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3-hydroxykynurenine and Psychotic Disorders

3-hydroxykynurenine has been researched along with Psychotic Disorders in 5 studies

3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.

Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)

Research Excerpts

ExcerptRelevanceReference
" Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist."3.85Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017)
"A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites."3.85Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017)
" In contrast, schizophrenia and psychosis are hypothesized to arise from increased metabolism of the NMDA receptor antagonist, kynurenic acid (KynA), leading to hypofunction of GABAergic interneurons, the disinhibition of pyramidal neurons and striatal hyperdopaminergia."3.85Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017)
"Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist."1.46Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017)
"Kynurenine was significantly lower in patients with PP and PD as compared to healthy postpartum women (p=0."1.43Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression. ( Bergink, V; Burgerhout, KM; Drexhage, HA; Hoogendijk, WJ; Kushner, SA; Myint, AM; Schütze, G; Schwarz, MJ; Veen, C, 2016)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wurfel, BE1
Drevets, WC1
Bliss, SA1
McMillin, JR1
Suzuki, H1
Ford, BN1
Morris, HM1
Teague, TK1
Dantzer, R1
Savitz, JB1
Curto, M1
Lionetto, L1
Fazio, F1
Corigliano, V1
Comparelli, A1
Ferracuti, S1
Simmaco, M1
Nicoletti, F1
Baldessarini, RJ1
Shilov, IuE1
Bezrukov, MV1
Veen, C1
Myint, AM1
Burgerhout, KM1
Schwarz, MJ1
Schütze, G1
Kushner, SA1
Hoogendijk, WJ1
Drexhage, HA1
Bergink, V1
Condray, R1
Dougherty, GG1
Keshavan, MS1
Reddy, RD1
Haas, GL1
Montrose, DM1
Matson, WR1
McEvoy, J1
Kaddurah-Daouk, R1
Yao, JK1

Reviews

1 review available for 3-hydroxykynurenine and Psychotic Disorders

ArticleYear
[Kynurenines in pathogenesis of endogenous psychiatric disorders].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2013, Issue:1

    Topics: Humans; Hydroxyindoleacetic Acid; Kynurenine; Mental Disorders; Psychotic Disorders; Tryptophan; Xan

2013

Trials

1 trial available for 3-hydroxykynurenine and Psychotic Disorders

ArticleYear
3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia.
    The international journal of neuropsychopharmacology, 2011, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Chromatography, High Pressu

2011

Other Studies

3 other studies available for 3-hydroxykynurenine and Psychotic Disorders

ArticleYear
Serum kynurenic acid is reduced in affective psychosis.
    Translational psychiatry, 2017, 05-02, Volume: 7, Issue:5

    Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Dep

2017
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
    Schizophrenia research, 2019, Volume: 208

    Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Ky

2019
Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression.
    Journal of affective disorders, 2016, Jan-01, Volume: 189

    Topics: Adult; Depression, Postpartum; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine;

2016