3-hydroxykynurenine has been researched along with Neurodegenerative Diseases in 4 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Boosting KYNA levels, through interference with the KP enzymes or through application of prodrugs/analogs with high bioavailability and potency, is a promising clinical approach." | 2.82 | Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword? ( Ostapiuk, A; Urbanska, EM, 2022) |
| "3-Hydroxykynurenine has been largely described as one of these toxic metabolites capable of inducing oxidative damage and cell death; consequently, this metabolite has been hypothesized to play a pivotal role in different neurological and psychiatric disorders." | 2.49 | 3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the central nervous system. ( Colín-González, AL; Maldonado, PD; Santamaría, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ostapiuk, A | 1 |
| Urbanska, EM | 1 |
| Capucciati, A | 1 |
| Galliano, M | 1 |
| Bubacco, L | 1 |
| Zecca, L | 1 |
| Casella, L | 1 |
| Monzani, E | 1 |
| Nicolis, S | 1 |
| Vecsei, L | 1 |
| Plangar, I | 1 |
| Szalardy, L | 1 |
| Colín-González, AL | 1 |
| Maldonado, PD | 1 |
| Santamaría, A | 1 |
2 reviews available for 3-hydroxykynurenine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Ky | 2022 |
3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the central nervous system.
Topics: Animals; Antioxidants; Biotransformation; Central Nervous System; Humans; Kynurenine; Neurodegenerat | 2013 |
2 other studies available for 3-hydroxykynurenine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Neuronal Proteins as Targets of 3-Hydroxykynurenine: Implications in Neurodegenerative Diseases.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Cells, Cultured; Chromatography, Liquid; Humans; Kynurenine; | 2019 |
Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?
Topics: Animals; Drug Design; Humans; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Quinolinic Aci | 2012 |