3-hydroxykynurenine has been researched along with Cataract in 9 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Age-related nuclear cataract is associated with coloration and insolubilization of lens proteins and extensive oxidation of cysteine and methionine residues." | 5.33 | 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis. ( Aquilina, JA; Hains, PG; Korlimbinis, A; Truscott, RJ, 2006) |
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 5.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "3-Hydroxykynurenine was detected at concentrations of 0." | 5.29 | Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general. ( Malina, HZ; Martin, XD, 1995) |
| "3-Hydroxykynurenine (3OHKyn), the precursor of UV filters in human lens, is highly autooxidizable, generates H2O2, and binds to lens proteins, yielding a tanned/yellow product resembling senile nuclear cataractous materials." | 3.70 | Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens. Relevance for senile nuclear cataract. ( Jamie, JF; Littlejohn, T; Takikawa, O; Truscott, RJ; Walker, MJ, 1999) |
| "The kynurenine pathway catabolite 3-hydroxykynurenine (3HK) and redox-active metals such as copper and iron are implicated in cataractogenesis." | 3.70 | 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. ( Atwood, CS; Bowden, EF; Bush, AI; Chylack, LT; Faget, KY; Goldstein, LE; Hartshorn, M; Huang, X; Leopold, MC; Lim, JT; Muffat, JA; Saunders, AJ; Scarpa, RC; Tanzi, RE, 2000) |
| "Age-related nuclear cataract is associated with coloration and insolubilization of lens proteins and extensive oxidation of cysteine and methionine residues." | 1.33 | 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis. ( Aquilina, JA; Hains, PG; Korlimbinis, A; Truscott, RJ, 2006) |
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 1.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "3-Hydroxykynurenine was detected at concentrations of 0." | 1.29 | Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general. ( Malina, HZ; Martin, XD, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Korlimbinis, A | 2 |
| Hains, PG | 1 |
| Truscott, RJ | 3 |
| Aquilina, JA | 1 |
| Malina, HZ | 2 |
| Martin, XD | 2 |
| Dhir, P | 1 |
| Akhtar, NJ | 1 |
| Sun, TX | 1 |
| Liang, JJ | 1 |
| Chiarugi, A | 1 |
| Rapizzi, E | 1 |
| Moroni, F | 2 |
| Takikawa, O | 1 |
| Littlejohn, T | 1 |
| Jamie, JF | 1 |
| Walker, MJ | 1 |
| Goldstein, LE | 1 |
| Leopold, MC | 1 |
| Huang, X | 1 |
| Atwood, CS | 1 |
| Saunders, AJ | 1 |
| Hartshorn, M | 1 |
| Lim, JT | 1 |
| Faget, KY | 1 |
| Muffat, JA | 1 |
| Scarpa, RC | 1 |
| Chylack, LT | 1 |
| Bowden, EF | 1 |
| Tanzi, RE | 1 |
| Bush, AI | 1 |
| Tomoda, A | 1 |
| Yoneyama, Y | 1 |
| Yamaguchi, T | 1 |
| Shirao, E | 1 |
| Kawasaki, K | 1 |
9 other studies available for 3-hydroxykynurenine and Cataract
| Article | Year |
|---|---|
3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis.
Topics: alpha-Crystallins; Animals; Catalysis; Cataract; Cattle; Chromatography, High Pressure Liquid; Cyste | 2006 |
Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.
Topics: Aging; Animals; Butterflies; Cataract; Humans; Kynurenine; Lens, Crystalline; Moths; Oxidation-Reduc | 2006 |
Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general.
Topics: Animals; Cataract; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Ciliary | 1995 |
Xanthurenic acid derivative formation in the lens is responsible for senile cataract in humans.
Topics: Adult; Aging; Cataract; Chromatography, Thin Layer; Crystallins; Deamination; Electrophoresis, Polya | 1996 |
Photooxidized products of recombinant alpha A-crystallin and W9F mutant.
Topics: Cataract; Crystallins; Humans; In Vitro Techniques; Kynurenine; Mutation; Oxidation-Reduction; Photo | 1999 |
The kynurenine metabolic pathway in the eye: studies on 3-hydroxykynurenine, a putative cataractogenic compound.
Topics: Alanine; Animals; Cataract; Ciliary Body; Eye; Hydrolases; Iris; Kynurenine; Kynurenine 3-Monooxygen | 1999 |
Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens. Relevance for senile nuclear cataract.
Topics: Aged; Cataract; Cell Line; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenin | 1999 |
3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction.
Topics: 3-Hydroxyanthranilic Acid; Animals; Ascorbic Acid; Cataract; Cattle; Copper; Crystallins; Electroche | 2000 |
Mechanism of coloration of human lenses induced by near-ultraviolet-photo-oxidized 3-hydroxykynurenine.
Topics: Amino Acids; Cataract; Color; Crystallins; Humans; Kynurenine; Lens Nucleus, Crystalline; Lens, Crys | 1990 |