3-methylcholanthrene has been researched along with Cachexia in 20 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carnitine treatment significantly lowered the tumour-induced rise in TG (% rise) in the sarcoma model (700 +/- 204 vs 251 +/- 51, P < 0." | 5.29 | Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock. ( Fiskum, G; Gallo, LL; Winter, BK, 1995) |
| "Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice." | 5.28 | Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991) |
| " To sustain immune function, the tumor-bearing host accelerates arginine's intestinal-renal axis by glutamine mobilization from skeletal muscle and this may promote cachexia." | 3.81 | Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats. ( Bading, JR; Buijs, N; Houdijk, AP; van Leeuwen, PA; Vermeulen, MA; Weeda, VB, 2015) |
| "Anorexia-cachexia is a common and severe cancer-related complication but the underlying mechanisms are largely unknown." | 1.39 | Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia. ( Blomqvist, A; Ihnatko, R; Post, C, 2013) |
| "While the pathophysiology of cancer anorexia-cachexia is poorly understood, evidence indicates that pro-inflammatory cytokines are key mediators of this response." | 1.36 | Deletion of the gene encoding MyD88 protects from anorexia in a mouse tumor model. ( Bäckhed, F; Blomqvist, A; Engblom, D; Ruud, J, 2010) |
| "Carnitine treatment significantly lowered the tumour-induced rise in TG (% rise) in the sarcoma model (700 +/- 204 vs 251 +/- 51, P < 0." | 1.29 | Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock. ( Fiskum, G; Gallo, LL; Winter, BK, 1995) |
| "Tumor growth, skeletal muscle atrophy, and gut hypoplasia were not reduced in the TB group maintained on fish oil-based TPN." | 1.29 | Immunostimulation following fish oil-based parenteral nutrition in tumor-bearing rats. ( Basanta, M; Chance, WT; Fischer, JE; Ogle, CK; Thomas, I; Zhang, X; Zhou, L, 1996) |
| "The cause of cancer cachexia is unclear." | 1.28 | Cancer cachexia is transmissible in plasma. ( Illig, KA; Maronian, N; Peacock, JL, 1992) |
| "Indomethacin-treated tumor-bearing mice were also less anorectic than untreated tumor-bearing mice, and their nutritional state, particularly lean body mass, was significantly improved by indomethacin at doses (1 micrograms/g) that did not influence the food intake or body composition in non-tumor-bearing mice." | 1.28 | Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. ( Andersson, C; Gelin, J; Lundholm, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ihnatko, R | 1 |
| Post, C | 1 |
| Blomqvist, A | 3 |
| Buijs, N | 1 |
| Vermeulen, MA | 1 |
| Weeda, VB | 1 |
| Bading, JR | 2 |
| Houdijk, AP | 1 |
| van Leeuwen, PA | 2 |
| Ruud, J | 2 |
| Bäckhed, F | 2 |
| Engblom, D | 2 |
| Wilhelms, DB | 1 |
| Nilsson, A | 1 |
| Eskilsson, A | 1 |
| Tang, YJ | 1 |
| Ströhle, P | 1 |
| Caesar, R | 1 |
| Schwaninger, M | 1 |
| Wunderlich, T | 1 |
| Wang, W | 1 |
| Andersson, M | 1 |
| Lõnnroth, C | 1 |
| Svanberg, E | 1 |
| Lundholm, K | 2 |
| Norrby, K | 1 |
| Winter, BK | 1 |
| Fiskum, G | 1 |
| Gallo, LL | 1 |
| Makino, T | 4 |
| Noguchi, Y | 5 |
| Ito, T | 2 |
| Matsumoto, A | 5 |
| Brauer, M | 1 |
| Inculet, RI | 1 |
| Bhatnagar, G | 1 |
| Marsh, GD | 1 |
| Driedger, AA | 1 |
| Thompson, RT | 1 |
| Nomura, K | 3 |
| Yoshikawa, T | 4 |
| Fukuzawa, K | 3 |
| Tuburaya, A | 1 |
| Yoshida, S | 1 |
| Smith, BK | 1 |
| Conn, CA | 1 |
| Kluger, MJ | 1 |
| Yamada, T | 1 |
| Tsuburaya, A | 1 |
| Chance, WT | 1 |
| Ogle, CK | 1 |
| Thomas, I | 1 |
| Zhou, L | 1 |
| Zhang, X | 1 |
| Basanta, M | 1 |
| Fischer, JE | 1 |
| Doi, C | 1 |
| Illig, KA | 1 |
| Maronian, N | 1 |
| Peacock, JL | 1 |
| Vydelingum, NA | 1 |
| Younes, RN | 1 |
| de Rooij, P | 1 |
| Brennan, MF | 1 |
| Gelin, J | 2 |
| Andersson, C | 1 |
| Stovroff, MC | 1 |
| Fraker, DL | 1 |
| Travis, WD | 1 |
| Norton, JA | 1 |
| Sherry, BA | 1 |
| Fong, Y | 1 |
| Marano, M | 1 |
| Wei, H | 1 |
| Cerami, A | 1 |
| Lowry, SF | 1 |
| Lundholm, KG | 1 |
| Moldawer, LL | 1 |
20 other studies available for 3-methylcholanthrene and Cachexia
| Article | Year |
|---|---|
Proteomic profiling of the hypothalamus in a mouse model of cancer-induced anorexia-cachexia.
Topics: Animals; Anorexia; Cachexia; Disease Models, Animal; Dynamin I; Gene Expression Regulation, Neoplast | 2013 |
Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats.
Topics: Animals; Arginine; Cachexia; Diet; Glutamine; Immune System; Intestinal Mucosa; Kidney; Male; Methyl | 2015 |
Deletion of the gene encoding MyD88 protects from anorexia in a mouse tumor model.
Topics: Animals; Anorexia; Appetite; Body Weight; Cachexia; Disease Models, Animal; Eating; Female; Methylch | 2010 |
Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells.
Topics: Animals; Anorexia; Brain; Cachexia; Chimera; Endothelial Cells; Inflammation; Methylcholanthrene; Mi | 2013 |
Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia.
Topics: Animals; Base Sequence; Body Weight; Cachexia; Dinoprostone; Disease Models, Animal; DNA Primers; DN | 2005 |
Tumor-bearing depresses distant mast-cell-mediated mitogenesis.
Topics: Animals; Cachexia; Male; Mast Cells; Mesentery; Methylcholanthrene; Mitosis; Neoplasm Transplantatio | 1984 |
Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock.
Topics: Animals; Cachexia; Carnitine; Cytokines; Infusion Pumps, Implantable; Interleukin-1; Interleukin-6; | 1995 |
Ultrastructural alterations of hepatocytes in the tumour-bearing, cachectic rat.
Topics: Animals; Body Weight; Cachexia; Endoplasmic Reticulum; Liver; Male; Methylcholanthrene; Microscopy, | 1994 |
Insulin protects against hepatic bioenergetic deterioration induced by cancer cachexia: an in vivo 31P magnetic resonance spectroscopy study.
Topics: Adenosine Triphosphate; Animals; Body Weight; Cachexia; Eating; Energy Metabolism; Fibrosarcoma; Ins | 1994 |
[Stimulation of tissue lipoprotein lipase activity in cancer cachectic rats: preliminary report].
Topics: Animals; Bezafibrate; Cachexia; Lipoprotein Lipase; Male; Methylcholanthrene; Rats; Rats, Inbred F34 | 1993 |
Experimental cachexia: effects of MCA sarcoma in the Fischer rat.
Topics: Animals; Body Temperature; Body Weight; Cachexia; Cytokines; Drinking; Eating; Male; Methylcholanthr | 1993 |
The possible role of TNF-alpha and IL-2 in inducing tumor-associated metabolic alterations.
Topics: Animals; Cachexia; Carcinogens; Energy Intake; Energy Metabolism; Interleukin-2; Lipoprotein Lipase; | 1996 |
Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats.
Topics: Animals; Blood Glucose; Cachexia; Insulin; Insulin Resistance; Lipoprotein Lipase; Male; Methylchola | 1996 |
Immunostimulation following fish oil-based parenteral nutrition in tumor-bearing rats.
Topics: Animals; Cachexia; Eicosapentaenoic Acid; Energy Intake; Fat Emulsions, Intravenous; Fish Oils; Immu | 1996 |
Alteration in immunoexpression of glucose transporter 2 in liver of tumour-bearing rats.
Topics: Animals; Cachexia; Glucose-6-Phosphatase; Hexokinase; Immunoenzyme Techniques; Liver; Male; Methylch | 1998 |
Cancer cachexia is transmissible in plasma.
Topics: Animals; Blood Transfusion; Body Weight; Cachexia; Eating; Male; Methylcholanthrene; Rats; Reference | 1992 |
Organ blood flow in Fischer-344 rats bearing MCA-induced sarcoma.
Topics: Animals; Blood Flow Velocity; Cachexia; Intestine, Small; Male; Methylcholanthrene; Muscles; Rats; R | 1991 |
Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia.
Topics: Animals; Body Weight; Cachexia; Cyclosporins; Eating; Female; Indomethacin; Interleukin-1; Interleuk | 1991 |
Altered macrophage activity and tumor necrosis factor: tumor necrosis and host cachexia.
Topics: Animals; Body Weight; Cachexia; Eating; Endotoxins; Macrophages; Male; Methylcholanthrene; Rats; Rat | 1989 |
Anticachectin/tumor necrosis factor-alpha antibodies attenuate development of cachexia in tumor models.
Topics: Adenocarcinoma; Animals; Cachexia; Female; Hematocrit; Immunization, Passive; Lung Neoplasms; Methyl | 1989 |