3-hydroxykynurenine has been researched along with Aging in 16 studies
3-hydroxykynurenine: RN given refers to cpd without isomeric designation
3-hydroxykynurenine : A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
hydroxykynurenine : A hydroxy-amino acid that is kynurenine substituted by a single hydroxy group at unspecified position. A "closed" class.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 5.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway." | 3.79 | A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. ( Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE, 2013) |
| "ARN cataract is also characterized by extensive oxidation, insolubilization, and cross-linking of polypeptides, particularly in the nucleus of the lens." | 1.33 | Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. ( Korlimbinis, A; Truscott, RJ, 2006) |
| "Beta-benzoylacrylic acid was readily reduced in lenses." | 1.30 | UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside. ( Bova, LM; Jamie, JF; Truscott, RJ; Wood, AM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Theofylaktopoulou, D | 2 |
| Midttun, Ø | 2 |
| Ulvik, A | 2 |
| Ueland, PM | 2 |
| Tell, GS | 1 |
| Vollset, SE | 1 |
| Nygård, O | 2 |
| Eussen, SJ | 2 |
| de Bie, J | 1 |
| Guest, J | 1 |
| Guillemin, GJ | 1 |
| Grant, R | 1 |
| Rakete, S | 1 |
| Nagaraj, RH | 1 |
| Tsentalovich, YP | 1 |
| Sherin, PS | 1 |
| Kopylova, LV | 1 |
| Cherepanov, IV | 1 |
| Grilj, J | 1 |
| Vauthey, E | 1 |
| Korlimbinis, A | 2 |
| Truscott, RJ | 4 |
| Aquilina, JA | 1 |
| Malina, HZ | 1 |
| Martin, XD | 1 |
| Ceresoli, G | 1 |
| Guidetti, P | 1 |
| Schwarcz, R | 1 |
| Dillon, J | 4 |
| Skonieczna, M | 1 |
| Mandal, K | 1 |
| Paik, D | 1 |
| Bova, LM | 2 |
| Wood, AM | 1 |
| Jamie, JF | 2 |
| Gaillard, ER | 2 |
| Zheng, L | 1 |
| Merriam, JC | 1 |
| Sweeney, MH | 1 |
| Ervin, LA | 1 |
| Atherton, SJ | 1 |
| Guilarte, TR | 1 |
| Wagner, HN | 1 |
1 trial available for 3-hydroxykynurenine and Aging
| Article | Year |
|---|---|
Substrate product ratios of enzymes in the kynurenine pathway measured in plasma as indicators of functional vitamin B-6 status.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Cross-Sectional Studies; Female; Humans; Hydrola | 2013 |
15 other studies available for 3-hydroxykynurenine and Aging
| Article | Year |
|---|---|
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inf | 2013 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynureni | 2016 |
Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification.
Topics: Aging; Eye Proteins; Humans; Kynurenine; Lens, Crystalline; Protein Processing, Post-Translational; | 2016 |
Photochemical properties of UV Filter molecules of the human eye.
Topics: Aging; Chromatography, High Pressure Liquid; Glucosides; Glutathione; Humans; Kynurenine; Lens, Crys | 2011 |
Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract.
Topics: Aging; Animals; Butterflies; Cataract; Humans; Kynurenine; Lens, Crystalline; Moths; Oxidation-Reduc | 2006 |
Protein-bound UV filters in normal human lenses: the concentration of bound UV filters equals that of free UV filters in the center of older lenses.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Crystallins | 2007 |
Xanthurenic acid derivative formation in the lens is responsible for senile cataract in humans.
Topics: Adult; Aging; Cataract; Chromatography, Thin Layer; Crystallins; Deamination; Electrophoresis, Polya | 1996 |
Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections.
Topics: Aging; Animals; Brain; Corpus Striatum; Functional Laterality; Glutamate Decarboxylase; Ibotenic Aci | 1997 |
The photochemical attachment of the O-glucoside of 3-hydroxykynurenine to alpha-crystallin: a model for lenticular aging.
Topics: Aging; Chromatography, High Pressure Liquid; Crystallins; Glucosides; Humans; In Vitro Techniques; K | 1999 |
UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside.
Topics: Acrylates; Adult; Aging; Benzoates; Chromatography, High Pressure Liquid; Deamination; Fetus; Glucos | 1999 |
Age-related changes in the absorption characteristics of the primate lens.
Topics: Absorption; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Child; Child, Preschool; Cry | 2000 |
Major changes in human ocular UV protection with age.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Glucosides; | 2001 |
Photochemically modified alpha-crystallin: a model system for aging in the primate lens.
Topics: Aging; Animals; Cattle; Crystallins; In Vitro Techniques; Kynurenine; Lens, Crystalline; Models, Bio | 2001 |
Time resolved spectroscopic studies on the intact human lens.
Topics: Aging; Crystallins; Humans; Kynurenine; Lens, Crystalline; Spectrometry, Fluorescence | 1990 |
Increased concentrations of 3-hydroxykynurenine in vitamin B6 deficient neonatal rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebellum; Cerebral Cortex; Chromatography, High Pressure | 1987 |