3-methylcholanthrene has been researched along with Cataract in 5 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 7.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Acetaminophen has been shown to be cataractogenic in mice and rabbits." | 7.67 | Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains. ( Basu, PK; Lubek, BM; Wells, PG, 1988) |
| " Cataract formation was induced in vitro by incubation in high-glucose solutions and in vivo by acetaminophen toxicity." | 3.73 | Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. ( Ruiz-Ederra, J; Verkman, AS, 2006) |
| "Acetaminophen can be enzymatically bioactivated, which may play a role in cataractogenesis." | 3.67 | Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. ( Avaria, M; Basu, PK; Lubek, BM; Wells, PG, 1988) |
| "Acetaminophen has been shown to be cataractogenic in mice and rabbits." | 3.67 | Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains. ( Basu, PK; Lubek, BM; Wells, PG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruiz-Ederra, J | 1 |
| Verkman, AS | 1 |
| Shichi, H | 1 |
| Gaasterland, DE | 1 |
| Jensen, NM | 1 |
| Nebert, DW | 1 |
| Ryan, AJ | 1 |
| Lubek, BM | 2 |
| Avaria, M | 1 |
| Basu, PK | 2 |
| Wells, PG | 2 |
5 other studies available for 3-methylcholanthrene and Cataract
| Article | Year |
|---|---|
Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice.
Topics: Acetaminophen; Animals; Aquaporin 1; Body Water; Cataract; Drug Combinations; Epithelial Cells; Fluo | 2006 |
Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen.
Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Cataract; Enzyme Induction; Methylcholanthren | 1978 |
In a mouse's eye.
Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Cataract; Humans; Methylcholanthrene; Mice; M | 1978 |
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits.
Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; | 1988 |
Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains.
Topics: Acetaminophen; Animals; Biotransformation; Cataract; Cytochrome P-450 CYP1A2; Cytochromes; Glucurona | 1988 |