3-methylcholanthrene has been researched along with Experimental Hepatoma in 66 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fibrosarcoma was induced in Wistar strain male albino rats by 20-methylcholanthrene." | 1.38 | Antiproliferative role of Indigofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats. ( Balasubramanian, MP; Kumar, SS; Rao, MR, 2012) |
| " The induction of SCEs followed a dose-response pattern with plateaus at high doses of PAH." | 1.27 | Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells. An in vitro system for the induction of SCEs. ( Bynum, G; Dean, RG; Hadley, E; Jacobson-Kram, D, 1983) |
| "A cell line derived from a Morris hepatoma, MH1C1, was examined for its in vitro expression of monooxygenases." | 1.27 | Induction of cytochrome(s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells. ( Bassi, AM; Chiarpotto, E; Dianzani, MU; Ferro, M; Marinari, UM; Nanni, G; Poli, G, 1984) |
| " The difference held for offspring of both (C57BL/6 X DBA)F1 and DBA mothers and it was of statistical significance for one or both sexes at most dosage levels." | 1.27 | Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene: positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism. ( Anderson, LM; Jones, AB; Ohshima, M; Riggs, CW, 1985) |
| "MeCh both reduced the incidence of hepatic neoplasms induced by 3'-MeDAB and delayed their development." | 1.26 | 3-Methylcholanthrene-inhibition of hepatocarcinogenesis in the rat due to 3'-methyl-4-dimethylaminoazobenzene or 2-acetylamino-fluorene: a comparative study. ( Flaks, A; Flaks, B, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (65.15) | 18.7374 |
| 1990's | 17 (25.76) | 18.2507 |
| 2000's | 4 (6.06) | 29.6817 |
| 2010's | 2 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, SS | 1 |
| Rao, MR | 1 |
| Balasubramanian, MP | 1 |
| Celius, T | 1 |
| Pansoy, A | 1 |
| Matthews, J | 1 |
| Okey, AB | 3 |
| Henderson, MC | 1 |
| Krueger, SK | 1 |
| Williams, DE | 1 |
| Timsit, YE | 1 |
| Riddick, DS | 3 |
| KITAURA, K | 1 |
| YAMADA, H | 1 |
| MIYAZI, T | 1 |
| KUHN, O | 1 |
| KOECKE, HU | 1 |
| KLEIN, M | 1 |
| ODASHIMA, S | 1 |
| Moorthy, B | 1 |
| Muthiah, K | 1 |
| Fazili, IS | 1 |
| Kondraganti, SR | 1 |
| Wang, L | 1 |
| Couroucli, XI | 1 |
| Jiang, W | 1 |
| Bielefeld, KA | 1 |
| Lee, C | 1 |
| Fujiwara, H | 1 |
| Aoki, H | 1 |
| Yoshioka, T | 1 |
| Tomita, S | 1 |
| Ikegami, R | 1 |
| Hamaoka, T | 1 |
| Kano, I | 1 |
| Nebert, DW | 2 |
| Dean, RG | 1 |
| Bynum, G | 1 |
| Jacobson-Kram, D | 1 |
| Hadley, E | 1 |
| Wiebel, FJ | 1 |
| Park, SS | 1 |
| Kiefer, F | 1 |
| Gelboin, HV | 1 |
| Frey, AB | 1 |
| Rosenfeld, MG | 1 |
| Dolan, WJ | 1 |
| Adesnik, M | 1 |
| Kreibich, G | 1 |
| Flaks, B | 2 |
| Flaks, A | 2 |
| Jones, H | 1 |
| Milsom, A | 1 |
| Lin, KH | 2 |
| Winters, AL | 2 |
| Lindahl, R | 4 |
| Ferro, M | 2 |
| Bassi, AM | 2 |
| Marinari, UM | 1 |
| Nanni, G | 1 |
| Chiarpotto, E | 1 |
| Poli, G | 1 |
| Dianzani, MU | 1 |
| Esparza, B | 1 |
| García, P | 1 |
| de las Heras, B | 1 |
| Piniés, LM | 1 |
| Chen, YT | 1 |
| Lang, MA | 1 |
| Jensen, NM | 1 |
| Negishi, M | 1 |
| Tukey, RH | 1 |
| Sidransky, E | 1 |
| Guenther, TM | 1 |
| Sadek, IA | 1 |
| Donato, MT | 1 |
| Gómez-Lechón, MJ | 1 |
| Penco, S | 1 |
| Herrero, E | 1 |
| Adamo, D | 1 |
| Castell, JV | 1 |
| Berberian, I | 1 |
| Chen, LC | 1 |
| Robinson, FR | 1 |
| Glauert, HP | 1 |
| Chow, CK | 1 |
| Robertson, LW | 2 |
| Huang, Y | 1 |
| Harper, PA | 1 |
| de Morais, SM | 1 |
| Giannone, JV | 1 |
| Degawa, M | 1 |
| Kojima, M | 1 |
| Yoshinari, K | 1 |
| Tada, M | 1 |
| Hashimoto, Y | 1 |
| Anderson, LM | 3 |
| Ruskie, S | 1 |
| Carter, J | 1 |
| Pittinger, S | 1 |
| Kovatch, RM | 2 |
| Riggs, CW | 3 |
| Courjault-Gautier, F | 1 |
| Antoine, B | 1 |
| Bens, M | 1 |
| Vallet, V | 1 |
| Cluzeaud, F | 1 |
| Pringault, E | 1 |
| Kahn, A | 1 |
| Toutain, H | 1 |
| Vandewalle, A | 1 |
| Gradelet, S | 1 |
| Le Bon, AM | 1 |
| Bergès, R | 1 |
| Suschetet, M | 1 |
| Astorg, P | 1 |
| Gressani, KM | 1 |
| Rollins, LA | 1 |
| Leone-Kabler, S | 1 |
| Cline, JM | 1 |
| Miller, MS | 1 |
| Reisdorph, R | 1 |
| Joy, KL | 1 |
| Kuttan, G | 1 |
| Kuttan, R | 2 |
| Rajeshkumar, NV | 1 |
| Embleton, MJ | 1 |
| Baldwin, RW | 2 |
| Ito, N | 2 |
| Tatematsu, M | 2 |
| Robins, RA | 1 |
| Rees, RC | 1 |
| Brooks, CG | 1 |
| Barone, C | 1 |
| Gentiloni, N | 1 |
| Bartoloni, C | 1 |
| Gambassi, G | 1 |
| Terranova, T | 1 |
| Nakanishi, K | 1 |
| Murasaki, G | 1 |
| Miyata, Y | 1 |
| Hirose, M | 1 |
| Lambiotte, M | 1 |
| Thierry, N | 1 |
| Marshall, MV | 1 |
| Arnott, MS | 1 |
| Jacobs, MM | 1 |
| Griffin, AC | 1 |
| Raha, A | 1 |
| Reddy, V | 1 |
| Xu, LC | 2 |
| Houser, WH | 1 |
| Bresnick, E | 2 |
| Chowdhury, NR | 1 |
| Saber, MA | 1 |
| Lahiri, P | 1 |
| Mackenzie, PI | 1 |
| Novikoff, PM | 1 |
| Becker, FF | 1 |
| Chowdhury, JR | 1 |
| Bock, KW | 2 |
| Münzel, PA | 1 |
| Röhrdanz, E | 1 |
| Schrenk, D | 1 |
| Eriksson, LC | 1 |
| Midorikawa, Y | 1 |
| Yamashita, T | 1 |
| Sendo, F | 1 |
| Huang, M | 1 |
| Bandlow, G | 1 |
| Härtl, R | 1 |
| Jones, AB | 2 |
| Ritter, E | 1 |
| Rautoma, P | 1 |
| Koivusalo, M | 1 |
| Eriksson, L | 2 |
| Sugiyama, T | 1 |
| Suzuki, K | 1 |
| Ookawara, T | 1 |
| Kurosawa, T | 1 |
| Taniguchi, N | 1 |
| Galeotti, T | 2 |
| Borrello, S | 2 |
| Leach, MF | 1 |
| Watanabe, M | 2 |
| Ohmachi, T | 2 |
| Sagami, I | 2 |
| Buchmann, A | 2 |
| Kunz, W | 2 |
| Wolf, CR | 2 |
| Oesch, F | 2 |
| Aterman, K | 1 |
| Dock, L | 1 |
| Scheu, G | 1 |
| Jernström, B | 1 |
| Martinez, M | 1 |
| Torndal, UB | 1 |
| Fujisawa-Sehara, A | 1 |
| Sogawa, K | 1 |
| Nishi, C | 1 |
| Fujii-Kuriyama, Y | 1 |
| Lafreniere, R | 1 |
| Rosenberg, SA | 1 |
| Schwarz, M | 1 |
| Schmitt, R | 1 |
| Bhat, GJ | 1 |
| Rangarajan, PN | 1 |
| Padmanaban, G | 1 |
| Holme, JA | 1 |
| Søderlund, EJ | 1 |
| Christensen, T | 1 |
| Trygg, B | 1 |
| Bjørnstad, C | 1 |
| Palombini, G | 1 |
| Minotti, G | 1 |
| Fujii, H | 1 |
| Yoshimoto, F | 1 |
| Masuda, S | 1 |
| Higashi, T | 1 |
| Nishii, T | 1 |
| Takamisawa, I | 1 |
| Tateishi, N | 1 |
| Sakamoto, Y | 1 |
| Lilienblum, W | 1 |
| Bock-Hennig, BS | 1 |
| Ohshima, M | 1 |
1 review available for 3-methylcholanthrene and Experimental Hepatoma
| Article | Year |
|---|---|
[Some contributions by chemical carcinogenesis--what is the animal model of human cancer? (author's transl)].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Cricetinae; Disease Models, Animal; Dogs; | 1978 |
65 other studies available for 3-methylcholanthrene and Experimental Hepatoma
| Article | Year |
|---|---|
Antiproliferative role of Indigofera aspalathoides on 20 methylcholanthrene induced fibrosarcoma in rats.
Topics: Animals; Antineoplastic Agents; Chemoprevention; Fibrosarcoma; Indigofera; Kidney; Liver; Liver Neop | 2012 |
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Cell Line, Tumor; Dose-Resp | 2010 |
Stimulation of hepatic signal transducer and activator of transcription 5b by GH is not altered by 3-methylcholanthrene.
Topics: Animals; Binding Sites; Biological Transport; Caseins; Cell Nucleus; DNA; DNA-Binding Proteins; Grow | 2002 |
[Effects of chrysene and 3-methylcholanthrene on DAB-induced liver tumors].
Topics: Animals; Carcinogens; Chrysenes; Hydrocarbons; Liver Neoplasms; Liver Neoplasms, Experimental; Methy | 1957 |
[Local effect of methylcholanthrene on the liver of the mouse and the problem of primary liver carcinoma].
Topics: Animals; Liver Neoplasms; Liver Neoplasms, Experimental; Methylcholanthrene; Mice; Sarcoma, Experime | 1957 |
Development of hepatomas in inbred albino mice following treatment with 20-methylcholanthrene.
Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Liver Neoplasms, Experimental; Methylcholanthre | 1959 |
Development of liver cancers in the rat by 20-methylcholanthrene painting following initial 4-dimethylaminoazobenzene feeding.
Topics: Animals; Bile Ducts, Intrahepatic; Carcinogens; Liver Neoplasms; Liver Neoplasms, Experimental; Meth | 1959 |
3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells.
Topics: Animals; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochromes; DNA Adduct | 2007 |
Regulation of aryl hydrocarbon receptor expression and function by glucocorticoids in mouse hepatoma cells.
Topics: Animals; Cell Line, Tumor; Dexamethasone; Glucocorticoids; Liver Neoplasms, Experimental; Methylchol | 2008 |
Establishment of a tumor-specific immunotherapy model utilizing TNP-reactive helper T cell activity and its application to the autochthonous tumor system.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Fibrosarcoma; Haptens; Imm | 1984 |
Ornithine decarboxylase induction in liver- and hepatoma-derived cell cultures: no detectable differences between control and 3-methylcholanthrene-treated cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carboxy-Lyases; Cells, Cultured; Culture Media; Cyclic AMP; | 1981 |
Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells. An in vitro system for the induction of SCEs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Crossing Over, Genetic; In | 1983 |
Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Benz( | 1984 |
Induction of cytochrome P-450 isozymes in rat hepatoma-derived cell cultures.
Topics: Animals; Cell Line; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inducti | 1984 |
Effects of inhibiting hepatocarcinogenesis upon the early fine structural changes induced in rat hepatocytes by 3'-methyl-4-dimethylaminoazobenzene.
Topics: Animals; Carcinogens; Liver; Liver Neoplasms, Experimental; Lysosomes; Male; Methylcholanthrene; Met | 1983 |
Regulation of aldehyde dehydrogenase activity in five rat hepatoma cell lines.
Topics: Aldehyde Dehydrogenase; Amanitins; Animals; Benzo(a)pyrene; Cell Line; Cycloheximide; Dactinomycin; | 1984 |
Induction of cytochrome(s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells.
Topics: Animals; Biotransformation; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cyto | 1984 |
3-Methylcholanthrene-inhibition of hepatocarcinogenesis in the rat due to 3'-methyl-4-dimethylaminoazobenzene or 2-acetylamino-fluorene: a comparative study.
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methylcholanth | 1982 |
[Changes in the serum immunoglobulin levels in mice with methylcholanthrene-induced fibrosarcoma].
Topics: Animals; Blood Proteins; Female; Fibrosarcoma; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; | 1982 |
Similarities between mouse and rat-liver microsomal cytochromes P-450 induced by 3-methylcholanthrene. Evidence from catalytic, immunologic, and recombinant DNA studies.
Topics: Animals; Cross Reactions; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; DNA, | 1982 |
Vitamin A and its inhibitory effect as tested on Egyptian toads.
Topics: Animals; Bufonidae; Diterpenes; Female; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Pal | 1981 |
Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthofl | 1994 |
Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl in rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Diterpenes; Drug Interact | 1995 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin versus 3-methylcholanthrene: comparative studies of Ah receptor binding, transformation, and induction of CYP1A1.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Binding Sites; Binding, Competitive; Cell Lin | 1994 |
Photoaffinity labeling of the Ah receptor with 3-[3H]methylcholanthrene and formation of a 165-kDa complex between the ligand-binding subunit and a novel cytosolic protein.
Topics: Affinity Labels; Animals; Cell Line; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Induction; Kine | 1994 |
DNA adduct formation of hepatocarcinogenic aromatic amines in rat liver: effect of cytochrome P450 inducers.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Imidazoles; Liver; Live | 1994 |
Fetal mouse susceptibility to transplacental carcinogenesis: differential influence of Ah receptor phenotype on effects of 3-methylcholanthrene, 12-dimethylbenz[a]anthracene, and benzo[a]pyrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Crosses, Genetic; Female; Li | 1995 |
Activity and inducibility of drug-metabolizing enzymes in immortalized hepatocyte-like cells (mhPKT) derived from a L-PK/Tag1 transgenic mouse.
Topics: Animals; Antigens, Polyomavirus Transforming; Bile Canaliculi; Carbohydrates; Cell Line, Transformed | 1997 |
Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinogens; Carotenoids; Diet; DNA Damage; Liver Ne | 1998 |
Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene.
Topics: Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p16; DNA Primers; Female; Genes, ras; Liver | 1998 |
Hypoxia exerts cell-type-specific effects on expression of the class 3 aldehyde dehydrogenase gene.
Topics: Aldehyde Dehydrogenase; Animals; Cell Hypoxia; Cells, Cultured; Cobalt; Down-Regulation; Epithelium, | 1998 |
Antioxidant and anticarcinogenic activity of Lycovin--an indigenous herbal preparation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Diethylnitrosamine; In Vitro Techniques; L | 1999 |
Cancare-a herbal formulation inhibits chemically induced tumours in experimental animals.
Topics: Animals; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Methylcholanthrene; Mice; Mice, | 2001 |
Tumour-related antigen specificities associated with 3-methylcholanthrene-treated rat embryo cells.
Topics: Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Cells, Cultured; Dimethyl Sulfoxide; Embryo, Mamm | 1979 |
Spontaneous development of cytotoxic activity in cultured lymphnode cells from tumour-bearing rats.
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Liver Neoplasms, Experimental; Lymph Nodes; Met | 1979 |
Effects of phenobarbital and 3-methylcolanthrene treatment on microsomes of Morris hepatoma 3924-A, tumour-bearing and normal rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Cell Membrane; Cytochrome P-450 Enzyme System; Cytochromes; Cyto | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Enhancement of aflatoxin B1 cytotoxicity in differentiated rat hepatoma cultures by a prior glucocorticoid treatment of the monolayer.
Topics: Aflatoxins; Animals; Cell Line; Cell Survival; Dexamethasone; Hybrid Cells; Liver Neoplasms, Experim | 1979 |
Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Hydroxyacetylaminofluorene; In Vitro Techniques; | 1979 |
Presence of the 4 S polycyclic hydrocarbon-binding protein in H4-II-E cells.
Topics: Animals; Benzo(a)pyrene; Carrier Proteins; Cytochrome P-450 Enzyme System; Gene Expression Regulatio | 1991 |
Expression of specific UDP-glucuronosyltransferase isoforms in carcinogen-induced preneoplastic rat liver nodules.
Topics: 2-Acetylaminofluorene; Animals; Glucuronates; Glucuronosyltransferase; Immunoblotting; Immunohistoch | 1991 |
Persistently increased expression of a 3-methylcholanthrene-inducible phenol uridine diphosphate-glucuronosyltransferase in rat hepatocyte nodules and hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies; Enzyme Induction; Glucuronosyltransferase; Liver Neoplas | 1990 |
Modulation of the immune response to transplanted tumors in rats by selective depletion of neutrophils in vivo using a monoclonal antibody: abrogation of specific transplantation resistance to chemical carcinogen-induced syngeneic tumors by selective depl
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies, Monoclonal; Fibrosarcoma; Graft Rejection; Im | 1990 |
Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Enzyme Induction; Ethion | 1990 |
Induction of cytochrome P450IA1 in rat hepatoma cell by polycyclic hydrocarbons and a dioxin.
Topics: Animals; Benzo(a)pyrene; Benzofurans; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; Gen | 1990 |
Selection and isolation of a new variant of DBA/2 mastocytoma P 815 X 2.
Topics: Animals; Ascites; Liver Neoplasms, Experimental; Mast-Cell Sarcoma; Methylcholanthrene; Mice; Mice, | 1989 |
Modification of transplacental tumorigenesis by 3-methylcholanthrene in mice by genotype at the Ah locus and pretreatment with beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Female; Fetal Diseases; Fetus; Flavonoids; Genotype; Li | 1989 |
Cytosolic aldehyde dehydrogenases of rat liver. Properties of forms present in liver nodules from 20-methylcholantrene treated and untreated rats, and in livers from 20-methylcholantrene treated normal rats.
Topics: Aldehyde Dehydrogenase; Animals; Cytosol; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Meth | 1989 |
Selective expression and induction of cytochrome P450PB and P450MC during the development of hereditary hepatitis and hepatoma of LEC rats.
Topics: Age Factors; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Syst | 1989 |
Cytochrome P-448 induction restores the propagation of .O2--induced lipid peroxidation in hepatoma microsomes.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochromes; Enzyme Induction; Kinetics; Lipid Peroxidation; Liver | 1988 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzym | 1986 |
Multiplicity of cytochrome P-450 in Morris hepatoma.
Topics: Animals; Cytochrome P-450 Enzyme System; Isoenzymes; Liver Neoplasms, Experimental; Methylcholanthre | 1986 |
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats.
Topics: Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Fem | 1986 |
Localized hepatocarcinogenesis: the response of the liver and kidney to implanted carcinogens.
Topics: Animals; Carcinogens; Drug Implants; Kidney Neoplasms; Liver Neoplasms; Liver Neoplasms, Experimenta | 1987 |
Benzo[a]pyrene metabolism and induction of enzyme-altered foci in regenerating rat liver.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme | 1988 |
Regulatory DNA elements localized remotely upstream from the drug-metabolizing cytochrome P-450c gene.
Topics: Acetyltransferases; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Chromosome Deletion; Ch | 1986 |
A novel approach to the generation and identification of experimental hepatic metastases in a murine model.
Topics: Adenocarcinoma; Animals; Cyclophosphamide; Dimethylhydrazines; Disease Models, Animal; DNA, Recombin | 1986 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver | 1987 |
Differential effects of cycloheximide on rat liver cytochrome P-450 gene transcription in the whole animal and hepatoma cell culture.
Topics: Animals; Cell Line; Cell Nucleus; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; G | 1987 |
Modulation of cytotoxic and genotoxic effects of 2-acetylaminofluorene in rat and hamster hepatocytes by 3-methylcholanthrene pre-treatment.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cells, Cultured; Cricetinae; DNA Repair; Hydroxyl | 1986 |
Restoration of hydroperoxide-dependent lipid peroxidation by 3-methylcholanthrene induction of cytochrome P-448 in hepatoma microsomes.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochromes; Ethylmorphine; Hydrogen Peroxide; Kinetics; Lipid Per | 1986 |
Microsomal monooxygenase system in Morris hepatoma: purification and characterization of cytochromes P-450 from Morris hepatoma 5123D of 3-methylcholanthrene-treated rats.
Topics: Animals; Catalysis; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Electrophoresis, | 1985 |
Comparison of drug-metabolizing activities in the livers of carcinogen-sensitive parent rats and carcinogen-resistant descendants.
Topics: Animals; Benzopyrene Hydroxylase; Biotransformation; Cytochrome P-450 Enzyme System; Drug Resistance | 1985 |
Protection against toxic redox cycles between benzo(a)pyrene-3,6-quinone and its quinol by 3-methylcholanthrene-inducible formation of the quinol mono- and diglucuronide.
Topics: Animals; Benzopyrenes; Glucuronates; Hydrogen-Ion Concentration; Kinetics; Liver Neoplasms, Experime | 1985 |
Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene: positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism.
Topics: Animals; Biotransformation; Female; Fetus; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mate | 1985 |