3-hydroxyflavone has been researched along with Disease Models, Animal in 99 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (7.07) | 29.6817 |
| 2010's | 67 (67.68) | 24.3611 |
| 2020's | 25 (25.25) | 2.80 |
| Authors | Studies |
|---|---|
| Abukhalil, MH; Al Hroob, AM; Althunibat, OY; Bin-Jumah, M; Germoush, MO; Mahmoud, AM | 1 |
| Aslan, H; Başoğlu, MS; Bingölballı, AG; Eren, E; Katılmış, H; Oztürkcan, S | 1 |
| Chen, X; Huo, Y; Li, H; Liu, Y; Ma, W; Shi, P; Tian, X; Wang, H; Xie, L; Zhang, J | 1 |
| Boyina, HK; Kalakotla, S; Pasangulapati, JP; Perumal, V; Ravula, AR; Teegala, SB | 1 |
| Chen, M; Feng, L; Li, Z; Ou, C; Que, D; Wei, J; Yan, J; Yang, P; Zhang, X; Zhong, X | 1 |
| An, L; Huang, J; Lu, G; Zhang, X; Zhu, D | 1 |
| Cai, G; Hou, L; Hu, CY; Huang, B; Jiang, F; Jiang, Y; Liu, D; Wang, C; Zheng, W | 1 |
| Chikenji, TS; Fujimiya, M; Miura, N; Miyajima, M; Saito, Y; Sato, T; Yamamoto, S | 1 |
| Chen, S; Ding, H; Li, X; Li, Y; Luo, E; Wen, Y; Zeng, H; Zhang, S; Zhong, W | 1 |
| Dinda, AK; Joshi, B; Reeta, KH; Sharma, U; Singh, D; Upadhyay, D; Wasan, H | 1 |
| Feng, P; Shu, S; Zhao, F | 1 |
| Cao, G; Cao, Z; Liu, Z; Shi, Y; Sun, R; Xu, Q; Yang, N; Zhang, C | 1 |
| Chen, J; Hu, Y; Li, Y; Qi, K; Wang, R; Wei, Y | 1 |
| Chan, EC; Edgley, AJ; Fan Gaskin, JC; Kong, RCK; Peshavariya, HM; Shah, MH | 1 |
| Ahn, J; Chang, SC; Ha, NC; Hong, DG; Kim, J; Lee, H; Lee, J; Lee, M; Lee, S; Yang, S | 1 |
| Wang, H; Wang, W | 1 |
| Gan, S; Ge, X; Li, B; Liu, L; Yu, H; Zhou, H | 1 |
| Bai, X; Guo, L; Luo, Q; Tan, K | 1 |
| Chen, G; Dai, X; Feng, J; Ge, C; Hu, LF; Kuang, Q; Lai, L; Li, H; Long, T; Sun, Y; Tan, J; Tang, T; Xiong, M; Xu, M; Yang, Q; Yi, C; Zhan, J; Zhong, S | 1 |
| Cao, T; Guo, CH; Waddington, JL; Zhen, XC; Zheng, LT | 1 |
| Dai, W; Jia, S; Li, Y | 1 |
| Li, BR; Wang, L; Xiao, ZY; Yu, XD; Zhao, JL | 1 |
| Kang, J; Oteiza, PI; Wang, Z | 1 |
| Awasthi, A; Corrie, L; Kapoor, B; Kaur, J; Khurana, N; Khurana, S; Khursheed, R; Kumar, R; Sharma, N; Singh, SK; Verma, S; Vyas, M | 1 |
| Bondonno, CP; Bondonno, NP; Cassidy, A; Croft, KD; Dalgaard, F; Hodgson, JM; Lewis, JR; Parmenter, BH; Scalbert, A | 1 |
| Kieu, T; Robbins, PD; Wong, A | 1 |
| Chenxu, G; Jun, T; Linfeng, H; Mingxin, X; Minxuan, X; Qin, K; Xianling, D; Yan, S | 1 |
| Armstrong, S; Beausejour, C; Beltran, PJ; Buscarlet, M; Cagnone, G; Chaney, SY; Crespo-Garcia, S; Dasgupta, S; Dejda, A; Dogan, T; Dubrac, A; Fournier, F; Girouard, G; Guber, V; Joyal, JS; Juneau, R; Mallette, FA; Marquess, D; O'Brien, R; Patel, P; Pilon, F; Rao, SR; Ryan, RD; Sapieha, P; Tsuruda, PR; Wilson, AM; Yohn, CB | 1 |
| Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L | 1 |
| Cai, Y; Chen, X; Ding, C; Liu, W; Liu, X; Sun, S; Zhang, J; Zhang, Y; Zhao, Y | 1 |
| Fang, S; Huang, S; Wang, C; Xu, B; Zhang, H; Zhang, Y | 1 |
| Chen, X; Liu, TT; Tang, K; Xu, XL; Zeng, Y; Zhang, W | 1 |
| Armando, A; Currais, A; Dargusch, R; Farrokhi, C; Maher, P; Quehenberger, O; Schubert, D | 1 |
| Li, W; Qi, ZW; Sun, LC; Wen, QK; Yan, ST; Zhang, GQ; Zhang, HB; Zhi, LD | 1 |
| Chua, BHL; Gong, S; Hamdy, RC; Lu, J; Shi, H; Wang, B; Wang, Y; Xu, X; Yang, L | 1 |
| Beshah, E; Davis, CD; Jang, S; Lakshman, S; Molokin, A; Solano-Aguilar, GI; Urban, JF; Vinyard, BT; Xie, Y | 1 |
| Kirby, BP; Ren, Z; Waddington, JL; Yan, P; Yang, H; Zhao, Y; Zhen, X; Zhu, L | 1 |
| Li, Q; Wang, J; Wu, X; Xie, J; Xu, Y; Yu, J; Zeng, Z; Zhu, X | 1 |
| Che, JH; Cho, SD; Choi, CS; Choo, GS; Jung, JY; Kim, BS; Kim, HJ; Kim, SK; Lee, HN; Nam, JS; Park, BK; Park, YS; Shin, SA | 1 |
| Bombardi Duarte, AC; de Oliveira, CTP; di Camilo Orfali, G; Priolli, DG; Santana, MG | 1 |
| Lu, C; Xiao, Z; Yu, J; Zhang, Y; Zhao, R | 1 |
| Jung, UJ; Kim, SR | 1 |
| Cheng, JL; Feng, HL; Jiang, HQ; Liang, WW; Wang, SY; Wang, TH; Wang, XD; Wang, Y; Yang, YQ; Zhang, CT | 1 |
| Huang, W; Li, ML; Shao, JY; Xia, MY | 1 |
| Chen, C; Cui, J; Liu, B; Yao, L | 1 |
| Bi, H; Chu, J; Li, L; Ren, M; Wang, J; Wang, X | 1 |
| Chen, JF; Du, YH; Feng, J; He, GQ; Liu, Y; Liu, YJ; Wang, JX; Wang, KJ; Zhang, W; Zheng, M | 1 |
| Han, J; Meng, F; Qu, D; Wang, D; Xu, M; Zhang, X; Zheng, Q | 1 |
| Chen, M; Huang, B; Li, Y; Shu, W; Yao, Y | 1 |
| Li, YS; Xu, SP | 1 |
| Chen, X; Cheng, K; Cui, C; Jia, XB; Qiao, CM; Shen, YQ; Sun, MF; Xu, YD; Yang, XS; Zhang, PH; Zhou, ZL; Zhu, YL | 1 |
| Guo, J; Liu, LH; Qu, CH; Sun, P; Wang, CX; Wang, SH; Yin, JB | 1 |
| Guo, L; Yan, X; Zhang, H | 1 |
| Bi, H; Chu, Q; Wang, C; Yu, H; Yuan, B | 1 |
| Fu, T; Li, L; Qin, J; Shen, J | 1 |
| Chen, L; Hu, C; Jia, Y; Liu, X; Pan, L; Wang, Y; You, L; Zhang, J; Zhao, L | 1 |
| Bi, X; Han, W; He, T; Jiang, W; Li, Y; Liu, C; Liu, Y; Xiao, T; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, B; Zhang, J; Zhao, J | 1 |
| El-Horany, HE; Gaballah, HH; Helal, DS | 1 |
| Bai, XJ; Gao, W; Li, ZF; Liu, QX; Liu, T; Liu, XH; Wang, YC; Xu, XE; Zheng, Q | 1 |
| Hui, SC; Kang, C; Lang, HD; Mi, MT; Wang, XL; Yi, L; Zhang, Y; Zhou, M; Zhu, XH | 1 |
| Chang, Y; Liang, C; Liang, G; Nie, Y; Xiao, D; Zeng, S; Zhan, S; Zheng, Q; Zheng, X | 1 |
| Coxam, V; Guicheux, J; Léotoing, L; Miot-Noirault, E; Wauquier, F; Wittrant, Y | 1 |
| Bishayee, K; Boujedaini, N; Khuda-Bukhsh, AR; Mukherjee, A; Sikdar, S | 1 |
| Jackson, DE; Linden, MD; Mosawy, S; Woodman, OL | 2 |
| Guo, XL; Liu, JY; Liu, RL; Lv, QQ; Wu, WJ; Yang, YP; Zhang, JX; Zhou, DS | 1 |
| Liang, J; Lindemeyer, AK; López-Valdés, HE; Martínez-Coria, H; Olsen, RW; Shao, XM; Shen, Y | 1 |
| Baltaci, AK; Caliskan, M; Demir, EA; Mogulkoc, R; Nurullahoglu Atalik, KE; Oz, M | 1 |
| Leo, CH; Woodman, OL | 1 |
| Cho, H; Elmaleh, DR; Hori, Y; Hudry, E; Hyman, BT; Irimia, D; Shoup, TM; Takahashi, K; Takeda, S; Wegmann, S | 1 |
| Cui, WG; Ma, Q; Wang, C; Zhao, X; Zhou, WH | 1 |
| Boya, P; Esteban-Martínez, L; Figueiredo-Pereira, C; Garcia-Ledo, L; Mauro-Lizcano, M; Seco, E; Serrano-Puebla, A; Vieira, HL | 1 |
| Chen, TM; Dai, D; Hu, LP; Lan, Q; Liu, B; Liu, J; Xie, J; Zhang, QY; Zhang, WD; Zhu, RZ | 1 |
| Hu, ZY; Li, XL; Liu, X; Ma, Q; Wang, C; Zhao, X; Zhou, DS; Zhou, WH | 1 |
| Cheng, CW; Hsieh, YH; Lin, CL; Lin, MT; Lin, TY; Tsai, JP; Wu, CC; Yang, SF | 1 |
| Jiao, P; Liu, Q; Wang, JT; Zhou, Y | 1 |
| Kumar, JM; Sahu, BD; Sistla, R | 1 |
| Das, J; Sharma, D; Singh, R | 1 |
| Avula, B; Belló, C; Beltrame, FL; Campagnoli, EB; Fernandes, D; Justo, ADS; Khan, IA; Kitagawa, RR; Lara, JE; Lemes, BM; Minozzo, BR; Nunes, OC; Petry, VEK; Vellosa, JCR | 1 |
| Adhami, VM; Gong, Y; Khan, MI; Lall, RK; Lucey, JA; Mukhtar, H; Syed, DN | 1 |
| Chen, J; Li, S; Liu, L; Wang, D; Zhu, X | 1 |
| Chen, H; Chen, W; Duan, RS; Li, FF; Li, H; Li, YB; Meng, QF; Sun, SM; Wang, CC; Wang, YJ; Yue, LT; Zhang, CJ; Zhang, M; Zhang, P; Zhang, Z | 1 |
| Adhami, VM; Mukhtar, E; Mukhtar, H; Siddiqui, IA; Verma, AK | 1 |
| Chen, J; Chen, Y; Chi, X; Guo, D; Jiang, Y; Jiang, Z; Lin, J; Lv, L; Pi, H; Qin, W; Yang, H | 1 |
| Choi, DY; Huh, JE; Jeon, G; Lee, JD; Park, DS; Woo, HS; Yang, HR | 1 |
| Gong, ZH; Li, YF; Liu, YQ; Zhang, LM; Zhang, YZ; Zhao, YM | 1 |
| Gross, HB; Kalgaonkar, S; Keen, CL; Yokoyama, W | 1 |
| Bodai, L; Dargusch, R; Gerard, PE; Maher, P; Marsh, JL; Purcell, JM | 1 |
| Chen, L; Lan, Z; Li, F; Li, P; Yang, Z; Zhang, C; Zhang, X; Zhou, Y | 1 |
| An, Y; Du, X; Huang, W; Li, S; Lin, M; Pan, J; Wang, Q; Xu, Y; Zhao, X; Zhen, L; Zhu, J | 1 |
| Gonzalez, C; Liang, J; Lindemeyer, AK; Olsen, RW; Shao, XM; Shen, Y; Spigelman, I | 1 |
| Arumugam, TV; Birkenmayer, G; Gelderblom, M; Gerloff, C; Lewerenz, J; Leypoldt, F; Ludewig, P; Magnus, T; Maher, P; Orozco, D; Thundyil, J; Tolosa, E | 1 |
| Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS | 1 |
| Chen, LF; Wang, XH; Wang, XQ; Yang, XM | 1 |
| Cogolludo, A; Duarte, J; Ibarra, M; Moreno, L; Perez-Vizcaino, F; Tamargo, J; Vera, R | 1 |
| Aruoma, OI; Datla, KP; Dexter, DT; Parkar, S; Rai, DK; Zbarsky, V | 1 |
| Callaway, JK; Dusting, GJ; Jarrott, B; Roulston, CL; Woodman, OL | 1 |
| Aquino, R; Capasso, A; Saturnino, P; Simone, FD | 1 |
| Cornish, KM; Sanderson, J; Williamson, G | 1 |
5 review(s) available for 3-hydroxyflavone and Disease Models, Animal
| Article | Year |
|---|---|
Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Flavonols; Glycation End Products, Advanced; Glycolysis; Humans; Long-Term Potentiation; Memory; Nervous System Diseases; Oxidative Stress; Phosphorylation; Signal Transduction | 2021 |
An overview and update on the epidemiology of flavonoid intake and cardiovascular disease risk.
Topics: Animals; Anthocyanins; Cardiovascular Diseases; Diet; Disease Models, Animal; Flavonoids; Flavonols; Humans; Meta-Analysis as Topic; Observational Studies as Topic; Randomized Controlled Trials as Topic | 2020 |
Literature Evidence and ARRIVE Assessment on Neuroprotective Effects of Flavonols in Neurodegenerative Diseases' Models.
Topics: Animals; Disease Models, Animal; Flavonols; Humans; Neurodegenerative Diseases; Neuroprotective Agents | 2018 |
Beneficial Effects of Flavonoids Against Parkinson's Disease.
Topics: Animals; Anthocyanins; Antioxidants; Antiparkinson Agents; Catechin; Cell Line; Corpus Striatum; Disease Models, Animal; Dopamine; Flavanones; Flavones; Flavonoids; Flavonols; Humans; Isoflavones; Kaempferols; Neuroprotective Agents; Oxidative Stress; Parkinson Disease | 2018 |
Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Agents; Diabetes Mellitus; Diabetic Angiopathies; Disease Models, Animal; Endothelium, Vascular; Flavonols; Humans; Hypoglycemic Agents; Oxidative Stress; Protein Kinase Inhibitors; Signal Transduction; Vasodilation; Vasodilator Agents | 2015 |
94 other study(ies) available for 3-hydroxyflavone and Disease Models, Animal
| Article | Year |
|---|---|
Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy.
Topics: Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Flavonoids; Flavonols; Glycated Hemoglobin; Heart Function Tests; Hyperglycemia; Hyperlipidemias; Inflammation; Male; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Streptozocin | 2019 |
Prevention of cisplatin ototoxicity: Efficacy of micronized flavonoid fraction in a guinea pig model.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cochlea; Diosmin; Disease Models, Animal; Ear Diseases; Female; Flavonoids; Guinea Pigs; Otoacoustic Emissions, Spontaneous | 2012 |
The role of miR-199b-3p in regulating Nrf2 pathway by dihydromyricetin to alleviate septic acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Disease Models, Animal; Flavonols; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; MicroRNAs; NF-E2-Related Factor 2; Sepsis | 2021 |
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling.
Topics: Animals; Aorta; Aortic Diseases; Cells, Cultured; Disease Models, Animal; Flavonols; Humans; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteogenesis; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction; Vascular Calcification | 2021 |
Isoastilbin inhibits neuronal apoptosis and oxidative stress in a rat model of ischemia-reperfusion injury in the brain: Involvement of SIRT1/3/6.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Disease Models, Animal; Flavonols; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Sirtuin 1 | 2022 |
Dihydromyricetin resists inflammation-induced muscle atrophy via ryanodine receptor-CaMKK-AMPK signal pathway.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Body Composition; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility; Flavonols; Glucose; Inflammation; Male; Mice; Molecular Imaging; Muscle, Skeletal; Muscular Atrophy; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior.
Topics: Animals; Behavior, Animal; Cell Line; Cellular Senescence; Depression; Disease Models, Animal; Female; Flavonols; Hippocampus; Lupus Erythematosus, Systemic; Mice; Mice, Inbred MRL lpr; Neurons; Senescence-Associated Secretory Phenotype; Senotherapeutics | 2021 |
Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Flavonols; Inflammasomes; Male; Mitophagy; Neuroinflammatory Diseases; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Sepsis-Associated Encephalopathy | 2022 |
Dihydromyricetin alleviates cerebral ischemia-reperfusion injury by attenuating apoptosis and astrogliosis in peri-infarct cortex.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Flavonols; Gliosis; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2022 |
Anti-osteoporosis Effect of Fisetin against Ovariectomy Induced Osteoporosis in Rats: In silico, in vitro and in vivo Activity.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Antioxidants; Bone Density; Cell Line; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Flavonols; Humans; Osteoporosis, Postmenopausal; Osteoprotegerin; Ovariectomy; Phytotherapy; RANK Ligand; Rats, Sprague-Dawley; Receptors, Calcitriol; Receptors, Estrogen | 2022 |
Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis.
Topics: Animals; Cytokines; Dendritic Cells; Disease Models, Animal; Flavonols; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Flavonols; Hypoxia-Inducible Factor 1, alpha Subunit; Illness Behavior; Lipopolysaccharides; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-akt; Signal Transduction; Toll-Like Receptor 4 | 2022 |
Inhibitory Effects of 3',4'-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts.
Topics: Animals; Collagen; Disease Models, Animal; Fibroblasts; Filtering Surgery; Flavonols; Glaucoma; Humans; Mice; Mice, Inbred C57BL; Mitomycin; Tenon Capsule | 2022 |
Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson's Disease Model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dopaminergic Neurons; Extracellular Signal-Regulated MAP Kinases; Flavones; Flavonols; Food Ingredients; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; Neuroprotective Agents; Parkinson Disease | 2022 |
Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease.
Topics: Animals; Disease Models, Animal; Flavonols; Interleukin-17; Keratinocytes; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Psoriasis; Reactive Oxygen Species; Signal Transduction; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2019 |
Fisetin Alleviates Atrial Inflammation, Remodeling, and Vulnerability to Atrial Fibrillation after Myocardial Infarction.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Fibrillation; Atrial Remodeling; Disease Models, Animal; Flavonoids; Flavonols; Male; Myocardial Infarction; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad3 Protein; Transcription Factor RelA | 2019 |
Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy.
Topics: Animals; Autophagy; Cells, Cultured; Diabetic Nephropathies; Disease Models, Animal; Flavonols; MicroRNAs; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Signal Transduction; Transfection | 2020 |
Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Echocardiography; Fibrosis; Flavonoids; Flavonols; Glucose Tolerance Test; Heart; Heart Diseases; Inflammation; Insulin; Insulin Resistance; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Rats; Rats, Wistar; Signal Transduction | 2020 |
Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson's disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; DEAD-box RNA Helicases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flavonols; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Morpholines; Oxidopamine; Parkinson Disease; Receptors, sigma; Ribonuclease III; Sigma-1 Receptor; Tamoxifen | 2020 |
Fisetin Modulates Human Oral Squamous Cell Carcinoma Proliferation by Blocking PAK4 Signaling Pathways.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Disease Models, Animal; Down-Regulation; Drug Screening Assays, Antitumor; Flavonoids; Flavonols; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neoplasms, Experimental; p21-Activated Kinases; Signal Transduction; Tumor Cells, Cultured | 2020 |
[Dihydromyricetin ameliorates chronic social defeat stress induced cognitive and affective disorder in mice].
Topics: Animals; Anxiety; Depression; Disease Models, Animal; Flavonols; Hippocampus; Learning; Memory; Mice; Mice, Inbred C57BL; Mood Disorders; Random Allocation; Sirtuin 1; Stress, Psychological | 2019 |
(-)-Epicatechin mitigates high fat diet-induced neuroinflammation and altered behavior in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Brain Diseases; Catechin; Diet, High-Fat; Disease Models, Animal; Flavonols; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL | 2020 |
Enhanced oral bioavailability and neuroprotective effect of fisetin through its SNEDDS against rotenone-induced Parkinson's disease rat model.
Topics: Administration, Oral; Animals; Biological Availability; Disease Models, Animal; Female; Flavonols; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone | 2020 |
The Ercc
Topics: Aging; Animals; Apoptosis; Cellular Senescence; Cockayne Syndrome; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Endonucleases; Flavonols; Mice; Xeroderma Pigmentosum | 2020 |
Fisetin protects against high fat diet-induced nephropathy by inhibiting inflammation and oxidative stress via the blockage of iRhom2/NF-κB signaling.
Topics: Animals; Carrier Proteins; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Flavonoids; Flavonols; Gene Expression Regulation; Humans; Inflammation; Kidney Diseases; Macrophages; Male; Mice; NF-kappa B; Obesity; Oxidative Stress; Signal Transduction | 2021 |
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.
Topics: Animals; Apoptosis; bcl-X Protein; Cellular Senescence; Collagen Type I, alpha 1 Chain; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Endothelial Cells; Female; Flavonols; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Pathologic; Retinal Diseases; Tacrolimus | 2021 |
Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Blood Glucose; Carboxymethylcellulose Sodium; Catalase; Disease Models, Animal; Estradiol; Female; Flavonols; Gene Expression; Glutathione Peroxidase; Humans; Insulin; Letrozole; Metformin; Ovary; Polycystic Ovary Syndrome; Progesterone; Rats; Rats, Wistar; Sirtuin 1; Steroid 17-alpha-Hydroxylase; Superoxide Dismutase; Testosterone | 2021 |
Astilbin ameliorates oxidative stress and apoptosis in D-galactose-induced senescence by regulating the PI3K/Akt/m-TOR signaling pathway in the brains of mice.
Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Body Weight; Brain; Catalase; Disease Models, Animal; Flavonols; Galactose; Gastrointestinal Microbiome; Male; Malondialdehyde; Mice, Inbred ICR; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Superoxide Dismutase; TOR Serine-Threonine Kinases | 2021 |
Anti‑inflammatory effects of dihydromyricetin in a mouse model of asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Flavonols; Goblet Cells; Immunoglobulin E; Immunoglobulin G; Mice; Mucus; Ovalbumin | 2017 |
Dihydromyricetin ameliorates atherosclerosis in LDL receptor deficient mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Aortic Diseases; Atherosclerosis; Cytokines; Diet, High-Fat; Disease Models, Animal; Flavonols; Foam Cells; Genetic Predisposition to Disease; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Lipoproteins, LDL; Liver; Male; Mice; Mice, Knockout; Oxidative Stress; Phenotype; Plaque, Atherosclerotic; RAW 264.7 Cells; Receptors, LDL | 2017 |
Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse.
Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Eicosanoids; Flavonoids; Flavonols; Immunohistochemistry; Maze Learning; Metabolomics; Mice; Mice, Transgenic; Visual Perception | 2018 |
Astilbin alleviates sepsis-induced acute lung injury by inhibiting the expression of macrophage inhibitory factor in rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Flavonols; Intramolecular Oxidoreductases; Lung; Macrophage Migration-Inhibitory Factors; Macrophages, Peritoneal; Male; Rats, Sprague-Dawley; Sepsis; Survival Analysis | 2017 |
Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Flavonoids; Flavonols; Male; Mice, Inbred C57BL; Mice, Transgenic; Phosphorylation; Receptor, trkB; Signal Transduction; Stress, Psychological; Tropomyosin | 2017 |
Flavanol-Rich Cocoa Powder Interacts with Lactobacillus rhamnossus LGG to Alter the Antibody Response to Infection with the Parasitic Nematode Ascaris suum.
Topics: Animal Feed; Animals; Antibodies, Helminth; Antinematodal Agents; Ascariasis; Ascaris suum; Cacao; Cells, Cultured; Chocolate; Disease Models, Animal; Feces; Flavonols; Gastrointestinal Microbiome; Host-Pathogen Interactions; Intestines; Lacticaseibacillus rhamnosus; Lymph Nodes; Macrophages, Alveolar; Parasite Egg Count; Probiotics; Sus scrofa; Th2 Cells; Time Factors | 2017 |
Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease Models, Animal; Flavonols; Glycogen Synthase Kinase 3 beta; Hindlimb Suspension; Hippocampus; Locomotion; Male; Mice; Mice, Inbred C57BL; Stress, Psychological; Swimming | 2018 |
Dihydromyricetin prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Animals; Disease Models, Animal; Flavonols; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocytes, Smooth Muscle; Pulmonary Artery; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Vascular Remodeling | 2017 |
Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models.
Topics: Animals; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Flavonoids; Flavonols; Humans; Immunoglobulin E; Inflammation; Interleukin-6; Lipopolysaccharides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; NF-kappa B; Nitric Oxide; Quercetin; RAW 264.7 Cells | 2018 |
Astilbin emulsion improves guinea pig lesions in a psoriasis-like model by suppressing IL-6 and IL-22 via p38 MAPK.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Transformed; Disease Models, Animal; Ear; Emulsions; Flavonols; Gene Expression Regulation; Guinea Pigs; Humans; Immunologic Factors; Interleukin-17; Interleukin-22; Interleukin-6; Interleukins; Keratinocytes; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Propranolol; Psoriasis; Signal Transduction | 2018 |
Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Antioxidants; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drosophila melanogaster; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flavonols; Free Radicals; Humans; Male; Mice; Motor Activity; Mutation; Neuroprotective Agents; Superoxide Dismutase-1 | 2018 |
Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-κB signaling pathway.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Cell Count; Cytokines; Disease Models, Animal; Flavonoids; Flavonols; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Ovalbumin; Pneumonia; Signal Transduction; Toll-Like Receptor 5 | 2018 |
Fisetin Protects against Intracerebral Hemorrhage-Induced Neuroinflammation in Aged Mice.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Astrocytes; Behavior, Animal; Brain; Brain Edema; Cerebral Hemorrhage; Collagenases; Cytokines; Disease Models, Animal; Flavonoids; Flavonols; Inflammation Mediators; Male; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; NF-kappa B; Signal Transduction | 2018 |
Dihydromyricetin relieves rheumatoid arthritis symptoms and suppresses expression of pro-inflammatory cytokines via the activation of Nrf2 pathway in rheumatoid arthritis model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Flavonols; Freund's Adjuvant; Heme Oxygenase (Decyclizing); Liver; Male; Malondialdehyde; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents; Brain; Cell Line, Transformed; Cognition Disorders; Cytokines; Disease Models, Animal; Encephalitis; Flavonols; Gene Expression Regulation; Humans; Inflammasomes; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Mutation; NLR Family, Pyrin Domain-Containing 3 Protein; Presenilin-1; RNA, Messenger; Time Factors | 2018 |
Astragalin and dihydromyricetin as adjuncts to histidine‑tryptophan‑ketoglutarate cardioplegia enhances protection during cardioplegic arrest.
Topics: Animals; Apoptosis; Biomarkers; Cardioplegic Solutions; Cardiotonic Agents; Cytokines; Disease Models, Animal; Flavonols; Glucose; Heart Arrest; Heart Arrest, Induced; Hemodynamics; Inflammation Mediators; Kaempferols; Male; Mannitol; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Potassium Chloride; Procaine; Rats; Recovery of Function; Ventricular Function | 2018 |
Dihydromyricetin from ampelopsis grossedentata protects against vascular neointimal formation via induction of TR3.
Topics: Ampelopsis; Animals; Carotid Arteries; Carotid Stenosis; Cell Line; Cell Proliferation; Disease Models, Animal; Flavonols; Humans; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Nuclear Receptor Subfamily 4, Group A, Member 1; Rats | 2018 |
Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation.
Topics: Animals; Blotting, Western; Cell Differentiation; Chemokine CXCL1; Chemokine CXCL2; Disease Models, Animal; Female; Flavonoids; Flavonols; Flow Cytometry; Interleukin-1beta; Interleukin-6; Lupus Erythematosus, Systemic; Lupus Nephritis; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Terpenes; Th17 Cells; Tumor Necrosis Factor-alpha | 2018 |
Neuroprotective effects of Astilbin on MPTP-induced Parkinson's disease mice: Glial reaction, α-synuclein expression and oxidative stress.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Astrocytes; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Flavonols; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; MPTP Poisoning; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Phosphatidylinositol 3-Kinases; Substantia Nigra | 2019 |
Protective role of Dihydromyricetin in Alzheimer's disease rat model associated with activating AMPK/SIRT1 signaling pathway.
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Apoptosis; Cognition; Cytokines; Disease Models, Animal; Flavonols; Gene Expression Regulation; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Male; Maze Learning; Memory; Neurons; Nootropic Agents; Peptide Fragments; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Stereotaxic Techniques | 2019 |
Protective effect of dihydromyricetin revents fatty liver through nuclear factor‑κB/p53/B‑cell lymphoma 2‑associated X protein signaling pathways in a rat model.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Disease Models, Animal; Fatty Liver; Flavonols; Gene Expression Regulation; Humans; Inflammation; Liver; NF-kappa B; Oxidative Stress; Rats; Signal Transduction; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2019 |
Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Flavonols; Neuroprotective Agents; Neurotransmitter Agents; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Signal Transduction | 2019 |
Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma.
Topics: Animals; Antioxidants; Blotting, Western; Cytokines; Disease Models, Animal; Electroretinography; Enzyme-Linked Immunosorbent Assay; Evoked Potentials, Visual; Female; Flavonoids; Flavonols; Glaucoma; Inflammation; Intraocular Pressure; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; NF-kappa B; Retina; Retinal Ganglion Cells; Tonometry, Ocular | 2019 |
Protective effect of 7,3',4'-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Flavonoids; Flavonols; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Random Allocation; Reactive Oxygen Species | 2019 |
MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells.
Topics: Animals; Cell Line; Disease Models, Animal; Doxorubicin; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Flavonols; Glucuronidase; Humans; Kidney; Kidney Diseases; Kidney Tubules; Klotho Proteins; Mice; MicroRNAs; Signal Transduction; Transforming Growth Factor beta1; Ureteral Obstruction | 2019 |
Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats.
Topics: Animals; Cell Cycle Proteins; Diet, High-Fat; Disease Models, Animal; Female; Flavonoids; Flavonols; Gene Expression Regulation; Hepatocyte Nuclear Factor 4; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Obesity; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Rats; Signal Transduction; Sucrose; Treatment Outcome | 2019 |
Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis in Mice Model.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Flavonols; Inflammasomes; Male; Mice; Mice, Inbred BALB C; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Sepsis | 2019 |
Synergy between dihydromyricetin intervention and irinotecan chemotherapy delays the progression of colon cancer in mouse models.
Topics: Animals; Chloride Channels; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Drug Synergism; Flavonols; Humans; Irinotecan; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins | 2019 |
Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.
Topics: Animals; Antioxidants; Arthritis, Gouty; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Flavonols; Glycosides; Gout; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice, Inbred BALB C; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Smilax; Tandem Mass Spectrometry; Uric Acid | 2019 |
The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts.
Topics: Animals; Bone Density Conservation Agents; Bone Resorption; Disease Models, Animal; Dual Specificity Phosphatase 1; Flavonoids; Flavonols; Gene Expression Regulation; Humans; MAP Kinase Kinase 4; Mice; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteoporosis; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-fos; RANK Ligand; Signal Transduction | 2013 |
Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2-M and induces ROS-independent apoptosis in A549 cells, targeting nuclear DNA.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Division; Cell Survival; Disease Models, Animal; DNA, Neoplasm; Dose-Response Relationship, Drug; Flavonols; G2 Phase; Humans; Lung Neoplasms; Mice; Plant Extracts; Plant Leaves; Reactive Oxygen Species; Thuja | 2014 |
The flavonols quercetin and 3',4'-dihydroxyflavonol reduce platelet function and delay thrombus formation in a model of type 1 diabetes.
Topics: Animals; Antioxidants; Blood Platelets; Carotid Arteries; Carotid Artery Injuries; Chlorides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Exocytosis; Ferric Compounds; Flavonols; Laser-Doppler Flowmetry; Mice; Mice, Inbred C57BL; Platelet Activation; Platelet Aggregation; Quercetin; Thrombosis | 2014 |
Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Factor; Chronic Disease; Disease Models, Animal; Dopamine; Flavonols; Food Preferences; Male; Mice, Inbred C57BL; Motor Activity; Serotonin; Signal Transduction; Stress, Psychological; Swimming | 2014 |
Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anxiety; Cognition Disorders; Disease Models, Animal; Flavonols; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2014 |
3',4'-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia.
Topics: Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Exploratory Behavior; Flavonols; Injections, Intraperitoneal; Learning Disabilities; Male; Memory; Memory Disorders; Neuroprotective Agents; Pattern Recognition, Physiological; Random Allocation; Rats, Wistar; Reperfusion Injury; Spatial Learning; Time Factors | 2017 |
A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Cromolyn Sodium; Disease Models, Animal; Drug Approval; Flavonoids; Flavonols; Humans; Mice; Mice, Transgenic; Microglia; Microscopy, Electron, Transmission; Peptide Fragments; United States; United States Food and Drug Administration | 2015 |
Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system.
Topics: 5-Hydroxytryptophan; Analgesics; Animals; Behavior, Animal; Biogenic Monoamines; Disease Models, Animal; Flavonoids; Flavonols; Hyperalgesia; Locomotion; Male; Mice; Monoamine Oxidase; Neuralgia; Pain Threshold; Receptors, Serotonin; Serotonin; Spinal Cord | 2015 |
New method to assess mitophagy flux by flow cytometry.
Topics: Amino Acids; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Fibroblasts; Flavonoids; Flavonols; Flow Cytometry; HeLa Cells; Humans; Lysosomes; Mice, Inbred C57BL; Mitochondria; Mitophagy; Niacinamide; Retina; Retinitis Pigmentosa | 2015 |
Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Carbon Tetrachloride; Caspase Inhibitors; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cytochromes c; Disease Models, Animal; Flavonols; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Liver; Liver Failure, Acute; Liver Regeneration; Male; Mice, Inbred C57BL; Mitochondria, Liver; Protein Kinase Inhibitors; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: Engagement of antioxidant mechanisms and spinal GABAA receptors.
Topics: Analgesics; Animals; Antioxidants; Bicuculline; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Flavonoids; Flavonols; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Oxidative Stress; Reactive Oxygen Species; Receptors, GABA-A; Spinal Cord; Streptozocin | 2015 |
Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway.
Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Synergism; Female; Flavonoids; Flavonols; HeLa Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Niacinamide; Phenylurea Compounds; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Sorafenib; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Protective Effect of Dihydromyricetin Against Lipopolysaccharide-Induced Acute Kidney Injury in a Rat Model.
Topics: Acute Kidney Injury; Animals; Calcium; Creatinine; Disease Models, Animal; Drug Interactions; Endotoxemia; Flavonols; Hyaluronan Receptors; Kidney; Lipopolysaccharides; Male; Osteopontin; Random Allocation; Rats; Rats, Sprague-Dawley | 2016 |
Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-κB signaling.
Topics: Animals; Colitis; Disease Models, Animal; Enzyme Activation; Flavonoids; Flavonols; Glutathione; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2016 |
Antiepileptic effect of fisetin in iron-induced experimental model of traumatic epilepsy in rats in the light of electrophysiological, biochemical, and behavioral observations.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Electrophysiological Phenomena; Epilepsy, Post-Traumatic; Flavonoids; Flavonols; Hippocampus; Iron; Lipid Peroxidation; Male; Oxidative Stress; Phytochemicals; Rats; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase | 2017 |
Anti-ulcer mechanisms of polyphenols extract of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae).
Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Ellagic Acid; Ethanol; Ethnopharmacology; Euphorbia; Female; Flavonols; Gallic Acid; Gastric Mucosa; Helicobacter pylori; Indomethacin; Methanol; Phytotherapy; Plant Bark; Plant Extracts; Plants, Medicinal; Polyphenols; Rats, Wistar; Signal Transduction; Solvents; Spectrometry, Mass, Electrospray Ionization; Stomach; Stomach Ulcer; Sulfonic Acids | 2016 |
Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Flavonoids; Flavonols; Hyaluronan Receptors; Hyaluronic Acid; Male; Mice; Molecular Weight; Prostatic Neoplasms | 2016 |
The Effects of Astilbin on Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Disease Models, Animal; Flavonols; Hippocampus; Mice; Mice, Transgenic | 2017 |
Astilbin ameliorates experimental autoimmune myasthenia gravis by decreased Th17 cytokines and up-regulated T regulatory cells.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Antigens, CD; Body Weight; Cell Proliferation; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flavonols; Flow Cytometry; HLA-DR alpha-Chains; Myasthenia Gravis, Autoimmune, Experimental; Rats; Rats, Inbred Lew; Sincalide; T-Lymphocytes, Regulatory; Th17 Cells | 2016 |
Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Flavonoids; Flavonols; Humans; Male; Mice; Mice, Nude; Neoplastic Stem Cells; Prostatic Neoplasms; Taxoids; Treatment Outcome; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2016 |
Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy.
Topics: Animals; Apoptosis; Autophagy; Caspase 3; Disease Models, Animal; Flavonols; Forkhead Box Protein O3; Liver Diseases; Mice; Mice, Inbred C57BL; Phosphorylation; Protective Agents; Reperfusion Injury | 2016 |
Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Collagen Type II; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Flavonoids; Flavonols; Humans; Hypersensitivity, Delayed; Imidazoles; Interleukin-1beta; Mice; Mice, Inbred DBA; Neovascularization, Pathologic; Oxazolone; Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Rhus; Synovial Membrane; Vascular Endothelial Growth Factor A | 2009 |
CTN-986, a compound extracted from cottonseeds, increases cell proliferation in hippocampus in vivo and in cultured neural progenitor cells in vitro.
Topics: Animals; Antidepressive Agents; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Flavonols; Glycosides; Gossypium; Hippocampus; Imipramine; Immunohistochemistry; Male; Mice; Mice, Inbred ICR; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Seeds; Stem Cells; Stress, Psychological | 2009 |
Effects of a flavonol-rich diet on select cardiovascular parameters in a Golden Syrian hamster model.
Topics: Abdominal Fat; Animals; Antioxidants; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Cholesterol; Cholesterol, Dietary; Cricetinae; Diet; Dietary Fats; Disease Models, Animal; Drug Therapy, Combination; Flavonols; Heart Rate; Hypercholesterolemia; Mesocricetus; Phytotherapy; Plant Preparations; Powders; Rutin; Vaccinium macrocarpon; Vitamin E | 2010 |
ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.
Topics: Animals; Disease Models, Animal; Drosophila; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flavonols; Gene Dosage; Gene Expression Regulation; Huntingtin Protein; Huntington Disease; JNK Mitogen-Activated Protein Kinases; Mice; Motor Activity; Nerve Tissue Proteins; Neuroprotective Agents; Nuclear Proteins; PC12 Cells; Rats; Resveratrol; Stilbenes; Survival Analysis | 2011 |
Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats.
Topics: Animals; Blood Urea Nitrogen; Connective Tissue Growth Factor; Creatinine; Dinoprostone; Disease Models, Animal; Drugs, Chinese Herbal; Flavonols; Fructose; Hyperuricemia; Interleukin-1; Kidney; Kidney Diseases; Male; Phytotherapy; Rats; Rats, Sprague-Dawley; Rhizome; Smilax; Transforming Growth Factor beta1; Uric Acid; Xanthine Oxidase | 2011 |
The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Brain; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Flavonoids; Flavonols; Hindlimb Suspension; Immobility Response, Tonic; Male; Mice; Mice, Inbred ICR; Monoamine Oxidase; Norepinephrine; Random Allocation; Serotonin; Swimming | 2012 |
Dihydromyricetin as a novel anti-alcohol intoxication medication.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholic Intoxication; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Flavonols; Male; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley | 2012 |
The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.
Topics: Animals; Anti-Inflammatory Agents; Brain Infarction; Cell Line; Dendritic Cells; Disease Models, Animal; Flavonoids; Flavonols; Humans; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 4; Mice; Microglia; Neuroprotective Agents; Phosphorylation; Reperfusion Injury; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Count; Chemokines; Chitinases; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Flavonoids; Flavonols; Genes, Reporter; Inflammation; Inflammation Mediators; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucin 5AC; Mucus; NF-kappa B; Nitric Oxide Synthase Type II; Ovalbumin; Protein Transport; Tumor Necrosis Factor-alpha | 2012 |
Treatment with quercetin and 3',4'-dihydroxyflavonol inhibits platelet function and reduces thrombus formation in vivo.
Topics: Animals; Antioxidants; Disease Models, Animal; Exocytosis; Female; Flavonols; Male; Mice; Platelet Aggregation; Quercetin; Thrombosis; Time Factors | 2013 |
[Effects of dihydromyricetin on tumor necrosis factor and NF-kappaB p65 of RAU rats].
Topics: Animals; Disease Models, Animal; Female; Flavonols; Humans; Macrophages; Male; Mouth Mucosa; Rats; Rats, Sprague-Dawley; Stomatitis, Aphthous; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2012 |
Effects of the flavonoid quercetin and its methylated metabolite isorhamnetin in isolated arteries from spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Flavonols; Iliac Artery; Inhibitory Concentration 50; Male; Phytotherapy; Plants, Medicinal; Quercetin; Rats; Rats, Inbred Strains; Rats, Wistar; Vascular Resistance | 2003 |
Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antioxidants; Curcumin; Disease Models, Animal; Dopamine; Flavanones; Flavonoids; Flavonols; Homovanillic Acid; Male; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Phenols; Quercetin; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2005 |
Using behaviour to predict stroke severity in conscious rats: post-stroke treatment with 3', 4'-dihydroxyflavonol improves recovery.
Topics: Animals; Behavior, Animal; Brain Mapping; Consciousness; Cytoprotection; Disease Models, Animal; Endothelin-1; Flavonols; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Prognosis; Rats; Rats, Wistar; Reproducibility of Results; Severity of Illness Index; Time Factors | 2008 |
Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro.
Topics: Animals; Asteraceae; Disease Models, Animal; Flavonoids; Flavonols; Guinea Pigs; Ileum; Male; Medicine, Traditional; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Peru; Phytotherapy; Plant Extracts; Substance Withdrawal Syndrome | 2000 |
Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract.
Topics: Animals; Blotting, Western; Calcium; Cataract; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme Inhibitors; Flavonols; Hydrogen Peroxide; Lens, Crystalline; Male; Mass Spectrometry; Organ Culture Techniques; Oxidation-Reduction; Quercetin; Rats; Rats, Wistar; Sodium | 2002 |