Page last updated: 2024-10-17

3-hydroxybutyric acid and Weight Loss

3-hydroxybutyric acid has been researched along with Weight Loss in 47 studies

3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.

Weight Loss: Decrease in existing BODY WEIGHT.

Research Excerpts

ExcerptRelevanceReference
"Dapagliflozin is a potent and selective sodium glucose cotransporter-2 (SGLT2) inhibitor which promotes urinary glucose excretion and induces weight loss."7.78Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. ( Cullen, MJ; Devenny, JJ; Godonis, HE; Harvey, SJ; Pelleymounter, MA; Rooney, S, 2012)
"Three clinical studies were conducted: a bariatric surgery cohort study of participants with morbid obesity who underwent either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) studied over four and twelve weeks, and two randomized placebo-controlled, crossover double blind studies of liraglutide vs."5.69Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity. ( Alexandrou, A; Angelidi, AM; Connelly, MA; Kokkinos, A; Mantzoros, CS; Mingrone, G; Sanoudou, D, 2023)
" Following weight loss, circulating concentrations of glucose, insulin, non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), leptin, gastrointestinal hormones and subjective ratings of appetite were compared when subjects were ketotic, and after refeeding."3.79Ketosis and appetite-mediating nutrients and hormones after weight loss. ( Delbridge, E; Kriketos, A; Prendergast, LA; Proietto, J; Purcell, K; Shulkes, A; Sumithran, P, 2013)
"Dapagliflozin is a potent and selective sodium glucose cotransporter-2 (SGLT2) inhibitor which promotes urinary glucose excretion and induces weight loss."3.78Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. ( Cullen, MJ; Devenny, JJ; Godonis, HE; Harvey, SJ; Pelleymounter, MA; Rooney, S, 2012)
"Weight loss is effective in decreasing liver fat in subjects who are homozygous for the rs738409 PNPLA3 G or C allele."2.76Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans. ( Ferrannini, E; Gastaldelli, A; Hakkarainen, A; Kotronen, A; Lundbom, J; Lundbom, N; Olkkonen, VM; Orho-Melander, M; Perttilä, J; Rissanen, A; Sevastianova, K; Suojanen, L; Yki-Järvinen, H, 2011)
"Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out."2.71Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study. ( Boyar, K; Di Rocco, A; Heymsfield, SB; Hyams, K; Nonas, C; Vanitallie, TB, 2005)
"Progressive weight loss is a hallmark feature of Huntington's disease, yet we found that the ketogenic diet-which generally causes weight loss in normal animals-delayed the reduction in body weight of the transgenic mice."1.37A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease. ( Geiger, JD; Kawamura, M; Masino, SA; Ross, JL; Ruiz, TL; Ruskin, DN, 2011)
"Diabetic TPN rats without insulin treatment had weight loss and negative nitrogen balance during the experiment."1.30MCT/LCT emulsion ameliorate liver fat deposition in insulin-treated diabetic rats receiving total parenteral nutrition. ( Chen, WJ; Lin, MT; Yeh, SL, 1998)
" An apparent improvement in utilization of even-MCT was observed between 6 and 18 h, as evidenced by a twofold vs a sixfold increase in 3-OH-butyrate (BHBA) concentration 1 h after dosing and a twofold vs 12-fold increase in plasma fatty acid concentration."1.28Utilization of medium-chain triglycerides by neonatal piglets: II. Effects of even- and odd-chain triglyceride consumption over the first 2 days of life on blood metabolites and urinary nitrogen excretion. ( Benevenga, NJ; Crenshaw, TD; Odle, J, 1989)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.38)18.7374
1990's6 (12.77)18.2507
2000's14 (29.79)29.6817
2010's18 (38.30)24.3611
2020's6 (12.77)2.80

Authors

AuthorsStudies
Mank, MM1
Reed, LF1
Walton, CJ1
Barup, MLT1
Ather, JL1
Poynter, ME1
Nasser, S1
Solé, T1
Vega, N1
Thomas, T1
Balcerczyk, A1
Strigini, M1
Pirola, L1
Spigoni, V1
Cinquegrani, G1
Iannozzi, NT1
Frigeri, G1
Maggiolo, G1
Maggi, M1
Parello, V1
Dei Cas, A1
Angelidi, AM1
Kokkinos, A1
Sanoudou, D1
Connelly, MA1
Alexandrou, A1
Mingrone, G1
Mantzoros, CS1
Martins, C1
Nymo, S1
Coutinho, SR1
Rehfeld, JF1
Hunter, GR1
Gower, BA1
Katsuya, S1
Kawata, Y1
Goto, T1
Tsubota, J1
Sahagun, E1
Ward, LM1
Kinzig, KP1
Stekovic, S1
Hofer, SJ1
Tripolt, N1
Aon, MA1
Royer, P1
Pein, L1
Stadler, JT1
Pendl, T1
Prietl, B1
Url, J1
Schroeder, S1
Tadic, J1
Eisenberg, T1
Magnes, C1
Stumpe, M1
Zuegner, E1
Bordag, N1
Riedl, R1
Schmidt, A1
Kolesnik, E1
Verheyen, N1
Springer, A1
Madl, T1
Sinner, F1
de Cabo, R1
Kroemer, G1
Obermayer-Pietsch, B1
Dengjel, J1
Sourij, H1
Pieber, TR1
Madeo, F1
Futatani, T1
Shimao, A1
Ina, S1
Higashiyama, H1
Fujita, S1
Ueno, K1
Igarashi, N1
Hatasaki, K1
Iovane, B1
Cangelosi, AM1
Bonaccini, I1
Di Mauro, D1
Scarabello, C1
Panigari, A1
Tiri, A1
Mastrorilli, C1
Fainardi, V1
Dodi, I1
Vanelli, M1
Newman, AW1
Miller, A1
Leal Yepes, FA1
Bitsko, E1
Nydam, D1
Mann, S1
LaFountain, RA1
Miller, VJ1
Barnhart, EC1
Hyde, PN1
Crabtree, CD1
McSwiney, FT1
Beeler, MK1
Buga, A1
Sapper, TN1
Short, JA1
Bowling, ML1
Kraemer, WJ1
Simonetti, OP1
Maresh, CM1
Volek, JS1
Hughes, TE1
Kim, DD1
Marjason, J1
Proietto, J2
Whitehead, JP1
Vath, JE1
Haviland, JA1
Reiland, H1
Butz, DE1
Tonelli, M1
Porter, WP1
Zucchi, R1
Scanlan, TS1
Chiellini, G1
Assadi-Porter, FM1
Sumithran, P1
Prendergast, LA1
Delbridge, E1
Purcell, K1
Shulkes, A1
Kriketos, A1
Poff, AM1
Ari, C1
Seyfried, TN1
D'Agostino, DP1
Matoulek, M2
Svobodova, S1
Vetrovska, R1
Stranska, Z1
Svacina, S2
Chen, JY1
Tran, C1
Hwang, L1
Deng, G1
Jung, ME1
Faull, KF1
Levine, MS1
Cepeda, C1
Franco, M1
Contreras, C1
Place, NJ1
Bozinovic, F1
Nespolo, RF1
Tulipani, S1
Griffin, J1
Palau-Rodriguez, M1
Mora-Cubillos, X1
Bernal-Lopez, RM1
Tinahones, FJ1
Corkey, BE1
Andres-Lacueva, C1
Mitsuhashi, Y1
Nagaoka, D1
Ishioka, K1
Bigley, KE1
Okawa, M1
Otsuji, K1
Bauer, JE1
Ruskin, DN1
Ross, JL1
Kawamura, M1
Ruiz, TL1
Geiger, JD1
Masino, SA1
Sevastianova, K1
Kotronen, A1
Gastaldelli, A1
Perttilä, J1
Hakkarainen, A1
Lundbom, J1
Suojanen, L1
Orho-Melander, M1
Lundbom, N1
Ferrannini, E1
Rissanen, A1
Olkkonen, VM1
Yki-Järvinen, H1
Devenny, JJ1
Godonis, HE1
Harvey, SJ1
Rooney, S1
Cullen, MJ1
Pelleymounter, MA1
Swithers, SE1
McCurley, M1
Wright, GL1
Morrison, R1
Fultz, ME1
Wright, G1
Mccumbee, W1
Wehner, P1
Studeny, M1
Meckling, KA1
O'Sullivan, C1
Saari, D1
Vanitallie, TB1
Nonas, C1
Di Rocco, A1
Boyar, K1
Hyams, K1
Heymsfield, SB1
Coleman, MD1
Nickols-Richardson, SM1
Kunesová, M1
Braunerová, R1
Hlavatý, P1
Tvrzická, E1
Stanková, B1
Skrha, J1
Hilgertová, J1
Hill, M1
Kopecký, J1
Wagenknecht, M1
Hainer, V1
Parízková, J1
Zák, A1
Slater, GJ1
Rice, AJ1
Sharpe, K1
Mujika, I1
Jenkins, D1
Hahn, AG1
Salas, A1
Esteve, M1
Mar Grasa, M1
Remesar, X1
Johnston, CS1
Tjonn, SL1
Swan, PD1
White, A1
Hutchins, H1
Sears, B1
Oikawa, S1
Oetzel, GR1
Vazquez, JA1
Kazi, U1
Madani, N1
Keim, NL1
Anderson, BL1
Barbieri, TF1
Wu, MM1
Teraki, Y1
Teraki, E1
Kawashima, M1
Nagashima, M1
Shiohara, T1
Santos, GA1
Silversides, FG1
Jonsson, NN1
McGowan, MR1
McGuigan, K1
Davison, TM1
Hussain, AM1
Kafi, M1
Matschoss, A1
Yeh, SL1
Lin, MT1
Chen, WJ1
Dardzinski, BJ1
Smith, SL1
Towfighi, J1
Williams, GD1
Vannucci, RC1
Smith, MB1
Rae, A1
Bond, D1
Evans, S1
North, F1
Roberman, B1
Walters, B1
Ivany, JM1
Anderson, DE1
Tornquist, SJ1
Cebra, CK1
Van Saun, RJ1
Smith, BB1
Mattoon, JS1
Odle, J1
Benevenga, NJ1
Crenshaw, TD1
Whitaker, DA1
Smith, EJ1
Kelly, JM1
Tisdale, MJ1
Brennan, RA1

Clinical Trials (11)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk[NCT03851874]28 participants (Actual)Interventional2011-10-31Completed
Liraglutide in Obesity and Diabetes: Identification of CNS Targets Using fMRI[NCT01562678]Phase 428 participants (Actual)Interventional2012-03-31Completed
Saxenda: Underlying Mechanisms and Clinical Outcomes[NCT02944500]Phase 428 participants (Actual)Interventional2016-11-30Active, not recruiting
The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy[NCT02673515]60 participants (Actual)Interventional2015-04-30Completed
Use of Oral 40% Destrogel to Prevent Hypoglycaemia in Late-term Births and SGA or LGA Term Newborns[NCT04185766]172 participants (Actual)Interventional2018-11-23Completed
Impact of Pre-Military Life Experiences/Exposures on Active-Duty Service Members' Psychological Health and Adjustment Over a Marine Battalion Deployment Cycle[NCT06070025]300 participants (Anticipated)Observational2023-01-22Enrolling by invitation
Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)[NCT04358835]0 participants (Actual)Interventional2020-09-01Withdrawn (stopped due to Study did not begin enrollment, multiple competing studies at same institution)
Effectiveness of the Treatment With Dapagliflozin and Metformin Compared to Metformin Monotherapy for Weight Loss on Diabetic and Prediabetic Patients With Obesity Class III[NCT03968224]Phase 2/Phase 390 participants (Anticipated)Interventional2018-07-07Recruiting
Combined Effects of SGLT2 Inhibition and GLP-1 Receptor Agonism on Food Intake, Body Weight and Central Satiety and Reward Circuits in Obese T2DM Patients[NCT03361098]Phase 465 participants (Actual)Interventional2017-09-18Completed
Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome[NCT05469997]50 participants (Anticipated)Interventional2023-01-31Not yet recruiting
Effect of a Lipidic and Proteic Controlled Diet on Resting Energy Expenditure, Body Composition and Symptoms in Patients With Parkinson's Disease[NCT02687698]36 participants (Anticipated)Interventional2016-02-29Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change Between Highly Desirable vs. Less Desirable Food Cues in the Effect Size of Cortical Activation During Food Visualization

Effect size (region of interest z-scores, derived from z-maps of the brain) shown below is the difference in parietal cortex activation to highly desirable (high fat or high calorie, e.g. cakes, pies, fries) versus less desirable (low fat or low calorie, e.g. vegetables, fruits) food cues for each treatment condition (liraglutide or placebo) at the end of the treatment period. (NCT01562678)
Timeframe: 18 days of Liraglutide or placebo treatment

Interventionz-scores of activation in cortex (Mean)
Liraglutide-0.42
Placebo0.53

Insulin Sensitivity (HOMA-IR)

"HOMA-Index was calculated by using the following formula:~HOMA-IR= FPG(mmol/l)*FSI (U/l)/22.5 FSI=fasting serum insulin FPG=fasting plasma glucose" (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Mean)
Alternate Day Fasting0.05
Control Group0.06

Insulin Sensitivity (ISI-Index)

ISI was calculated by using the following formula: ISI=0,222-0,00333 x BMI-0,0000779 x Ins120-0,000422 x age FSI=fasting serum insulin FPG=fasting plasma glucose (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Median)
Alternate Day Fasting0
Control Group0

Insulin Sensitivity (Matsuda-Index)

"Matsuda index was calculated by using the following formula:~Matsuda-Index = 10000√(FPG∗FSI)∗(mean glucose*mean insulin) FSI=fasting serum insulin FPG=fasting plasma glucose" (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Median)
Alternate Day Fasting-0.4
Control Group-0.7

Insulin Sensitivity (QUICKI)

QUICKI was calculated by using the following formula: QUICKI= log(FSI)+log (FPG) FSI=fasting serum insulin FPG=fasting plasma glucose (NCT02673515)
Timeframe: 4 weeks (from Baseline to 4 weeks)

Interventionno unit (Median)
Alternate Day Fasting0
Control Group0

Blood Pressure (Systolic and Diastolic)

Change of blood pressure from Baseline to 4 weeks (NCT02673515)
Timeframe: 4 weeks

,
InterventionmmHg (Median)
Systolic blood pressureDiastolic blood pressure
Alternate Day Fasting-4.5-2.5
Control Group-10

Reviews

2 reviews available for 3-hydroxybutyric acid and Weight Loss

ArticleYear
Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Carbohydrates; Diet, Ketogenic; Humans; Ketone Bodies; Ketones

2022
Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss.
    Obesity (Silver Spring, Md.), 2016, Volume: 24, Issue:12

    Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Amino Acids, Branched-Chain; Bariatric Surgery; Behavior Ther

2016

Trials

12 trials available for 3-hydroxybutyric acid and Weight Loss

ArticleYear
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity.
    Metabolism: clinical and experimental, 2023, Volume: 138

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Citrates; Cohort Studies; Diabetes Mellitus, Type 2; Gastrecto

2023
Daily Intake of D-β-Hydroxybutyric Acid (D-BHB) Reduces Body Fat in Japanese Adult Participants: A Randomized, Double-Blind, Placebo-Controlled Study.
    Journal of nutritional science and vitaminology, 2023, Volume: 69, Issue:2

    Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Adult; Body Composition; Double-Blind Method; East Asian Peop

2023
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.
    Cell metabolism, 2019, 09-03, Volume: 30, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adult; Aging; Biomarkers; Body Mass Index; Caloric Restriction; Energy Intake

2019
Capillary Blood Ketone Levels as an Indicator of Inadequate Breast Milk Intake in the Early Neonatal Period.
    The Journal of pediatrics, 2017, Volume: 191

    Topics: 3-Hydroxybutyric Acid; Acid-Base Imbalance; Biomarkers; Breast Feeding; Capillaries; Dehydration; Fe

2017
Ascending dose-controlled trial of beloranib, a novel obesity treatment for safety, tolerability, and weight loss in obese women.
    Obesity (Silver Spring, Md.), 2013, Volume: 21, Issue:9

    Topics: 3-Hydroxybutyric Acid; Adiponectin; Aminopeptidases; Anti-Obesity Agents; Aspergillus; Biological Pr

2013
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.
    The American journal of clinical nutrition, 2011, Volume: 94, Issue:1

    Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Adult; Caloric Restriction; Dietary Carbohydrates; Energy Met

2011
Comparison of a low-fat diet to a low-carbohydrate diet on weight loss, body composition, and risk factors for diabetes and cardiovascular disease in free-living, overweight men and women.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:6

    Topics: 3-Hydroxybutyric Acid; Adult; Blood Pressure; Body Composition; Cardiovascular Diseases; Diabetes Me

2004
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Antiparkinson Agents; Cholesterol; Combined Modality The

2005
The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women.
    Physiological research, 2006, Volume: 55, Issue:1

    Topics: 3-Hydroxybutyric Acid; Caloric Restriction; Diet, Reducing; Dietary Supplements; Docosahexaenoic Aci

2006
Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets.
    The American journal of clinical nutrition, 2006, Volume: 83, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Arachidonic Acid; Body Composition; Body Mass Index; Cholesterol, LDL;

2006
Protein metabolism during weight reduction with very-low-energy diets: evaluation of the independent effects of protein and carbohydrate on protein sparing.
    The American journal of clinical nutrition, 1995, Volume: 62, Issue:1

    Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Ammonia; Analysis of Variance; Blood Glucose; Body Compos

1995
A randomised controlled trial of dietary energy restriction in the management of obese women with gestational diabetes.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2000, Volume: 40, Issue:4

    Topics: 3-Hydroxybutyric Acid; Adult; Birth Weight; Blood Glucose; Diabetes, Gestational; Diet, Reducing; En

2000

Other Studies

33 other studies available for 3-hydroxybutyric acid and Weight Loss

ArticleYear
Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 02-01, Volume: 322, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Asthma; Bronchial Hyperreactivity; Diet, High-Fat; Diet, Ketogenic;

2022
Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney.
    Molecular metabolism, 2022, Volume: 65

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Diet, High-Fat; Diet, Ketogenic; Dietary Carbohydrate

2022
Association between Fat-Free Mass Loss, Changes in Appetite, and Weight Regain in Individuals with Obesity.
    The Journal of nutrition, 2023, Volume: 153, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Appetite; Ghrelin; Humans; Male; Middle Aged; Obesity; Peptide YY; Wei

2023
Attenuation of stress-induced weight loss with a ketogenic diet.
    Physiology & behavior, 2019, 12-01, Volume: 212

    Topics: 3-Hydroxybutyric Acid; Animals; Behavior, Animal; Body Weight; Corticosterone; Corticotropin-Releasi

2019
Diabetic ketoacidosis at the onset of Type 1 diabetes in young children Is it time to launch a tailored campaign for DKA prevention in children <5 years?
    Acta bio-medica : Atenei Parmensis, 2018, 01-08, Volume: 89, Issue:1

    Topics: 3-Hydroxybutyric Acid; Adolescent; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diabetic Keto

2018
The effect of the transition period and postpartum body weight loss on macrophage infiltrates in bovine subcutaneous adipose tissue.
    Journal of dairy science, 2019, Volume: 102, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Diet; Energy Metabolism; Female; Lactation; Lipolysis; Macro

2019
Extended Ketogenic Diet and Physical Training Intervention in Military Personnel.
    Military medicine, 2019, 10-01, Volume: 184, Issue:9-10

    Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Adult; Body Composition; Diet, Ketogenic; Female; Humans; Mal

2019
NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T(1)AM treatment.
    Obesity (Silver Spring, Md.), 2013, Volume: 21, Issue:12

    Topics: 3-Hydroxybutyric Acid; Animals; Body Weight; Breath Tests; Dietary Proteins; Dose-Response Relations

2013
Ketosis and appetite-mediating nutrients and hormones after weight loss.
    European journal of clinical nutrition, 2013, Volume: 67, Issue:7

    Topics: 3-Hydroxybutyric Acid; Adult; Aged; Appetite Regulation; Body Mass Index; Caloric Restriction; Diet,

2013
The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cell Line, Tumor; Combined Modality Therapy; Diet, Ke

2013
Post-exercise changes of beta hydroxybutyrate as a predictor of weight changes.
    Physiological research, 2014, Volume: 63, Issue:Suppl 2

    Topics: 3-Hydroxybutyric Acid; Adult; Biomarkers; Exercise Therapy; Female; Humans; Middle Aged; Obesity; Ti

2014
Partial Amelioration of Peripheral and Central Symptoms of Huntington's Disease via Modulation of Lipid Metabolism.
    Journal of Huntington's disease, 2016, Volume: 5, Issue:1

    Topics: 3-Hydroxybutyric Acid; Animals; Cholesterol; Diet, Ketogenic; Female; Huntington Disease; Inhibitory

2016
Leptin levels, seasonality and thermal acclimation in the Microbiotherid marsupial Dromiciops gliroides: Does photoperiod play a role?
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2017, Volume: 203

    Topics: 3-Hydroxybutyric Acid; Acclimatization; Adiposity; Animals; Chile; Cholesterol; Hibernation; Leptin;

2017
Postprandial lipid-related metabolites are altered in dogs fed dietary diacylglycerol and low glycemic index starch during weight loss.
    The Journal of nutrition, 2010, Volume: 140, Issue:10

    Topics: 3-Hydroxybutyric Acid; Animals; Cholesterol; Dietary Carbohydrates; Dietary Fats; Diglycerides; Dog

2010
A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease.
    Physiology & behavior, 2011, Jul-06, Volume: 103, Issue:5

    Topics: 3-Hydroxybutyric Acid; Age Factors; Animals; Diet, Ketogenic; Disease Models, Animal; Female; Humans

2011
Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats.
    Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:8

    Topics: 3-Hydroxybutyric Acid; Animals; Anti-Obesity Agents; Benzhydryl Compounds; Blood Glucose; Caloric Re

2012
Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats.
    Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:8

    Topics: 3-Hydroxybutyric Acid; Animals; Anti-Obesity Agents; Benzhydryl Compounds; Blood Glucose; Caloric Re

2012
Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats.
    Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:8

    Topics: 3-Hydroxybutyric Acid; Animals; Anti-Obesity Agents; Benzhydryl Compounds; Blood Glucose; Caloric Re

2012
Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats.
    Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:8

    Topics: 3-Hydroxybutyric Acid; Animals; Anti-Obesity Agents; Benzhydryl Compounds; Blood Glucose; Caloric Re

2012
Effects of 2-mercaptoacetate on ingestive behavior in 18- and 21-day-old rats.
    Behavioural brain research, 2002, Nov-15, Volume: 136, Issue:2

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Suckling; Blood Glucose; Body Weight; Diet; Dose-Res

2002
Effect of fasting on vascular contractility in lean and obese Zucker rats.
    Clinical nutrition (Edinburgh, Scotland), 2003, Volume: 22, Issue:4

    Topics: 3-Hydroxybutyric Acid; Animals; Aorta, Thoracic; Blood Pressure; Disease Models, Animal; Epinephrine

2003
Urinary ketones reflect serum ketone concentration but do not relate to weight loss in overweight premenopausal women following a low-carbohydrate/high-protein diet.
    Journal of the American Dietetic Association, 2005, Volume: 105, Issue:4

    Topics: 3-Hydroxybutyric Acid; Adult; Biomarkers; Diet, Reducing; Dietary Carbohydrates; Dietary Proteins; F

2005
Body-mass management of Australian lightweight rowers prior to and during competition.
    Medicine and science in sports and exercise, 2005, Volume: 37, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Age Factors; Australia; Body Water; Body Weight; CD3 Complex; Dehydrat

2005
Rats treated with oleoyl-oestrone maintain glucidic homeostasis: comparisons with a pair-fed model.
    The British journal of nutrition, 2005, Volume: 94, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adiponectin; Administration, Oral; Animals; Anti-Obesity Agents; Blood Glucos

2005
Decreased insulin response in dairy cows following a four-day fast to induce hepatic lipidosis.
    Journal of dairy science, 2006, Volume: 89, Issue:8

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Composition; Cattle; Fasting; Fatty Acids, Nones

2006
Moderate diet restriction alters the substrate and hormone response to exercise.
    Medicine and science in sports and exercise, 1994, Volume: 26, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Body Composition; Carbohydrate Metabolism; Carbohydrate

1994
Ketosis is involved in the origin of prurigo pigmentosa.
    Journal of the American Academy of Dermatology, 1996, Volume: 34, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Diabetes Mellitus, Type 1; Feeding and Eating Disorders; F

1996
Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism.
    Poultry science, 1996, Volume: 75, Issue:11

    Topics: 3-Hydroxybutyric Acid; Albinism; Animals; Body Temperature; Body Weight; Chickens; Docosahexaenoic A

1996
Relationships among calving season, heat load, energy balance and postpartum ovulation of dairy cows in a subtropical environment.
    Animal reproduction science, 1997, Volume: 47, Issue:4

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cattle; Cohort Studies; Energy Metabolism; Female; Ho

1997
MCT/LCT emulsion ameliorate liver fat deposition in insulin-treated diabetic rats receiving total parenteral nutrition.
    Clinical nutrition (Edinburgh, Scotland), 1998, Volume: 17, Issue:6

    Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabete

1998
Increased plasma beta-hydroxybutyrate, preserved cerebral energy metabolism, and amelioration of brain damage during neonatal hypoxia ischemia with dexamethasone pretreatment.
    Pediatric research, 2000, Volume: 48, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Brain; Dexamethasone; Energy Metabolism; Hypoxia-I

2000
Propylene glycol toxicosis in a llama.
    Journal of the American Veterinary Medical Association, 2001, Jan-15, Volume: 218, Issue:2

    Topics: 3-Hydroxybutyric Acid; Abdomen; Animals; Anti-Ulcer Agents; Aspartate Aminotransferases; Camelids, N

2001
Metabolic changes and induction of hepatic lipidosis during feed restriction in llamas.
    American journal of veterinary research, 2001, Volume: 62, Issue:7

    Topics: 3-Hydroxybutyric Acid; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biopsy, Needle; C

2001
Utilization of medium-chain triglycerides by neonatal piglets: II. Effects of even- and odd-chain triglyceride consumption over the first 2 days of life on blood metabolites and urinary nitrogen excretion.
    Journal of animal science, 1989, Volume: 67, Issue:12

    Topics: 3-Hydroxybutyric Acid; Animals; Animals, Newborn; Blood Glucose; Hematocrit; Hydroxybutyrates; Nitro

1989
Milk production, weight changes and blood biochemical measurements in dairy cattle receiving recombinant bovine somatotropin.
    The Veterinary record, 1989, Jan-28, Volume: 124, Issue:4

    Topics: 3-Hydroxybutyric Acid; Animals; Cattle; Eating; Female; Growth Hormone; Hydroxybutyrates; Lactation;

1989
A comparison of long-chain triglycerides and medium-chain triglycerides on weight loss and tumour size in a cachexia model.
    British journal of cancer, 1988, Volume: 58, Issue:5

    Topics: 3-Hydroxybutyric Acid; Adenocarcinoma; Animals; Cachexia; Colonic Neoplasms; Dietary Fats; Disease M

1988