3-methylcholanthrene has been researched along with Colonic Neoplasms in 27 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we observed that deficiency of either Fas or FasL resulted in significantly increased incidence of 3-methylcholanthrene-induced spontaneous sarcoma development in mice." | 3.78 | NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression. ( Bardhan, K; Ganapathy, V; Lee, JR; Liles, GB; Liu, F; Liu, K; Thangaraju, M; Waller, JL; Yang, D, 2012) |
| "Since human colorectal tumors are insensitive to most chemotherapeutic agents, there is a need for the discovery of new drugs that would show activity against this disease." | 1.28 | Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems. ( Beaune, PH; Chabot, GG; de Waziers, I; Gouyette, A; Janot, F; Massaad, L; Morizet, J; Ribrag, V, 1992) |
| "The incidences of colon neoplasms were 6% with BP exposure, 20% with 3-MC and 95% with MNU." | 1.27 | Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea. ( Wang, CX; Watanabe, K; Weisburger, JH; Williams, GM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (55.56) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coker-Gurkan, A | 1 |
| Arisan, ED | 1 |
| Obakan, P | 1 |
| Guvenir, E | 1 |
| Unsal, NP | 1 |
| Liu, F | 1 |
| Bardhan, K | 1 |
| Yang, D | 1 |
| Thangaraju, M | 1 |
| Ganapathy, V | 1 |
| Waller, JL | 1 |
| Liles, GB | 1 |
| Lee, JR | 1 |
| Liu, K | 1 |
| N'Guyen, QB | 1 |
| Fallone, F | 1 |
| Seree, E | 2 |
| Fina, F | 1 |
| Villard, PH | 1 |
| Guigal, N | 2 |
| De Meo, M | 1 |
| Lacarelle, B | 1 |
| Martin, PM | 1 |
| Barra, Y | 2 |
| RACK, FJ | 1 |
| KAUFMAN, N | 1 |
| SIMEONE, FA | 1 |
| MORI, K | 1 |
| ICHII, S | 1 |
| SHIGETA, Y | 1 |
| Yamakawa, S | 1 |
| Asai, T | 1 |
| Uchida, T | 1 |
| Matsukawa, M | 1 |
| Akizawa, T | 1 |
| Oku, N | 1 |
| Kanazawa, K | 1 |
| Jessup, JM | 1 |
| Kahan, BD | 1 |
| LeGrue, SJ | 1 |
| Rutzky, L | 1 |
| Pellis, NR | 1 |
| Duane, WC | 1 |
| Behrens, JC | 1 |
| Kelly, SG | 1 |
| Levine, AS | 1 |
| Diwan, BA | 1 |
| Blackman, KE | 1 |
| Rosenberg, DW | 1 |
| Leff, T | 1 |
| Mullen, CA | 1 |
| Petropoulos, D | 1 |
| Lowe, RM | 1 |
| Hardy, B | 1 |
| Kovjazin, R | 1 |
| Raiter, A | 1 |
| Ganor, N | 1 |
| Novogrodsky, A | 1 |
| Li, W | 1 |
| Harper, PA | 1 |
| Tang, BK | 1 |
| Okey, AB | 1 |
| Nguyen, QB | 1 |
| Charvet, B | 1 |
| Desobry, A | 1 |
| Coomes, ML | 1 |
| Mason, WA | 1 |
| Muijsson, IE | 1 |
| Cantrell, ET | 1 |
| Anderson, DE | 1 |
| Busbee, DL | 1 |
| Brodsky, LH | 1 |
| Feinberg, RF | 1 |
| Sorof, S | 1 |
| Abeyounis, CJ | 1 |
| Milgrom, F | 1 |
| Massaad, L | 1 |
| de Waziers, I | 1 |
| Ribrag, V | 1 |
| Janot, F | 1 |
| Beaune, PH | 1 |
| Morizet, J | 1 |
| Gouyette, A | 1 |
| Chabot, GG | 1 |
| Ebina, T | 1 |
| Murata, K | 1 |
| Gallinger, S | 1 |
| Hoskin, DW | 1 |
| Mullen, JB | 1 |
| Wong, AH | 1 |
| Roder, JC | 1 |
| Wang, CX | 1 |
| Watanabe, K | 1 |
| Weisburger, JH | 1 |
| Williams, GM | 1 |
| Hill, MJ | 1 |
| Leibowitz, S | 1 |
| Schwartz, RS | 1 |
| Angel Basombrío, M | 1 |
| Hellström, IE | 1 |
| Hellström, KE | 1 |
| Pierce, GE | 1 |
| Hollis, DP | 1 |
| Economou, JS | 1 |
| Parks, LC | 1 |
| Eggleston, JC | 1 |
| Saryan, LA | 1 |
| Czeister, JL | 1 |
2 reviews available for 3-methylcholanthrene and Colonic Neoplasms
| Article | Year |
|---|---|
Malignancy as a complication of immunosuppressive therapy.
Topics: Animals; Antibiotics, Antineoplastic; Antibody Formation; Antigens, Neoplasm; Breast Neoplasms; Burk | 1971 |
The immunology of cancer.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Complex; Antigens, Neoplasm; Breast Neoplasms; Colon | 1973 |
25 other studies available for 3-methylcholanthrene and Colonic Neoplasms
| Article | Year |
|---|---|
Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; bcl-2-Associated X Protein; Blotting, Western; CDC2 Pro | 2014 |
NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression.
Topics: Animals; Apoptosis; Caspase 8; Colonic Neoplasms; Embryo, Mammalian; Fas Ligand Protein; fas Recepto | 2012 |
Serum increases CYP1A1 induction by 3-methylcholanthrene.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Blood Proteins; Carcinoma; Cattle; Colo | 2002 |
Experimental carcinogenesis: the effect of 20-methylcholanthrene applied directly to the colon in mice.
Topics: Animals; Carcinogenesis; Colonic Neoplasms; Methylcholanthrene; Mice; Neoplasms, Experimental | 1955 |
Further studies on the gastric lesions of rats by oral administration of methylcholanthrene, with a case of colonic adenocarcinoma.
Topics: Adenocarcinoma; Administration, Oral; Animals; Colonic Neoplasms; Methylcholanthrene; Neoplasms, Exp | 1955 |
(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Catechin; Cell Division; Cell M | 2004 |
[Bile acids and cancer of the large intestine].
Topics: Animals; Colonic Neoplasms; Deoxycholic Acid; Feces; Humans; Methylcholanthrene; Rats | 1984 |
Soluble factors from murine and human tumors induce suppressor cells.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Dinitrochlorobenzene; Female; Fibrosarcoma; H | 1984 |
A method for measurement of nanogram quantities of 3-methylcholanthrene in stool samples.
Topics: Cholic Acid; Cholic Acids; Chromatography, High Pressure Liquid; Colonic Neoplasms; Deoxycholic Acid | 1984 |
Carcinogenic effects of combined treatment of inbred mice with 3-methylcholanthrene and 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Interactions; Leukemia, Experim | 1980 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes.
Topics: Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Cyclophosphamide; Cytosine Deaminase; Dimet | 1996 |
A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice.
Topics: Animals; Antibodies, Monoclonal; Carcinoma; Cell Line; Colonic Neoplasms; Female; Fibrosarcoma; Huma | 1997 |
Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Benz(a)Anthracenes; Blotting, Northern; Catalysis; C | 1998 |
Serum induces a transcriptional activation of CYP1A1 gene in HepG2 independently of the AhR pathway.
Topics: Adenocarcinoma; Animals; Blood; Carcinoma, Hepatocellular; Cattle; Chloramphenicol O-Acetyltransfera | 2001 |
Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase in cultured human lymphocytes.
Topics: Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Colonic Neoplasms; Cytochrome P-450 CYP2C8; Cytochro | 1976 |
Carcinogen-protein complexes in hamster colon and glandular stomach during long-term administration of 3-methylcholanthrene.
Topics: Animals; Colon; Colonic Neoplasms; Cricetinae; Cytosol; Gastric Mucosa; In Vitro Techniques; Male; M | 1978 |
A thermostable antigen characteristic for carcinogen-induced rat intestinal tumors.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Carcinoembryonic Antigen; Colonic Neoplasms; Cross Reac | 1976 |
Comparison of mouse and human colon tumors with regard to phase I and phase II drug-metabolizing enzyme systems.
Topics: Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Colorectal Neoplasms; Cytochrome P-450 Enzyme Sys | 1992 |
Antitumor effect of PSK at a distant site: tumor-specific immunity and combination with other chemotherapeutic agents.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols | 1992 |
Comparison of cellular immunotherapies and anti-CD3 in the treatment of MCA-38-LD experimental hepatic metastases in C57BL/6 mice.
Topics: Adenocarcinoma; Animals; Antigens, Differentiation, T-Lymphocyte; Brain Neoplasms; CD3 Complex; Cell | 1990 |
Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea.
Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cricetinae; Male; Mesocricetus; Methylcholanthrene; Meth | 1985 |
Colon cancer: a disease of fibre depletion or of dietary excess?
Topics: Africa; Americas; Asia; Bacterial Infections; Bile Acids and Salts; Carcinogens; Colon; Colonic Neop | 1974 |
Cell-bound immune reactions against tumor specific transplantation antigens.
Topics: Animals; Antigens; Child, Preschool; Colonic Neoplasms; Culture Techniques; Female; Gammaretrovirus; | 1969 |
Nuclear magnetic resonance studies of several experimental and human malignant tumors.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Colonic Neoplasms; Fibrosarcoma; Humans; Kidney N | 1973 |