3-methylcholanthrene has been researched along with Down Syndrome in 2 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The fibroblasts with trisomy 21, however, did not show an increased sensitivity to MC treatment when compared with normal fibroblasts, expressed in the number of SCEs per nucleus found in the cells." | 1.27 | Increased SCE inducibility by low doses of methylcholanthrene in lymphocytes obtained from patients with Down's disease. ( Lapis, K; Major, J; Szende, B; Thész, Z, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Major, J | 2 |
| Szende, B | 1 |
| Lapis, K | 1 |
| Thész, Z | 1 |
2 other studies available for 3-methylcholanthrene and Down Syndrome
| Article | Year |
|---|---|
Mitotic delay in peripheral blood lymphocytes and fibroblast cultures obtained from a child with Down's syndrome and from a healthy child.
Topics: Case-Control Studies; Cells, Cultured; Child; Child, Preschool; Down Syndrome; Fibroblasts; Humans; | 1994 |
Increased SCE inducibility by low doses of methylcholanthrene in lymphocytes obtained from patients with Down's disease.
Topics: Dose-Response Relationship, Drug; Down Syndrome; Female; Fibroblasts; Humans; In Vitro Techniques; L | 1985 |