3-methylcholanthrene has been researched along with Liver Failure in 2 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 7.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 3.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahman, TM | 1 |
| Selden, AC | 1 |
| Hodgson, HJ | 1 |
| Tateno, C | 1 |
| Yoshizane, Y | 1 |
| Saito, N | 1 |
| Kataoka, M | 1 |
| Utoh, R | 1 |
| Yamasaki, C | 1 |
| Tachibana, A | 1 |
| Soeno, Y | 1 |
| Asahina, K | 1 |
| Hino, H | 1 |
| Asahara, T | 1 |
| Yokoi, T | 1 |
| Furukawa, T | 1 |
| Yoshizato, K | 1 |
2 other studies available for 3-methylcholanthrene and Liver Failure
| Article | Year |
|---|---|
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim | 2002 |
Near completely humanized liver in mice shows human-type metabolic responses to drugs.
Topics: Adolescent; Adult; Albumins; Animals; Child; Chimera; Complement C3-C5 Convertases; Complement C3a; | 2004 |