3-methylcholanthrene has been researched along with Hepatic Encephalopathy in 2 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 7.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 3.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "To elucidate the pathogenesis of hepatic encephalopathy (HE), we developed a new HE model with behaviour disorder." | 1.35 | A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder. ( Isobe-Harima, Y; Itamoto, K; Miura, I; Murata, T; Sakaida, I; Segawa, M; Shinoda, K; Taura, Y; Terai, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahman, TM | 1 |
| Selden, AC | 1 |
| Hodgson, HJ | 1 |
| Isobe-Harima, Y | 1 |
| Terai, S | 1 |
| Miura, I | 1 |
| Segawa, M | 1 |
| Murata, T | 1 |
| Itamoto, K | 1 |
| Taura, Y | 1 |
| Shinoda, K | 1 |
| Sakaida, I | 1 |
2 other studies available for 3-methylcholanthrene and Hepatic Encephalopathy
| Article | Year |
|---|---|
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim | 2002 |
A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder.
Topics: Acetaminophen; Amino Acids; Animals; Astrocytes; Blotting, Western; Brain; Disease Models, Animal; E | 2008 |