3-hydroxykynurenine has been researched along with Disease Models, Animal in 19 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been shown that a possible pathogenetic mechanism of neurodegeneration in the mouse model of glaucoma (DBA/2J) may be an alteration of kynurenic acid (KYNA) in the retina." | 8.02 | Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma. ( Avitabile, T; Choragiewicz, T; Fiedorowicz, M; Grieb, P; Kamińska, A; Kocki, T; Nowakowska, D; Rejdak, R; Toro, MD; Turski, WA; Wertejuk, K; Wełniak-Kaminska, M; Zweifel, S, 2021) |
| "The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD)." | 7.73 | Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. ( Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B, 2006) |
| "It has been shown that a possible pathogenetic mechanism of neurodegeneration in the mouse model of glaucoma (DBA/2J) may be an alteration of kynurenic acid (KYNA) in the retina." | 4.02 | Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma. ( Avitabile, T; Choragiewicz, T; Fiedorowicz, M; Grieb, P; Kamińska, A; Kocki, T; Nowakowska, D; Rejdak, R; Toro, MD; Turski, WA; Wertejuk, K; Wełniak-Kaminska, M; Zweifel, S, 2021) |
| " Notably, the anti-parasitic drugs pyrimethamine and sulfadiazine, a standard treatment of toxoplasmosis, significantly reduced 3-HK and KYNA levels in the brain of infected mice when applied between 28 and 56 days post-infection." | 3.80 | Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia. ( Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH, 2014) |
| "The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD)." | 3.73 | Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. ( Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B, 2006) |
| "Despite advances in our understanding of endotoxic shock, novel therapeutic interventions that can reduce the burden of sepsis remain elusive." | 1.62 | 3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice. ( Ando, T; Hoshi, M; Kubo, H; Nakamoto, K; Saito, K; Tashita, C; Tezuka, H; Yamamoto, Y, 2021) |
| "These changes preceded the onset of EEG seizures, which had a mean onset of 108 h after inoculation." | 1.35 | Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. ( Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Fiedorowicz, M | 1 |
| Choragiewicz, T | 1 |
| Turski, WA | 1 |
| Kocki, T | 1 |
| Nowakowska, D | 1 |
| Wertejuk, K | 1 |
| Kamińska, A | 1 |
| Avitabile, T | 1 |
| Wełniak-Kaminska, M | 1 |
| Grieb, P | 1 |
| Zweifel, S | 1 |
| Rejdak, R | 1 |
| Toro, MD | 1 |
| Hoshi, M | 1 |
| Kubo, H | 1 |
| Ando, T | 1 |
| Tashita, C | 1 |
| Nakamoto, K | 1 |
| Yamamoto, Y | 2 |
| Tezuka, H | 1 |
| Saito, K | 2 |
| Clement, CC | 1 |
| D'Alessandro, A | 1 |
| Thangaswamy, S | 1 |
| Chalmers, S | 1 |
| Furtado, R | 1 |
| Spada, S | 1 |
| Mondanelli, G | 1 |
| Ianni, F | 1 |
| Gehrke, S | 1 |
| Gargaro, M | 1 |
| Manni, G | 1 |
| Cara, LCL | 1 |
| Runge, P | 1 |
| Tsai, WL | 1 |
| Karaman, S | 1 |
| Arasa, J | 1 |
| Fernandez-Rodriguez, R | 1 |
| Beck, A | 1 |
| Macchiarulo, A | 1 |
| Gadina, M | 1 |
| Halin, C | 1 |
| Fallarino, F | 1 |
| Skobe, M | 1 |
| Veldhoen, M | 1 |
| Moretti, S | 1 |
| Formenti, S | 1 |
| Demaria, S | 1 |
| Soni, RK | 1 |
| Galarini, R | 1 |
| Sardella, R | 1 |
| Lauvau, G | 1 |
| Putterman, C | 1 |
| Alitalo, K | 1 |
| Grohmann, U | 1 |
| Santambrogio, L | 1 |
| Wang, Z | 1 |
| Xu, R | 1 |
| Shen, G | 1 |
| Feng, J | 1 |
| Notarangelo, FM | 1 |
| Wilson, EH | 1 |
| Horning, KJ | 1 |
| Thomas, MA | 1 |
| Harris, TH | 1 |
| Fang, Q | 1 |
| Hunter, CA | 1 |
| Schwarcz, R | 6 |
| Hou, W | 1 |
| Huang, G | 1 |
| Cao, X | 1 |
| Zhang, Y | 1 |
| Zhang, J | 1 |
| Li, Y | 1 |
| Reyes-Ocampo, J | 1 |
| Ramírez-Ortega, D | 1 |
| Cervantes, GI | 1 |
| Pineda, B | 1 |
| Balderas, PM | 1 |
| González-Esquivel, D | 1 |
| Sánchez-Chapul, L | 1 |
| Lugo-Huitrón, R | 1 |
| Silva-Adaya, D | 1 |
| Ríos, C | 1 |
| Jiménez-Anguiano, A | 1 |
| Pérez-de la Cruz, V | 1 |
| Eskelund, A | 1 |
| Budac, DP | 1 |
| Sanchez, C | 1 |
| Elfving, B | 1 |
| Wegener, G | 1 |
| Liu, XC | 1 |
| Erhardt, S | 1 |
| Goiny, M | 1 |
| Engberg, G | 1 |
| Mathé, AA | 1 |
| Tashiro, T | 1 |
| Murakami, Y | 1 |
| Mouri, A | 1 |
| Imamura, Y | 1 |
| Nabeshima, T | 1 |
| Lin, HM | 1 |
| Barnett, MP | 1 |
| Roy, NC | 1 |
| Joyce, NI | 1 |
| Zhu, S | 1 |
| Armstrong, K | 1 |
| Helsby, NA | 1 |
| Ferguson, LR | 1 |
| Rowan, DD | 1 |
| Laugeray, A | 1 |
| Launay, JM | 1 |
| Callebert, J | 1 |
| Surget, A | 1 |
| Belzung, C | 1 |
| Barone, PR | 1 |
| Sathyasaikumar, KV | 2 |
| Stachowski, EK | 1 |
| Amori, L | 1 |
| Guidetti, P | 4 |
| Muchowski, PJ | 2 |
| Campesan, S | 1 |
| Green, EW | 1 |
| Breda, C | 1 |
| Kyriacou, CP | 1 |
| Giorgini, F | 1 |
| Bates, GP | 1 |
| Graham, RK | 1 |
| Hayden, MR | 1 |
| Leavitt, BR | 1 |
| MacDonald, ME | 1 |
| Slow, EJ | 1 |
| Wheeler, VC | 1 |
| Woodman, B | 1 |
| Bellac, CL | 1 |
| Coimbra, RS | 1 |
| Christen, S | 1 |
| Leib, SL | 1 |
| Lehrmann, E | 1 |
| Löve, A | 1 |
| Williamson, J | 1 |
| Bertram, EH | 1 |
| Reddy, PH | 1 |
| Tagle, DA | 1 |
| Baran, H | 1 |
| Kepplinger, B | 1 |
| Herrera-Marschitz, M | 1 |
| Stolze, K | 1 |
| Lubec, G | 1 |
| Nohl, H | 1 |
19 other studies available for 3-hydroxykynurenine and Disease Models, Animal
| Article | Year |
|---|---|
Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Genetic Diseases, Inborn; Glauc | 2021 |
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Topics: Activating Transcription Factor 4; Animals; Disease Models, Animal; Humans; Interleukin-6; Kynurenin | 2021 |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Topics: Animals; Biogenic Amines; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Endothelial Cel | 2021 |
Metabolic Response in Rabbit Urine to Occurrence and Relief of Unilateral Ureteral Obstruction.
Topics: Acetic Acid; Alanine; Analysis of Variance; Animals; Biomarkers; Citric Acid; Creatinine; Disease Mo | 2018 |
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic | 2014 |
Suppression of experimental autoimmune glomerulonephritis by tryptophan.
Topics: 3-Hydroxyanthranilic Acid; Animals; Anti-Glomerular Basement Membrane Disease; Apoptosis; CD4-Positi | 2014 |
Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production.
Topics: 3-Hydroxyanthranilic Acid; Animals; Astrocytes; Brain; Cells, Cultured; Cerebral Cortex; Disease Mod | 2015 |
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous C | 2016 |
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression.
Topics: Animals; Cerebellum; Chromatography, Liquid; Corpus Striatum; Depressive Disorder; Disease Models, A | 2017 |
Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Depressive Disorder, Major; Disease Models, Ani | 2017 |
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease.
Topics: Animals; Chromatography, Liquid; Cluster Analysis; Crohn Disease; Disease Models, Animal; Germ-Free | 2010 |
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.
Topics: Animals; Brain; Chronic Disease; Depressive Disorder, Major; Disease Models, Animal; Hydroxyindoleac | 2010 |
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.
Topics: Age Factors; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; H | 2010 |
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington | 2011 |
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Topics: Age Factors; Animals; Brain Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Di | 2006 |
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Brain; Disease Models, Animal; Encephalitis; Enzyme A | 2006 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Di | 2008 |
Early kynurenergic impairment in Huntington's disease and in a transgenic animal model.
Topics: Aged; Animals; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease; Kynurenine; M | 2000 |
Increased kynurenic acid in the brain after neonatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia; Brain; Disease Models, Animal; Kynurenic Acid; Kynurenine; Rats | 2001 |