3-ketolithocholic-acid and Colonic-Neoplasms

3-ketolithocholic-acid has been researched along with Colonic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 3-ketolithocholic-acid and Colonic-Neoplasms

Article	Year
Vitamin D receptor as an intestinal bile acid sensor. Science (New York, N.Y.), 2002, May-17, Volume: 296, Issue:5571 The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We show that VDR also functions as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. VDR is an order of magnitude more sensitive to LCA and its metabolites than are other nuclear receptors. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. These studies offer a mechanism that may explain the proposed protective effects of vitamin D and its receptor against colon cancer. Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cell Line; Colonic Neoplasms; COS Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dimerization; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Histone Acetyltransferases; Humans; Intestine, Small; Ligands; Lithocholic Acid; Male; Mice; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Promoter Regions, Genetic; Rats; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors; Transfection	2002

Article

Year

Vitamin D receptor as an intestinal bile acid sensor.

Science (New York, N.Y.), 2002, May-17, Volume: 296, Issue:5571

The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We show that VDR also functions as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. VDR is an order of magnitude more sensitive to LCA and its metabolites than are other nuclear receptors. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. These studies offer a mechanism that may explain the proposed protective effects of vitamin D and its receptor against colon cancer.

Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cell Line; Colonic Neoplasms; COS Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dimerization; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Histone Acetyltransferases; Humans; Intestine, Small; Ligands; Lithocholic Acid; Male; Mice; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Promoter Regions, Genetic; Rats; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Transcription Factors; Transfection

2002