3-hydroxykynurenine has been researched along with Akinetic-Rigid Variant of Huntington Disease in 11 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD)." | 7.73 | Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. ( Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B, 2006) |
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 6.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD)." | 3.73 | Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. ( Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B, 2006) |
| "Boosting KYNA levels, through interference with the KP enzymes or through application of prodrugs/analogs with high bioavailability and potency, is a promising clinical approach." | 2.82 | Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword? ( Ostapiuk, A; Urbanska, EM, 2022) |
| "Quinolinic acid is an agonist at the population of glutamate receptors which are sensitive to N-methyl-D-aspartate (NMDA), and kynurenic acid is an antagonist at several glutamate receptors." | 2.42 | Tryptophan metabolites and brain disorders. ( Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW, 2003) |
| "3-Hydroxykynurenine was substantially and significantly increased in all three brain areas studied in Huntington's disease, but not significantly increased in the cortex in Alzheimer's disease, when compared to matched controls." | 1.28 | Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease. ( Pearson, SJ; Reynolds, GP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ostapiuk, A | 1 |
| Urbanska, EM | 1 |
| Winkler, D | 1 |
| Beconi, M | 1 |
| Toledo-Sherman, LM | 1 |
| Prime, M | 1 |
| Ebneth, A | 1 |
| Dominguez, C | 1 |
| Muñoz-Sanjuan, I | 1 |
| Sathyasaikumar, KV | 2 |
| Stachowski, EK | 1 |
| Amori, L | 1 |
| Guidetti, P | 4 |
| Muchowski, PJ | 2 |
| Schwarcz, R | 5 |
| Campesan, S | 1 |
| Green, EW | 1 |
| Breda, C | 1 |
| Kyriacou, CP | 1 |
| Giorgini, F | 1 |
| Stone, TW | 1 |
| Mackay, GM | 1 |
| Forrest, CM | 1 |
| Clark, CJ | 1 |
| Darlington, LG | 1 |
| Bates, GP | 1 |
| Graham, RK | 1 |
| Hayden, MR | 1 |
| Leavitt, BR | 1 |
| MacDonald, ME | 1 |
| Slow, EJ | 1 |
| Wheeler, VC | 1 |
| Woodman, B | 1 |
| Guilarte, TR | 1 |
| Eastman, CL | 1 |
| Reddy, PH | 1 |
| Tagle, DA | 1 |
| Pearson, SJ | 2 |
| Reynolds, GP | 2 |
2 reviews available for 3-hydroxykynurenine and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Ky | 2022 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; | 2003 |
9 other studies available for 3-hydroxykynurenine and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).
Topics: Animals; Cell Line; CHO Cells; Chromatography, Liquid; Cricetulus; Dogs; Drug Discovery; Enzyme Assa | 2013 |
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.
Topics: Age Factors; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; H | 2010 |
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington | 2011 |
3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease?
Topics: Aged; Animals; Butyrates; Case-Control Studies; Cerebellum; Corpus Striatum; Frontal Lobe; Humans; H | 2003 |
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Topics: Age Factors; Animals; Brain Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Di | 2006 |
Is 3-hydroxykynurenine an endogenous neurotoxin in Huntington's disease?
Topics: Humans; Huntington Disease; Kynurenine; Neurotoxins | 1993 |
Early kynurenergic impairment in Huntington's disease and in a transgenic animal model.
Topics: Aged; Animals; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease; Kynurenine; M | 2000 |
Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease.
Topics: Aged; Alzheimer Disease; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Female; Humans; Huntingt | 1992 |
Increased brain 3-hydroxykynurenine in Huntington's disease.
Topics: Brain Chemistry; Cerebral Cortex; Humans; Huntington Disease; Kynurenine; Tryptophan | 1989 |