyanides; Cytochromes; Dealkylat | 1972 |
Effects of polycyclic hydrocarbons on ribonucleic acid synthesis in rat liver nuclei and hamster embryo cells.
Topics: Acrylamides; Adrenalectomy; Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Nucleus; Cricetinae; Cyt | 1972 |
[Transplacental action of 3-methylcholanthrene and benz(a)pyrene on 4 generations of mice].
Topics: Animals; Benzopyrenes; Female; Maternal-Fetal Exchange; Methylcholanthrene; Mice; Neoplasms, Experim | 1971 |
Effects of 3-methylcholanthrene and some related compounds upon the benzpyrene hydroxylase activity in fetal rat liver explants.
Topics: Animals; Benzopyrenes; Enzyme Activation; Enzyme Induction; Female; Fetus; Gestational Age; Kinetics | 1971 |
[Effect of thymectomy on transplacental sensitization by 3-methylcholanthrene and benz( )pyrene].
Topics: Animals; Benzopyrenes; Female; Male; Maternal-Fetal Exchange; Methylcholanthrene; Mice; Neoplasms, E | 1971 |
Transplacental carcinogenic effect of 3-methylcholanthrene in mice and its quantitation in fetal tissues.
Topics: Animals; Animals, Newborn; Carbon Isotopes; Chromatography, Thin Layer; Female; Fetus; Liver; Lung; | 1971 |
Inhibition of tumor induction in chemical carcinogenesis in the mammary gland.
Topics: Adenofibroma; Adenosine; Animals; Carbon Isotopes; Carcinogens; Castration; Cesarean Section; DNA; E | 1971 |
Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Survival; Cell Transformation, Neoplastic; Cells, Cu | 1971 |
[Estrogen dependency of the uterus and murine uterine carcinoma--incorporation of 3H-estradiol-17-beta].
Topics: Adenocarcinoma; Adrenal Glands; Animals; Carcinoma, Squamous Cell; Estradiol; Estrogens; Estrone; Es | 1969 |
Possible association of embryonal antigen(s) with several primary 3-methylcholanthrene-induced murine sarcomas.
Topics: Animals; Antigens; Cell Transformation, Neoplastic; Cross Reactions; Embryo, Mammalian; Female; Fibr | 1970 |
[Studies on the mechanism of enzyme induction. XV. Induction pattern and submicroscopic changes in the liver following application of phenylbutazone in rats of different ages].
Topics: Age Factors; Aminopyrine; Animals; Animals, Newborn; Ascorbic Acid; Cholestasis; Endoplasmic Reticul | 1970 |
Effect of 17-beta-estradiol and testosterone on aryl hydrocarbon hydroxylase activity in mouse tissues in vivo and in cell culture.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Castration; DNA; Embryo, Mammalian; Estradiol; Estrus; Fe | 1970 |
Microsomal N-demethylase activity in developing rat liver after administration of 3-methylcholanthrene.
Topics: Age Factors; Animals; Carbon Isotopes; Enzyme Induction; Female; Fetus; Liver; Male; Maternal-Fetal | 1968 |
[Experimental study of endocrine changes and the origin of uterine cancer].
Topics: Animals; Carcinoma, Squamous Cell; Castration; Estrogens; Estrus; Female; Methylcholanthrene; Mice; | 1968 |
[Alkaline phosphatase activity in lung tissues of XVII-G and C57BL mice].
Topics: Age Factors; Alkaline Phosphatase; Animals; Benz(a)Anthracenes; Bile Ducts; Female; Fluorenes; Histo | 1969 |
Origin of delayed development of drug metabolism in the newborn rat.
Topics: Animals; Animals, Newborn; Coumarins; Female; Methylcholanthrene; Phenobarbital; Pregnancy; Pregnanc | 1969 |
Effect of feeding benzpyrene on reproduction in the rat.
Topics: Animals; Benzopyrenes; Female; Fetus; Fluorescence; In Vitro Techniques; Methylcholanthrene; Milk; P | 1964 |
Autonomy and dependence of preneoplastic mammary nodules in mice.
Topics: Adrenalectomy; Animals; Carcinogens; Castration; Estrus; Female; Mammary Glands, Animal; Mammary Neo | 1965 |
Lipid composition of rat mammary carcinomas, mammary glands, and related tissues: endocrine influences.
Topics: Adipose Tissue; Animals; Anthracenes; Cholesterol; Chromatography, Gas; Estradiol; Fatty Acids; Fema | 1966 |
The effect of methylcholanthrene and different social conditions on the appearance of breast tumours in NZY mice.
Topics: Animals; Breeding; Carcinogens; Environment; Female; Lactation; Leukemia, Experimental; Mammary Neop | 1966 |