3-methylcholanthrene has been researched along with Porphyrias in 5 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chick-embryo liver cells in culture were used to study the mechanism by which hexachlorobenzene (HCB) and other chlorobenzenes cause hepatic porphyria with accumulation of uroporphyrin (URO)." | 3.67 | Induction of porphyria in cultured chick-embryo hepatocytes by halogenated aromatic compounds. ( Bement, WJ; Bonkovsky, HL; Lambrecht, RW; Sinclair, JF; Sinclair, PR, 1986) |
| "Uroporphyria was produced by injecting animals with iron-dextran and giving the porphyrin precursor 5-aminolaevulinic acid in the drinking water." | 1.30 | Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. ( Bement, WJ; Dalton, T; Gorman, N; Nebert, DW; Sinclair, JF; Sinclair, PR; Smith, AG; Walton, HS, 1998) |
| "The porphyria is not dependent on pretreatment with iron and persists for at least 21 days after withdrawal of ALA." | 1.27 | Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid. ( Bement, WJ; Elder, GH; Gorman, N; Lambrecht, RW; Roberts, AG; Sinclair, JA; Sinclair, PR; Urquhart, AJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakano, K | 1 |
| Ishizuka, M | 1 |
| Sakamoto, KQ | 1 |
| Fujita, S | 1 |
| Sinclair, PR | 4 |
| Gorman, N | 2 |
| Dalton, T | 1 |
| Walton, HS | 1 |
| Bement, WJ | 3 |
| Sinclair, JF | 3 |
| Smith, AG | 1 |
| Nebert, DW | 1 |
| Sundstrom, SA | 1 |
| Smith, EL | 1 |
| Urquhart, AJ | 1 |
| Elder, GH | 1 |
| Roberts, AG | 1 |
| Lambrecht, RW | 2 |
| Sinclair, JA | 1 |
| Bonkovsky, HL | 1 |
5 other studies available for 3-methylcholanthrene and Porphyrias
| Article | Year |
|---|---|
Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A2; Iron; Male; Methylcholanthrene; Mice; Mice, I | 2009 |
Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enz | 1998 |
Effect of 17 alpha-ethynylestradiol on the induction of cytochrome P-450 by 3-methylcholanthrene in cultured chick embryo hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chick Embryo; Cytochrome P-450 CYP1A1; Cyto | 1988 |
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Hexachloroben | 1988 |
Induction of porphyria in cultured chick-embryo hepatocytes by halogenated aromatic compounds.
Topics: Animals; Cells, Cultured; Chick Embryo; Chlorobenzenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 En | 1986 |