3-hydroxykynurenine has been researched along with Bipolar Disorder in 4 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation-related changes in the concentrations of kynurenine-pathway metabolites occur in depression secondary to medical conditions but have not been well characterized in primary bipolar disorder (BD), with contradictory results potentially attributable to the presence or absence of psychosis and/or medication effects." | 7.81 | Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. ( Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE, 2015) |
| "Kynurenine is an intermediate in the inflammatory cascade and can be peripherally measured to proxy inflammatory activity." | 5.46 | Tryptophan breakdown and cognition in bipolar disorder. ( Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Hörmanseder, C; Kainzbauer, N; Maget, A; Mangge, H; Mansur, RB; McIntyre, RS; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, EZ; Schütze, G; Schwarz, MJ; Zelzer, S, 2017) |
| " Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist." | 3.85 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| "A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites." | 3.85 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| " In contrast, schizophrenia and psychosis are hypothesized to arise from increased metabolism of the NMDA receptor antagonist, kynurenic acid (KynA), leading to hypofunction of GABAergic interneurons, the disinhibition of pyramidal neurons and striatal hyperdopaminergia." | 3.85 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| "Inflammation-related changes in the concentrations of kynurenine-pathway metabolites occur in depression secondary to medical conditions but have not been well characterized in primary bipolar disorder (BD), with contradictory results potentially attributable to the presence or absence of psychosis and/or medication effects." | 3.81 | Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. ( Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE, 2015) |
| "Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist." | 1.46 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| "Kynurenine is an intermediate in the inflammatory cascade and can be peripherally measured to proxy inflammatory activity." | 1.46 | Tryptophan breakdown and cognition in bipolar disorder. ( Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Hörmanseder, C; Kainzbauer, N; Maget, A; Mangge, H; Mansur, RB; McIntyre, RS; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, EZ; Schütze, G; Schwarz, MJ; Zelzer, S, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wurfel, BE | 2 |
| Drevets, WC | 2 |
| Bliss, SA | 1 |
| McMillin, JR | 1 |
| Suzuki, H | 1 |
| Ford, BN | 2 |
| Morris, HM | 1 |
| Teague, TK | 2 |
| Dantzer, R | 2 |
| Savitz, JB | 1 |
| Platzer, M | 1 |
| Dalkner, N | 1 |
| Fellendorf, FT | 1 |
| Birner, A | 1 |
| Bengesser, SA | 1 |
| Queissner, R | 1 |
| Kainzbauer, N | 1 |
| Pilz, R | 1 |
| Herzog-Eberhard, S | 1 |
| Hamm, C | 1 |
| Hörmanseder, C | 1 |
| Maget, A | 1 |
| Rauch, P | 1 |
| Mangge, H | 1 |
| Fuchs, D | 1 |
| Zelzer, S | 1 |
| Schütze, G | 1 |
| Moll, N | 1 |
| Schwarz, MJ | 1 |
| Mansur, RB | 1 |
| McIntyre, RS | 1 |
| Reininghaus, EZ | 1 |
| Johansson, AS | 1 |
| Owe-Larsson, B | 1 |
| Asp, L | 1 |
| Kocki, T | 1 |
| Adler, M | 1 |
| Hetta, J | 1 |
| Gardner, R | 1 |
| Lundkvist, GB | 1 |
| Urbanska, EM | 1 |
| Karlsson, H | 1 |
| Savitz, J | 1 |
| Victor, TA | 1 |
| Bodurka, J | 1 |
| Bellgowan, PS | 1 |
4 other studies available for 3-hydroxykynurenine and Bipolar Disorder
| Article | Year |
|---|---|
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Dep | 2017 |
Tryptophan breakdown and cognition in bipolar disorder.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Cognition; Female; Humans; Kynurenic Acid; Kynurenine | 2017 |
Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: cytokine challenge increases production of 3-hydroxykynurenine.
Topics: Adult; Bipolar Disorder; Cells, Cultured; Cytokines; Female; Fibroblasts; Gene Expression Regulation | 2013 |
Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.
Topics: Adult; Amygdala; Bipolar Disorder; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Mi | 2015 |