3-hydroxykynurenine has been researched along with Nerve Degeneration in 5 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 7.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 3.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| "These changes preceded the onset of EEG seizures, which had a mean onset of 108 h after inoculation." | 1.35 | Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. ( Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amori, L | 1 |
| Wu, HQ | 1 |
| Marinozzi, M | 1 |
| Pellicciari, R | 1 |
| Guidetti, P | 2 |
| Schwarcz, R | 3 |
| Campesan, S | 1 |
| Green, EW | 1 |
| Breda, C | 1 |
| Sathyasaikumar, KV | 1 |
| Muchowski, PJ | 1 |
| Kyriacou, CP | 1 |
| Giorgini, F | 1 |
| Wszelaki, N | 1 |
| Melzig, MF | 1 |
| Bellac, CL | 1 |
| Coimbra, RS | 1 |
| Christen, S | 1 |
| Leib, SL | 1 |
| Lehrmann, E | 1 |
| Löve, A | 1 |
| Williamson, J | 1 |
| Bertram, EH | 1 |
5 other studies available for 3-hydroxykynurenine and Nerve Degeneration
| Article | Year |
|---|---|
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.
Topics: Adenosine; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; D | 2009 |
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington | 2011 |
Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line.
Topics: Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Dose-Response | 2012 |
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Brain; Disease Models, Animal; Encephalitis; Enzyme A | 2006 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Di | 2008 |