3-methylcholanthrene has been researched along with Chemical and Drug Induced Liver Injury in 38 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 7.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| " Four groups of nontumored, female, C57BL/6 mice and four groups of C57BL/6 mice with pulmonary metastases from a 3-methylcholanthrene-induced fibrosarcoma (MCA-105) were treated every 6 hr for 4 days by intraperitoneal injections of IL-2 alone, IL-2 and IL-8, IL-8 alone, or an equal volume of saline which served as our control." | 3.69 | Interleukin-8 suppresses the toxicity and antitumor effect of interleukin-2. ( Doak, KW; Edwards, MJ; Heniford, BT; Klar, EA; Miller, FN; Wilson, MA, 1994) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 3.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| " Recent results showed that emodin is the potential toxic components of PMT, but the molecular mechanisms of emodin on liver toxicity remain to be elucidated." | 1.72 | Emodin-induced hepatotoxicity is enhanced by 3-methylcholanthrene through activating aryl hydrocarbon receptor and inducing CYP1A1 in vitro and in vivo. ( Gao, Y; Ruan, P; Wang, M; Wang, Y; Xiao, C; Zhang, G; Zhang, Z, 2022) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "The effects of acetaminophen and its major toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), have been investigated in hepatocytes isolated from 3-methylcholanthrene-pretreated and -untreated rats, respectively." | 1.27 | The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. ( Moldéus, P; Moore, G; Moore, M; Nelson, S; Orrenius, S; Thor, H, 1985) |
| "Phenobarbital pretreatment provided little or no protection." | 1.26 | Iodipamide hepatotoxicity in the rat. ( Barnhart, JL; Burk, RF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (84.21) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Wang, M | 1 |
| Zhang, Z | 1 |
| Ruan, P | 1 |
| Zhang, G | 1 |
| Xiao, C | 1 |
| Wang, Y | 1 |
| Gao, Y | 1 |
| Blake, DA | 1 |
| Rozman, RS | 1 |
| Cascorbi, HF | 1 |
| Krantz, JC | 1 |
| Fander, U | 1 |
| Haas, W | 1 |
| Kröner, H | 1 |
| Leo, MA | 1 |
| Lowe, N | 1 |
| Lieber, CS | 2 |
| Sato, C | 1 |
| Nakano, M | 1 |
| Ellouk-Achard, S | 1 |
| Levresse, V | 1 |
| Martin, C | 1 |
| Pham-Huy, C | 1 |
| Dutertre-Catella, H | 1 |
| Thevenin, M | 1 |
| Warnet, JM | 1 |
| Claude, JR | 1 |
| Heniford, BT | 1 |
| Edwards, MJ | 1 |
| Wilson, MA | 1 |
| Klar, EA | 1 |
| Doak, KW | 1 |
| Miller, FN | 1 |
| Sinclair, PR | 1 |
| Gorman, N | 1 |
| Walton, HS | 1 |
| Bement, WJ | 1 |
| Dalton, TP | 1 |
| Sinclair, JF | 1 |
| Smith, AG | 1 |
| Nebert, DW | 3 |
| Kitagawa, Y | 1 |
| Kuroiwa, Y | 1 |
| Burk, RF | 1 |
| Barnhart, JL | 1 |
| Parkki, MG | 1 |
| Thorgeirsson, SS | 3 |
| Lambert, GH | 1 |
| Mitchell, JR | 5 |
| Snodgrass, WR | 1 |
| Gillette, JR | 4 |
| Felton, JS | 1 |
| Drew, RT | 1 |
| Harper, C | 1 |
| Gupta, BN | 1 |
| Talley, FA | 1 |
| Mgbodile, MU | 1 |
| Holscher, M | 1 |
| Neal, RA | 1 |
| Sesardic, D | 1 |
| Rich, KJ | 1 |
| Edwards, RJ | 1 |
| Davies, DS | 1 |
| Boobis, AR | 1 |
| Moore, M | 1 |
| Thor, H | 1 |
| Moore, G | 1 |
| Nelson, S | 1 |
| Moldéus, P | 1 |
| Orrenius, S | 1 |
| Nakae, D | 1 |
| Oakes, JW | 1 |
| Farber, JL | 1 |
| Lubek, BM | 1 |
| Avaria, M | 1 |
| Basu, PK | 1 |
| Wells, PG | 1 |
| Okey, AB | 1 |
| Roberts, EA | 1 |
| Harper, PA | 1 |
| Denison, MS | 1 |
| Duddy, SK | 1 |
| Hsia, MT | 1 |
| Murase, T | 1 |
| Hazama, H | 1 |
| Okuno, H | 1 |
| Shiozaki, Y | 1 |
| Sameshima, Y | 1 |
| Jorgensen, SJ | 1 |
| Potter, WZ | 3 |
| Davis, DC | 2 |
| Jollow, DJ | 4 |
| Brodie, BB | 2 |
| Reuber, MD | 2 |
| Kondrat'eva, AF | 1 |
| Carlson, GP | 2 |
| Reid, WD | 2 |
| Ilett, KF | 1 |
| Glick, JM | 1 |
| Krishna, G | 2 |
| Pani, P | 1 |
| Torrielli, MV | 1 |
| Gabriel, L | 1 |
| Gravela, E | 1 |
| Zampaglione, N | 1 |
| Stripp, B | 1 |
| Hamrick, M | 1 |
| Christie, B | 1 |
| Eichelbaum, M | 1 |
| Grollman, S | 1 |
| Glover, EL | 1 |
2 reviews available for 3-methylcholanthrene and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Induction of drug-metabolizing enzymes: mechanisms and consequences.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Chemical and Drug Induced Li | 1986 |
[The combined action of ionizing radiation and carcinogens].
Topics: Animals; Benz(a)Anthracenes; Bone Neoplasms; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma, | 1969 |
36 other studies available for 3-methylcholanthrene and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Emodin-induced hepatotoxicity is enhanced by 3-methylcholanthrene through activating aryl hydrocarbon receptor and inducing CYP1A1 in vitro and in vivo.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Emodin; Methylcholanthrene | 2022 |
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; D | 1967 |
The damage of the hepatic mixed functional oxygenase system by CCl4: significance of incorporation of 14CCl4 metabolites in vivo.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Choleca | 1982 |
Decreased hepatic vitamin A after drug administration in men and in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Humans; Kidney; Liver; Liver Diseases; Methylcholan | 1984 |
Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Pois | 1981 |
Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism.
Topics: Acetaminophen; Animals; Calcium; Carmustine; Chemical and Drug Induced Liver Injury; Cytosol; Energy | 1995 |
Interleukin-8 suppresses the toxicity and antitumor effect of interleukin-2.
Topics: Animals; Chemical and Drug Induced Liver Injury; Edema; Female; Fibrosarcoma; Interleukin-2; Interle | 1994 |
CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.
Topics: Aminolevulinic Acid; Animals; Antibodies; Blotting, Western; Chemical and Drug Induced Liver Injury; | 2000 |
Effect of phenobarbital and 3-methylcholanthrene on decrease in pH in liver induced by 3'-methyl-4-dimethylaminoazobenzene, of partial hepatectomy and hepatotoxic agents.
Topics: Animals; Chemical and Drug Induced Liver Injury; Hepatectomy; Hydrogen-Ion Concentration; In Vitro T | 1979 |
Iodipamide hepatotoxicity in the rat.
Topics: Age Factors; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Dos | 1979 |
The role of glutathione in the toxicity of styrene.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Drug Interactions | 1978 |
Genetic aspects of toxicity during development.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Acetaminophen; Alleles; Animals; Aryl | 1976 |
The role of biotransformation in chemical-induced liver injury.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cr | 1976 |
Genetic differences in the aromatic hydrocarbon-inducible n-hydroxylation of 2-acetylaminofluorene and acetaminophen-produced hepatotoxicity in mice.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Enzyme Induct | 1975 |
Effects of vinyl chloride exposures to rats pretreated with phenobarbital.
Topics: Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1975 |
A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity.
Topics: Aflatoxins; Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cysteine; C | 1975 |
Selective destruction of cytochrome P-450d and associated monooxygenase activity by carbon tetrachloride in the rat.
Topics: Animals; Blotting, Western; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1989 |
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Calcium-Transporting ATPases; Cell Membrane; Chemica | 1985 |
Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Acetaminophen; Animals; Carmustine; Chemical and Drug Induced Liver Injury; Deferoxamine; Drug Syner | 1988 |
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits.
Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; | 1988 |
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and | 1987 |
Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Famotidine; Glutathione; | 1986 |
Dose schedules in bleomycin treatment.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Chemical and Drug Induced Liver Injury; Female; Inj | 1972 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L | 1973 |
Effect of 3-methylcholanthrene on hyperplastic and early neoplastic hepatic lesions induced in rats by carbon tetrachloride.
Topics: Age Factors; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Carcinogens; Carcinoma, | 1970 |
Effect of phenobarbital and 3-methylcholanthrene pretreatment on the hepatotoxicity of 1,1,1-trichloroethane and 1,1,2-trichloroethane.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1973 |
Enhancement of the hepatotoxicity of trichloroethylene by inducers of drug metabolism.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1974 |
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Gl | 1974 |
Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis.
Topics: Animals; Autoradiography; Bromine; Bronchial Diseases; Carbon Isotopes; Chemical and Drug Induced Li | 1973 |
Further observation on the effects of 3-methylcholanthrene and phenobarbital on carbon tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cell Sur | 1973 |
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver | 1973 |
3-Methylcholanthrene blocks hepatic necrosis induced by administration of bromobenzene or carbon tetrachloride.
Topics: Animals; Benzene Derivatives; Bromine; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Indu | 1971 |
Effect of 3-methylcholanthrene on experimentally induced cirrhosis. A study using rats of varying ages.
Topics: Age Factors; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug S | 1970 |