3-methylcholanthrene has been researched along with Porphyria in 5 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chick-embryo liver cells in culture were used to study the mechanism by which hexachlorobenzene (HCB) and other chlorobenzenes cause hepatic porphyria with accumulation of uroporphyrin (URO)." | 3.67 | Induction of porphyria in cultured chick-embryo hepatocytes by halogenated aromatic compounds. ( Bement, WJ; Bonkovsky, HL; Lambrecht, RW; Sinclair, JF; Sinclair, PR, 1986) |
| "Uroporphyria was produced by injecting animals with iron-dextran and giving the porphyrin precursor 5-aminolaevulinic acid in the drinking water." | 1.30 | Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. ( Bement, WJ; Dalton, T; Gorman, N; Nebert, DW; Sinclair, JF; Sinclair, PR; Smith, AG; Walton, HS, 1998) |
| "The porphyria is not dependent on pretreatment with iron and persists for at least 21 days after withdrawal of ALA." | 1.27 | Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid. ( Bement, WJ; Elder, GH; Gorman, N; Lambrecht, RW; Roberts, AG; Sinclair, JA; Sinclair, PR; Urquhart, AJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakano, K | 1 |
| Ishizuka, M | 1 |
| Sakamoto, KQ | 1 |
| Fujita, S | 1 |
| Sinclair, PR | 4 |
| Gorman, N | 2 |
| Dalton, T | 1 |
| Walton, HS | 1 |
| Bement, WJ | 3 |
| Sinclair, JF | 3 |
| Smith, AG | 1 |
| Nebert, DW | 1 |
| Sundstrom, SA | 1 |
| Smith, EL | 1 |
| Urquhart, AJ | 1 |
| Elder, GH | 1 |
| Roberts, AG | 1 |
| Lambrecht, RW | 2 |
| Sinclair, JA | 1 |
| Bonkovsky, HL | 1 |
5 other studies available for 3-methylcholanthrene and Porphyria
| Article | Year |
|---|---|
Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A2; Iron; Male; Methylcholanthrene; Mice; Mice, I | 2009 |
Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enz | 1998 |
Effect of 17 alpha-ethynylestradiol on the induction of cytochrome P-450 by 3-methylcholanthrene in cultured chick embryo hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chick Embryo; Cytochrome P-450 CYP1A1; Cyto | 1988 |
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Hexachloroben | 1988 |
Induction of porphyria in cultured chick-embryo hepatocytes by halogenated aromatic compounds.
Topics: Animals; Cells, Cultured; Chick Embryo; Chlorobenzenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 En | 1986 |