3-hydroxyproline and Retinal-Degeneration

The steps in the formal pathogenesis of proliferative vitreoretinopathy (inflammation, proliferation, the synthesis of extracellular matrix, and contraction) provide the target points for medical treatment. A survey of the relevant drugs is given. Anti-inflammatory agents (steroids, heparin) and antiproliferative agents (colchicine, daunomycin, and fluoropyrimidines) are discussed, as are anticollagen agents (penicillamin and cis-hydroxyprolin). Clinical studies were performed with colchicine, daunomycin, fluorouracil, and steroids. Our experimental and clinical data indicate that the therapeutical results might be improved by the combination of two drugs. A two-factorial, controlled clinical study is proposed, using an antiproliferative and an anti-inflammatory drug.

Topics: Blood-Retinal Barrier; Colchicine; Daunorubicin; Fluorouracil; Heparin; Humans; Hydroxyproline; Isomerism; Penicillamine; Retinal Degeneration; Steroids; Vitreous Body