3-hydroxybutyryl-coenzyme-a and Infertility--Male

3-hydroxybutyryl-coenzyme-a has been researched along with Infertility--Male* in 1 studies

Other Studies

1 other study(ies) available for 3-hydroxybutyryl-coenzyme-a and Infertility--Male

Article	Year
Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. Molecular cell, 2017, Sep-07, Volume: 67, Issue:5 Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with active transcription in mammalian cells. Here we report that the chromodomain Y-like transcription corepressor CDYL negatively regulates histone Kcr by acting as a crotonyl-CoA hydratase to convert crotonyl-CoA to β-hydroxybutyryl-CoA. We showed that the negative regulation of histone Kcr by CDYL is intrinsically linked to its transcription repression activity and functionally implemented in the reactivation of sex chromosome-linked genes in round spermatids and genome-wide histone replacement in elongating spermatids. Significantly, Cdyl transgenic mice manifest dysregulation of histone Kcr and reduction of male fertility with a decreased epididymal sperm count and sperm cell motility. Our study uncovers a biochemical pathway in the regulation of histone Kcr and implicates CDYL-regulated histone Kcr in spermatogenesis, adding to the understanding of the physiology of male reproduction and the mechanism of the spermatogenic failure in AZFc (Azoospermia Factor c)-deleted infertile men. Topics: Acyl Coenzyme A; Animals; Co-Repressor Proteins; Enoyl-CoA Hydratase; Fertility; Genetic Predisposition to Disease; HeLa Cells; Histone Acetyltransferases; Histones; Humans; Hydro-Lyases; Infertility, Male; Kinetics; Lysine; Male; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Protein Domains; Protein Processing, Post-Translational; Proteins; RNA Interference; Sf9 Cells; Sperm Count; Sperm Motility; Spermatogenesis; Spermatozoa; Testis; Transfection	2017

Article

Year

Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis.

Molecular cell, 2017, Sep-07, Volume: 67, Issue:5

Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with active transcription in mammalian cells. Here we report that the chromodomain Y-like transcription corepressor CDYL negatively regulates histone Kcr by acting as a crotonyl-CoA hydratase to convert crotonyl-CoA to β-hydroxybutyryl-CoA. We showed that the negative regulation of histone Kcr by CDYL is intrinsically linked to its transcription repression activity and functionally implemented in the reactivation of sex chromosome-linked genes in round spermatids and genome-wide histone replacement in elongating spermatids. Significantly, Cdyl transgenic mice manifest dysregulation of histone Kcr and reduction of male fertility with a decreased epididymal sperm count and sperm cell motility. Our study uncovers a biochemical pathway in the regulation of histone Kcr and implicates CDYL-regulated histone Kcr in spermatogenesis, adding to the understanding of the physiology of male reproduction and the mechanism of the spermatogenic failure in AZFc (Azoospermia Factor c)-deleted infertile men.

Topics: Acyl Coenzyme A; Animals; Co-Repressor Proteins; Enoyl-CoA Hydratase; Fertility; Genetic Predisposition to Disease; HeLa Cells; Histone Acetyltransferases; Histones; Humans; Hydro-Lyases; Infertility, Male; Kinetics; Lysine; Male; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Protein Domains; Protein Processing, Post-Translational; Proteins; RNA Interference; Sf9 Cells; Sperm Count; Sperm Motility; Spermatogenesis; Spermatozoa; Testis; Transfection

2017