3-hydroxykynurenine has been researched along with Neuroblastoma in 5 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 7.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 3.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| "3-Hydroxykynurenine (3-HK), which is an endogenous metabolite of tryptophan in the kynurenine pathway, is a potential neurotoxin in several neurodegenerative disorders." | 1.32 | Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine. ( Choi, BS; Jeong, JH; Kim, HJ; Kim, MK; Lee, TJ; Park, ES, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wszelaki, N | 2 |
| Melzig, MF | 2 |
| Jeong, JH | 1 |
| Kim, HJ | 1 |
| Lee, TJ | 1 |
| Kim, MK | 1 |
| Park, ES | 1 |
| Choi, BS | 1 |
| Lee, MW | 1 |
| Park, SC | 1 |
| Chae, HS | 1 |
| Bach, JH | 1 |
| Lee, HJ | 1 |
| Lee, SH | 1 |
| Kang, YK | 1 |
| Kim, KY | 1 |
| Lee, WB | 1 |
| Kim, SS | 1 |
| Eastman, CL | 1 |
| Guilarte, TR | 1 |
1 review available for 3-hydroxykynurenine and Neuroblastoma
| Article | Year |
|---|---|
Cytotoxicity of 3-hydroxykynurenine: implications for CNS damage in neonatal vitamin B-6 deficiency.
Topics: Animals; Animals, Newborn; Antioxidants; Brain; Brain Chemistry; Cell Death; Hybrid Cells; Hydrolase | 1991 |
4 other studies available for 3-hydroxykynurenine and Neuroblastoma
| Article | Year |
|---|---|
Research on an in vitro cell system for testing the neurotoxicity of kynurenine pathway metabolites.
Topics: Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Survival; Coloring Agents; Fluorescent | 2011 |
Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line.
Topics: Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Dose-Response | 2012 |
Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine.
Topics: Apoptosis; Caspase 3; Caspases; Catechin; Cell Survival; Dose-Response Relationship, Drug; Humans; K | 2004 |
The protective role of HSP90 against 3-hydroxykynurenine-induced neuronal apoptosis.
Topics: Apoptosis; Bisbenzimidazole; Blotting, Western; Caspases; Cell Line; Cell Survival; Cytoprotection; | 2001 |