3-hydroxykynurenine has been researched along with Deficiency, Pyridoxine in 15 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investigated the associations of PLP with metabolites of one-carbon metabolism, tryptophan catabolism, and inflammation in OC users, and evaluated the effects of OCs on these metabolites." | 9.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| "PLP is associated with biomarkers of one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in OC users." | 9.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| "We therefore explored vitamin B6 deficiency and resulting high 3-hydroxykynurenine (3-HK) levels as risk factor for nodding syndrome in Northern Uganda." | 5.43 | Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda. ( Arony, DA; Bodo, B; Moi, KL; Obol, JH; Odida, M; Odong, PO; Wanyama, R, 2016) |
| "Nodding syndrome was first reported in Uganda in 2003 among internally displaced populations." | 5.43 | Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda. ( Arony, DA; Bodo, B; Moi, KL; Obol, JH; Odida, M; Odong, PO; Wanyama, R, 2016) |
| "To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investigated the associations of PLP with metabolites of one-carbon metabolism, tryptophan catabolism, and inflammation in OC users, and evaluated the effects of OCs on these metabolites." | 5.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| "PLP is associated with biomarkers of one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in OC users." | 5.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| "We therefore explored vitamin B6 deficiency and resulting high 3-hydroxykynurenine (3-HK) levels as risk factor for nodding syndrome in Northern Uganda." | 1.43 | Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda. ( Arony, DA; Bodo, B; Moi, KL; Obol, JH; Odida, M; Odong, PO; Wanyama, R, 2016) |
| "Nodding syndrome was first reported in Uganda in 2003 among internally displaced populations." | 1.43 | Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda. ( Arony, DA; Bodo, B; Moi, KL; Obol, JH; Odida, M; Odong, PO; Wanyama, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sande, JS | 1 |
| Ulvik, A | 3 |
| Midttun, Ø | 5 |
| Ueland, PM | 6 |
| Hammer, HB | 1 |
| Valen, M | 1 |
| Apalset, EM | 1 |
| Gjesdal, CG | 1 |
| da Silva, VR | 1 |
| Rios-Avila, L | 3 |
| Lamers, Y | 1 |
| Ralat, MA | 1 |
| Quinlivan, EP | 1 |
| Garrett, TJ | 1 |
| Coats, B | 3 |
| Shankar, MN | 1 |
| Percival, SS | 1 |
| Chi, YY | 3 |
| Muller, KE | 1 |
| Stacpoole, PW | 3 |
| Gregory, JF | 3 |
| Theofylaktopoulou, D | 1 |
| Nygård, O | 1 |
| Eussen, SJ | 1 |
| Ralat, M | 1 |
| Obol, JH | 1 |
| Arony, DA | 1 |
| Wanyama, R | 1 |
| Moi, KL | 1 |
| Bodo, B | 1 |
| Odong, PO | 1 |
| Odida, M | 1 |
| Gylling, B | 1 |
| Myte, R | 1 |
| Schneede, J | 1 |
| Hallmans, G | 1 |
| Häggström, J | 1 |
| Johansson, I | 1 |
| Van Guelpen, B | 1 |
| Palmqvist, R | 1 |
| Takeuchi, F | 2 |
| Shibata, Y | 2 |
| Eastman, CL | 1 |
| Guilarte, TR | 4 |
| Ubbink, JB | 1 |
| Vermaak, WJ | 1 |
| Bissbort, SH | 1 |
| Kimoto, M | 1 |
| Ogawa, T | 1 |
| Sasaoka, K | 1 |
| Tsubouchi, R | 1 |
| Izuta, S | 1 |
| Block, LD | 1 |
| Wagner, HN | 3 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vitamin B6 Effects on One-Carbon Metabolism[NCT01128244] | Phase 2/Phase 3 | 13 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Vitamin B6 Dependence of One-Carbon Metabolism[NCT00877812] | 45 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
For all subjects, the concentration of plasma cystathionine in fasting blood samples taken before and after the supplementation period will provide a functional measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | micromol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Cystathionine Concentration | 0.14 | 0.13 |
For all subjects, the concentration of plasma pyridoxal phosphate in fasting blood samples taken before and after the supplementation period will provide a direct measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | nmol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Pyridoxal Phosphate Concentration | 25.8 | 143 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of homocysteine remethylation from serine-derived carbon before and after vitamin B6 supplementation. These flux values may be slightly higher than flux of total homocysteine remethylation in Outcome Measure 1 because of the small contribution of methionine salvage to the flux measured in Outcome Measure 2. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Homocysteine Remethylation Flux From Serine | 6.60 | 6.92 |
For all subjects, analysis of blood samples before and after vitamin B6 supplementation will allow evaluation of discriminating biomarkers using targeted metabolite profile analysis of one-carbon metabolism and tryptophan catabolism constituents. Also, we will conduct exploratory evaluation and potential identification of new biomarkers using metabolomics analysis on subjects before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: April, 2010 - June, 2014
| Intervention | microl/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Secondary Analysis: Plasma 3-hydroxykynurenine Concentration | 25.9 | 27.3 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of total remethylation of homocysteine before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Total Homocysteine Remethylation Flux | 6.07 | 5.63 |
1 review available for 3-hydroxykynurenine and Deficiency, Pyridoxine
| Article | Year |
|---|---|
Cytotoxicity of 3-hydroxykynurenine: implications for CNS damage in neonatal vitamin B-6 deficiency.
Topics: Animals; Animals, Newborn; Antioxidants; Brain; Brain Chemistry; Cell Death; Hybrid Cells; Hydrolase | 1991 |
2 trials available for 3-hydroxykynurenine and Deficiency, Pyridoxine
12 other studies available for 3-hydroxykynurenine and Deficiency, Pyridoxine
| Article | Year |
|---|---|
Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors.
Topics: Adult; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Female; Humans; Kynurenine; Longitudin | 2019 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine | 2013 |
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Topics: 3-Hydroxyanthranilic Acid; Adult; Biomarkers; Carbon; Contraceptives, Oral; Cystathionine; Dietary S | 2015 |
Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Female; Humans; Kynurenine; Logistic Mode | 2016 |
Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Colorectal Neoplasms; Female; Humans; Inflammation; K | 2017 |
Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Lyases; Male; Mixed Func | 1984 |
High-performance liquid chromatographic assay of human lymphocyte kynureninase activity levels.
Topics: 3-Hydroxyanthranilic Acid; Chromatography, High Pressure Liquid; Humans; Hydrolases; Kynurenine; Lym | 1991 |
Accumulation of 3-hydroxy-L-kynurenine sulfate and ethanolamine in urine of the rat injected with 1-aminoproline.
Topics: Animals; Ethanolamine; Ethanolamines; Kynurenine; Male; Proline; Rats; Rats, Inbred Strains; Vitamin | 1991 |
Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection.
Topics: Animals; Hydrolases; Kidney; Kynurenic Acid; Kynurenine; Liver; Lyases; Male; Rats; Rats, Inbred Str | 1989 |
The putative endogenous convulsant 3-hydroxykynurenine decreases benzodiazepine receptor binding affinity: implications to seizures associated with neonatal vitamin B-6 deficiency.
Topics: Animals; Brain; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Kynurenine; Male; Rat | 1988 |
3-Hydroxykynurenine as a possible mechanism of epileptic seizures associated with neonatal vitamin B6 deficiency.
Topics: Animals; Animals, Newborn; Brain; Epilepsy; Female; Kynurenine; Pregnancy; Rats; Synaptic Transmissi | 1986 |
Increased concentrations of 3-hydroxykynurenine in vitamin B6 deficient neonatal rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebellum; Cerebral Cortex; Chromatography, High Pressure | 1987 |